calcium channel blocker

One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools.

ChEBI ID: 38215

Members (36)

Member	Definition	Class
2-aminoethoxydiphenyl borate	An organoboron compound that is diphenylborane in which the borane hydrogen is replaced by a 2-aminoethoxy group.	2-aminoethoxydiphenylborane
amlodipine	A fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.	amlodipine
amlodipine besylate	The benzenesulfonate salt of amlodipine.	amlodipine benzenesulfonate
bepridil	A tertiary amine in which the substituents on nitrogen are benzyl, phenyl and 3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl.	bepridil
bevantolol	A propanolamine that is 3-aminopropane-1,2-diol in which the hydrogen of the primary hydroxy group is substituted by 3-methylphenyl and one of the hydrogens attached to the nitrogen is substituted by 2-(3,4-dimethoxyphenyl)ethyl. A beta1 adrenoceptor antagonist, it has been shown to be as effective as other beta-blockers for the treatment of angina pectoris and hypertension.	bevantolol
cilnidipine	A diesterified 1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium channel blocker, it is used as an antihypertensive.	cilnidipine
cinnarizine		cinnarizine
cobaltous chloride	A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.	cobalt dichloride
cromolyn	A dicarboxylic acid that is the bis-chromone derivative of glycerol. It is effective as a mast cell stabilizer.	cromoglycic acid
d 888	A nitrile that acts as an L-type calcium channel blocker.	devapamil
diethylstilbestrol	An olefinic compound that is trans-hex-3-ene in which the hydrogens at positions 3 and 4 have been replaced by p-hydroxyphenyl groups.	diethylstilbestrol
diltiazem	A 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate in which both stereocentres have S configuration. A calcium-channel blocker and vasodilator, it is used as the hydrochloride in the management of angina pectoris and hypertension.	diltiazem
diltiazem hydrochloride	A hydrochloride salt resulting from the reaction of equimolar amounts of diltiazem and hydrogen chloride. A calcium-channel blocker and vasodilator, it is used in the management of angina pectoris and hypertension.	diltiazem hydrochloride
dotarizine	An N-alkylpiperazine in which the two amino hydrogens of piperazine have been replaced by diphenylmethyl and 3-(2-phenyl-1,3-dioxolan-2-yl)propyl groups. A calcium channel blocker and serotonin (5-HT2) receptor antagonist used in the treatment of migraine.	dotarizine
eupatorin	A trimethoxyflavone that is 6-hydroxyluteolin in which the phenolic hydogens at positions 4', 6 and 7 have been replaced by methyl groups.	eupatorin
fasudil	An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.	fasudil
fasudil hydrochloride	A hydrochloride obtained by reaction of fasudil with one equivalent of hydrochloric acid.	fasudil hydrochloride
felodipine	The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.	felodipine
gabapentin	A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.	gabapentin
gsk-5498a	A member of the class of pyrazoles that is 1H-pyrazole substituted by 2-fluoro-6-(trifluoromethyl)benzyl and (2,6-difluorobenzoyl)amino groups at positions 1 and 3, respectively. It is a inhibitor of Ca(2+) release-activated Ca(2+) (CRAC) channel and inhibits the release of mast cell mediators and T-cell cytokines in human and rat preparations.	GSK-5498A
lamotrigine	A member of the class of 1,2,4-triazines in which the triazene skeleton is substituted by amino groups at positions 3 and 5, and by a 2,3-dichlorophenyl group at position 6.	lamotrigine
lanperisone	A 2-methyl-3-(pyrrolidin-1-yl)-1-[4-(trifluoromethyl)phenyl]propan-1-one in which the methyl group at position 2 adopts R-configuration. It is a muscle relaxant and induces ferroptosis in cancer cells.	lanperisone
magnesium sulfate	A magnesium salt having sulfate as the counterion.	magnesium sulfate
nemadipine-a	A dihydropyridine that is that is 1,4-dihydropyridine which is substituted at positions 2 and 6 by methyl groups, at positions 3 and 5 by ethoxycarbonyl groups, and at position 4 by a pentafluorophenyl group. An L-type calcium channel alpha1-subunit antagonist. When exposed to the microscopic soil nematode Caenorhabditis elegans, nemadipine-A induces a variety of defects including those affecting morphology and egg laying.	nemadipine-A
nickel chloride	A compound of nickel and chloride in which the ratio of nickel (in the +2 oxidation state) to chloride is 1:2.	nickel dichloride
nifedipine		nifedipine
nimodipine	A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.	nimodipine
nitrendipine	A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in the treatment of hypertension.	nitrendipine
ochratoxin a	A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.	ochratoxin A
ochratoxin b	A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid. Ochratoxin B differs from the more naturally abundant ochratoxin A in the absence of the dihydroisocoumarin chlorine atom. It has cytotoxic effects on kidney and liver cells in vitro but only minor effects in vivo, due to its rapid metabolism and excretion. It inhibits cell proliferation of human liver HepG2 cells at doses as low as 1 mug/ ml but lacks the genotoxic activity of ochratoxin A, even at higher concentrations.	ochratoxin B
oxybutynin	A racemate comprising equimolar amounts of (R)-oxybutynin and esoxybutynin. An antispasmodic used for the treatment of overactive bladder.	4-(diethylamino)but-2-yn-1-ol; oxybutynin
pregabalin	A gamma-amino acid that is gamma-aminobutyric acid (GABA) carrying an isobutyl substitutent at the beta-position (the S-enantiomer). Binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues.	pregabalin
thapsigargin	An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.	thapsigargin
tilmicosin	A macrolide antibiotic with formula C46H80N2O13. It is used for the treatment of respiratory disease in cattle at high risk of developing bovine respiratory disease associated with Mannheimia haemolytica.	tilmicosin
tranilast	An amidobenzoic acid that is anthranilic acid in which one of the anilino hydrogens is replaced by a 3,4-dimethoxycinnamoyl group.	tranilast
u-50488	A monocarboxylic acid amide obtained by formal condensation between the carboxy group of 3,4-dichlorophenylacetic acid and the secondary amino group of (1R,2R)-N-methyl-2-(pyrrolidin-1-yl)cyclohexanamine	U50488

Research

Studies (67,755)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	16,753 (24.73)	18.7374
1990's	16,291 (24.04)	18.2507
2000's	15,519 (22.90)	29.6817
2010's	15,081 (22.26)	24.3611
2020's	4,111 (6.07)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	10,252 (13.23%)	5.53%
Reviews	5,666 (7.31%)	6.00%
Case Studies	5,003 (6.46%)	4.05%
Observational	297 (0.38%)	0.25%
Other	56,277 (72.62%)	84.16%

Protein Targets (720)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	Homo sapiens (human)	Potency	22.8955	1	6
15-lipoxygenase, partial	Homo sapiens (human)	Potency	6.6102	1	2
67.9K protein	Vaccinia virus	Potency	12.5070	2	11
acetylcholinesterase	Homo sapiens (human)	Potency	17.7238	1	2
acid sphingomyelinase	Homo sapiens (human)	Potency	26.7449	1	4
activating transcription factor 6	Homo sapiens (human)	Potency	35.0860	1	3
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	26.5854	1	16
alpha-galactosidase	Homo sapiens (human)	Potency	27.7170	2	2
Alpha-synuclein	Homo sapiens (human)	Potency	31.2224	1	3
AR protein	Homo sapiens (human)	Potency	26.9987	11	73
aryl hydrocarbon receptor	Homo sapiens (human)	Potency	6.0008	2	14
arylsulfatase A	Homo sapiens (human)	Potency	11.2257	1	6
ATAD5 protein, partial	Homo sapiens (human)	Potency	16.3662	4	21
Ataxin-2	Homo sapiens (human)	Potency	18.1751	2	10
ATP-dependent phosphofructokinase	Trypanosoma brucei brucei TREU927	Potency	20.8752	3	11
ATPase family AAA domain-containing protein 5	Homo sapiens (human)	Potency	15.1681	2	7
atrial natriuretic peptide receptor 1 precursor	Homo sapiens (human)	Potency	9.3392	1	4
atrial natriuretic peptide receptor 2 precursor	Homo sapiens (human)	Potency	14.3981	1	4
beta-2 adrenergic receptor	Homo sapiens (human)	Potency	28.1838	1	1
Bloom syndrome protein isoform 1	Homo sapiens (human)	Potency	249.9047	2	14
bromodomain adjacent to zinc finger domain 2B	Homo sapiens (human)	Potency	62.0468	1	6
C-terminal-binding protein 1	Homo sapiens (human)	Potency	10.6928	1	1
caspase 7, apoptosis-related cysteine protease	Homo sapiens (human)	Potency	33.4915	1	1
caspase-3	Cricetulus griseus (Chinese hamster)	Potency	33.4915	1	1
caspase-3	Homo sapiens (human)	Potency	33.4915	1	1
Caspase-7	Cricetulus griseus (Chinese hamster)	Potency	33.4915	1	1
Cellular tumor antigen p53	Homo sapiens (human)	Potency	23.6021	3	19
cellular tumor antigen p53 isoform a	Homo sapiens (human)	Potency	18.4921	2	9
Chain A, 2-oxoglutarate Oxygenase	Homo sapiens (human)	Potency	24.4458	1	11
Chain A, Beta-lactamase	Escherichia coli K-12	Potency	80.1249	2	10
Chain A, Cruzipain	Trypanosoma cruzi	Potency	39.8107	1	5
Chain A, Ferritin light chain	Equus caballus (horse)	Potency	32.9390	2	10
Chain A, HADH2 protein	Homo sapiens (human)	Potency	19.8357	2	7
Chain A, JmjC domain-containing histone demethylation protein 3A	Homo sapiens (human)	Potency	61.3991	1	4
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	Homo sapiens (human)	Potency	15.4078	2	9
Chain A, Putative fructose-1,6-bisphosphate aldolase	Giardia intestinalis	Potency	12.7415	1	3
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	Homo sapiens (human)	Potency	31.2292	1	9
Chain B, HADH2 protein	Homo sapiens (human)	Potency	19.8357	2	7
chaperonin-containing TCP-1 beta subunit homolog	Homo sapiens (human)	Potency	15.8489	1	1
chromobox protein homolog 1	Homo sapiens (human)	Potency	29.2547	2	15
ClpP	Bacillus subtilis	Potency	11.2202	1	1
cytochrome P450 2C19 precursor	Homo sapiens (human)	Potency	11.8961	1	2
cytochrome P450 2C9 precursor	Homo sapiens (human)	Potency	23.7358	1	2
cytochrome P450 2C9, partial	Homo sapiens (human)	Potency	9.6487	1	10
cytochrome P450 2D6	Homo sapiens (human)	Potency	17.2448	1	15
cytochrome P450 2D6 isoform 1	Homo sapiens (human)	Potency	10.3120	1	5
cytochrome P450 3A4 isoform 1	Homo sapiens (human)	Potency	9.2320	2	24
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	6.0070	2	15
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	Homo sapiens (human)	Potency	29.7400	1	11
D(1A) dopamine receptor	Homo sapiens (human)	Potency	8.3011	3	11
D(1A) dopamine receptor	Sus scrofa (pig)	Potency	11.2815	1	3
Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)	Potency	25.1189	1	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	Homo sapiens (human)	Potency	19.9526	1	1
DNA polymerase beta	Homo sapiens (human)	Potency	79.4328	1	1
DNA polymerase III, partial	Bacillus subtilis	Potency	21.1923	1	1
DNA polymerase iota isoform a (long)	Homo sapiens (human)	Potency	29.9897	1	3
DNA polymerase kappa isoform 1	Homo sapiens (human)	Potency	25.3525	1	3
dopamine D1 receptor	Homo sapiens (human)	Potency	14.5580	1	2
endonuclease IV	Escherichia coli	Potency	10.9837	1	3
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	24.4724	12	77
estrogen receptor 2 (ER beta)	Homo sapiens (human)	Potency	24.3338	3	13
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	24.0881	9	85
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	17.5880	2	26
EWS/FLI fusion protein	Homo sapiens (human)	Potency	28.8101	4	11
eyes absent homolog 2 isoform a	Homo sapiens (human)	Potency	10.6928	1	1
farnesoid X nuclear receptor	Homo sapiens (human)	Potency	28.6709	5	20
flap endonuclease 1	Homo sapiens (human)	Potency	8.1310	1	3
Fumarate hydratase	Homo sapiens (human)	Potency	29.1362	1	8
G	Vesicular stomatitis virus	Potency	9.6487	1	10
GABA theta subunit	Rattus norvegicus (Norway rat)	Potency	9.2320	1	12
GALC protein	Homo sapiens (human)	Potency	0.7079	1	3
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Potency	9.2320	1	12
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Potency	9.2320	1	12
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Potency	9.2320	1	12
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Potency	9.2320	1	12
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Potency	9.2320	1	12
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Potency	9.2320	1	12
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Potency	9.2320	1	12
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Potency	9.2320	1	12
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Potency	9.2320	1	12
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Potency	9.2320	1	12
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Potency	9.2320	1	12
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Potency	9.2320	1	12
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Potency	9.2320	1	12
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Potency	9.2320	1	12
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Potency	9.2320	1	12
geminin	Homo sapiens (human)	Potency	19.7511	3	35
GLI family zinc finger 3	Homo sapiens (human)	Potency	19.9107	3	23
glp-1 receptor, partial	Homo sapiens (human)	Potency	12.7142	3	8
GLS protein	Homo sapiens (human)	Potency	12.8120	2	11
glucocerebrosidase	Homo sapiens (human)	Potency	37.0814	1	3
glucocorticoid receptor [Homo sapiens]	Homo sapiens (human)	Potency	19.0675	5	29
Glutamate receptor 2	Rattus norvegicus (Norway rat)	Potency	30.4688	1	7
GTP-binding nuclear protein Ran isoform 1	Homo sapiens (human)	Potency	3.6626	1	1
Guanine nucleotide-binding protein G	Homo sapiens (human)	Potency	28.1838	1	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	Homo sapiens (human)	Potency	17.6022	2	7
heat shock protein beta-1	Homo sapiens (human)	Potency	35.4333	2	8
Histamine H2 receptor	Cavia porcellus (domestic guinea pig)	Potency	18.5140	2	14
histone acetyltransferase KAT2A isoform 1	Homo sapiens (human)	Potency	37.0814	1	3
Histone H2A.x	Cricetulus griseus (Chinese hamster)	Potency	71.5271	2	4
histone-lysine N-methyltransferase 2A isoform 2 precursor	Homo sapiens (human)	Potency	30.7879	1	5
HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)	Potency	9.6487	1	10
huntingtin isoform 2	Homo sapiens (human)	Potency	27.9339	1	4
hypothetical protein, conserved	Trypanosoma brucei	Potency	16.7058	2	2
hypoxia-inducible factor 1 alpha subunit	Homo sapiens (human)	Potency	36.9184	2	9
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	Homo sapiens (human)	Potency	9.8589	3	13
IDH1	Homo sapiens (human)	Potency	18.4664	1	7
importin subunit beta-1 isoform 1	Homo sapiens (human)	Potency	3.6626	1	1
Inositol hexakisphosphate kinase 1	Homo sapiens (human)	Potency	9.6487	1	20
Inositol monophosphatase 1	Rattus norvegicus (Norway rat)	Potency	8.1724	2	11
Integrin alpha-IIb	Homo sapiens (human)	Potency	16.5301	1	5
Integrin beta-3	Homo sapiens (human)	Potency	16.5301	1	5
Interferon beta	Homo sapiens (human)	Potency	13.6783	3	20
interleukin 8	Homo sapiens (human)	Potency	74.9780	1	1
lamin isoform A-delta10	Homo sapiens (human)	Potency	15.0198	2	18
lethal factor (plasmid)	Bacillus anthracis str. A2012	Potency	20.0203	1	3
Luciferase	Photinus pyralis (common eastern firefly)	Potency	18.0830	4	8
lysosomal alpha-glucosidase preproprotein	Homo sapiens (human)	Potency	23.3507	4	4
M-phase phosphoprotein 8	Homo sapiens (human)	Potency	27.7326	1	10
Microtubule-associated protein tau	Homo sapiens (human)	Potency	15.6440	2	15
mitogen-activated protein kinase 1	Homo sapiens (human)	Potency	22.3902	2	11
muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)	Potency	11.6856	2	10
muscleblind-like protein 1 isoform 1	Homo sapiens (human)	Potency	33.9745	1	4
Neuronal acetylcholine receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Potency	11.2202	1	1
Neuronal acetylcholine receptor subunit beta-2	Rattus norvegicus (Norway rat)	Potency	11.2202	1	1
neuropeptide S receptor isoform A	Homo sapiens (human)	Potency	15.6485	3	8
NFKB1 protein, partial	Homo sapiens (human)	Potency	19.7020	2	4
nonstructural protein 1	Influenza A virus (A/WSN/1933(H1N1))	Potency	27.2150	1	9
NPC intracellular cholesterol transporter 1 precursor	Homo sapiens (human)	Potency	36.8537	1	4
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	30.2193	4	27
nuclear factor erythroid 2-related factor 2 isoform 2	Homo sapiens (human)	Potency	29.0929	1	2
nuclear factor NF-kappa-B p105 subunit isoform 1	Homo sapiens (human)	Potency	44.6684	1	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	Homo sapiens (human)	Potency	31.3193	1	3
Nuclear receptor ROR-gamma	Homo sapiens (human)	Potency	50.1579	1	2
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	15.1395	2	29
nuclear receptor subfamily 1, group I, member 2	Rattus norvegicus (Norway rat)	Potency	10.0000	1	1
nuclear receptor subfamily 1, group I, member 3	Homo sapiens (human)	Potency	17.4663	3	23
Ornithine decarboxylase	Rattus norvegicus (Norway rat)	Potency	19.9526	1	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	Homo sapiens (human)	Potency	35.4813	1	1
Parkin	Homo sapiens (human)	Potency	13.8115	3	11
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Homo sapiens (human)	Potency	57.9898	2	2
peripheral myelin protein 22	Rattus norvegicus (Norway rat)	Potency	14.5627	1	7
peripheral myelin protein 22 isoform 1	Homo sapiens (human)	Potency	58.7864	1	6
peroxisome proliferator activated receptor gamma	Homo sapiens (human)	Potency	23.0457	5	16
peroxisome proliferator-activated receptor delta	Homo sapiens (human)	Potency	37.1680	5	15
phosphopantetheinyl transferase	Bacillus subtilis	Potency	41.9124	2	10
PINK1	Homo sapiens (human)	Potency	39.8107	1	1
plasminogen precursor	Mus musculus (house mouse)	Potency	4.1692	1	2
polyprotein	Zika virus	Potency	29.1362	1	8
polyunsaturated fatty acid lipoxygenase ALOX12	Homo sapiens (human)	Potency	16.2676	1	4
Polyunsaturated fatty acid lipoxygenase ALOX15B	Homo sapiens (human)	Potency	14.5977	1	4
potassium voltage-gated channel subfamily H member 2 isoform d	Homo sapiens (human)	Potency	16.5608	1	7
PPM1D protein	Homo sapiens (human)	Potency	14.7136	1	4
pregnane X nuclear receptor	Homo sapiens (human)	Potency	25.3387	3	17
pregnane X receptor	Rattus norvegicus (Norway rat)	Potency	70.7946	1	1
progesterone receptor	Homo sapiens (human)	Potency	20.8600	2	14
pyruvate kinase	Leishmania mexicana mexicana	Potency	12.5893	2	2
pyruvate kinase PKM isoform b	Homo sapiens (human)	Potency	19.9526	2	2
Rap guanine nucleotide exchange factor 4	Homo sapiens (human)	Potency	48.5236	1	3
RAR-related orphan receptor gamma	Mus musculus (house mouse)	Potency	28.2631	2	19
ras-related protein Rab-9A	Homo sapiens (human)	Potency	21.0481	1	5
regulator of G-protein signaling 4	Homo sapiens (human)	Potency	18.3216	1	12
retinoic acid nuclear receptor alpha variant 1	Homo sapiens (human)	Potency	29.9903	3	21
retinoid X nuclear receptor alpha	Homo sapiens (human)	Potency	30.7044	4	17
serine/threonine-protein kinase mTOR isoform 1	Homo sapiens (human)	Potency	15.3707	4	12
serine/threonine-protein kinase PLK1	Homo sapiens (human)	Potency	17.3396	1	2
Single-stranded DNA cytosine deaminase	Homo sapiens (human)	Potency	50.1187	1	3
SMAD family member 2	Homo sapiens (human)	Potency	5.1298	2	2
SMAD family member 3	Homo sapiens (human)	Potency	5.1298	2	2
Smad3	Homo sapiens (human)	Potency	23.5754	1	8
snurportin-1	Homo sapiens (human)	Potency	3.6626	1	1
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	Potency	21.8525	1	11
survival motor neuron protein isoform d	Homo sapiens (human)	Potency	11.1840	1	9
TAR DNA-binding protein 43	Homo sapiens (human)	Potency	32.3756	1	5
TDP1 protein	Homo sapiens (human)	Potency	18.7610	2	71
thioredoxin glutathione reductase	Schistosoma mansoni	Potency	89.1251	1	1
thioredoxin reductase	Rattus norvegicus (Norway rat)	Potency	21.4361	4	23
Thrombopoietin	Homo sapiens (human)	Potency	5.7925	2	4
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	18.1584	3	32
thyroid hormone receptor beta isoform a	Homo sapiens (human)	Potency	446.5231	4	6
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	32.8082	5	20
tumor necrosis factor	Homo sapiens (human)	Potency	10.5909	1	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	Homo sapiens (human)	Potency	19.9040	2	2
urokinase plasminogen activator surface receptor precursor	Mus musculus (house mouse)	Potency	4.1692	1	2
urokinase-type plasminogen activator precursor	Mus musculus (house mouse)	Potency	4.1692	1	2
USP1 protein, partial	Homo sapiens (human)	Potency	44.6401	1	16
v-jun sarcoma virus 17 oncogene homolog (avian)	Homo sapiens (human)	Potency	24.0742	2	7
vitamin D (1,25- dihydroxyvitamin D3) receptor	Homo sapiens (human)	Potency	30.1923	5	12
vitamin D3 receptor isoform VDRA	Homo sapiens (human)	Potency	21.9800	5	32
Voltage-dependent calcium channel gamma-2 subunit	Mus musculus (house mouse)	Potency	30.4688	1	7

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	Homo sapiens (human)	IC50	8.3760	2	2
3-oxo-5-alpha-steroid 4-dehydrogenase 1	Rattus norvegicus (Norway rat)	IC50	1.1200	1	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	Rattus norvegicus (Norway rat)	IC50	1.1200	1	1
5-hydroxytryptamine receptor 1A	Rattus norvegicus (Norway rat)	IC50	1.0830	1	1
5-hydroxytryptamine receptor 1A	Rattus norvegicus (Norway rat)	Ki	0.6190	1	1
5-hydroxytryptamine receptor 1B	Rattus norvegicus (Norway rat)	IC50	1.0830	1	1
5-hydroxytryptamine receptor 1B	Rattus norvegicus (Norway rat)	Ki	0.6190	1	1
5-hydroxytryptamine receptor 2A	Homo sapiens (human)	IC50	2.5750	1	2
5-hydroxytryptamine receptor 2A	Rattus norvegicus (Norway rat)	IC50	10.0000	1	1
5-hydroxytryptamine receptor 2A	Homo sapiens (human)	Ki	0.7360	1	2
5-hydroxytryptamine receptor 2A	Rattus norvegicus (Norway rat)	Ki	0.0006	1	2
5-hydroxytryptamine receptor 2B	Homo sapiens (human)	IC50	1.5543	1	3
5-hydroxytryptamine receptor 2B	Homo sapiens (human)	Ki	0.9890	1	3
5-hydroxytryptamine receptor 2C	Homo sapiens (human)	IC50	34.5460	1	2
5-hydroxytryptamine receptor 2C	Homo sapiens (human)	Ki	18.0955	1	2
5-hydroxytryptamine receptor 4	Cavia porcellus (domestic guinea pig)	IC50	34.5460	1	2
5-hydroxytryptamine receptor 4	Cavia porcellus (domestic guinea pig)	Ki	18.0955	1	2
5-hydroxytryptamine receptor 6	Homo sapiens (human)	IC50	7.8950	1	2
5-hydroxytryptamine receptor 6	Homo sapiens (human)	Ki	3.6660	1	2
5-hydroxytryptamine receptor 7	Cavia porcellus (domestic guinea pig)	IC50	12.4000	1	2
Acetylcholinesterase	Homo sapiens (human)	IC50	25.5500	1	1
Adenosine receptor A1	Homo sapiens (human)	IC50	5.2785	1	2
Adenosine receptor A1	Homo sapiens (human)	Ki	3.0790	1	2
Adenosine receptor A2a	Homo sapiens (human)	IC50	9.0130	1	1
Adenosine receptor A2a	Homo sapiens (human)	Ki	73.3650	4	4
Adenosine receptor A2a	Rattus norvegicus (Norway rat)	Ki	23.8750	1	4
Adenosine receptor A3	Homo sapiens (human)	IC50	3.4930	1	3
Adenosine receptor A3	Homo sapiens (human)	Ki	6.1591	3	8
Aldehyde oxidase	Homo sapiens (human)	IC50	0.4600	1	1
Aldo-keto reductase family 1 member B1	Rattus norvegicus (Norway rat)	IC50	3.0324	1	3
Aldo-keto reductase family 1 member B1	Rattus norvegicus (Norway rat)	Ki	1.9203	2	5
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	3.4930	1	3
Alpha-1A adrenergic receptor	Homo sapiens (human)	Ki	2.3440	1	1
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	1.9743	1	3
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	3.4930	1	3
Alpha-1B adrenergic receptor	Homo sapiens (human)	Ki	7.9430	1	1
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	1.9743	1	3
Alpha-1D adrenergic receptor	Homo sapiens (human)	IC50	5.9965	1	2
Alpha-1D adrenergic receptor	Homo sapiens (human)	Ki	3.7547	2	3
Alpha-2A adrenergic receptor	Homo sapiens (human)	IC50	5.0577	1	3
Alpha-2A adrenergic receptor	Homo sapiens (human)	Ki	1.8967	1	3
Alpha-2A adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	5.3700	1	1
Alpha-2B adrenergic receptor	Homo sapiens (human)	IC50	6.9700	1	2
Alpha-2B adrenergic receptor	Homo sapiens (human)	Ki	3.1815	1	2
Alpha-2B adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	5.3700	1	1
Alpha-2C adrenergic receptor	Homo sapiens (human)	IC50	5.8677	1	3
Alpha-2C adrenergic receptor	Homo sapiens (human)	Ki	0.8523	1	3
Alpha-2C adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	5.3700	1	1
Amyloid-beta precursor protein	Homo sapiens (human)	Ki	0.0059	1	1
Androgen receptor	Rattus norvegicus (Norway rat)	IC50	14.1254	1	1
ATP-binding cassette sub-family C member 3	Homo sapiens (human)	IC50	133.0000	1	10
ATP-dependent translocase ABCB1	Homo sapiens (human)	IC50	88.9563	10	12
Beta-1 adrenergic receptor	Homo sapiens (human)	IC50	22.0880	1	1
Beta-1 adrenergic receptor	Homo sapiens (human)	Ki	12.7550	1	1
Bile acid receptor	Homo sapiens (human)	IC50	6.9600	1	2
Bile salt export pump	Homo sapiens (human)	IC50	170.4696	6	26
Bile salt export pump	Rattus norvegicus (Norway rat)	IC50	522.7000	1	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	IC50	156.2397	6	6
C-C chemokine receptor type 2	Homo sapiens (human)	IC50	24.0637	3	3
C-C chemokine receptor type 2	Homo sapiens (human)	Ki	0.8470	1	1
C-C motif chemokine 2	Homo sapiens (human)	IC50	6.9183	1	1
Calcium release-activated calcium channel protein 1	Homo sapiens (human)	IC50	1.0000	1	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	Homo sapiens (human)	IC50	4.3643	1	3
cAMP-dependent protein kinase catalytic subunit alpha	Bos taurus (cattle)	IC50	1.8043	1	12
cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)	IC50	4.5800	1	1
cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)	Ki	0.4600	1	1
cAMP-dependent protein kinase catalytic subunit alpha	Mus musculus (house mouse)	Ki	0.4950	1	2
cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)	IC50	4.5800	1	1
cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)	Ki	0.4600	1	1
cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)	IC50	4.5800	1	1
cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)	Ki	0.4600	1	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	IC50	7.1500	1	1
Canalicular multispecific organic anion transporter 1	Homo sapiens (human)	IC50	125.5000	2	10
Cannabinoid receptor 1	Homo sapiens (human)	IC50	1.7360	1	1
Cannabinoid receptor 1	Homo sapiens (human)	Ki	1.3710	1	1
Carbonic anhydrase 1	Homo sapiens (human)	IC50	91.5000	1	2
Carbonic anhydrase 2	Homo sapiens (human)	IC50	91.5000	1	2
Cathepsin B	Homo sapiens (human)	IC50	50.0000	1	1
Cell division control protein 42 homolog	Homo sapiens (human)	IC50	6.5000	2	2
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit	Bos taurus (cattle)	IC50	2.2800	1	5
Chain A, Rho-associated protein kinase 1	Homo sapiens (human)	Ki	0.5300	1	3
Chain B, Rho-associated protein kinase 1	Homo sapiens (human)	Ki	0.5300	1	1
Chain E, cAMP-dependent protein kinase, alpha-catalytic subunit	Mus musculus (house mouse)	Ki	0.5300	1	1
Chain I, cAMP-dependent protein kinase inhibitor alpha	synthetic construct	IC50	2.2800	1	2
Chain I, cAMP-dependent protein kinase inhibitor, alpha form	synthetic construct	Ki	0.5300	1	1
Cruzipain	Trypanosoma cruzi	IC50	212.0000	2	2
Cysteinyl leukotriene receptor 1	Homo sapiens (human)	IC50	17.7450	1	1
Cysteinyl leukotriene receptor 1	Homo sapiens (human)	Ki	8.8720	1	1
Cytochrome P450 1A1	Homo sapiens (human)	Ki	0.2100	1	1
Cytochrome P450 1A2	Homo sapiens (human)	IC50	0.3000	1	1
Cytochrome P450 1B1	Homo sapiens (human)	Ki	0.0350	2	2
Cytochrome P450 2C19	Homo sapiens (human)	IC50	2.5333	1	3
Cytochrome P450 2C9	Homo sapiens (human)	IC50	10.5456	2	7
Cytochrome P450 2J2	Homo sapiens (human)	IC50	16.9850	1	4
Cytochrome P450 3A4	Homo sapiens (human)	IC50	69.0240	3	4
Cytochrome P450 3A4	Homo sapiens (human)	Ki	1.3500	2	2
D(1A) dopamine receptor	Homo sapiens (human)	IC50	7.7630	1	1
D(1A) dopamine receptor	Homo sapiens (human)	Ki	3.8820	1	1
D(2) dopamine receptor	Homo sapiens (human)	IC50	7.0485	1	2
D(2) dopamine receptor	Homo sapiens (human)	Ki	2.3495	1	2
D(3) dopamine receptor	Homo sapiens (human)	IC50	3.1589	1	3
D(3) dopamine receptor	Homo sapiens (human)	Ki	1.0729	1	3
Delta-type opioid receptor	Homo sapiens (human)	IC50	2.7180	1	1
Delta-type opioid receptor	Rattus norvegicus (Norway rat)	IC50	8.7167	2	3
Delta-type opioid receptor	Homo sapiens (human)	Ki	5.9553	6	9
Delta-type opioid receptor	Mus musculus (house mouse)	Ki	3.2500	4	4
Delta-type opioid receptor	Rattus norvegicus (Norway rat)	Ki	5.0000	1	1
Dihydrofolate reductase	Escherichia coli K-12	IC50	348.9000	1	1
Dihydrofolate reductase	Escherichia coli K-12	Ki	15.2400	1	1
Estrogen receptor	Homo sapiens (human)	IC50	0.1312	6	6
Estrogen receptor	Homo sapiens (human)	Ki	0.0002	5	5
Estrogen receptor 1	Homo sapiens (human)	IC50	50.0000	1	1
Estrogen receptor beta	Homo sapiens (human)	IC50	0.1588	4	4
Estrogen receptor beta	Homo sapiens (human)	Ki	0.0003	3	3
estrogen receptor beta isoform 1	Homo sapiens (human)	IC50	50.0000	1	1
fructose-bisphosphate aldolase	Mycobacterium tuberculosis H37Rv	IC50	9.9910	1	1
G-protein coupled receptor 35	Homo sapiens (human)	Ki	2.3400	1	1
G-protein coupled receptor 55	Homo sapiens (human)	IC50	1.4652	1	1
Glucocorticoid receptor	Homo sapiens (human)	IC50	10.6000	1	1
Glucocorticoid receptor	Homo sapiens (human)	Ki	4.8180	1	1
Glutathione reductase, mitochondrial	Homo sapiens (human)	IC50	23.4000	1	1
Glutathione reductase, mitochondrial	Homo sapiens (human)	Ki	17.4000	1	1
Glycine receptor subunit alpha-1	Rattus norvegicus (Norway rat)	IC50	10.6000	1	1
Glycine receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Ki	4.8180	1	1
Glycine receptor subunit alpha-2	Rattus norvegicus (Norway rat)	IC50	10.6000	1	1
Glycine receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Ki	4.8180	1	1
Glycine receptor subunit alpha-3	Rattus norvegicus (Norway rat)	IC50	10.6000	1	1
Glycine receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Ki	4.8180	1	1
Glycine receptor subunit beta	Rattus norvegicus (Norway rat)	IC50	10.6000	1	1
Glycine receptor subunit beta	Rattus norvegicus (Norway rat)	Ki	4.8180	1	1
Hematopoietic prostaglandin D synthase	Homo sapiens (human)	IC50	11.6000	2	2
high affinity choline transporter 1 isoform a	Homo sapiens (human)	IC50	12.5893	1	1
Histamine H1 receptor	Homo sapiens (human)	IC50	0.0740	1	1
Histamine H1 receptor	Homo sapiens (human)	Ki	0.0086	1	1
Indoleamine 2,3-dioxygenase 1	Mus musculus (house mouse)	IC50	46.0000	1	1
Indoleamine 2,3-dioxygenase 2	Mus musculus (house mouse)	IC50	1.5000	1	1
Kappa-type opioid receptor	Cavia porcellus (domestic guinea pig)	IC50	0.0958	2	2
Kappa-type opioid receptor	Homo sapiens (human)	IC50	0.3543	14	15
Kappa-type opioid receptor	Mus musculus (house mouse)	IC50	0.0027	2	3
Kappa-type opioid receptor	Rattus norvegicus (Norway rat)	IC50	5.2303	4	5
Kappa-type opioid receptor	Cavia porcellus (domestic guinea pig)	Ki	0.0191	13	16
Kappa-type opioid receptor	Homo sapiens (human)	Ki	0.0756	26	27
Kappa-type opioid receptor	Mus musculus (house mouse)	Ki	0.0081	1	1
Kappa-type opioid receptor	Rattus norvegicus (Norway rat)	Ki	0.0005	2	2
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase	Mycobacterium tuberculosis H37Rv	IC50	2,500.0000	1	1
Lethal factor	Bacillus anthracis	IC50	4.8000	1	1
Lethal(3)malignant brain tumor-like protein 1	Homo sapiens (human)	IC50	100.0000	1	1
Lethal(3)malignant brain tumor-like protein 3	Homo sapiens (human)	IC50	54.0000	1	1
Lethal(3)malignant brain tumor-like protein 4	Homo sapiens (human)	IC50	100.0000	1	1
MBT domain-containing protein 1	Homo sapiens (human)	IC50	100.0000	1	1
Mitogen-activated protein kinase 14	Homo sapiens (human)	IC50	32.9030	1	1
MO15-related protein kinase Pfmrk	Plasmodium falciparum (malaria parasite P. falciparum)	IC50	500.0000	1	1
Mu-type opioid receptor	Homo sapiens (human)	IC50	4.0250	1	2
Mu-type opioid receptor	Rattus norvegicus (Norway rat)	IC50	8.7167	2	3
Mu-type opioid receptor	Cavia porcellus (domestic guinea pig)	Ki	0.5226	6	13
Mu-type opioid receptor	Homo sapiens (human)	Ki	1.1857	2	3
Mu-type opioid receptor	Mus musculus (house mouse)	Ki	0.5050	3	4
Mu-type opioid receptor	Rattus norvegicus (Norway rat)	Ki	1.3345	5	6
Multidrug resistance-associated protein 4	Homo sapiens (human)	IC50	108.1600	1	10
Muscarinic acetylcholine receptor M1	Homo sapiens (human)	IC50	5.8958	1	3
Muscarinic acetylcholine receptor M1	Homo sapiens (human)	Ki	0.8526	3	5
Muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)	Ki	0.0059	1	1
Muscarinic acetylcholine receptor M2	Homo sapiens (human)	IC50	0.0270	1	1
Muscarinic acetylcholine receptor M2	Homo sapiens (human)	Ki	0.0114	4	4
Muscarinic acetylcholine receptor M2	Rattus norvegicus (Norway rat)	Ki	0.0105	2	2
Muscarinic acetylcholine receptor M3	Homo sapiens (human)	IC50	6.3989	1	3
Muscarinic acetylcholine receptor M3	Homo sapiens (human)	Ki	0.6789	4	6
Muscarinic acetylcholine receptor M3	Rattus norvegicus (Norway rat)	Ki	0.0031	2	2
Muscarinic acetylcholine receptor M4	Homo sapiens (human)	IC50	1.8310	1	2
Muscarinic acetylcholine receptor M4	Homo sapiens (human)	Ki	0.1713	2	3
Muscarinic acetylcholine receptor M5	Homo sapiens (human)	IC50	0.3811	1	2
Muscarinic acetylcholine receptor M5	Homo sapiens (human)	Ki	0.1871	2	3
Myosin light chain kinase, smooth muscle	Homo sapiens (human)	IC50	9.0733	3	3
Myosin light chain kinase, smooth muscle	Homo sapiens (human)	Ki	36.0000	1	1
Myotonin-protein kinase	Homo sapiens (human)	IC50	8.0000	1	1
NACHT, LRR and PYD domains-containing protein 3	Mus musculus (house mouse)	IC50	25.0000	1	1
NEDD8-activating enzyme E1 regulatory subunit isoform a	Homo sapiens (human)	IC50	34.7000	1	1
NEDD8-conjugating enzyme Ubc12	Homo sapiens (human)	IC50	34.7000	1	1
Nuclear receptor subfamily 1 group I member 2	Homo sapiens (human)	IC50	14.6000	1	1
perilipin-1	Homo sapiens (human)	IC50	9.6190	1	1
perilipin-5	Homo sapiens (human)	IC50	7.1330	1	1
Platelet-activating factor receptor	Cavia porcellus (domestic guinea pig)	Ki	73.3100	1	1
Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)	Ki	0.0001	1	1
Polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus (rabbit)	IC50	9.0320	1	2
Potassium channel subfamily K member 2	Homo sapiens (human)	IC50	0.4000	1	1
Potassium channel subfamily K member 2	Bos taurus (cattle)	IC50	4.3150	1	2
Potassium voltage-gated channel subfamily A member 1	Homo sapiens (human)	IC50	120.0000	1	2
Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)	IC50	6.1000	1	1
Potassium voltage-gated channel subfamily E member 1	Homo sapiens (human)	IC50	158.4890	1	1
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	IC50	64.4288	18	32
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	Ki	6.5095	4	4
Potassium voltage-gated channel subfamily KQT member 1	Homo sapiens (human)	IC50	158.4890	1	1
procathepsin L isoform 1 preproprotein	Homo sapiens (human)	IC50	50.0000	1	1
Prostaglandin G/H synthase 1	Homo sapiens (human)	IC50	5.6000	1	1
Protein kinase C epsilon type	Homo sapiens (human)	IC50	3.0000	2	2
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)	IC50	1.1000	1	1
Rho-associated protein kinase 1	Homo sapiens (human)	IC50	1.0502	10	10
Rho-associated protein kinase 1	Homo sapiens (human)	Ki	0.4300	6	7
Rho-associated protein kinase 2	Bos taurus (cattle)	IC50	1.8042	1	12
Rho-associated protein kinase 2	Homo sapiens (human)	IC50	1.3060	14	14
Rho-associated protein kinase 2	Rattus norvegicus (Norway rat)	IC50	1.9000	1	1
Rho-associated protein kinase 2	Homo sapiens (human)	Ki	0.3300	1	1
Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)	IC50	5.0000	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	Oryctolagus cuniculus (rabbit)	IC50	21.0010	4	4
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	Homo sapiens (human)	Ki	0.0001	1	1
Serine/threonine-protein kinase N1	Homo sapiens (human)	IC50	1.7000	1	1
Serine/threonine-protein kinase N2	Homo sapiens (human)	IC50	1.8533	3	3
Sigma non-opioid intracellular receptor 1	Homo sapiens (human)	IC50	0.0321	1	2
Sigma non-opioid intracellular receptor 1	Rattus norvegicus (Norway rat)	IC50	10.0000	1	1
Sigma non-opioid intracellular receptor 1	Homo sapiens (human)	Ki	0.0136	1	2
Sodium channel protein type 1 subunit alpha	Homo sapiens (human)	IC50	27.3333	3	3
Sodium channel protein type 1 subunit alpha	Rattus norvegicus (Norway rat)	IC50	82.6333	2	3
Sodium channel protein type 10 subunit alpha	Homo sapiens (human)	IC50	55.2000	5	5
Sodium channel protein type 11 subunit alpha	Homo sapiens (human)	IC50	27.3333	3	3
Sodium channel protein type 2 subunit alpha	Homo sapiens (human)	IC50	34.8333	6	6
Sodium channel protein type 2 subunit alpha	Rattus norvegicus (Norway rat)	IC50	63.5800	4	5
Sodium channel protein type 3 subunit alpha	Homo sapiens (human)	IC50	24.7500	4	4
Sodium channel protein type 3 subunit alpha	Rattus norvegicus (Norway rat)	IC50	82.6333	2	3
Sodium channel protein type 4 subunit alpha	Homo sapiens (human)	IC50	27.3333	3	3
Sodium channel protein type 4 subunit alpha	Homo sapiens (human)	Ki	17.0000	1	1
Sodium channel protein type 5 subunit alpha	Homo sapiens (human)	IC50	41.0730	7	7
Sodium channel protein type 7 subunit alpha	Homo sapiens (human)	IC50	27.3333	3	3
Sodium channel protein type 8 subunit alpha	Homo sapiens (human)	IC50	27.3333	3	3
Sodium channel protein type 9 subunit alpha	Homo sapiens (human)	IC50	24.7500	4	4
Sodium-dependent dopamine transporter	Homo sapiens (human)	IC50	2.0796	1	4
Sodium-dependent dopamine transporter	Homo sapiens (human)	Ki	1.6525	1	4
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	IC50	4.7743	2	4
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	Ki	4.7554	2	4
Sodium-dependent serotonin transporter	Homo sapiens (human)	IC50	6.7910	1	2
Sodium-dependent serotonin transporter	Homo sapiens (human)	Ki	3.6080	1	2
Solute carrier family 22 member 1	Homo sapiens (human)	IC50	12.4000	1	1
Solute carrier family 22 member 20	Mus musculus (house mouse)	Ki	48.9890	1	2
Solute carrier family 22 member 6	Mus musculus (house mouse)	Ki	6.2548	1	2
Stromal interaction molecule 1	Homo sapiens (human)	IC50	1.0000	1	1
Substance-K receptor	Homo sapiens (human)	IC50	9.5530	1	1
Substance-K receptor	Homo sapiens (human)	Ki	3.1840	1	1
Thromboxane-A synthase	Homo sapiens (human)	IC50	340.9843	2	3
Transient receptor potential cation channel subfamily A member 1	Homo sapiens (human)	IC50	125.9465	1	2
Transient receptor potential cation channel subfamily M member 2	Homo sapiens (human)	IC50	1.8800	5	5
Transient receptor potential cation channel subfamily V member 2	Homo sapiens (human)	IC50	10.0000	1	1
Tyrosine-protein kinase Fyn	Homo sapiens (human)	IC50	14.2330	1	1
ubiquitin-conjugating enzyme E2 N	Homo sapiens (human)	IC50	20.0000	1	1
UDP-glucose 4-epimerase	Homo sapiens (human)	IC50	75.0000	1	1
Vasopressin V1a receptor	Homo sapiens (human)	IC50	25.9250	1	1
Vasopressin V1a receptor	Homo sapiens (human)	Ki	10.4010	1	1
Voltage-dependent calcium channel gamma-1 subunit	Homo sapiens (human)	IC50	14.0000	1	1
Voltage-dependent calcium channel gamma-2 subunit	Homo sapiens (human)	IC50	14.0000	1	1
Voltage-dependent calcium channel gamma-3 subunit	Homo sapiens (human)	IC50	14.0000	1	1
Voltage-dependent calcium channel gamma-4 subunit	Homo sapiens (human)	IC50	14.0000	1	1
Voltage-dependent calcium channel gamma-5 subunit	Homo sapiens (human)	IC50	14.0000	1	1
Voltage-dependent calcium channel gamma-6 subunit	Homo sapiens (human)	IC50	14.0000	1	1
Voltage-dependent calcium channel gamma-7 subunit	Homo sapiens (human)	IC50	14.0000	1	1
Voltage-dependent calcium channel gamma-8 subunit	Homo sapiens (human)	IC50	14.0000	1	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	Homo sapiens (human)	IC50	7.0149	2	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	Homo sapiens (human)	Ki	0.0190	2	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	Mus musculus (house mouse)	Ki	0.1201	1	2
Voltage-dependent calcium channel subunit alpha-2/delta-2	Homo sapiens (human)	IC50	14.0000	1	1
Voltage-dependent calcium channel subunit alpha-2/delta-2	Homo sapiens (human)	Ki	0.0990	1	1
Voltage-dependent calcium channel subunit alpha-2/delta-3	Homo sapiens (human)	IC50	14.0000	1	1
Voltage-dependent calcium channel subunit alpha-2/delta-4	Homo sapiens (human)	IC50	14.0000	1	1
Voltage-dependent L-type calcium channel subunit alpha-1C	Cavia porcellus (domestic guinea pig)	IC50	2.5340	9	19
Voltage-dependent L-type calcium channel subunit alpha-1C	Homo sapiens (human)	IC50	134.1453	22	22
Voltage-dependent L-type calcium channel subunit alpha-1C	Mus musculus (house mouse)	IC50	1.2000	1	1
Voltage-dependent L-type calcium channel subunit alpha-1C	Rattus norvegicus (Norway rat)	IC50	9.6969	8	11
Voltage-dependent L-type calcium channel subunit alpha-1C	Homo sapiens (human)	Ki	0.0077	2	4
Voltage-dependent L-type calcium channel subunit alpha-1C	Rattus norvegicus (Norway rat)	Ki	0.0518	6	8
Voltage-dependent L-type calcium channel subunit alpha-1D	Mus musculus (house mouse)	IC50	1.2000	1	1
Voltage-dependent L-type calcium channel subunit alpha-1D	Rattus norvegicus (Norway rat)	IC50	0.6723	4	4
Voltage-dependent L-type calcium channel subunit alpha-1D	Rattus norvegicus (Norway rat)	Ki	0.0257	4	5
Voltage-dependent L-type calcium channel subunit alpha-1D	Homo sapiens (human)	IC50	3.9660	10	10
Voltage-dependent L-type calcium channel subunit alpha-1D	Homo sapiens (human)	Ki	0.0147	1	2
Voltage-dependent L-type calcium channel subunit alpha-1F	Homo sapiens (human)	IC50	4.2567	9	9
Voltage-dependent L-type calcium channel subunit alpha-1F	Mus musculus (house mouse)	IC50	1.2000	1	1
Voltage-dependent L-type calcium channel subunit alpha-1F	Homo sapiens (human)	Ki	0.0147	1	2
Voltage-dependent L-type calcium channel subunit alpha-1S	Homo sapiens (human)	IC50	4.2567	9	9
Voltage-dependent L-type calcium channel subunit alpha-1S	Mus musculus (house mouse)	IC50	1.2000	1	1
Voltage-dependent L-type calcium channel subunit alpha-1S	Rattus norvegicus (Norway rat)	IC50	0.6723	4	4
Voltage-dependent L-type calcium channel subunit alpha-1S	Homo sapiens (human)	Ki	0.0147	1	2
Voltage-dependent L-type calcium channel subunit alpha-1S	Rattus norvegicus (Norway rat)	Ki	0.0220	4	6
Voltage-dependent L-type calcium channel subunit beta-1	Homo sapiens (human)	IC50	14.0000	1	1
Voltage-dependent L-type calcium channel subunit beta-2	Homo sapiens (human)	IC50	7.0149	2	2
Voltage-dependent L-type calcium channel subunit beta-3	Homo sapiens (human)	IC50	14.0000	1	1
Voltage-dependent L-type calcium channel subunit beta-4	Homo sapiens (human)	IC50	14.0000	1	1
Voltage-dependent N-type calcium channel subunit alpha-1B	Homo sapiens (human)	IC50	16.9000	4	4
Voltage-dependent P/Q-type calcium channel subunit alpha-1A	Homo sapiens (human)	IC50	14.0000	1	1
Voltage-dependent R-type calcium channel subunit alpha-1E	Homo sapiens (human)	IC50	14.0000	1	1
Voltage-dependent T-type calcium channel subunit alpha-1G	Homo sapiens (human)	IC50	14.0000	1	1
Voltage-dependent T-type calcium channel subunit alpha-1H	Homo sapiens (human)	IC50	19.0000	2	2
Voltage-dependent T-type calcium channel subunit alpha-1I	Homo sapiens (human)	IC50	14.0000	1	1

Activation Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
26S proteasome regulatory subunit 6B	Homo sapiens (human)	Kd	30.0000	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)	Kd	30.0000	1	1
5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)	Kd	30.0000	1	1
5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)	Kd	30.0000	1	1
AarF domain-containing protein kinase 1	Homo sapiens (human)	Kd	30.0000	1	1
Actin-related protein 2	Homo sapiens (human)	Kd	30.0000	1	1
Actin-related protein 3	Homo sapiens (human)	Kd	30.0000	1	1
Activated CDC42 kinase 1	Homo sapiens (human)	Kd	30.0000	1	1
Activin receptor type-1	Homo sapiens (human)	Kd	30.0000	1	1
Activin receptor type-1B	Homo sapiens (human)	Kd	30.0000	1	1
Activin receptor type-2B	Homo sapiens (human)	Kd	30.0000	1	1
Acyl-CoA dehydrogenase family member 10	Homo sapiens (human)	Kd	30.0000	1	1
Acyl-CoA dehydrogenase family member 11	Homo sapiens (human)	Kd	30.0000	1	1
Adenine phosphoribosyltransferase	Homo sapiens (human)	Kd	30.0000	1	1
Adenosine kinase	Homo sapiens (human)	Kd	30.0000	1	1
Adenylate kinase 2, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	1
ADP/ATP translocase 2	Homo sapiens (human)	Kd	30.0000	1	1
ADP/ATP translocase 3	Homo sapiens (human)	Kd	30.0000	1	1
AP2-associated protein kinase 1	Homo sapiens (human)	Kd	30.0000	1	1
ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)	Kd	30.0000	1	1
ATP-dependent RNA helicase DDX1	Homo sapiens (human)	Kd	30.0000	1	1
ATP-dependent RNA helicase DDX3X	Homo sapiens (human)	Kd	30.0000	1	1
ATP-dependent RNA helicase DDX42	Homo sapiens (human)	Kd	30.0000	1	1
ATP-dependent RNA helicase DHX30	Homo sapiens (human)	Kd	30.0000	1	2
Atypical kinase COQ8A, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	1
Aurora kinase A	Homo sapiens (human)	Kd	30.0000	1	1
Aurora kinase B	Homo sapiens (human)	Kd	15.5700	2	2
Beta-adrenergic receptor kinase 1	Homo sapiens (human)	Kd	30.0000	1	1
BMP-2-inducible protein kinase	Homo sapiens (human)	Kd	33.7880	1	1
Bone morphogenetic protein receptor type-1A	Homo sapiens (human)	Kd	30.0000	1	1
Bone morphogenetic protein receptor type-1B	Homo sapiens (human)	Kd	30.0000	1	1
Bone morphogenetic protein receptor type-2	Homo sapiens (human)	Kd	30.0000	1	1
Breakpoint cluster region protein	Homo sapiens (human)	Kd	30.0000	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)	Kd	30.0000	1	1
Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)	Kd	30.0000	1	1
Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)	Kd	30.0000	1	1
Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)	Kd	30.0000	1	2
cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)	Kd	30.0000	1	1
cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)	Kd	30.0000	1	1
cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)	Kd	30.0000	1	1
cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)	Kd	30.0000	1	1
Casein kinase I isoform alpha	Homo sapiens (human)	Kd	30.0000	1	1
Casein kinase I isoform delta	Homo sapiens (human)	Kd	30.0000	1	1
Casein kinase I isoform epsilon	Homo sapiens (human)	Kd	30.0000	1	1
Casein kinase I isoform gamma-1	Homo sapiens (human)	Kd	30.0000	1	1
Casein kinase I isoform gamma-2	Homo sapiens (human)	Kd	30.0000	1	1
Casein kinase I isoform gamma-3	Homo sapiens (human)	Kd	30.0000	1	1
Casein kinase II subunit alpha'	Homo sapiens (human)	Kd	30.0000	1	1
Cell division cycle 7-related protein kinase	Homo sapiens (human)	Kd	30.0000	1	1
cGMP-dependent protein kinase 1	Homo sapiens (human)	Kd	30.0000	1	1
Choline-phosphate cytidylyltransferase A	Homo sapiens (human)	Kd	30.0000	1	1
Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)	Kd	30.0000	1	1
Citron Rho-interacting kinase	Homo sapiens (human)	Kd	48.8760	1	1
Cyclin-dependent kinase 1	Homo sapiens (human)	Kd	30.0000	1	1
Cyclin-dependent kinase 12	Homo sapiens (human)	Kd	3.4800	1	1
Cyclin-dependent kinase 13	Homo sapiens (human)	Kd	4.5180	1	1
Cyclin-dependent kinase 16	Homo sapiens (human)	Kd	30.0000	1	2
Cyclin-dependent kinase 17	Homo sapiens (human)	Kd	30.0000	1	1
Cyclin-dependent kinase 2	Homo sapiens (human)	Kd	30.0000	1	1
Cyclin-dependent kinase 3	Homo sapiens (human)	Kd	30.0000	1	1
Cyclin-dependent kinase 4	Homo sapiens (human)	Kd	30.0000	1	1
Cyclin-dependent kinase 6	Homo sapiens (human)	Kd	30.0000	1	1
Cyclin-dependent kinase 7	Homo sapiens (human)	Kd	30.0000	1	1
Cyclin-dependent kinase 9	Homo sapiens (human)	Kd	4.2510	1	1
Cyclin-dependent-like kinase 5	Homo sapiens (human)	Kd	30.0000	1	1
Cyclin-G-associated kinase	Homo sapiens (human)	Kd	30.0000	1	1
Cysteine--tRNA ligase, cytoplasmic	Homo sapiens (human)	Kd	30.0000	1	1
Cytochrome c1, heme protein, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	1
dCTP pyrophosphatase 1	Homo sapiens (human)	Kd	30.0000	1	2
Delta(24)-sterol reductase	Homo sapiens (human)	Kd	30.0000	1	1
Deoxycytidine kinase	Homo sapiens (human)	Kd	30.0000	1	1
Discoidin domain-containing receptor 2	Homo sapiens (human)	Kd	30.0000	1	1
DNA replication licensing factor MCM4	Homo sapiens (human)	Kd	30.0000	1	1
DNA topoisomerase 2-alpha	Homo sapiens (human)	Kd	30.0000	1	1
DNA topoisomerase 2-beta	Homo sapiens (human)	Kd	30.0000	1	1
DnaJ homolog subfamily A member 1	Homo sapiens (human)	Kd	30.0000	1	1
Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)	Kd	30.0000	1	1
Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)	Kd	30.0000	1	1
Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)	Kd	30.0000	1	1
Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)	Kd	30.0000	1	1
Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)	Kd	30.0000	1	1
Dual specificity protein kinase CLK1	Homo sapiens (human)	Kd	0.1520	1	1
Dual specificity protein kinase CLK2	Homo sapiens (human)	Kd	30.0000	1	1
Dual specificity protein kinase CLK3	Homo sapiens (human)	Kd	30.0000	1	1
Dual specificity protein kinase CLK4	Homo sapiens (human)	Kd	30.0000	1	1
Dual specificity protein kinase TTK	Homo sapiens (human)	Kd	30.0000	1	2
Dual specificity testis-specific protein kinase 1	Homo sapiens (human)	Kd	30.0000	1	1
Dual specificity testis-specific protein kinase 2	Homo sapiens (human)	Kd	30.0000	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)	Kd	30.0000	1	1
Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	1
EKC/KEOPS complex subunit TP53RK	Homo sapiens (human)	Kd	30.0000	1	1
Electron transfer flavoprotein subunit beta	Homo sapiens (human)	Kd	30.0000	1	1
Elongation factor Tu, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	1
Envelope glycoprotein	Ebola virus - Mayinga, Zaire, 1976	Kd	290.0000	1	1
Ephrin type-A receptor 1	Homo sapiens (human)	Kd	30.0000	1	1
Ephrin type-A receptor 2	Homo sapiens (human)	Kd	30.0000	1	1
Ephrin type-A receptor 4	Homo sapiens (human)	Kd	30.0000	1	1
Ephrin type-A receptor 5	Homo sapiens (human)	Kd	30.0000	1	1
Ephrin type-A receptor 7	Homo sapiens (human)	Kd	30.0000	1	1
Ephrin type-B receptor 2	Homo sapiens (human)	Kd	30.0000	1	1
Ephrin type-B receptor 3	Homo sapiens (human)	Kd	30.0000	1	2
Ephrin type-B receptor 4	Homo sapiens (human)	Kd	30.0000	1	1
Ephrin type-B receptor 6	Homo sapiens (human)	Kd	30.0000	1	1
Epidermal growth factor receptor	Homo sapiens (human)	Kd	30.0000	1	1
Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)	Kd	30.0000	1	1
Estrogen receptor	Homo sapiens (human)	EC50	0.0025	5	5
Estrogen receptor beta	Homo sapiens (human)	EC50	0.0045	2	2
Estrogen-related receptor gamma	Homo sapiens (human)	EC50	0.6300	2	2
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	Homo sapiens (human)	Kd	30.0000	1	1
Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)	Kd	30.0000	1	1
Eukaryotic translation initiation factor 5B	Homo sapiens (human)	Kd	30.0000	1	1
Exosome RNA helicase MTR4	Homo sapiens (human)	Kd	30.0000	1	1
Ferrochelatase, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	1
Fibroblast growth factor receptor 1	Homo sapiens (human)	Kd	30.0000	1	1
Focal adhesion kinase 1	Homo sapiens (human)	Kd	30.0000	1	1
G protein-coupled receptor kinase 6	Homo sapiens (human)	Kd	30.0000	1	1
G-protein coupled receptor 35	Homo sapiens (human)	EC50	1.9455	4	4
General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)	Kd	30.0000	1	1
Glycine--tRNA ligase	Homo sapiens (human)	Kd	30.0000	1	1
Glycogen phosphorylase, brain form	Homo sapiens (human)	Kd	30.0000	1	1
Glycogen phosphorylase, liver form	Homo sapiens (human)	Kd	30.0000	1	1
Glycogen synthase kinase-3 alpha	Homo sapiens (human)	Kd	30.0000	1	1
Glycogen synthase kinase-3 beta	Homo sapiens (human)	Kd	30.0000	1	1
GTP-binding nuclear protein Ran	Homo sapiens (human)	Kd	30.0000	1	1
Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)	Kd	30.0000	1	1
Heme oxygenase 2	Homo sapiens (human)	Kd	30.0000	1	1
Hepatocyte growth factor receptor	Homo sapiens (human)	Kd	30.0000	1	1
High affinity nerve growth factor receptor	Homo sapiens (human)	Kd	30.0000	1	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)	Kd	30.0000	1	1
Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)	Kd	30.0000	1	1
Insulin receptor	Homo sapiens (human)	Kd	30.0000	1	1
Insulin-like growth factor 1 receptor	Homo sapiens (human)	Kd	30.0000	1	1
Integrin-linked protein kinase	Homo sapiens (human)	Kd	30.0000	1	1
Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)	Kd	30.0000	1	1
Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)	Kd	30.0000	1	1
Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)	Kd	30.0000	1	1
Kappa-type opioid receptor	Homo sapiens (human)	EC50	0.0416	32	32
Kappa-type opioid receptor	Mus musculus (house mouse)	EC50	1.6365	3	3
LIM domain kinase 1	Homo sapiens (human)	Kd	30.0000	1	1
LIM domain kinase 2	Homo sapiens (human)	Kd	30.0000	1	2
Long-chain-fatty-acid--CoA ligase 5	Homo sapiens (human)	Kd	30.0000	1	1
Macrophage-stimulating protein receptor	Homo sapiens (human)	Kd	30.0000	1	2
MAP kinase-activated protein kinase 2	Homo sapiens (human)	Kd	30.0000	1	1
MAP kinase-activated protein kinase 5	Homo sapiens (human)	Kd	30.0000	1	1
MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)	Kd	30.0000	1	1
MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)	Kd	30.0000	1	1
Maternal embryonic leucine zipper kinase	Homo sapiens (human)	Kd	1.9220	1	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)	Kd	30.0000	1	1
Midasin	Homo sapiens (human)	Kd	30.0000	1	2
Mitogen-activated protein kinase 1	Homo sapiens (human)	Kd	30.0000	1	2
Mitogen-activated protein kinase 10	Homo sapiens (human)	EC50	1.2400	1	1
Mitogen-activated protein kinase 10	Homo sapiens (human)	Kd	30.0000	1	1
Mitogen-activated protein kinase 11	Homo sapiens (human)	Kd	30.0000	1	1
Mitogen-activated protein kinase 14	Homo sapiens (human)	Kd	30.0000	1	1
Mitogen-activated protein kinase 15	Homo sapiens (human)	Kd	30.0000	1	1
Mitogen-activated protein kinase 3	Homo sapiens (human)	Kd	30.0000	1	1
Mitogen-activated protein kinase 7	Homo sapiens (human)	Kd	30.0000	1	1
Mitogen-activated protein kinase 8	Homo sapiens (human)	EC50	1.2400	1	1
Mitogen-activated protein kinase 8	Homo sapiens (human)	Kd	30.0000	1	1
Mitogen-activated protein kinase 9	Homo sapiens (human)	EC50	1.2400	1	1
Mitogen-activated protein kinase 9	Homo sapiens (human)	Kd	30.0000	1	1
Mitogen-activated protein kinase kinase kinase 1	Homo sapiens (human)	Kd	30.0000	1	1
Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)	Kd	30.0000	1	1
Mitogen-activated protein kinase kinase kinase 2	Homo sapiens (human)	Kd	30.0000	1	1
Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)	Kd	30.0000	1	1
Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)	Kd	30.0000	1	1
Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)	Kd	30.0000	1	1
Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)	Kd	30.0000	1	2
Mitogen-activated protein kinase kinase kinase 6	Homo sapiens (human)	Kd	30.0000	1	1
Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (human)	Kd	30.0000	1	1
Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (human)	Kd	30.0000	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens (human)	Kd	30.0000	1	1
Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)	Kd	30.0000	1	1
Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (human)	Kd	30.0000	1	1
Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)	Kd	30.0000	1	1
Mu-type opioid receptor	Cavia porcellus (domestic guinea pig)	EC50	0.0460	1	2
Mu-type opioid receptor	Homo sapiens (human)	EC50	4.8400	1	1
Multifunctional protein ADE2	Homo sapiens (human)	Kd	30.0000	1	1
Muscarinic acetylcholine receptor	Cavia porcellus (domestic guinea pig)	Kd	0.0794	1	1
Muscarinic acetylcholine receptor M2	Homo sapiens (human)	Kd	0.0398	1	1
Myosin light chain kinase 3	Homo sapiens (human)	Kd	30.0000	1	1
Myosin light chain kinase, smooth muscle	Homo sapiens (human)	Kd	30.0000	1	1
Myosin-10	Homo sapiens (human)	Kd	30.0000	1	1
Myosin-14	Homo sapiens (human)	Kd	30.0000	1	1
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)	Kd	30.0000	1	1
Non-receptor tyrosine-protein kinase TNK1	Homo sapiens (human)	Kd	30.0000	1	1
Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)	Kd	30.0000	1	1
NUAK family SNF1-like kinase 2	Homo sapiens (human)	Kd	30.0000	1	1
Nuclear receptor subfamily 1 group I member 2	Homo sapiens (human)	EC50	14.9557	4	7
Nuclear receptor subfamily 1 group I member 2	Rattus norvegicus (Norway rat)	EC50	23.4000	1	1
Nucleolar GTP-binding protein 1	Homo sapiens (human)	Kd	30.0000	1	2
Obg-like ATPase 1	Homo sapiens (human)	Kd	30.0000	1	1
PAS domain-containing serine/threonine-protein kinase	Homo sapiens (human)	Kd	30.0000	1	1
Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)	Kd	30.0000	1	1
Peroxisomal acyl-coenzyme A oxidase 3	Homo sapiens (human)	Kd	30.0000	1	1
Phenylalanine--tRNA ligase beta subunit	Homo sapiens (human)	Kd	30.0000	1	1
Phosphatidylethanolamine-binding protein 1	Homo sapiens (human)	Kd	30.0000	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)	Kd	30.0000	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (human)	Kd	30.0000	1	1
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (human)	Kd	30.0000	1	1
Platelet-derived growth factor receptor beta	Homo sapiens (human)	Kd	30.0000	1	1
Potassium channel subfamily K member 2	Homo sapiens (human)	EC50	4.3050	1	2
Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)	Kd	30.0000	1	1
Protein kinase C alpha type	Homo sapiens (human)	Kd	30.0000	1	1
Protein kinase C beta type	Homo sapiens (human)	Kd	30.0000	1	1
Protein kinase C delta type	Homo sapiens (human)	Kd	4.7890	1	1
Protein kinase C iota type	Homo sapiens (human)	Kd	30.0000	1	1
Protein kinase C theta type	Homo sapiens (human)	Kd	30.0000	1	1
Protein kinase C zeta type	Homo sapiens (human)	Kd	30.0000	1	1
Protein-tyrosine kinase 2-beta	Homo sapiens (human)	Kd	30.0000	1	1
Protein-tyrosine kinase 6	Homo sapiens (human)	Kd	30.0000	1	1
Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)	Kd	30.0000	1	1
Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)	Kd	30.0000	1	1
Putative heat shock protein HSP 90-beta 2	Homo sapiens (human)	Kd	30.0000	1	1
Pyridoxal kinase	Homo sapiens (human)	Kd	30.0000	1	2
RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)	Kd	30.0000	1	1
RAC-beta serine/threonine-protein kinase	Homo sapiens (human)	Kd	30.0000	1	1
RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)	Kd	30.0000	1	1
Ras-related C3 botulinum toxin substrate 1	Homo sapiens (human)	Kd	30.0000	1	1
Ras-related protein Rab-10	Homo sapiens (human)	Kd	30.0000	1	2
Ras-related protein Rab-27A	Homo sapiens (human)	Kd	30.0000	1	1
Ras-related protein Rab-6A	Homo sapiens (human)	Kd	30.0000	1	1
Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	30.0000	1	1
Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)	Kd	30.0000	1	1
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)	Kd	30.0000	1	1
Rho-associated protein kinase 1	Homo sapiens (human)	Kd	0.9060	1	1
Rho-associated protein kinase 2	Homo sapiens (human)	Kd	0.5105	2	2
Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)	Kd	30.0000	1	1
Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)	Kd	30.0000	1	1
Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)	Kd	30.0000	1	1
Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)	Kd	30.0000	1	1
Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)	Kd	30.0000	1	1
Ribosomal protein S6 kinase beta-1	Homo sapiens (human)	Kd	30.0000	1	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)	Kd	2.4510	1	1
RNA cytidine acetyltransferase	Homo sapiens (human)	Kd	30.0000	1	1
S-adenosylmethionine synthase isoform type-2	Homo sapiens (human)	Kd	30.0000	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	Oryctolagus cuniculus (rabbit)	Kd	0.0002	1	1
Septin-9	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase 10	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase 16	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase 26	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase 3	Homo sapiens (human)	Kd	30.0000	1	1
serine/threonine-protein kinase 33 isoform a	Homo sapiens (human)	EC50	9.5830	1	1
Serine/threonine-protein kinase 4	Homo sapiens (human)	Kd	30.0000	1	2
Serine/threonine-protein kinase A-Raf	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase Chk1	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase D2	Homo sapiens (human)	Kd	6.4160	1	1
Serine/threonine-protein kinase D3	Homo sapiens (human)	Kd	23.3410	1	1
Serine/threonine-protein kinase LATS1	Homo sapiens (human)	Kd	4.1700	1	1
Serine/threonine-protein kinase MARK2	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase MRCK gamma	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase N1	Homo sapiens (human)	Kd	0.8410	1	1
Serine/threonine-protein kinase N2	Homo sapiens (human)	Kd	2.5990	1	1
Serine/threonine-protein kinase N3	Homo sapiens (human)	Kd	0.0990	1	1
Serine/threonine-protein kinase Nek1	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase Nek2	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase Nek3	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase Nek7	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase Nek9	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase NLK	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase PAK 2	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase PAK 4	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase pim-1	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase PLK1	Homo sapiens (human)	Kd	30.0000	1	2
Serine/threonine-protein kinase PLK4	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase SIK2	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase SIK3	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase STK11	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase TAO1	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase TAO2	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase TAO3	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase TBK1	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase ULK1	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase ULK3	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens (human)	Kd	30.0000	1	1
Signal recognition particle receptor subunit alpha	Homo sapiens (human)	Kd	30.0000	1	1
STE20-like serine/threonine-protein kinase	Homo sapiens (human)	Kd	30.0000	1	1
STE20-related kinase adapter protein alpha	Homo sapiens (human)	Kd	30.0000	1	1
Structural maintenance of chromosomes protein 1A	Homo sapiens (human)	Kd	30.0000	1	1
Structural maintenance of chromosomes protein 2	Homo sapiens (human)	Kd	30.0000	1	1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	2
TGF-beta receptor type-1	Homo sapiens (human)	Kd	30.0000	1	1
TGF-beta receptor type-2	Homo sapiens (human)	Kd	30.0000	1	1
Thyroid hormone receptor-associated protein 3	Homo sapiens (human)	Kd	30.0000	1	1
TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)	Kd	30.0000	1	1
Transient receptor potential cation channel subfamily A member 1	Mus musculus (house mouse)	EC50	1.6667	1	3
Transient receptor potential cation channel subfamily V member 1	Homo sapiens (human)	EC50	129.0000	1	1
Tyrosine--tRNA ligase, cytoplasmic	Homo sapiens (human)	Kd	30.0000	1	1
Tyrosine-protein kinase ABL1	Homo sapiens (human)	Kd	30.0000	1	1
Tyrosine-protein kinase ABL2	Homo sapiens (human)	Kd	30.0000	1	2
Tyrosine-protein kinase BTK	Homo sapiens (human)	Kd	30.0000	1	1
Tyrosine-protein kinase CSK	Homo sapiens (human)	Kd	30.0000	1	1
Tyrosine-protein kinase Fer	Homo sapiens (human)	Kd	30.0000	1	1
Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)	Kd	30.0000	1	1
Tyrosine-protein kinase Fgr	Homo sapiens (human)	Kd	30.0000	1	1
Tyrosine-protein kinase FRK	Homo sapiens (human)	Kd	30.0000	1	1
Tyrosine-protein kinase Fyn	Homo sapiens (human)	Kd	30.0000	1	2
Tyrosine-protein kinase HCK	Homo sapiens (human)	Kd	30.0000	1	1
Tyrosine-protein kinase JAK1	Homo sapiens (human)	Kd	30.0000	1	1
Tyrosine-protein kinase Lck	Homo sapiens (human)	Kd	30.0000	1	1
Tyrosine-protein kinase Lyn	Homo sapiens (human)	Kd	30.0000	1	2
Tyrosine-protein kinase SYK	Homo sapiens (human)	Kd	30.0000	1	1
Tyrosine-protein kinase Tec	Homo sapiens (human)	Kd	30.0000	1	1
Tyrosine-protein kinase Yes	Homo sapiens (human)	Kd	30.0000	1	1
U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)	Kd	30.0000	1	1
UMP-CMP kinase	Homo sapiens (human)	Kd	30.0000	1	1
Uncharacterized aarF domain-containing protein kinase 5	Homo sapiens (human)	Kd	30.0000	1	1
Uncharacterized protein FLJ45252	Homo sapiens (human)	Kd	30.0000	1	2
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	1
Wee1-like protein kinase	Homo sapiens (human)	Kd	30.0000	1	1

Other Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Beta-2 adrenergic receptor	Cavia porcellus (domestic guinea pig)	ID50	0.0100	1	1
cAMP-dependent protein kinase catalytic subunit alpha isoform Calpha1	Homo sapiens (human)	AC50	1.1975	2	2
Cytochrome P450 1A2	Homo sapiens (human)	INH	10.0000	1	1
Cytochrome P450 2D6	Homo sapiens (human)	INH	3.6000	1	1
Cytochrome P450 3A4	Homo sapiens (human)	INH	10.0000	1	1
Cytochrome P450 3A4	Homo sapiens (human)	Km	23.0000	1	1
Delta-type opioid receptor	Rattus norvegicus (Norway rat)	Activity	25.0000	1	1
Delta-type opioid receptor	Mus musculus (house mouse)	Ke	0.0412	1	1
Kappa-type opioid receptor	Homo sapiens (human)	ED50	0.0270	1	1
Kappa-type opioid receptor	Mus musculus (house mouse)	Ke	0.0078	2	2
Leukotriene B4 receptor 1	Homo sapiens (human)	ID50	0.0100	1	1
Leukotriene B4 receptor 2	Homo sapiens (human)	ID50	0.0100	1	1
MSH	Drosophila melanogaster (fruit fly)	AC50	0.5940	1	1
Mu-type opioid receptor	Mus musculus (house mouse)	Ke	0.0315	1	1
Muscarinic acetylcholine receptor M1	Homo sapiens (human)	ID50	700,000.0050	2	2
Muscarinic acetylcholine receptor M1	Homo sapiens (human)	Kb	0.0100	1	1
Muscarinic acetylcholine receptor M2	Homo sapiens (human)	ID50	700,000.0050	2	2
Muscarinic acetylcholine receptor M2	Homo sapiens (human)	Kb	0.0980	1	4
Muscarinic acetylcholine receptor M3	Homo sapiens (human)	ID50	700,000.0050	2	2
Muscarinic acetylcholine receptor M4	Homo sapiens (human)	ID50	700,000.0050	2	2
Muscarinic acetylcholine receptor M5	Homo sapiens (human)	ID50	700,000.0050	2	2
Phospholipase A2, membrane associated	Homo sapiens (human)	ID50	0.0100	1	1
Platelet-activating factor receptor	Homo sapiens (human)	ID50	0.0100	1	1
serine/threonine-protein kinase 33 isoform a	Homo sapiens (human)	AC50	9.3400	2	3
Sodium channel protein type 4 subunit alpha	Homo sapiens (human)	Kr	1,440.0000	1	1
Solute carrier family 22 member 11	Homo sapiens (human)	Km	22.9000	1	1
Solute carrier family 22 member 19	Mus musculus (house mouse)	Km	2.0000	1	1
Solute carrier family 22 member 6	Homo sapiens (human)	Km	0.4200	1	1
Solute carrier family 22 member 6	Rattus norvegicus (Norway rat)	Km	1.3350	2	2
Solute carrier family 22 member 8	Homo sapiens (human)	Km	0.7500	1	1
Solute carrier family 22 member 8	Rattus norvegicus (Norway rat)	Km	0.7390	1	1
Solute carrier organic anion transporter family member 1A1	Rattus norvegicus (Norway rat)	Km	22.8000	2	2
Solute carrier organic anion transporter family member 1A3	Rattus norvegicus (Norway rat)	Km	11.1000	2	2
Transient receptor potential cation channel subfamily V member 1	Homo sapiens (human)	Activity	10.0000	1	1
Transient receptor potential cation channel subfamily V member 2	Homo sapiens (human)	Activity	10.0000	1	1
Transient receptor potential cation channel subfamily V member 3	Homo sapiens (human)	Activity	10.0000	1	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	Homo sapiens (human)	INH	0.0390	1	1
Voltage-dependent L-type calcium channel subunit alpha-1C	Homo sapiens (human)	ID50	0.0100	1	2

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calcium channel blocker

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Protein Targets (720)

Potency Measurements

Inhibition Measurements

Activation Measurements

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