| Condition | Indicated | Relationship Strength | Studies | Trials |
|---|
Neuroblastoma
A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51) | 0 | 2.74 | 3 | 0 |
Adrenal Cancer
[description not available] | 0 | 7.2 | 13 | 1 |
Bone Cancer
[description not available] | 0 | 2.08 | 1 | 0 |
Paraganglioma, Gangliocytic
[description not available] | 0 | 5.28 | 4 | 1 |
Bone Neoplasms
Tumors or cancer located in bone tissue or specific BONES. | 0 | 2.08 | 1 | 0 |
Paraganglioma
A neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion, such as the carotid body, or medulla of the adrenal gland (usually called a chromaffinoma or pheochromocytoma). It is more common in women than in men. (Stedman, 25th ed; from Segen, Dictionary of Modern Medicine, 1992) | 0 | 5.28 | 4 | 1 |
Idiopathic Parkinson Disease
[description not available] | 0 | 7.62 | 15 | 0 |
Depression
Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders. | 0 | 2.08 | 1 | 0 |
Parkinson Disease
A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75) | 0 | 7.62 | 15 | 0 |
ANS (Autonomic Nervous System) Diseases
[description not available] | 0 | 10.39 | 15 | 10 |
Hypotension, Postural
[description not available] | 0 | 9.99 | 12 | 9 |
Hypotension, Orthostatic
A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure 3 minutes after the person has risen from supine to standing. Symptoms generally include DIZZINESS, blurred vision, and SYNCOPE. | 0 | 9.99 | 12 | 9 |
Metastase
[description not available] | 0 | 4.89 | 4 | 2 |
Pheochromocytoma, Extra-Adrenal
[description not available] | 0 | 7.95 | 16 | 2 |
Neoplasm Metastasis
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site. | 0 | 4.89 | 4 | 2 |
Pheochromocytoma
A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298) | 0 | 7.95 | 16 | 2 |
Dysautonomia
[description not available] | 0 | 2.05 | 1 | 0 |
Anhidrosis
[description not available] | 0 | 2.05 | 1 | 0 |
Abnormal Deep Tendon Reflex
[description not available] | 0 | 2.05 | 1 | 0 |
Autonomic Failure, Progressive
[description not available] | 0 | 5.42 | 5 | 1 |
Sicca Syndrome
[description not available] | 0 | 2.05 | 1 | 0 |
Autoimmune Diseases of the Nervous System
Disorders caused by cellular or humoral immune responses primarily directed towards nervous system autoantigens. The immune response may be directed towards specific tissue components (e.g., myelin) and may be limited to the central nervous system (e.g., MULTIPLE SCLEROSIS) or the peripheral nervous system (e.g., GUILLAIN-BARRE SYNDROME). | 0 | 2.05 | 1 | 0 |
Autonomic Failure, Pure
[description not available] | 0 | 2.05 | 1 | 0 |
Reflex, Abnormal
An abnormal response to a stimulus applied to the sensory components of the nervous system. This may take the form of increased, decreased, or absent reflexes. | 0 | 2.05 | 1 | 0 |
Sjogren's Syndrome
Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis. | 0 | 2.05 | 1 | 0 |
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. | 0 | 2.46 | 2 | 0 |
Experimental Hepatoma
[description not available] | 0 | 2.05 | 1 | 0 |
Cancer of Ovary
[description not available] | 0 | 2.46 | 2 | 0 |
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. | 0 | 2.46 | 2 | 0 |
MEA 2a
[description not available] | 0 | 3.35 | 2 | 0 |
Disease Exacerbation
[description not available] | 0 | 2.96 | 4 | 0 |
Autosomal Dominant Juvenile Parkinson Disease
[description not available] | 0 | 4.74 | 2 | 1 |
Abnormal Movements
[description not available] | 0 | 2.05 | 1 | 0 |
Parkinsonian Disorders
A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA. | 0 | 4.74 | 2 | 1 |
Cancer of Liver
[description not available] | 0 | 2.47 | 2 | 0 |
Liver Neoplasms
Tumors or cancer of the LIVER. | 0 | 2.47 | 2 | 0 |
Neuroendocrine Tumors
Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition. | 0 | 4.15 | 3 | 1 |
Ambulation Disorders, Neurologic
[description not available] | 0 | 2.07 | 1 | 0 |
Cortical Lewy Body Disease
[description not available] | 0 | 2.07 | 1 | 0 |
Amentia
[description not available] | 0 | 2.07 | 1 | 0 |
Hallucination of Body Sensation
[description not available] | 0 | 2.48 | 2 | 0 |
Dementia
An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness. | 0 | 2.07 | 1 | 0 |
Hallucinations
Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real. They may be of organic origin or associated with MENTAL DISORDERS. | 0 | 2.48 | 2 | 0 |
Lewy Body Disease
A neurodegenerative disease characterized by dementia, mild parkinsonism, and fluctuations in attention and alertness. The neuropsychiatric manifestations tend to precede the onset of bradykinesia, MUSCLE RIGIDITY, and other extrapyramidal signs. DELUSIONS and visual HALLUCINATIONS are relatively frequent in this condition. Histologic examination reveals LEWY BODIES in the CEREBRAL CORTEX and BRAIN STEM. SENILE PLAQUES and other pathologic features characteristic of ALZHEIMER DISEASE may also be present. (From Neurology 1997;48:376-380; Neurology 1996;47:1113-1124) | 0 | 2.07 | 1 | 0 |
Cancer of Lung
[description not available] | 0 | 2.07 | 1 | 0 |
Experimental Neoplasms
[description not available] | 0 | 2.07 | 1 | 0 |
Local Neoplasm Recurrence
[description not available] | 0 | 2.44 | 2 | 0 |
Lung Neoplasms
Tumors or cancer of the LUNG. | 0 | 2.07 | 1 | 0 |
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed) | 0 | 5.25 | 4 | 1 |
Angiomatosis Retinae
[description not available] | 0 | 3.84 | 2 | 1 |
Cancer of Pancreas
[description not available] | 0 | 3.45 | 1 | 1 |
von Hippel-Lindau Disease
An autosomal dominant disorder caused by mutations in a tumor suppressor gene. This syndrome is characterized by abnormal growth of small blood vessels leading to a host of neoplasms. They include HEMANGIOBLASTOMA in the RETINA; CEREBELLUM; and SPINAL CORD; PHEOCHROMOCYTOMA; pancreatic tumors; and renal cell carcinoma (see CARCINOMA, RENAL CELL). Common clinical signs include HYPERTENSION and neurological dysfunctions. | 0 | 3.84 | 2 | 1 |
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA). | 0 | 3.45 | 1 | 1 |
Cushing's Syndrome
[description not available] | 0 | 2.08 | 1 | 0 |
Cancer of the Thymus
[description not available] | 0 | 2.08 | 1 | 0 |
Ectopic ACTH Syndrome
[description not available] | 0 | 2.08 | 1 | 0 |
ACTH Syndrome, Ectopic
Symptom complex due to ACTH production by non-pituitary neoplasms. | 0 | 2.08 | 1 | 0 |
Cushing Syndrome
A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent. | 0 | 2.08 | 1 | 0 |
Thymus Neoplasms
Tumors or cancer of the THYMUS GLAND. | 0 | 2.08 | 1 | 0 |
Alcohol Abuse
[description not available] | 0 | 2.08 | 1 | 0 |
Alcoholism
A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4) | 0 | 2.08 | 1 | 0 |
Anxiety
Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS. | 0 | 2.08 | 1 | 0 |
Chronic Illness
[description not available] | 0 | 9.62 | 9 | 9 |
Neurally Mediated Faint
[description not available] | 0 | 9.62 | 9 | 9 |
Symptom Cluster
[description not available] | 0 | 9.62 | 9 | 9 |
Tachyarrhythmia
[description not available] | 0 | 9.72 | 10 | 9 |
Chronic Disease
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2). | 0 | 9.62 | 9 | 9 |
Syndrome
A characteristic symptom complex. | 0 | 9.62 | 9 | 9 |
Tachycardia
Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia. | 0 | 9.72 | 10 | 9 |
Bladder Cancer
[description not available] | 0 | 2.01 | 1 | 0 |
Lymph Node Metastasis
[description not available] | 0 | 2.01 | 1 | 0 |
Urinary Bladder Neoplasms
Tumors or cancer of the URINARY BLADDER. | 0 | 2.01 | 1 | 0 |
Cancer of the Thyroid
[description not available] | 0 | 2.01 | 1 | 0 |
Thyroid Neoplasms
Tumors or cancer of the THYROID GLAND. | 0 | 2.01 | 1 | 0 |
Carcinoma, Medullary
A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992) | 0 | 2.01 | 1 | 0 |
Blood Pressure, High
[description not available] | 0 | 2.42 | 2 | 0 |
Hypertension
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. | 0 | 2.42 | 2 | 0 |
Aging
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. | 0 | 3.4 | 1 | 1 |
Bradyarrhythmia
[description not available] | 0 | 2.02 | 1 | 0 |
Complication, Intraoperative
[description not available] | 0 | 2.02 | 1 | 0 |
Circulatory Collapse
[description not available] | 0 | 2.02 | 1 | 0 |
Bradycardia
Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK. | 0 | 2.02 | 1 | 0 |
Shock
A pathological condition manifested by failure to perfuse or oxygenate vital organs. | 0 | 2.02 | 1 | 0 |
Diffuse Myofascial Pain Syndrome
[description not available] | 0 | 2.03 | 1 | 0 |
Fibromyalgia
A common nonarticular rheumatic syndrome characterized by myalgia and multiple points of focal muscle tenderness to palpation (trigger points). Muscle pain is typically aggravated by inactivity or exposure to cold. This condition is often associated with general symptoms, such as sleep disturbances, fatigue, stiffness, HEADACHES, and occasionally DEPRESSION. There is significant overlap between fibromyalgia and the chronic fatigue syndrome (FATIGUE SYNDROME, CHRONIC). Fibromyalgia may arise as a primary or secondary disease process. It is most frequent in females aged 20 to 50 years. (From Adams et al., Principles of Neurology, 6th ed, p1494-95) | 0 | 2.03 | 1 | 0 |
Dominant Hereditary Sensory Neuropathy, Type III
[description not available] | 0 | 2.04 | 1 | 0 |
Dysautonomia, Familial
An autosomal disorder of the peripheral and autonomic nervous systems limited to individuals of Ashkenazic Jewish descent. Clinical manifestations are present at birth and include diminished lacrimation, defective thermoregulation, orthostatic hypotension (HYPOTENSION, ORTHOSTATIC), fixed pupils, excessive SWEATING, loss of pain and temperature sensation, and absent reflexes. Pathologic features include reduced numbers of small diameter peripheral nerve fibers and autonomic ganglion neurons. (From Adams et al., Principles of Neurology, 6th ed, p1348; Nat Genet 1993;4(2):160-4) | 0 | 2.04 | 1 | 0 |
Cardiomyopathy, Hypertrophic Obstructive
[description not available] | 0 | 2.92 | 1 | 0 |
Cardiomyopathy, Hypertrophic
A form of CARDIAC MUSCLE disease, characterized by left and/or right ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR; HYPERTROPHY, RIGHT VENTRICULAR), frequent asymmetrical involvement of the HEART SEPTUM, and normal or reduced left ventricular volume. Risk factors include HYPERTENSION; AORTIC STENOSIS; and gene MUTATION; (FAMILIAL HYPERTROPHIC CARDIOMYOPATHY). | 0 | 2.92 | 1 | 0 |
Multiple System Atrophy Syndrome
[description not available] | 0 | 5.96 | 5 | 0 |
Multiple System Atrophy
A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92) | 0 | 5.96 | 5 | 0 |
Atherosclerotic Parkinsonism
[description not available] | 0 | 1.97 | 1 | 0 |
Parkinson Disease, Secondary
Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected condition. Examples include parkinsonism caused by vascular injury, drugs, trauma, toxin exposure, neoplasms, infections and degenerative or hereditary conditions. Clinical features may include bradykinesia, rigidity, parkinsonian gait, and masked facies. In general, tremor is less prominent in secondary parkinsonism than in the primary form. (From Joynt, Clinical Neurology, 1998, Ch38, pp39-42) | 0 | 1.97 | 1 | 0 |