An oxo steroid carrying an oxo group at position 20.
| Member | Definition | Role |
|---|
| 1-dehydroprogesterone | A 3-oxo Delta(4)-steroid that is progesterone which has been oxidised to introduce a double bond between positions 1 and 2. | Delta(1)-progesterone |
| 11-dehydrocorticosterone | An 11-oxo steroid that is corticosterone in which the hydroxy substituent at the 11beta position has been oxidised to give the corresponding ketone. | 11-dehydrocorticosterone |
| 11-hydroxyprogesterone, (11alpha)-isomer | A 11alpha-hydroxy steroid that is pregn-4-ene-3,20-dione substituted by a hydroxy group at position 11. | 11alpha-hydroxyprogesterone |
| 16-dehydropregnenolone | A 3beta-hydroxy-Delta(5)-steroid that is pregnenolone with a double bond between positions 16 and 17. | 16,17-didehydropregnenolone |
| 16-dehydroprogesterone | | 16,17-didehydroprogesterone |
| 18-hydroxycorticosterone | A 18-hydroxy steroid that is corticosterone substituted by a hydroxy group at position 18. | 18-hydroxycorticosterone |
| 18-hydroxydeoxycorticosterone | | 18-hydroxydeoxycorticosterone |
| 19-hydroxydeoxycorticosterone | | 19-hydroxy-11-deoxycorticosterone |
| 3 alpha,17 alpha-dihydroxy-5 beta-pregnan-20-one | A 17alpha-hydroxy steroid that is 3alpha-hydroxy-5beta-pregnan-20-one carrying an additional hydroxy group at position 17alpha. | 3alpha,17alpha-dihydroxy-5beta-pregnan-20-one |
| 5-alpha-dihydroprogesterone | A C21-steroid hormone that is 5alpha-pregnane substituted by oxo groups at positions 3 and 20. It is a metabolite of progestrone. | 5alpha-pregnane-3,20-dione |
| 5beta-pregnane-3,20-dione | A C21-steroid that is 5beta-pregnane with oxo groups at positions 3 and 20. | 5beta-pregnane-3,20-dione |
| 6 beta-hydroxycortisol | A C21-steroid that is cortisol bearing an additional hydroxy substituent at the 6beta-position. In humans, it is produced as a metabolite of cortisol by cytochrome p450-3A4 (CYP3A4, an important enzyme involved in the metabolism of a variety of exogenous and endogenous compounds) and can be used to detect moderate and potent CYP3A4 inhibition in vivo. | 6beta-hydroxycortisol |
| aldosterone | A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney. | aldosterone |
| algestone | A C21-steroid that is pregn-4-ene substituted by oxo groups at position 3 and 20 and hydroxy groups at positions 16 and 17. | algestone |
| amcinonide | | amcinonide |
| beclomethasone | A 17alpha-hydroxy steroid that is prednisolone in which the hydrogens at the 9alpha and 16beta positions are substituted by a chlorine and a methyl group, respectively. | beclomethasone |
| beclomethasone dipropionate | A steroid ester comprising beclomethasone having propionyl groups at the 17- and 21-positions. | beclomethasone dipropionate |
| betamethasone | | betamethasone |
| betamethasone acetate | | betamethasone acetate |
| betamethasone valerate | A steroid ester that is betamethasone in which the hydroxy group at the 17alpha position has been converted to the corresponding pentanoate ester. | betamethasone valerate |
| betamethasone-17,21-dipropionate | A steroid ester that is betamethasone in which the hydroxy hydrogens at positions 17 and 21 are replaced by propanoyl groups. It is used in combination with calcipotriene hydrate, a synthetic vitamin D analogue, for the topical treatment of plaque psoriasis in adult patients. | betamethasone dipropionate |
| clobetasol | A 3-oxo-Delta(1),Delta(4)-steroid that is 16beta-methylpregna-1,4-diene-3,20-dione bearing hydroxy groups at the 11beta and 17alpha positions, fluorine at position 9, and a chlorine substituent at position 21. It is used as its 17alpha-propionate ester to treat various skin disorders, including exzema and psoriasis. | clobetasol |
| clobetasol propionate | The 17-O-propionate ester of clobetasol. A potent corticosteroid, it is used to treat various skin disorders, including exzema and psoriasis. | clobetasol propionate |
| clocortolone pivalate | The 21-O-pivalate ester of clocortolone. It is used for the relief of inflammatory and pruritic (itching) skin disorders. | clocortolone pivalate |
| corticosterone | A 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands. | corticosterone |
| cortisol 21-sulfate | A steroid sulfate obtained by the formal condensation of hydroxy group at position 21 of cortisol with sulfuric acid. | cortisol 21-sulfate |
| cortisone | A C21-steroid that is pregn-4-ene substituted by hydroxy groups at positions 17 and 21 and oxo group at positions 3, 11 and 20. | cortisone |
| cyproterone | | cyproterone |
| cyproterone acetate | A steroid ester resulting from the formal condensation of the carboxy group of acetic acid with the 17-hydroxy group of cyproterone. It is an antiandrogenic drug which has recently been recognized to promote the occurrence and growth of intracranial meningiomas. | cyproterone acetate |
| demegestone | | demegestone |
| desonide | Triamcinolone acetonide with hydrogen instead of the fluorine substituent at position 9. A corticosteroid anti-inflammatory, it is used topically as a cream, ointment or lotion for the treatment of various skin disorders. | desonide |
| desoximetasone | Dexamethasone in which the hydroxy group at the 17alpha position is substituted by hydrogen. A synthetic corticosteroid with glucocorticoid activity, it is used as an anti-inflammatory and anti-pruritic in the treatment of various skin disorders, including skin allergies and psoriasis. | desoximetasone |
| desoxycorticosterone | A mineralocorticoid that is progesterone substituted at position 21 by a hydroxy group. | 11-deoxycorticosterone |
| diflorasone | The 16beta-analogue of flumethasone. It is used as the 17,21-diacetate as a topical anti-inflammatory and antipruritic in the treatment of various skin disorders. | diflorasone |
| diflorasone diacetate | The 17,21-diacetate derivative of diflorasone. It is used topically for its anti-inflammatory and antipruritic properties in the treatment of various skin disorders. | diflorasone diacetate |
| dydrogesterone | | dydrogesterone |
| fludrocortisone | | fludrocortisone |
| fludrocortisone acetate | An acetate ester resulting from the formal condensation of the primary hydroxy group of fludrocortisone with acetic acid. A synthetic corticosteroid, it has glucocorticoid actions about 10 times as potent as hydrocortisone, while its mineralocorticoid actions are over 100 times as potent. It is used in partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenal hyperplasia. | fludrocortisone acetate |
| flumethasone | | flumethasone |
| flumethasone pivalate | | flumethasone pivalate |
| flunisolide | | flunisolide |
| fluocinolone acetonide | A fluorinated steroid that is flunisolide in which the hydrogen at position 9 is replaced by fluorine. A corticosteroid with glucocorticoid activity, it is used (both as the anhydrous form and as the dihydrate) in creams, gels and ointments for the treatment of various skin disorders. | fluocinolone acetonide |
| fluorometholone | A member of the class of glucocorticoids that is Delta(1)-progesterone substituted at positions 11beta and 17 by hydroxy groups, at position 6alpha by a methyl group and at position 9 by a fluoro group. Used for the treatment of corticosteroid-responsive inflammation of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe. | fluorometholone |
| hydroxydione | A 3-oxo-5beta-steroid formed from 11-deoxycorticosterone by reduction across the C4-C5 double bond. | 5beta-dihydrodeoxycorticosterone |
| medroxyprogesterone | A 3-oxo Delta(4)-steroid that is pregn-4-ene-3,20-dione substituted by an alpha-hydroxy group at position 17 and a methyl group at position 6. | medroxyprogesterone |
| medroxyprogesterone acetate | An acetate ester resulting from the formal condensation of the 17alpha-hydroxy group of medroxyprogesterone with the carboxy group of acetic acid. A widely used progestin in menopausal hormone therapy and in progestogen-only birth control. | medroxyprogesterone acetate |
| megestrol | A 3-oxo Delta(4)-steroid that is pregna-4,6-diene-3,20-dione substituted by a methyl group at position 6 and a hydroxy group at position 17. | megestrol |
| megestrol acetate | A steroid ester resulting from the formal condensation of the hydroxy group of megestrol with the carboxy group of acetic acid. It is an appetite stimulant used for the treatment of anorexia and cachexia. Also used for birth control and for the treatment of breast cancer. | megestrol acetate |
| methylprednisolone acetate | An acetate ester resulting from the formal condensation of the 21-hydroxy function of 6alpha-methylprednisolone compound with acetic acid. | methylprednisolone acetate |
| mometasone furoate | | mometasone furoate |
| nisone | | cortancyl |
| osaterone acetate | | Osaterone acetate |
| prednisolone | A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone. | prednisolone |
| prednisolone hemisuccinate | A hemisuccinate resulting from the formal condensation of the 21-hydroxy group prednisolone with one of the carboxy groups of succinic acid. It is used to treat mild to moderate non-infectious eye allergies and inflammation, including damage caused by chemical and thermal burns. | prednisolone succinate |
| prednisolone phosphate | A synthetic glucocorticoid resulting from the formal condensation of the 21-hydroxy group of prednisolone with one of the hydroxy groups of phosphoric acid. It is a prodrug for prednisolone that is activated in vivo by phosphatases. | prednisolone phosphate |
| prednisone | A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid. | prednisone |
| pregnenolone | A 20-oxo steroid that is pregn-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 20. | pregnenolone |
| progesterone 11-hemisuccinate, (11alpha)-isomer | A steroid ester that is the O-succinoyl derivative of 11alpha-hydroxyprogesterone. | 11alpha-hydroxyprogesterone hemisuccinate |
| promegestone | A progestin consisting of 17beta-propionylestra-4,9-dien-3-one substituted at position 17 by a methyl group. | promegestone |
| pulmicort | A glucocorticoid steroid having a highly oxygenated pregna-1,4-diene structure. It is used mainly in the treatment of asthma and non-infectious rhinitis and for treatment and prevention of nasal polyposis. | budesonide |
| rimexolone | | rimexolone |
| sch 22219 | A prednisolone compound having an alpha-chloro substituent at the 7-position, an alpha-methyl substituent at the 16-position and O-propanoyl groups at the 17- and 21-positions. | alclometasone dipropionate |
| tetrahydrocortisol | | tetrahydrocortisol |
| triamcinolone | A C21-steroid hormone that is 1,4-pregnadiene-3,20-dione carrying four hydroxy substituents at positions 11beta, 16alpha, 17alpha and 21 as well as a fluoro substituent at position 9. Used in the form of its 16,17-acetonide to treat various skin infections. | triamcinolone |
| triamcinolone acetonide | A synthetic glucocorticoid that is the 16,17-acetonide of triamcinolone. Used to treat various skin infections. | triamcinolone acetonide |
| trimegestone | | trimegestone |
| ulipristal | | Ulipristal |
| ulipristal acetate | A 20-oxo steroid obtained by acetylation of the 17-hydroxy group of (11beta,17alpha)-17-acetyl-11-[4-(dimethylamino)phenyl]-3-oxoestra-4,9-dien-17-ol (ulipristal). A selective progesterone receptor modulator, which is employed as an emergency contraceptive. | ulipristal acetate |