A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. Included in this class are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
| Member | Definition | Class |
|---|
| acebutolol | An ether that is the 2-acetyl-4-(butanoylamino)phenyl ether of the primary hydroxy group of 3-(propan-2-ylamino)propane-1,2-diol. | acebutolol |
| acebutolol hydrochloride | The hydrochloride salt of acebutolol, prepared using equimolar amounts of acebutolol and hydrogen chloride. | acebutolol hydrochloride |
| amezinium | A pyridazinium ion that is pyridazin-1-ium which is substituted by a phenyl, amino and methoxy groups at positions 1, 4 and 6, respectively. | amezinium |
| bambuterol | A carbamate ester that is terbutaline in which both of the phenolic hydroxy groups have been protected as the corresponding N,N-dimethylcarbamates. A long acting beta-adrenoceptor agonist used in the treatment of asthma, it is a prodrug for terbutaline. | bambuterol |
| bambuterol hydrochloride | The hydrochloride salt of bambuterol. A long acting beta-adrenoceptor agonist used in the treatment of asthma, it is a prodrug for terbutaline. | bambuterol hydrochloride |
| benzphetamine | Dextroamphetamine in which the the hydrogens attached to the amino group are substituted by a methyl and a benzyl group. A sympathomimetic agent with properties similar to dextroamphetamine, it is used as its hydrochloride salt in the treatment of obesity. | benzphetamine |
| berotek | A member of the class resorcinols that is 5-(1-hydroxyethyl)benzene-1,3-diol in which one of the methyl hydrogens is replaced by a 1-(4-hydroxyphenyl)propan-2-amino group. A beta2-adrenergic agonist, it is used (as the hydrobromide salt) as a bronchodilator in the management of reversible airway obstruction. | fenoterol |
| clenbuterol | A substituted aniline that is 2,6-dichloroaniline in which the hydrogen at position 4 has been replaced by a 2-(tert-butylamino)-1-hydroxyethyl group. | clenbuterol |
| cocaine | A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca. | cocaine |
| dextroamphetamine | A 1-phenylpropan-2-amine that has S configuration. | (S)-amphetamine |
| diazoxide | A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies. | diazoxide |
| dipivefrin | The dipivalate ester of (+-)-epinephrine (racepinephrine). A pro-drug of epinephrine, the hydrochloride is used topically as eye drops to reduce intra-ocular pressure in the treatment of open-angle glaucoma or ocular hypertension. | dipivefrin |
| dipivefrin hydrochloride | The hydrochloride salt of dipivefrin. It is used topically as eye drops to reduce intra-ocular pressure in the treatment of open-angle glaucoma or ocular hypertension. | dipivefrin hydrochloride |
| dobutamine | A catecholamine that is 4-(3-aminobutyl)phenol in which one of the hydrogens attached to the nitrogen is substituted by a 2-(3,4-dihydroxyphenyl)ethyl group. A beta1-adrenergic receptor agonist that has cardiac stimulant action without evoking vasoconstriction or tachycardia, it is used as the hydrochloride to increase the contractility of the heart in the management of acute heart failure. | dobutamine |
| dobutamine hydrochloride | The hydrochloride salt of dobutamine. A beta1-adrenergic receptor agonist that has cardiac stimulant action without evoking vasoconstriction or tachycardia, it is used to increase the contractility of the heart in the management of acute heart failure. | dobutamine hydrochloride |
| ephedrine | A phenethylamine alkaloid that is 2-phenylethanamine substituted by a methyl group at the amino nitrogen and a methyl and a hydroxy group at position 2 and 1 respectively. | (-)-ephedrine |
| fenoterol | The hydrobromide salt of fenoterol. A beta2-adrenergic agonist, it is used as a bronchodilator in the management of reversible airway obstruction. | fenoterol hydrobromide |
| isoproterenol | A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders. | isoprenaline |
| L-isoprenaline | An optically active phenylethanolamine compound having an isopropyl substituent attached to the nitrogen atom. | L-isoprenaline |
| metaraminol | A member of the class of phenylethanolamines that is 2-amino-1-phenylethanol substituted by a methyl group at position 2 and a phenolic hydroxy group at position 1. A sympathomimetic agent , it is used in the treatment of hypotension. | metaraminol |
| midodrine | An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine. | midodrine |
| midodrine hydrochloride | A hydrochloride resulting from the combination of equimolar amounts of midodrine and hydrogen chloride. Midodrine is a direct-acting sympathomimetic with selective alpha-adrenergic agonist activity. The hydrochloride salt is used as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine. | midodrine hydrochloride |
| nab-365 | A hydrochloride that is the monohydrochloride salt of clenbuterol. | clenbuterol hydrochloride |
| oxymetazoline | A member of the class of phenols that is 2,4-dimethylphenol which is substituted at positions 3 and 6 by 4,5-dihydro-1H-imidazol-2-ylmethyl and tert-butyl groups, respectively. A direct-acting sympathomimetic with marked alpha-adrenergic activity, it is a vasoconstrictor that is used (generally as the hydrochloride salt) to relieve nasal congestion. | oxymetazoline |
| oxymetazoline hydrochloride | A hydrochloride salt resulting from the reaction of equimolar quantities of oxymetazoline and hydrogen chloride. A direct-acting sympathomimetic with marked alpha-adrenergic activity, it is a vasoconstrictor that is used to relieve nasal congestion. | oxymetazoline hydrochloride |
| phenmetrazine | A member of the class of morpholines that is morpholine substituted with a phenyl group at position 2 and a methyl group at position 3. | phenmetrazine |
| phentermine | | phentermine |
| phenylephrine | A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring. | phenylephrine |
| pseudoephedrine | A member of the class of the class of phenylethanolamines that is (1S)-2-(methylamino)-1-phenylethan-1-ol in which the pro-S hydrogen at position 2 is replaced by a methyl group. | pseudoephedrine |
| st 1059 | An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-amino-1-hydroxyethyl group. The immediate and active metabolite of midrodine, it is a direct-acting sympathomimetic with selective alpha-adrenergic agonist activity. Midrodine is used (generally as its hydrochloride salt) as a prodrug for deglymidodrine, which acts as a peripheral vasoconstrictor in the treatment of certain hypotensive states. | deglymidodrine |
| terbutaline | A member of the class of phenylethanolamines that is catechol substituted at position 5 by a 2-(tert-butylamino)-1-hydroxyethyl group. | terbutaline |
| tetrahydrozoline | | tetryzoline |
| tetrahydrozoline hydrochloride | The hydrochloride salt of tetryzoline. It is used as a nasal decongestant. | tetrahydrozoline hydrochloride |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 0.3981 | 1 | 1 |
| 2,3-bisphosphoglycerate-independent phosphoglycerate mutase | Leishmania major strain Friedlin | Potency | 28.8710 | 1 | 2 |
| 67.9K protein | Vaccinia virus | Potency | 0.4467 | 1 | 1 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 19.2522 | 2 | 2 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 26.4659 | 1 | 3 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 21.2596 | 1 | 3 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 32.4648 | 2 | 2 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 10.0000 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 29.0522 | 3 | 3 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 26.6032 | 1 | 1 |
| arylsulfatase A | Homo sapiens (human) | Potency | 14.9006 | 1 | 3 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 1.8349 | 1 | 1 |
| Ataxin-2 | Homo sapiens (human) | Potency | 16.5745 | 2 | 6 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 9.9225 | 1 | 4 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 4.6829 | 2 | 3 |
| beta-2 adrenergic receptor | Homo sapiens (human) | Potency | 4.3192 | 4 | 13 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.0034 | 2 | 4 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 17.4124 | 1 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 16.4613 | 1 | 5 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 6.5931 | 1 | 6 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 5.1120 | 1 | 2 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 4.3726 | 2 | 8 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 12.4597 | 1 | 4 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 6.9740 | 1 | 2 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 49.1687 | 1 | 3 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 4.3726 | 2 | 8 |
| chaperonin GroEL | Methanococcus maripaludis S2 | Potency | 100.0000 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 76.9477 | 2 | 8 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 9.2824 | 1 | 3 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 0.7943 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 17.5916 | 1 | 8 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 7.4286 | 1 | 5 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 22.6694 | 2 | 16 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 0.4754 | 1 | 3 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 2.2445 | 2 | 6 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 18.4927 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 10.9903 | 1 | 3 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 3.0832 | 1 | 4 |
| endonuclease IV | Escherichia coli | Potency | 25.1189 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 12.8779 | 4 | 4 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 31.6704 | 2 | 2 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 5.8216 | 6 | 10 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 5.2344 | 1 | 10 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 23.1541 | 4 | 13 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 2.2387 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 22.6694 | 1 | 8 |
| GALC protein | Homo sapiens (human) | Potency | 0.7079 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 22.6694 | 1 | 8 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 22.6694 | 1 | 8 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 22.6694 | 1 | 8 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 22.6694 | 1 | 8 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 22.6694 | 1 | 8 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 22.6694 | 1 | 8 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 22.6694 | 1 | 8 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 22.6694 | 1 | 8 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 22.6694 | 1 | 8 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 22.6694 | 1 | 8 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 22.6694 | 1 | 8 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 22.6694 | 1 | 8 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 22.6694 | 1 | 8 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 22.6694 | 1 | 8 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 22.6694 | 1 | 8 |
| geminin | Homo sapiens (human) | Potency | 8.7590 | 3 | 14 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 6.1882 | 2 | 6 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 4.4958 | 3 | 13 |
| GLS protein | Homo sapiens (human) | Potency | 10.2163 | 2 | 12 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 6.4418 | 1 | 1 |
| glucokinase regulatory protein | Homo sapiens (human) | Potency | 19.7020 | 1 | 2 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 2.3107 | 1 | 3 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 7.0795 | 1 | 1 |
| guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1 | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 23.2809 | 1 | 1 |
| hexokinase-4 isoform 1 | Homo sapiens (human) | Potency | 19.7020 | 1 | 2 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 6.2214 | 2 | 7 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 28.6437 | 1 | 3 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 51.8363 | 2 | 3 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 0.2703 | 2 | 8 |
| IDH1 | Homo sapiens (human) | Potency | 29.0929 | 1 | 2 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 2.3107 | 1 | 3 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 11.1557 | 2 | 9 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 6.3010 | 1 | 2 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 39.8107 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 37.0529 | 1 | 3 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 6.9456 | 2 | 3 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 4.0875 | 2 | 5 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 9.1063 | 2 | 2 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 5.1454 | 1 | 2 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 8.3417 | 2 | 8 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 43.7744 | 2 | 2 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 0.1549 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 12.5893 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 19.3351 | 2 | 2 |
| Ornithine decarboxylase | Rattus norvegicus (Norway rat) | Potency | 7.9433 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 2.0307 | 1 | 3 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 2.2541 | 1 | 4 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 67.9031 | 1 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 30.1607 | 2 | 2 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 44.9793 | 1 | 5 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 7.9433 | 1 | 1 |
| polyprotein | Zika virus | Potency | 2.2387 | 1 | 1 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 10.2918 | 1 | 2 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 10.2057 | 1 | 3 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 10.0000 | 2 | 2 |
| pyruvate kinase PKM isoform b | Homo sapiens (human) | Potency | 7.9433 | 2 | 2 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 15.3281 | 1 | 3 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 47.9904 | 1 | 2 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 13.6310 | 1 | 6 |
| RGS12 | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 18.2885 | 2 | 3 |
| Smad3 | Homo sapiens (human) | Potency | 0.8540 | 1 | 2 |
| snurportin-1 | Homo sapiens (human) | Potency | 2.3107 | 1 | 3 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 18.2579 | 1 | 5 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 1.5849 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 18.5089 | 2 | 21 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 11.9827 | 2 | 13 |
| Thrombopoietin | Homo sapiens (human) | Potency | 3.1623 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 10.9634 | 2 | 2 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 7.1169 | 5 | 25 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 17.5464 | 1 | 3 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 7.9433 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 7.9433 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 25.2940 | 2 | 4 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 2.6844 | 1 | 2 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 56.4541 | 1 | 3 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 1.3288 | 1 | 2 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 2.9548 | 3 | 4 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | IC50 | 1.3288 | 1 | 2 |
| 5-hydroxytryptamine receptor 1B | Homo sapiens (human) | Ki | 0.0003 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 0.6064 | 2 | 3 |
| 5-hydroxytryptamine receptor 1D | Homo sapiens (human) | Ki | 0.0004 | 1 | 1 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 1.2850 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | IC50 | 0.0855 | 2 | 2 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.3670 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 3.0560 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | IC50 | 0.0855 | 2 | 2 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 1.9450 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 0.5780 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | IC50 | 0.0855 | 2 | 2 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.3030 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 0.5780 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 0.3030 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 5A | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 5B | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 1.6700 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 0.7750 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 100.0000 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 25.0000 | 4 | 4 |
| Acetylcholinesterase | Rattus norvegicus (Norway rat) | IC50 | 30.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 0.3830 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 0.3800 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Alpha-1A adrenergic receptor | Bos taurus (cattle) | Ki | 0.4732 | 1 | 2 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Ki | 0.1378 | 3 | 4 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 6.8698 | 5 | 7 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | Ki | 0.5842 | 3 | 4 |
| Alpha-1B adrenergic receptor | Mesocricetus auratus (golden hamster) | Ki | 3.8204 | 3 | 4 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 20.8000 | 2 | 2 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | IC50 | 1.4790 | 1 | 2 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Ki | 0.7112 | 3 | 4 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 7.5755 | 5 | 6 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 0.0230 | 1 | 1 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 52.8772 | 2 | 2 |
| Alpha-2A adrenergic receptor | Bos taurus (cattle) | Ki | 0.0015 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.1610 | 19 | 23 |
| Alpha-2A adrenergic receptor | Mus musculus (house mouse) | Ki | 0.0913 | 3 | 3 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 1.8385 | 15 | 17 |
| Alpha-2A adrenergic receptor | Sus scrofa (pig) | Ki | 0.0210 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 2.1195 | 1 | 2 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 52.8772 | 2 | 2 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 0.4541 | 17 | 21 |
| Alpha-2B adrenergic receptor | Mus musculus (house mouse) | Ki | 0.0913 | 3 | 3 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 1.7487 | 17 | 19 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | IC50 | 2.6330 | 1 | 1 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 52.8772 | 2 | 2 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.1218 | 18 | 22 |
| Alpha-2C adrenergic receptor | Mus musculus (house mouse) | Ki | 0.0913 | 3 | 3 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 1.8385 | 15 | 17 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | Ki | 14.4000 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Bos taurus (cattle) | Ki | 300.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | Ki | 280.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | Ki | 370.0000 | 2 | 2 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 0.3380 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| ATP-binding cassette sub-family C member 8 | Homo sapiens (human) | IC50 | 470.5000 | 4 | 4 |
| ATP-sensitive inward rectifier potassium channel 11 | Homo sapiens (human) | IC50 | 470.5000 | 4 | 4 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | IC50 | 0.7820 | 1 | 4 |
| Beta-1 adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.2125 | 2 | 2 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | Ki | 0.6784 | 2 | 5 |
| Beta-1 adrenergic receptor | Mus musculus (house mouse) | Ki | 0.2200 | 2 | 2 |
| Beta-1 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 4.5833 | 3 | 3 |
| Beta-2 adrenergic receptor | Canis lupus familiaris (dog) | IC50 | 0.6667 | 2 | 3 |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.0600 | 1 | 1 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | IC50 | 0.7760 | 2 | 4 |
| Beta-2 adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.2125 | 2 | 2 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | Ki | 0.3004 | 10 | 12 |
| Beta-2 adrenergic receptor | Mesocricetus auratus (golden hamster) | Ki | 0.1360 | 1 | 1 |
| Beta-2 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.6761 | 1 | 1 |
| Beta-2 adrenergic receptor | Bos taurus (cattle) | Ki | 0.1100 | 2 | 2 |
| Beta-3 adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.2125 | 2 | 2 |
| Beta-3 adrenergic receptor | Homo sapiens (human) | Ki | 18.6209 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 602.0182 | 5 | 11 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Homo sapiens (human) | Ki | 1.1150 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | Ki | 1.1150 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | Ki | 1.1150 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 1.9200 | 1 | 1 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 4.3500 | 1 | 1 |
| Carbonic anhydrase 13 | Homo sapiens (human) | Ki | 9.5300 | 1 | 1 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 12.0200 | 1 | 1 |
| Carbonic anhydrase 15 | Mus musculus (house mouse) | Ki | 0.3900 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 0.4800 | 1 | 1 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 7.4000 | 1 | 1 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 8.9800 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 0.7300 | 1 | 1 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 0.8900 | 1 | 1 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 9.4700 | 1 | 1 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 4.3000 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 9.8200 | 1 | 1 |
| Carboxylic ester hydrolase | Rattus norvegicus (Norway rat) | IC50 | 0.0030 | 1 | 1 |
| Cholinesterase | Equus caballus (horse) | IC50 | 0.1193 | 1 | 1 |
| Cholinesterase | Homo sapiens (human) | IC50 | 0.0033 | 4 | 4 |
| Coagulation factor VII | Homo sapiens (human) | IC50 | 740.0000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 1.1000 | 1 | 2 |
| D | Rattus norvegicus (Norway rat) | IC50 | 5.7544 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 50.0000 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | Ki | 30.0000 | 2 | 2 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.3300 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 4.9850 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 3.1965 | 2 | 2 |
| D(4) dopamine receptor | Homo sapiens (human) | Ki | 2.9000 | 1 | 1 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 5.5510 | 1 | 1 |
| Fatty acid-binding protein, heart | Homo sapiens (human) | IC50 | 0.3670 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit theta | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| guanine nucleotide-binding protein subunit alpha-15 | Homo sapiens (human) | IC50 | 29.8680 | 1 | 1 |
| high affinity choline transporter 1 isoform a | Homo sapiens (human) | IC50 | 0.0600 | 2 | 6 |
| Leukotriene B4 receptor 1 | Homo sapiens (human) | Ki | 0.5240 | 1 | 1 |
| Leukotriene B4 receptor 2 | Homo sapiens (human) | Ki | 0.5240 | 1 | 1 |
| Lysosomal Pro-X carboxypeptidase | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Macrophage migration inhibitory factor | Homo sapiens (human) | IC50 | 98.1000 | 1 | 1 |
| Macrophage migration inhibitory factor | Homo sapiens (human) | Ki | 77.1000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Ki | 61.3985 | 2 | 2 |
| Muscarinic acetylcholine receptor M2 | Sus scrofa (pig) | Ki | 0.2344 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 3.2610 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 0.4550 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 1.3320 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 0.9570 | 1 | 1 |
| Nischarin | Homo sapiens (human) | Ki | 0.0062 | 1 | 2 |
| Phenylethanolamine N-methyltransferase | Bos taurus (cattle) | Ki | 435.3333 | 2 | 3 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 1.1845 | 1 | 2 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 5.5410 | 6 | 6 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | IC50 | 1.5393 | 2 | 3 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Ki | 4.9440 | 2 | 2 |
| Sodium-dependent dopamine transporter | Mus musculus (house mouse) | IC50 | 0.2000 | 1 | 1 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | IC50 | 1.3496 | 47 | 67 |
| Sodium-dependent dopamine transporter | Mus musculus (house mouse) | Ki | 0.8500 | 1 | 1 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | Ki | 25.8768 | 25 | 40 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 0.3708 | 35 | 36 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 0.4103 | 31 | 35 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 1.2212 | 23 | 24 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 1.5354 | 31 | 34 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 1.2403 | 24 | 25 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | IC50 | 0.8885 | 15 | 18 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 0.5452 | 32 | 36 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | Ki | 0.5521 | 18 | 27 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | IC50 | 4.1700 | 1 | 1 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | Ki | 95.8000 | 1 | 1 |
| Tissue factor | Homo sapiens (human) | IC50 | 740.0000 | 1 | 1 |
| trace amine-associated receptor 1 | Homo sapiens (human) | IC50 | 0.1571 | 1 | 1 |
| Transporter | Rattus norvegicus (Norway rat) | IC50 | 3.2277 | 13 | 15 |
| Transporter | Rattus norvegicus (Norway rat) | Ki | 2.3643 | 15 | 18 |
| Tryptophan 5-hydroxylase 1 | Rattus norvegicus (Norway rat) | Ki | 0.4900 | 1 | 1 |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | IC50 | 3.9750 | 1 | 1 |
| Tyrosine-protein kinase Lck | Homo sapiens (human) | IC50 | 5.5190 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | EC50 | 0.0700 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | EC50 | 12.5694 | 2 | 2 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Kd | 4.4668 | 1 | 2 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | EC50 | 0.0200 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Kd | 4.4668 | 1 | 2 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | EC50 | 0.0200 | 1 | 1 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | Kd | 4.4668 | 1 | 2 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | EC50 | 0.0200 | 1 | 1 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | Kd | 4.4668 | 1 | 2 |
| 5-hydroxytryptamine receptor 2A | Mus musculus (house mouse) | EC50 | 38.1152 | 2 | 2 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | Kd | 4.4668 | 1 | 2 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | Kd | 4.4668 | 1 | 2 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | Kd | 4.4668 | 1 | 2 |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | Kd | 4.4668 | 1 | 2 |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | Kd | 4.4668 | 1 | 2 |
| 5-hydroxytryptamine receptor 4 | Rattus norvegicus (Norway rat) | Kd | 4.4668 | 1 | 2 |
| 5-hydroxytryptamine receptor 5A | Rattus norvegicus (Norway rat) | Kd | 4.4668 | 1 | 2 |
| 5-hydroxytryptamine receptor 5B | Rattus norvegicus (Norway rat) | Kd | 4.4668 | 1 | 2 |
| 5-hydroxytryptamine receptor 6 | Rattus norvegicus (Norway rat) | Kd | 4.4668 | 1 | 2 |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | Kd | 4.4668 | 1 | 2 |
| Alpha-1A adrenergic receptor | Bos taurus (cattle) | EC50 | 0.0090 | 1 | 1 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | EC50 | 1.0390 | 7 | 7 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | EC50 | 5.8585 | 6 | 6 |
| Alpha-1B adrenergic receptor | Cricetulus griseus (Chinese hamster) | EC50 | 0.0100 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | EC50 | 8.7860 | 4 | 4 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | EC50 | 0.1547 | 2 | 2 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 25.1189 | 1 | 1 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 25.1189 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | EC50 | 0.3400 | 1 | 1 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 25.1189 | 1 | 1 |
| alternatively spliced Trp4 | Mus musculus (house mouse) | EC50 | 3.3500 | 1 | 1 |
| ATP-binding cassette sub-family C member 8 | Homo sapiens (human) | EC50 | 23.0167 | 6 | 6 |
| ATP-sensitive inward rectifier potassium channel 11 | Homo sapiens (human) | EC50 | 23.0167 | 6 | 6 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | EC50 | 0.2993 | 27 | 28 |
| Beta-1 adrenergic receptor | Mus musculus (house mouse) | EC50 | 0.9800 | 1 | 1 |
| Beta-1 adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 0.0070 | 1 | 1 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | Kd | 63.6607 | 1 | 7 |
| Beta-1 adrenergic receptor | Cavia porcellus (domestic guinea pig) | EC50 | 0.0229 | 2 | 6 |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | EC50 | 0.7588 | 8 | 11 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | EC50 | 0.5004 | 33 | 36 |
| Beta-2 adrenergic receptor | Mesocricetus auratus (golden hamster) | EC50 | 0.0200 | 1 | 1 |
| Beta-2 adrenergic receptor | Mus musculus (house mouse) | EC50 | 0.9800 | 1 | 1 |
| Beta-2 adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 0.0070 | 1 | 1 |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | Kd | 0.0251 | 1 | 1 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | Kd | 28.2546 | 6 | 16 |
| Beta-2 adrenergic receptor | Bos taurus (cattle) | Kd | 1.4487 | 1 | 3 |
| Beta-3 adrenergic receptor | Homo sapiens (human) | EC50 | 0.2913 | 26 | 27 |
| Beta-3 adrenergic receptor | Mus musculus (house mouse) | EC50 | 0.9800 | 1 | 1 |
| Beta-3 adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 0.0470 | 2 | 2 |
| Beta-3 adrenergic receptor | Homo sapiens (human) | Kd | 63.6607 | 1 | 7 |
| Beta-adrenergic receptor kinase 1 | Homo sapiens (human) | Kd | 3.8000 | 1 | 2 |
| Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION | synthetic construct | Kd | 0.4000 | 1 | 1 |
| Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION | synthetic construct | Kd | 0.4000 | 1 | 1 |
| Chain H, Fab M82G2, Heavy chain | Mus musculus (house mouse) | Kd | 0.1400 | 1 | 2 |
| Chain L, Fab M82G2, Light chain | Mus musculus (house mouse) | Kd | 0.1400 | 1 | 2 |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | EC50 | 0.0130 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | EC50 | 0.0030 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | EC50 | 0.0030 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | EC50 | 0.0030 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | EC50 | 0.0030 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | EC50 | 0.0030 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | EC50 | 0.0030 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | EC50 | 0.0030 | 1 | 1 |
| guanine nucleotide-binding protein subunit alpha-15 | Homo sapiens (human) | EC50 | 29.8680 | 1 | 2 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | EC50 | 0.0398 | 1 | 1 |
| mu-type opioid receptor isoform MOR-1 | Homo sapiens (human) | EC50 | 92.4917 | 2 | 3 |
| Nicotinamide phosphoribosyltransferase | Homo sapiens (human) | Kd | 230.0000 | 1 | 1 |
| NPYLR7B | Aedes aegypti (yellow fever mosquito) | EC50 | 0.0390 | 1 | 4 |
| Oxytocin receptor | Rattus norvegicus (Norway rat) | EC50 | 0.0030 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Rattus norvegicus (Norway rat) | EC50 | 0.9900 | 1 | 1 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | EC50 | 0.0250 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | EC50 | 0.9900 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | EC50 | 0.2100 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | EC50 | 0.1400 | 1 | 1 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | EC50 | 1.7650 | 1 | 1 |
| Taste receptor type 2 member 1 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 10 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 13 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 14 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 16 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 19 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 20 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 3 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 30 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 31 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 38 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 39 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 4 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 40 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 41 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 42 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 43 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 45 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 46 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 5 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 50 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 60 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 7 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 8 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 9 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Trace amine-associated receptor 1 | Homo sapiens (human) | EC50 | 1.3816 | 5 | 6 |
| Trace amine-associated receptor 1 | Macaca mulatta (Rhesus monkey) | EC50 | 1.0100 | 1 | 1 |
| Trace amine-associated receptor 1 | Mus musculus (house mouse) | EC50 | 0.1039 | 5 | 5 |
| Trace amine-associated receptor 1 | Rattus norvegicus (Norway rat) | EC50 | 0.5328 | 6 | 6 |
| Vasopressin V1a receptor | Rattus norvegicus (Norway rat) | EC50 | 1.0000 | 1 | 1 |