ascorbic-acid and Paraganglioma

Pheochromocytomas and paragangliomas (PCPG) are usually benign neuroendocrine tumors. However, PCPGs with mutations in the succinate dehydrogenase B subunit (. We studied the genetic alterations of cluster I PCPGs compared with cluster II PCPGs, which usually present as benign tumors. By targeting the signature molecular pathway, we investigated the therapeutic effect of ascorbic acid on PCPGs using. By investigating PCPG cells with low SDHB levels, we show that pseudohypoxia resulted in elevated expression of iron transport proteins, including transferrin (TF), transferrin receptor 2 (TFR2), and the divalent metal transporter 1 (. The data here demonstrate that targeting redox homeostasis as a cancer vulnerability with pharmacologic ascorbic acid is a promising therapeutic strategy for

Topics: Animals; Antioxidants; Apoptosis; Ascorbic Acid; Cell Line, Tumor; Disease Models, Animal; DNA Damage; Drug Screening Assays, Antitumor; Female; Gene Knockdown Techniques; Humans; Iron; Mice; Mutation; Oxidative Stress; Paraganglioma; Pheochromocytoma; Reactive Oxygen Species; Succinate Dehydrogenase