Page last updated: 2024-08-05 15:21:57
antimitotic
Any compound that inhibits cell division (mitosis).
ChEBI ID: 64911
Members (16)
| Member | Definition | Class |
|---|---|---|
| 2-acetylaminofluorene | The parent of the class of 2-acetamidofluorenes, being an ortho-fused polycyclic arene that consists of 9H-fluorene bearing an acetamido substituent at position 2. It is a carcinogenic and mutagenic derivative of fluorene. | 2-acetamidofluorene |
| 2-methoxyestradiol | A 17beta-hydroxy steroid, being 17beta-estradiol methoxylated at C-2. | 2-methoxy-17beta-estradiol |
| aphidicolin | A tetracyclic diterpenoid that has an tetradecahydro-8,11a-methanocyclohepta[a]naphthalene skeleton with two hydroxymethyl substituents at positions 4 and 9, two methyl substituents at positions 4 and 11b and two hydroxy substituents at positions 3 and 9. An antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication. | aphidicolin |
| cafenstrole | cafenstrole | |
| ceratamine a | An organic heterobicyclic compound, which is imidazo[4,5-d]azepin-5(6H)-one substituted by a 3,5-dibromo-4-methoxybenzyl group at position 4, a methyl group at position 6 and a methylamino group at position 2. It is an antimitotic alkaloid isolated from the marine sponge Pseudoceratina. | ceratamine A |
| hydroxyurea | A member of the class of ureas that is urea in which one of the hydrogens is replaced by a hydroxy group. An antineoplastic used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease. | hydroxyurea |
| laulimalide | A macrolide with formula C30H42O7 that is isolated from the marine sponges, Cacospongia mycofijiensis and Hyattella sp. | laulimalide |
| maytansine | An organic heterotetracyclic compound and 19-membered macrocyclic lactam antibiotic originally isolated from the Ethiopian shrub Maytenus serrata but also found in other Maytenus species. It exhibits cytotoxicity against many tumour cell lines. | maytansine |
| mefenacet | mefenacet | |
| monastrol | A racemate comprising equimolar amounts of R- and S-monastrol. | ethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate; monastrol |
| myrmicacin | A medium-chain fatty acid that is decanoic acid substituted at position 3 by a hydroxy group. | 3-hydroxydecanoic acid |
| nocodazole | A member of the class of benzimidazoles that is benzimidalole which is substituted at position 2 by a (methoxycarbonyl)amino group and at position 5 by a 2-thienoyl group. It is an antineoplastic agent that exerts its effect by depolymerising microtubules. | nocodazole |
| oryzalin | A sulfonamide that is benzenesulfonamide substituted at positions 3 and 5 by nitro groups and at position 4 by a dipropylamino group. | oryzalin |
| pederin | A polyketide and carboxamide produced by a (Pseudomonas) bacterial endosymbiont of certain rove beetles (genus Paederus). Pederin is the agent responsible for the vesicant effects (linear or Paederus dermatitis) when the beetle is crushed against the skin. It is a powerful inhibitor of protein biosynthesis and mitosis and a potent antitumour agent. | pederin |
| podophyllotoxin | An organic heterotetracyclic compound that has a furonaphthodioxole skeleton bearing a 3,4,5-trimethoxyphenyl substituent. It is found in the roots and rhizomes of Podophyllum species and is used for the topical treatment of genital warts. | podophyllotoxin |
| rhizoxin | An macrolide antibiotic isolated from the pathogenic plant fungus Rhizopus microsporus. It also exhibits antitumour and antimitotic activity. | rhizoxin |
Research
Studies (20,122)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 6,194 (30.78) | 18.7374 |
| 1990's | 3,857 (19.17) | 18.2507 |
| 2000's | 4,719 (23.45) | 29.6817 |
| 2010's | 4,269 (21.22) | 24.3611 |
| 2020's | 1,083 (5.38) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1,088 (5.07%) | 5.53% |
| Reviews | 1,462 (6.81%) | 6.00% |
| Case Studies | 1,152 (5.37%) | 4.05% |
| Observational | 43 (0.20%) | 0.25% |
| Other | 17,716 (82.55%) | 84.16% |
Protein Targets (233)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 11.6831 | 2 | 6 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 68.8024 | 2 | 3 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 19.5709 | 1 | 3 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 8.0790 | 1 | 3 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 17.0303 | 9 | 32 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 21.9770 | 2 | 9 |
| arylsulfatase A | Homo sapiens (human) | Potency | 23.9341 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 4.1316 | 5 | 5 |
| Ataxin-2 | Homo sapiens (human) | Potency | 9.3265 | 1 | 4 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 22.7508 | 1 | 2 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 12.5560 | 2 | 7 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 3.0404 | 1 | 2 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 25.0604 | 2 | 4 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 26.0254 | 1 | 2 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 65.1933 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 26.0254 | 1 | 2 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 65.1933 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 12.2898 | 2 | 4 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 28.2141 | 2 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 16.0797 | 1 | 5 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 50.2499 | 2 | 3 |
| CREB-binding protein | Homo sapiens (human) | Potency | 1.1946 | 3 | 3 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 9.7183 | 1 | 3 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 2.4201 | 1 | 3 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 25.1846 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 12.3731 | 2 | 7 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 1.9720 | 2 | 3 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 12.0583 | 1 | 3 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 1.4125 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 23.7781 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 15.2027 | 10 | 31 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 46.0042 | 2 | 4 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 21.3126 | 10 | 28 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 11.7960 | 2 | 6 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 4.3838 | 4 | 13 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 21.6972 | 2 | 5 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 14.3479 | 1 | 5 |
| G | Vesicular stomatitis virus | Potency | 2.4201 | 1 | 3 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 10.9515 | 1 | 4 |
| GALC protein | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 10.9515 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 10.9515 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 10.9515 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 10.9515 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 10.9515 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 10.9515 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 10.9515 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 10.9515 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 10.9515 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 10.9515 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 10.9515 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 10.9515 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 10.9515 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 10.9515 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 10.9515 | 1 | 4 |
| geminin | Homo sapiens (human) | Potency | 0.9722 | 4 | 14 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 9.5907 | 3 | 9 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 5.2487 | 1 | 2 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 27.3316 | 4 | 8 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 8.5597 | 1 | 3 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 29.3717 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 9.7183 | 1 | 9 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 22.9010 | 2 | 4 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 94.2348 | 1 | 3 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 2.4201 | 1 | 3 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 0.5389 | 2 | 2 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 58.9930 | 2 | 2 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 1.0515 | 2 | 8 |
| IDH1 | Homo sapiens (human) | Potency | 1.3318 | 1 | 4 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 2.4201 | 1 | 6 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 28.1838 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 6.4170 | 3 | 13 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 3.8059 | 2 | 9 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 0.5482 | 2 | 4 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 22.1032 | 1 | 2 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 39.5068 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 15.0654 | 1 | 2 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 1.5874 | 2 | 4 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 3.9045 | 1 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 16.2334 | 3 | 10 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 8.7190 | 1 | 4 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 54.0269 | 1 | 2 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 11.1031 | 2 | 5 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 0.1000 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 20.6147 | 3 | 12 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 0.7574 | 2 | 3 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 37.3046 | 1 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 35.9630 | 3 | 3 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 26.5957 | 2 | 6 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 89.1251 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 4.9562 | 1 | 2 |
| polyprotein | Zika virus | Potency | 14.3479 | 1 | 5 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 3.1218 | 1 | 6 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 19.0256 | 3 | 8 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 22.3872 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 14.8111 | 2 | 6 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 15.6890 | 2 | 11 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 0.1122 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 0.2119 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 17.9278 | 3 | 16 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 10.5219 | 2 | 8 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 1.8172 | 2 | 3 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 34.2617 | 2 | 3 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 34.2617 | 2 | 3 |
| Smad3 | Homo sapiens (human) | Potency | 0.7079 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 1.0685 | 1 | 4 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 4.9321 | 2 | 27 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 18.9232 | 3 | 5 |
| Thrombopoietin | Homo sapiens (human) | Potency | 0.0126 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 12.5963 | 3 | 10 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 0.0178 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 18.1992 | 5 | 8 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 36.7085 | 2 | 2 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 4.9562 | 1 | 2 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 4.9562 | 1 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 35.7168 | 2 | 2 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 5.5279 | 2 | 8 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 10.8368 | 2 | 3 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 38.0934 | 1 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 8.5597 | 1 | 3 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 3-ketoacyl-CoA synthase 18 | Arabidopsis thaliana (thale cress) | IC50 | 0.1995 | 1 | 1 |
| 3-ketoacyl-CoA synthase 20 | Arabidopsis thaliana (thale cress) | IC50 | 0.3981 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 11.6750 | 1 | 2 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 7.4310 | 1 | 2 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 2.1430 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 1.1220 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 2.1430 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 1.1220 | 1 | 1 |
| Adenosine receptor A1 | Homo sapiens (human) | IC50 | 50.3300 | 1 | 1 |
| Adenosine receptor A1 | Homo sapiens (human) | Ki | 29.4330 | 1 | 1 |
| Adenosine receptor A2a | Homo sapiens (human) | IC50 | 7.5090 | 1 | 1 |
| Adenosine receptor A2a | Homo sapiens (human) | Ki | 4.2190 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 8.5950 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 8.5240 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 21.0610 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 7.8980 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 12.0790 | 1 | 2 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Aurora kinase A | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Calcium-activated potassium channel subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 0.5600 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 28.0000 | 1 | 1 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 113.0000 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 31.0000 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 23.0000 | 1 | 1 |
| Chain A, Glutathione-requiring prostaglandin D synthase | Homo sapiens (human) | IC50 | 65.0000 | 1 | 1 |
| Cytochrome P450 1A1 | Homo sapiens (human) | Ki | 62.0000 | 2 | 2 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 0.0160 | 1 | 1 |
| Cytochrome P450 1B1 | Homo sapiens (human) | Ki | 36.0000 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 4.0000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 0.6000 | 1 | 1 |
| DNA polymerase alpha catalytic subunit | Homo sapiens (human) | IC50 | 5.1500 | 6 | 6 |
| DNA polymerase beta | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| DNA polymerase beta | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| DNA polymerase catalytic subunit | Human alphaherpesvirus 1 strain 17 | IC50 | 0.5000 | 1 | 1 |
| DNA polymerase catalytic subunit | Human alphaherpesvirus 1 strain KOS | IC50 | 0.4380 | 1 | 1 |
| DNA polymerase catalytic subunit | Human herpesvirus 3 strain Dumas | IC50 | 1.6000 | 1 | 2 |
| DNA polymerase catalytic subunit | Human herpesvirus 5 strain AD169 | IC50 | 0.4435 | 2 | 2 |
| DNA polymerase catalytic subunit | Human herpesvirus 6 (strain Uganda-1102) | IC50 | 0.4000 | 1 | 1 |
| DNA polymerase delta catalytic subunit | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| DNA polymerase lambda | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| DNA polymerase subunit gamma-1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| G-protein coupled receptor 84 | Homo sapiens (human) | Ki | 3.3100 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit theta | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Glucocorticoid receptor | Homo sapiens (human) | IC50 | 0.0140 | 1 | 1 |
| Kinesin-like protein KIF11 | Homo sapiens (human) | IC50 | 12.8247 | 9 | 9 |
| Kinesin-like protein KIFC1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| nuclear receptor subfamily 0 group B member 1 | Homo sapiens (human) | IC50 | 1.4892 | 1 | 2 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | IC50 | 18.0000 | 2 | 3 |
| Prostaglandin G/H synthase 2 | Mus musculus (house mouse) | IC50 | 18.0000 | 2 | 3 |
| Ribonucleoside-diphosphate reductase large subunit | Homo sapiens (human) | IC50 | 997.0000 | 1 | 1 |
| Similar to alpha-tubulin isoform 1 | Bos taurus (cattle) | IC50 | 6.0547 | 15 | 30 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 6.2320 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 4.9460 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 8.5950 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 8.5240 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 6.0530 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 3.2160 | 1 | 1 |
| steroidogenic factor 1 | Homo sapiens (human) | IC50 | 67.5235 | 1 | 2 |
| Tubulin alpha-1A chain | Homo sapiens (human) | IC50 | 43.2300 | 9 | 11 |
| Tubulin alpha-1A chain | Sus scrofa (pig) | IC50 | 4.4043 | 14 | 23 |
| Tubulin alpha-1A chain | Sus scrofa (pig) | Ki | 2.1800 | 1 | 1 |
| Tubulin alpha-1B chain | Homo sapiens (human) | IC50 | 43.2300 | 9 | 11 |
| Tubulin alpha-1C chain | Homo sapiens (human) | IC50 | 43.2300 | 9 | 11 |
| Tubulin alpha-3C chain | Homo sapiens (human) | IC50 | 43.2300 | 9 | 11 |
| Tubulin alpha-3E chain | Homo sapiens (human) | IC50 | 43.2300 | 9 | 11 |
| Tubulin alpha-4A chain | Homo sapiens (human) | IC50 | 43.2300 | 9 | 11 |
| Tubulin beta chain | Homo sapiens (human) | IC50 | 43.2300 | 9 | 11 |
| Tubulin beta chain | Sus scrofa (pig) | IC50 | 0.7633 | 11 | 18 |
| Tubulin beta chain | Sus scrofa (pig) | Ki | 2.1800 | 1 | 1 |
| Tubulin beta-1 chain | Homo sapiens (human) | IC50 | 43.2300 | 9 | 11 |
| Tubulin beta-2A chain | Homo sapiens (human) | IC50 | 43.2300 | 9 | 11 |
| Tubulin beta-2B chain | Bos taurus (cattle) | IC50 | 650.1359 | 21 | 22 |
| Tubulin beta-2B chain | Homo sapiens (human) | IC50 | 43.2300 | 9 | 11 |
| Tubulin beta-3 chain | Homo sapiens (human) | IC50 | 43.2300 | 9 | 11 |
| Tubulin beta-4A chain | Homo sapiens (human) | IC50 | 43.2300 | 9 | 11 |
| Tubulin beta-4B chain | Homo sapiens (human) | IC50 | 43.2300 | 9 | 11 |
| Tubulin beta-6 chain | Homo sapiens (human) | IC50 | 43.2300 | 9 | 11 |
| Tubulin beta-8 chain | Homo sapiens (human) | IC50 | 43.2300 | 9 | 11 |
| Tyrosine-protein kinase ABL1 | Homo sapiens (human) | IC50 | 0.6400 | 1 | 1 |
| Urease | Canavalia ensiformis (jack bean) | Ki | 25.6600 | 1 | 1 |
| Urease subunit alpha | Helicobacter pylori 26695 | IC50 | 100.0000 | 1 | 1 |
| Urease subunit beta | Helicobacter pylori 26695 | IC50 | 100.0000 | 1 | 1 |
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| DNA polymerase alpha catalytic subunit | Homo sapiens (human) | EC50 | 2.0000 | 1 | 1 |
| G-protein coupled receptor 84 | Homo sapiens (human) | EC50 | 17.9250 | 2 | 2 |
| Regulatory protein E2 | human papillomavirus 11 | Kd | 20.1000 | 1 | 1 |
| Regulatory protein E2 | Human papillomavirus 16 | Kd | 70.5000 | 1 | 1 |
| Regulatory protein E2 | Human papillomavirus type 1a | Kd | 206.2875 | 4 | 4 |
| Sex hormone-binding globulin | Homo sapiens (human) | Kd | 0.0008 | 1 | 1 |
| Stromelysin-1 | Homo sapiens (human) | Kd | 25,000.0000 | 1 | 1 |
| Tubulin alpha-1A chain | Homo sapiens (human) | EC50 | 0.9000 | 1 | 1 |
| Tubulin alpha-1A chain | Homo sapiens (human) | Kd | 21.5000 | 1 | 1 |
| Tubulin alpha-1A chain | Sus scrofa (pig) | Kd | 70.5000 | 1 | 1 |
| Tubulin alpha-1B chain | Homo sapiens (human) | EC50 | 0.9000 | 1 | 1 |
| Tubulin alpha-1B chain | Homo sapiens (human) | Kd | 21.5000 | 1 | 1 |
| Tubulin alpha-1C chain | Homo sapiens (human) | EC50 | 0.9000 | 1 | 1 |
| Tubulin alpha-1C chain | Homo sapiens (human) | Kd | 21.5000 | 1 | 1 |
| Tubulin alpha-3C chain | Homo sapiens (human) | EC50 | 0.9000 | 1 | 1 |
| Tubulin alpha-3C chain | Homo sapiens (human) | Kd | 21.5000 | 1 | 1 |
| Tubulin alpha-3E chain | Homo sapiens (human) | EC50 | 0.9000 | 1 | 1 |
| Tubulin alpha-3E chain | Homo sapiens (human) | Kd | 21.5000 | 1 | 1 |
| Tubulin alpha-4A chain | Homo sapiens (human) | EC50 | 0.9000 | 1 | 1 |
| Tubulin alpha-4A chain | Homo sapiens (human) | Kd | 21.5000 | 1 | 1 |
| Tubulin beta chain | Homo sapiens (human) | EC50 | 0.9000 | 1 | 1 |
| Tubulin beta chain | Homo sapiens (human) | Kd | 21.5000 | 1 | 1 |
| Tubulin beta chain | Sus scrofa (pig) | Kd | 70.5000 | 1 | 1 |
| Tubulin beta-1 chain | Homo sapiens (human) | EC50 | 0.9000 | 1 | 1 |
| Tubulin beta-1 chain | Homo sapiens (human) | Kd | 21.5000 | 1 | 1 |
| Tubulin beta-2A chain | Homo sapiens (human) | EC50 | 0.9000 | 1 | 1 |
| Tubulin beta-2A chain | Homo sapiens (human) | Kd | 21.5000 | 1 | 1 |
| Tubulin beta-2B chain | Homo sapiens (human) | EC50 | 0.9000 | 1 | 1 |
| Tubulin beta-2B chain | Homo sapiens (human) | Kd | 21.5000 | 1 | 1 |
| Tubulin beta-3 chain | Homo sapiens (human) | EC50 | 0.9000 | 1 | 1 |
| Tubulin beta-3 chain | Homo sapiens (human) | Kd | 21.5000 | 1 | 1 |
| Tubulin beta-4A chain | Homo sapiens (human) | EC50 | 0.9000 | 1 | 1 |
| Tubulin beta-4A chain | Homo sapiens (human) | Kd | 21.5000 | 1 | 1 |
| Tubulin beta-4B chain | Homo sapiens (human) | EC50 | 0.9000 | 1 | 1 |
| Tubulin beta-4B chain | Homo sapiens (human) | Kd | 21.5000 | 1 | 1 |
| Tubulin beta-6 chain | Homo sapiens (human) | EC50 | 0.9000 | 1 | 1 |
| Tubulin beta-6 chain | Homo sapiens (human) | Kd | 21.5000 | 1 | 1 |
| Tubulin beta-8 chain | Homo sapiens (human) | EC50 | 0.9000 | 1 | 1 |
| Tubulin beta-8 chain | Homo sapiens (human) | Kd | 21.5000 | 1 | 1 |
Other Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Carbonic anhydrase 2 | Homo sapiens (human) | Kinact | 28.0000 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Kinact | 23.0000 | 1 | 1 |
| interferon gamma precursor | Homo sapiens (human) | AC50 | 5.8000 | 2 | 4 |
| PAX8 | Homo sapiens (human) | AC50 | 0.2600 | 1 | 1 |
| Similar to alpha-tubulin isoform 1 | Bos taurus (cattle) | INH | 2.2000 | 1 | 2 |
| Tubulin alpha-1A chain | Homo sapiens (human) | Activity | 23.5000 | 1 | 1 |
| Tubulin alpha-1B chain | Homo sapiens (human) | Activity | 23.5000 | 1 | 1 |
| Tubulin alpha-1C chain | Homo sapiens (human) | Activity | 23.5000 | 1 | 1 |
| Tubulin alpha-3C chain | Homo sapiens (human) | Activity | 23.5000 | 1 | 1 |
| Tubulin alpha-3E chain | Homo sapiens (human) | Activity | 23.5000 | 1 | 1 |
| Tubulin alpha-4A chain | Homo sapiens (human) | Activity | 23.5000 | 1 | 1 |
| Tubulin beta chain | Homo sapiens (human) | Activity | 23.5000 | 1 | 1 |
| Tubulin beta-1 chain | Homo sapiens (human) | Activity | 23.5000 | 1 | 1 |
| Tubulin beta-2A chain | Homo sapiens (human) | Activity | 23.5000 | 1 | 1 |
| Tubulin beta-2B chain | Homo sapiens (human) | Activity | 23.5000 | 1 | 1 |
| Tubulin beta-2B chain | Bos taurus (cattle) | INH | 2.2000 | 1 | 1 |
| Tubulin beta-3 chain | Homo sapiens (human) | Activity | 23.5000 | 1 | 1 |
| Tubulin beta-4A chain | Homo sapiens (human) | Activity | 23.5000 | 1 | 1 |
| Tubulin beta-4B chain | Homo sapiens (human) | Activity | 23.5000 | 1 | 1 |
| Tubulin beta-6 chain | Homo sapiens (human) | Activity | 23.5000 | 1 | 1 |
| Tubulin beta-8 chain | Homo sapiens (human) | Activity | 23.5000 | 1 | 1 |