A substance that can carry oxygen to and carbon dioxide away from the tissues when introduced into the blood stream. Blood substitutes are used to replace hemoglobin in severe hemorrhage and also to perfuse isolated organs.
ChEBI ID: 38849
| Member | Definition | Class |
|---|---|---|
| perflubron | A haloalkane that is perfluorooctane in which a fluorine attached to one of the terminal carbons has been replaced by a bromine. | perflubron |
| perfluoro-n-methyldecahydroisoquinoline | perfluoro-N-methyldecahydroisoquinoline | |
| perfluorodecalin | A fluorocarbon that is decalin in which every hydrogen is replaced by fluorine. Capable of dissolving large quantities of oxygen, it has been used as the basis of an artificial blood substitute. | perfluorodecalin |
| perfluorotributylamine | An organofluorine compound that is tributylamine in which all the hydrogens have been replaced by fluorine atoms. | perfluorotributylamine |
| perfluorotripropylamine | perfluorotripropylamine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 189 (19.83) | 18.7374 |
| 1990's | 402 (42.18) | 18.2507 |
| 2000's | 172 (18.05) | 29.6817 |
| 2010's | 152 (15.95) | 24.3611 |
| 2020's | 38 (3.99) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 34 (3.09%) | 5.53% |
| Reviews | 34 (3.09%) | 6.00% |
| Case Studies | 46 (4.19%) | 4.05% |
| Observational | 1 (0.09%) | 0.25% |
| Other | 984 (89.54%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 1.1883 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 21.3174 | 1 | 1 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 0.7079 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 13.3332 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 25.1436 | 2 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |