Page last updated: 2024-08-05 15:15:24
calmodulin antagonist
An antagonist that interferes with the action of the calcium-binding messenger protein calmodulin.
ChEBI ID: 130181
Members (4)
| Member | Definition | Class |
|---|---|---|
| calmidazolium | An imidazolium ion that is imidazolium cation substituted by a bis(4-chlorophenyl)methyl group at position 1 and a 2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl group at position 3. It acts as an antagonist of calmodulin, a calcium binding messenger protein. | calmidazolium |
| calmidazolium | The organic choride salt of calmidazolium. | calmidazolium chloride |
| pentamidine | A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease. | pentamidine |
| trifluoperazine | A member of the class of phenothiazines that is phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position. | trifluoperazine |
Research
Studies (6,094)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 2,895 (47.51) | 18.7374 |
| 1990's | 1,677 (27.52) | 18.2507 |
| 2000's | 734 (12.04) | 29.6817 |
| 2010's | 636 (10.44) | 24.3611 |
| 2020's | 152 (2.49) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 293 (4.39%) | 5.53% |
| Reviews | 287 (4.30%) | 6.00% |
| Case Studies | 517 (7.75%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5,577 (83.56%) | 84.16% |
Protein Targets (213)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 13.3622 | 2 | 6 |
| acid sphingomyelinase | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 13.1374 | 1 | 3 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 11.2202 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 25.1456 | 3 | 7 |
| Ataxin-2 | Homo sapiens (human) | Potency | 28.7968 | 1 | 2 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 15.1014 | 1 | 1 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 16.4816 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 27.1622 | 2 | 3 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 17.9008 | 2 | 2 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 17.5594 | 2 | 2 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 21.4865 | 2 | 2 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 8.9125 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 0.1995 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 32.9838 | 1 | 2 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 0.1995 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 53.7248 | 2 | 3 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 7.5093 | 1 | 3 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 1.1038 | 1 | 3 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 13.5093 | 2 | 5 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 0.5106 | 2 | 2 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 16.4816 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 42.9517 | 2 | 2 |
| endonuclease IV | Escherichia coli | Potency | 31.6228 | 1 | 1 |
| enteropeptidase precursor | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 21.1401 | 3 | 3 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 21.8434 | 1 | 5 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 15.5016 | 4 | 12 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 84.2790 | 1 | 2 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 11.7704 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 13.8993 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 13.8993 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 13.8993 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 13.8993 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 13.8993 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 13.8993 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 13.8993 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 13.8993 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 13.8993 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 13.8993 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 13.8993 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 13.8993 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 13.8993 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 13.8993 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 13.8993 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 13.8993 | 1 | 3 |
| geminin | Homo sapiens (human) | Potency | 16.4115 | 4 | 6 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 18.5482 | 1 | 2 |
| GLS protein | Homo sapiens (human) | Potency | 22.8741 | 2 | 2 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| glucokinase regulatory protein | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| Glycoprotein hormones alpha chain | Homo sapiens (human) | Potency | 14.1254 | 1 | 2 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 34.3005 | 1 | 2 |
| hexokinase-4 isoform 1 | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 12.5893 | 1 | 2 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| IDH1 | Homo sapiens (human) | Potency | 5.1735 | 1 | 1 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 1.4125 | 1 | 1 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 18.6800 | 1 | 6 |
| isocitrate dehydrogenase 1, partial | Homo sapiens (human) | Potency | 23.4648 | 3 | 3 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 12.6450 | 2 | 3 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 17.5594 | 1 | 2 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 36.5836 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 30.0499 | 1 | 3 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 25.1189 | 2 | 2 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 2 | 2 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 11.2202 | 2 | 2 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 15.8489 | 1 | 1 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 58.0479 | 1 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 7.1912 | 2 | 2 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 18.1056 | 1 | 1 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 37.9330 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 34.1133 | 1 | 3 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 12.5893 | 1 | 1 |
| polyprotein | Zika virus | Potency | 11.7704 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 18.6800 | 1 | 4 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 79.0240 | 1 | 2 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 22.7835 | 1 | 2 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 18.4493 | 4 | 6 |
| Smad3 | Homo sapiens (human) | Potency | 21.0880 | 1 | 3 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 23.7358 | 1 | 2 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 7.4428 | 2 | 10 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 27.5708 | 1 | 3 |
| Thrombopoietin | Homo sapiens (human) | Potency | 15.8489 | 2 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 14.4334 | 4 | 4 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 12.5893 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 12.5893 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 51.5206 | 2 | 5 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 71.6999 | 1 | 3 |
| WRN | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 10 kDa chaperonin | Escherichia coli | IC50 | 175.0000 | 2 | 2 |
| 10 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 175.0000 | 2 | 2 |
| 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase | Homo sapiens (human) | Ki | 0.0080 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 1.6390 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.4680 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 3.2780 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 1.7170 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 3.2780 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 1.7170 | 1 | 1 |
| 60 kDa chaperonin | Escherichia coli | IC50 | 175.0000 | 2 | 2 |
| 60 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 175.0000 | 2 | 2 |
| Acrosin | Sus scrofa (pig) | Ki | 2.3000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 2.2140 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 2.1960 | 1 | 1 |
| alkaline phosphatase, germ cell type preproprotein | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| alkaline phosphatase, intestinal | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.3500 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.3500 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.3500 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 1.3750 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.5160 | 1 | 1 |
| Amiloride-sensitive amine oxidase [copper-containing] | Homo sapiens (human) | Ki | 0.2900 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 0.7930 | 1 | 1 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | IC50 | 10.9738 | 1 | 2 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | Ki | 8.9905 | 1 | 2 |
| Apoptotic peptidase activating factor 1 | Homo sapiens (human) | IC50 | 56.3500 | 2 | 2 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 8.1333 | 3 | 3 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Ki | 6.5000 | 1 | 1 |
| Aurora kinase B | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| bcl-2-related protein A1 | Mus musculus (house mouse) | IC50 | 6.2300 | 1 | 1 |
| Beta-glucuronidase | Rattus norvegicus (Norway rat) | IC50 | 7.8000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 257.6000 | 4 | 5 |
| C-8 sterol isomerase | Saccharomyces cerevisiae S288C | Ki | 0.5000 | 1 | 1 |
| Calcium-dependent protein kinase 4 | Plasmodium falciparum 3D7 | Ki | 150.0000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| caspase-3 isoform a preproprotein | Homo sapiens (human) | IC50 | 7.1400 | 1 | 1 |
| caspase-9 isoform alpha precursor | Homo sapiens (human) | IC50 | 7.1400 | 1 | 1 |
| Coagulation factor X | Homo sapiens (human) | IC50 | 10.4000 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 75.0000 | 3 | 3 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 75.0000 | 3 | 3 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 75.0000 | 3 | 3 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 19.8667 | 3 | 3 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 75.0000 | 3 | 3 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0160 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 3.9980 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 1.3580 | 1 | 1 |
| Diamine acetyltransferase 1 | Homo sapiens (human) | Ki | 2.0000 | 1 | 1 |
| DNA-dependent protein kinase catalytic subunit | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Emopamil-binding protein-like | Homo sapiens (human) | Ki | 0.0039 | 1 | 1 |
| Genome polyprotein | IC50 | 0.7000 | 1 | 1 | |
| Glutamate receptor ionotropic, NMDA 1 | Homo sapiens (human) | IC50 | 0.7200 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Homo sapiens (human) | IC50 | 0.7200 | 1 | 1 |
| Glyceraldehyde-3-phosphate dehydrogenase | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| intestinal alkaline phosphatase precursor | Mus musculus (house mouse) | IC50 | 14.6000 | 1 | 1 |
| Lysozyme C-1 | Rattus norvegicus (Norway rat) | IC50 | 9.0000 | 1 | 1 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 1.7033 | 3 | 3 |
| Multidrug and toxin extrusion protein 2 | Homo sapiens (human) | IC50 | 6.5500 | 2 | 2 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 1.4250 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 0.5070 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 1.5800 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 0.2200 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 2.8850 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 2.0730 | 1 | 1 |
| NADPH oxidase 1 | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | IC50 | 10.9738 | 1 | 2 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | Ki | 8.9905 | 1 | 2 |
| Plasminogen | Homo sapiens (human) | IC50 | 28.4000 | 3 | 5 |
| Pleiotropic ABC efflux transporter of multiple drugs | Saccharomyces cerevisiae S288C | IC50 | 1.4000 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 13.8895 | 4 | 5 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | Ki | 8.9905 | 1 | 2 |
| Protein arginine N-methyltransferase 1 | Homo sapiens (human) | IC50 | 81.0000 | 2 | 2 |
| Protein arginine N-methyltransferase 5 | Homo sapiens (human) | IC50 | 582.0000 | 1 | 1 |
| Protein kinase C alpha type | Rattus norvegicus (Norway rat) | IC50 | 500.0000 | 1 | 1 |
| Protein kinase C beta type | Rattus norvegicus (Norway rat) | IC50 | 500.0000 | 1 | 1 |
| Protein kinase C delta type | Rattus norvegicus (Norway rat) | IC50 | 500.0000 | 1 | 1 |
| Protein kinase C epsilon type | Rattus norvegicus (Norway rat) | IC50 | 500.0000 | 1 | 1 |
| Protein kinase C eta type | Rattus norvegicus (Norway rat) | IC50 | 500.0000 | 1 | 1 |
| Protein kinase C gamma type | Rattus norvegicus (Norway rat) | IC50 | 500.0000 | 1 | 1 |
| Protein kinase C theta type | Rattus norvegicus (Norway rat) | IC50 | 500.0000 | 1 | 1 |
| Protein kinase C zeta type | Rattus norvegicus (Norway rat) | IC50 | 500.0000 | 1 | 1 |
| Protein S100-B | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Protein tyrosine phosphatase type IVA 1 | Homo sapiens (human) | IC50 | 0.3000 | 1 | 1 |
| Protein tyrosine phosphatase type IVA 2 | Homo sapiens (human) | IC50 | 0.3000 | 1 | 1 |
| Protein tyrosine phosphatase type IVA 3 | Homo sapiens (human) | IC50 | 35.8333 | 3 | 3 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | Oryctolagus cuniculus (rabbit) | IC50 | 22.7500 | 1 | 2 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Ki | 0.0150 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 3.1590 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 2.5100 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 2.2140 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 2.1960 | 1 | 1 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | IC50 | 22.1000 | 1 | 1 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | IC50 | 1.2000 | 1 | 1 |
| Solute carrier family 22 member 3 | Homo sapiens (human) | IC50 | 9.5000 | 1 | 1 |
| SUMO-1 | Homo sapiens (human) | IC50 | 36.2450 | 2 | 2 |
| Suppressor of tumorigenicity 14 protein | Homo sapiens (human) | Ki | 1.1600 | 1 | 1 |
| Transcriptional activator protein LuxR | Aliivibrio fischeri | IC50 | 7.0000 | 1 | 1 |
| Trypanothione reductase | Trypanosoma cruzi | IC50 | 72.0000 | 1 | 1 |
| Trypanothione reductase | Trypanosoma cruzi | Ki | 23.0000 | 1 | 1 |
| Trypsin-1 | Homo sapiens (human) | IC50 | 43.3333 | 1 | 3 |
| Ubiquitin carboxyl-terminal hydrolase 1 | Homo sapiens (human) | IC50 | 8.0000 | 1 | 1 |
| ubiquitin-conjugating enzyme E2 N | Homo sapiens (human) | IC50 | 8.2315 | 2 | 2 |
| Urokinase-type plasminogen activator | Homo sapiens (human) | IC50 | 43.3333 | 1 | 3 |
| WD repeat-containing protein 48 | Homo sapiens (human) | IC50 | 8.0000 | 1 | 1 |
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | Kd | 0.0010 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | Kd | 0.0010 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | Kd | 0.0010 | 1 | 1 |
| 5-hydroxytryptamine receptor 5A | Homo sapiens (human) | EC50 | 92.4890 | 1 | 1 |
| Albumin | Rattus norvegicus (Norway rat) | Kd | 14.0000 | 1 | 1 |
| Calmodulin | Bos taurus (cattle) | Kd | 3.4000 | 1 | 1 |
| Calmodulin-1 | Homo sapiens (human) | Kd | 1.0000 | 1 | 1 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | Kd | 0.0005 | 1 | 1 |
| delta-type opioid receptor | Homo sapiens (human) | EC50 | 47.9575 | 2 | 2 |
| insulin-degrading enzyme isoform 1 | Homo sapiens (human) | EC50 | 28.3680 | 2 | 2 |
| mu-type opioid receptor isoform MOR-1 | Homo sapiens (human) | EC50 | 47.9575 | 2 | 2 |
| Protein S100-B | Homo sapiens (human) | Kd | 1.0000 | 1 | 1 |
| Protein S100-B | Rattus norvegicus (Norway rat) | Kd | 47.0000 | 2 | 2 |
Other Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| DNA repair protein RAD52 homolog isoform a | Homo sapiens (human) | AC50 | 13.0000 | 1 | 1 |
| heat shock protein 90, putative | Plasmodium falciparum 3D7 | AC50 | 5.4700 | 1 | 1 |
| heat shock protein HSP 90-alpha isoform 2 | Homo sapiens (human) | AC50 | 7.0650 | 1 | 1 |
| Pleiotropic ABC efflux transporter of multiple drugs | Saccharomyces cerevisiae S288C | INH | 8.3000 | 1 | 1 |
| Snq2p | Saccharomyces cerevisiae EC1118 | INH | 6.9000 | 1 | 1 |