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tetracyclic diterpenoid

A diterpenoid with a tetracyclic skeleton.

ChEBI ID: 52557

Members (21)

MemberDefinitionRole
10-deacetylbaccatine iii10-deacetylbaccatin III
6-hydroxytaxolA taxane diterpenoid that consists of paclitaxel bearing an additional hydroxy substituent at the 6alpha-position.6-hydroxypaclitaxel
aphidicolinA tetracyclic diterpenoid that has an tetradecahydro-8,11a-methanocyclohepta[a]naphthalene skeleton with two hydroxymethyl substituents at positions 4 and 9, two methyl substituents at positions 4 and 11b and two hydroxy substituents at positions 3 and 9. An antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication.aphidicolin
atractyligenineA diterpenoid isolated from coffee silverskin. It inhibits cutaneous photoaging.atractyligenin
baccatin iiiA tetracyclic diterpenoid isolated from plant species of the genus Taxus.baccatin III
cabazitaxelA tetracyclic diterpenoid that is 10-deacetylbaccatin III having O-methyl groups attached at positions 7 and 10 as well as an O-(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl group attached at position 13. Acts as a microtubule inhibitor, binds tubulin and promotes microtubule assembly and simultaneously inhibits disassembly.cabazitaxel
docetaxel anhydrousA tetracyclic diterpenoid that is paclitaxel with the N-benzyloxycarbonyl group replaced by N-tert-butoxycarbonyl, and the acetoxy group at position 10 replaced by a hydroxy group.docetaxel anhydrous
grayanotoxin iA tetracyclic diterpenoid that is grayanotoxane in which the pro-R hydrogen at position 14 is substituted by an acetoxy group and in which the 3beta-, 5-, 6beta-, 10-, and 16- positions are substituted by hydroxy groups.grayanotoxin I
ingenolA tetracyclic diterpenoid that is 1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a-methanocyclopenta[a]cyclopropa[e][10]annulen-11-one substituted at positions 5, 5a and 6 by hydroxy groups, positions 1, 1, 7 and 9 by methyl groups, position 4 by a hydroxymethyl group and position 1 by an oxo group (the 1aR,2S,5R,5aR,6S,8aS,9R,10aR diastereomer).ingenol
komaroviquinoneA tetracyclic diterpenoid isolated from Dracocephalum komarovii and has been shown to exhibit trypanocidal activity.komaroviquinone
paclitaxelA tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.paclitaxel
phorbolA diterpenoid with the structure of tigliane hydroxylated at C-4, -9, -12(beta), -13 and -20, with an oxo group at C-3 and unsaturation at the 1- and 6-positions.phorbol
rebaudioside aA rebaudioside that is rubusoside in which the hydroxy groups at positions 3 and 4 of the beta-D-glucopyranosyloxy group at the 13alpha position have both been converted to the corresponding beta-D-glucopyranoside.rebaudioside A
rebaudioside dA rebaudioside that is rebaudioside A in which the hydroxy group at position 2 of the beta-D-glucosyl ester moiety has been converted to the corresponding beta-D-glucoside. Found in minute quantities in the leaves of Stevia rebaudiana.rebaudioside D
rebaudioside mA rebaudioside that is rebaudioside A in which the the hydroxy groups at positions 2 and 3 of the beta-D-glucosyl ester moiety have both been converted to the corresponding beta-D-glucoside. Found in very low concentraitions in the leaves of Stevia Rebaudiana, it is more than 200 times sweeter than sucrose.rebaudioside M
rubusosideA steviol glycoside that is steviol in which both the carboxy group and the tertiary allylic hydroxy group have been converted to their corresponding beta-D-glucosides. A precious bioactive natural sweetener which mainly exists the in Chinese sweet tea plant, Rubus suavissimus.rubusoside
sordaricinA tetracyclic diterpenoid that is produced by several fungi including Sordaria araneosa.sordaricin
spongia-13(16),14-dien-19-oic acidA tetracyclic diterpenoid that is 3b,4,5,5a,6,7,8,9,9a,9b,10,11-dodecahydrophenanthro[1,2-c]furan substituted by methyl groups at positions 3b, 6 and 9 and a carboxy group at position 6. Isolated from Spongia, it exhibits inhibitory activity against androgen receptor.spongia-13(16),14-dien-19-oic acid
steviolAn ent-kaurane diterpenoid that is 5beta,8alpha,9beta,10alpha-kaur-16-en-18-oic acid in which the hydrogen at position 13 has been replaced by a hydroxy group.steviol
steviosideA diterpene glycoside that is rubusoside in which the hydroxy group at position 2 of the allylic beta-D-glucoside has been converted to the corresponding beta-D-glucoside. It is a natural herbal sweetener that is 250-300 times sweeter than sucrose (though with a bitter aftertaste), extracted from the Stevia rebaudiana plant native to South America.stevioside
tiamulinA carbotricyclic compound that is pleuromutilin in which the hydroxyacetate group is replaced by a 2-{[2-(diethylamino)ethyl]sulfanyl}acetate group. An antibacterial drug, tiamulin is used in veterinary medicine (generally as its hydrogen fumarate salt) for the treatment of swine dysentery caused by Serpulina hyodysenteriae.tiamulin

Research

Studies (43,054)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-19901,024 (2.38)18.7374
1990's4,430 (10.29)18.2507
2000's12,740 (29.59)29.6817
2010's18,714 (43.47)24.3611
2020's6,146 (14.28)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials9,088 (18.72%)5.53%
Reviews4,552 (9.38%)6.00%
Case Studies3,329 (6.86%)4.05%
Observational251 (0.52%)0.25%
Other31,333 (64.53%)84.16%