ascorbic-acid and Iritis

Myeloperoxidase (MPO) is present at high levels in polymorphonuclear leukocytes (PMNs) and has been used as a marker to quantify the accumulation of PMNs in inflamed tissues. MPO activity in inflamed ocular tissues was inhibited by aspirates of aqueous humor. This inhibition could be duplicated by the addition of ascorbic acid at concentrations equivalent to those present in the aliquots of aqueous humor. Similarly, aqueous humor and ascorbic acid inhibited MPO from isolated rabbit leukocytes. Therefore, ascorbic acid appears to inhibit the functional activity of the peroxidase in PMNs, thus preventing potential tissue damage by this enzyme when released during leukocyte degranulation in inflammation. Ascorbic acid might fulfill a role as an endogenous anti-inflammatory agent in the eye.

Topics: Animals; Aqueous Humor; Ascorbic Acid; Ciliary Body; Depression, Chemical; Iritis; Neutrophils; Peroxidase; Peroxidases; Rabbits; Uveitis

Topics: Animals; Aqueous Humor; Ascorbic Acid; Ciliary Body; Dose-Response Relationship, Radiation; Eye; Inflammation; Intraocular Pressure; Iritis; Rabbits; Time Factors; X-Rays

Topics: Animals; Aqueous Humor; Ascorbic Acid; Biological Transport, Active; Endotoxins; Eye Proteins; Injections; Intraocular Pressure; Iritis; Leukocytes; Prostaglandins; Rabbits; Recurrence; Serum Albumin, Bovine; Shigella flexneri; Tritium; Uvea; Uveitis; Vitreous Body

Topics: Animals; Aqueous Humor; Ascorbic Acid; Biochemical Phenomena; Biochemistry; Humans; Iritis; Rabbits; Research