Page last updated: 2024-09-28

Eosinophilia-Myalgia Syndrome

A complex systemic syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart. Diagnostic features generally include EOSINOPHILIA, myalgia severe enough to limit usual activities of daily living, and the absence of coexisting infectious, autoimmune or other conditions that may induce eosinophilia. Biopsy of affected tissue reveals a microangiopathy associated with diffuse inflammation involving connective tissue. (From Spitzer et al., J Rheumatol Suppl 1996 Oct;46:73-9; Blackburn WD, Semin Arthritis Rheum 1997 Jun;26(6):788-93)

Synonyms(4)

Synonym
Eosinophilia-Myalgia Syndrome, L-Tryptophan-Related
Syndrome, Eosinophilia-Myalgia, L-Tryptophan-Related
L-Tryptophan-Related Eosinophilia-Myalgia Syndrome
Eosinophilia-Myalgia Syndrome

Research

Studies (206)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's179 (86.89)12.5806
2000's19 (9.22)18.1394
2010's6 (2.91)28.8240
2020's2 (0.97)9.53
DrugIndicatedRelationship StrengthStudiesTrials
5-hydroxytryptophan0low70
acetaldehyde0low10
beta-alanine0low10
2,3-diaminopropionic acid0low10
formaldehyde0low10
histamine0low20
kynurenine0low40
melatonin0low30
pyridoxine0low30
quinolinic acid0low30
hydroxyindoleacetic acid0low10
azathioprine0low10
chlorpromazine0low10
ciprofloxacin0low10
dapsone0low10
debrisoquin0low10
fenfluramine0low10
gentamicin0low10
haloperidol0low10
hydralazine0low10
ketotifen0low10
khellin0low10
lansoprazole0low10
mephenytoin0low10
metyrapone0low10
mianserin0low10
omeprazole0low10
fenclonine0low10
sanguinarine0low10
prednisolone0low20
prednisone0low80
alanine0low100
lysine0low10
leucine0low10
aniline0low50
phenylalanine0low10
colchicine0low10
tryptophan0medium1712
methylprednisolone0medium51
methylphenazonium methosulfate0low10
chromium0low10
cefazolin0low10
dexfenfluramine0low10
1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid0low60
3-phenylamino-1,2-propanediol0low20
1,1'-ethylidene bis(tryptophan)0low210
tryptoline0low10
3-(phenylamino)alanine0low100
methotrexate0low30
deflazacort0low10
benzofurans0low10
zithromax0low10
phosphorus0low20
phosphocreatine0low20
g(m1) ganglioside0medium11
cellulose0low10
calpain0low10
sodium glutamate0low10
interleukin-80low20
ascorbic acid0low10
cyclosporine0low10
iminoquinone0low10
neopterin0low10
acetylcellulose0low10
carbidopa0low20

Protein Targets (878)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE130013
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
phosphopantetheinyl transferase150015
Microtubule-associated protein tau120012
aldehyde dehydrogenase 1 family, member A1140014
glucocerebrosidase4004
vitamin D3 receptor isoform VDRA110011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30202
Sodium- and chloride-dependent GABA transporter 20202
acetylcholinesterase100010
hypoxia-inducible factor 1 alpha subunit8008
RAR-related orphan receptor gamma140014
SMAD family member 25005
SMAD family member 35005
GLI family zinc finger 3190019
AR protein210021
caspase 7, apoptosis-related cysteine protease5005
thyroid stimulating hormone receptor130013
estrogen receptor 2 (ER beta)100010
nuclear receptor subfamily 1, group I, member 3130013
progesterone receptor130013
glucocorticoid receptor [Homo sapiens]180018
retinoic acid nuclear receptor alpha variant 1170017
retinoid X nuclear receptor alpha130013
estrogen-related nuclear receptor alpha190019
farnesoid X nuclear receptor9009
pregnane X nuclear receptor140014
estrogen nuclear receptor alpha200020
peroxisome proliferator-activated receptor delta110011
peroxisome proliferator activated receptor gamma120012
vitamin D (1,25- dihydroxyvitamin D3) receptor140014
caspase-35005
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a110011
thyroid stimulating hormone receptor7007
activating transcription factor 66006
thyrotropin-releasing hormone receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a4004
v-jun sarcoma virus 17 oncogene homolog (avian)110011
Histone H2A.x5005
Caspase-73003
caspase-33003
thyroid hormone receptor beta isoform 2160016
heat shock protein beta-17007
nuclear factor erythroid 2-related factor 2 isoform 1160016
Voltage-dependent calcium channel gamma-2 subunit100010
Cellular tumor antigen p53130013
Glutamate receptor 2101011
ATPase family AAA domain-containing protein 59009
Ataxin-2140014
Chain A, TYROSYL-DNA PHOSPHODIESTERASE8008
Carbonic anhydrase 10004
Carbonic anhydrase 20016
Alanine racemase, biosynthetic0001
5-hydroxytryptamine receptor 1D0103
Glutamate receptor ionotropic, NMDA 1 0508
Proton-coupled amino acid transporter 10304
Adenosine deaminase0001
Carbonic anhydrase 40002
Steroid C26-monooxygenase0011
Cytochrome P450 1300011
Cytochrome P450 1300011
Chain A, Hyaluronidase, phage associated0101
thioredoxin glutathione reductase4004
cytochrome P450 family 3 subfamily A polypeptide 4160016
IDH18008
euchromatic histone-lysine N-methyltransferase 2200020
chromobox protein homolog 1150015
nuclear factor erythroid 2-related factor 2 isoform 26006
lethal(3)malignant brain tumor-like protein 1 isoform I2002
geminin150015
lethal factor (plasmid)8008
lamin isoform A-delta10220022
Polyphenol oxidase 20101
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0101
Alpha-2B adrenergic receptor09110
Spike glycoprotein91212
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
Chain A, Ferritin light chain3003
interleukin 86006
thioredoxin reductase160016
ATAD5 protein, partial100010
Fumarate hydratase7007
TDP1 protein180018
EWS/FLI fusion protein120012
G100010
polyprotein7007
P531001
arylsulfatase A9009
aryl hydrocarbon receptor110011
Bloom syndrome protein isoform 16006
peripheral myelin protein 22 isoform 18008
hemoglobin subunit beta1001
cellular tumor antigen p53 isoform a6006
DNA polymerase iota isoform a (long)9009
peripheral myelin protein 22110011
survival motor neuron protein isoform d7007
cytochrome P450 3A4 isoform 1150015
M-phase phosphoprotein 88008
muscleblind-like protein 1 isoform 15005
muscarinic acetylcholine receptor M19009
Gamma-aminobutyric acid receptor subunit pi151016
ATP-binding cassette sub-family C member 3014014
Multidrug resistance-associated protein 4014016
Bile salt export pump0606
Bile salt export pump022022
Interferon beta140014
HLA class I histocompatibility antigen, B alpha chain 100010
Gamma-aminobutyric acid receptor subunit beta-1151016
Gamma-aminobutyric acid receptor subunit delta151016
Gamma-aminobutyric acid receptor subunit gamma-2151016
Gamma-aminobutyric acid receptor subunit alpha-5151016
Gamma-aminobutyric acid receptor subunit alpha-3151016
Gamma-aminobutyric acid receptor subunit gamma-1151016
Gamma-aminobutyric acid receptor subunit alpha-2151016
Gamma-aminobutyric acid receptor subunit alpha-4151016
Gamma-aminobutyric acid receptor subunit gamma-3151016
Gamma-aminobutyric acid receptor subunit alpha-6151016
Nuclear receptor ROR-gamma7007
Gamma-aminobutyric acid receptor subunit alpha-1151016
Gamma-aminobutyric acid receptor subunit beta-3151016
Gamma-aminobutyric acid receptor subunit beta-2151016
GABA theta subunit151016
Inositol hexakisphosphate kinase 1100010
Canalicular multispecific organic anion transporter 1014014
Gamma-aminobutyric acid receptor subunit epsilon151016
Protein-arginine deiminase type-40303
cytochrome P450 2C9, partial100010
regulator of G-protein signaling 4110011
Cytochrome P450 3A409010
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent betaine transporter0101
Glutamate receptor ionotropic, NMDA 2A 0407
Glutamate receptor ionotropic, NMDA 2B0407
Glutamate receptor ionotropic, NMDA 2C0407
Glutamate receptor ionotropic, NMDA 2D0407
Glutamate receptor ionotropic, NMDA 3B0407
Glutamate receptor ionotropic, NMDA 3A0407
Chain A, Putative fructose-1,6-bisphosphate aldolase8008
Chain A, JmjC domain-containing histone demethylation protein 3A4004
Luciferase8008
Smad36006
apical membrane antigen 1, AMA14004
cytochrome P450 2D69009
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
Solute carrier family 22 member 60202
Solute carrier family 15 member 10101
Solute carrier family 22 member 60203
Solute carrier family 22 member 80203
Solute carrier family 22 member 110102
Solute carrier family 22 member 80101
Proteasome subunit beta type-110001
USP1 protein, partial100010
NFKB1 protein, partial4004
Thrombopoietin5005
NADPH oxidase 10101
67.9K protein5005
Snq2p0001
Adenylate cyclase type 1 0303
Spike glycoprotein0123
Replicase polyprotein 1ab0224
cytochrome P450 2D6 isoform 1100010
D(1A) dopamine receptor4004
potassium voltage-gated channel subfamily H member 2 isoform d8008
histone deacetylase 9 isoform 31001
mitogen-activated protein kinase 13003
atrial natriuretic peptide receptor 2 precursor5005
ras-related protein Rab-9A8008
serine/threonine-protein kinase mTOR isoform 14004
DNA polymerase kappa isoform 13003
histone acetyltransferase KAT2A isoform 15005
Proteasome subunit alpha type-70001
Solute carrier family 22 member 1 0203
Polyunsaturated fatty acid lipoxygenase ALOX15B6006
Transmembrane protease serine 20123
Glutamate receptor ionotropic, NMDA 2D0101
Transient receptor potential cation channel subfamily V member 10202
Glutamate receptor ionotropic, NMDA 3B0101
Voltage-dependent L-type calcium channel subunit alpha-1F0202
5-hydroxytryptamine receptor 40808
Potassium channel subfamily K member 20202
Epidermal growth factor receptor0202
Albumin0123
Albumin0022
Major prion protein0022
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Receptor tyrosine-protein kinase erbB-20101
Major prion protein0011
Integrin beta-34004
Cytochrome P450 1A20516
Tyrosine-protein kinase Fyn0101
Procathepsin L0224
Aldo-keto reductase family 1 member B10606
Muscarinic acetylcholine receptor M20909
Muscarinic acetylcholine receptor M40808
ATP-dependent translocase ABCB107010
Muscarinic acetylcholine receptor M10303
Muscarinic acetylcholine receptor M30303
Muscarinic acetylcholine receptor M40303
Integrin alpha-IIb4004
5-hydroxytryptamine receptor 1A0516
5-hydroxytryptamine receptor 2C0708
Muscarinic acetylcholine receptor M50404
Muscarinic acetylcholine receptor M50909
Alpha-2A adrenergic receptor0909
Replicase polyprotein 1a0123
Replicase polyprotein 1ab0123
Replicase polyprotein 1ab0224
Cys-loop ligand-gated ion channel0101
Calmodulin-10213
Replicase polyprotein 1ab0325
Cytochrome P450 2D60718
Muscarinic acetylcholine receptor M20303
Muscarinic acetylcholine receptor M10909
Cytochrome P450 2C9 0909
Polyunsaturated fatty acid lipoxygenase ALOX150202
Angiotensin-converting enzyme0303
D(2) dopamine receptor06110
5-hydroxytryptamine receptor 2A0707
Alpha-1B adrenergic receptor0617
Sphingomyelin phosphodiesterase0101
Alpha-2C adrenergic receptor0707
D0505
D(3) dopamine receptor0505
5-hydroxytryptamine receptor 1A010010
Alpha-2B adrenergic receptor0617
D(2) dopamine receptor0303
Muscarinic acetylcholine receptor M30808
Proteasome subunit beta type-10001
Substance-K receptor0202
D(1A) dopamine receptor08010
D(4) dopamine receptor0519
D(1B) dopamine receptor0305
Adenylate cyclase type 30303
Alpha-2C adrenergic receptor0617
UDP-glucuronosyltransferase 1A40104
Alpha-2A adrenergic receptor0617
Alpha-1D adrenergic receptor0617
Sodium-dependent noradrenaline transporter 0606
Sodium-dependent dopamine transporter0505
Histamine H2 receptor09211
Alpha-1D adrenergic receptor010010
D(1B) dopamine receptor0404
Proteasome subunit alpha type-10001
Proteasome subunit alpha type-20001
Proteasome subunit alpha type-30001
Proteasome subunit alpha type-40001
Adenylate cyclase type 20303
Adenylate cyclase type 40303
Proteasome subunit beta type-80001
Proteasome subunit beta type-90001
Proteasome subunit alpha type-50001
Proteasome subunit beta type-40001
Proteasome subunit beta type-60001
Proteasome subunit beta type-50001
5-hydroxytryptamine receptor 2A0808
5-hydroxytryptamine receptor 2C0808
5-hydroxytryptamine receptor 1B0909
Trypanothione reductase0202
D(4) dopamine receptor0404
5-hydroxytryptamine receptor 2B0505
Histamine H1 receptor0235
Sodium-dependent serotonin transporter0606
Melanocortin receptor 40202
5-hydroxytryptamine receptor 7 0404
Melanocortin receptor 50202
Pleiotropic ABC efflux transporter of multiple drugs0102
5-hydroxytryptamine receptor 70404
Histamine H1 receptor010212
Mu-type opioid receptor0415
D(3) dopamine receptor08112
Sodium channel protein type 1 subunit alpha0202
Sodium channel protein type 4 subunit alpha0202
Adenylate cyclase type 80303
Proteasome subunit beta type-100001
Delta-type opioid receptor0202
Kappa-type opioid receptor0202
5-hydroxytryptamine receptor 2B0808
Melanocortin receptor 30202
Alpha-1A adrenergic receptor0718
Histamine H2 receptor111115
Proteasome subunit beta type-30001
Proteasome subunit beta type-20001
D(1A) dopamine receptor2103
5-hydroxytryptamine receptor 609010
5-hydroxytryptamine receptor 70202
Cytochrome P450 2J20606
Gastrin/cholecystokinin type B receptor0202
Proteasome subunit alpha type-60012
D(2) dopamine receptor0607
Calmodulin 0112
Aldehyde oxidase 10101
Sodium channel protein type 7 subunit alpha0202
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Sodium-dependent dopamine transporter 0202
Adenylate cyclase type 60303
Adenylate cyclase type 50303
Glutamate receptor ionotropic, NMDA 10101
Aldehyde oxidase0202
Potassium voltage-gated channel subfamily H member 20809
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, NMDA 2B0101
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Sodium channel protein type 5 subunit alpha0202
Glutamate receptor ionotropic, NMDA 2C0101
Sodium channel protein type 9 subunit alpha0202
Nuclear receptor subfamily 3 group C member 3 0202
Adenylyl cyclase 7 0303
Proteasome subunit alpha-type 80001
Glutamate receptor ionotropic, NMDA 3A0101
D0202
Sodium channel protein type 2 subunit alpha0202
Proteasome subunit beta type-70001
Sigma non-opioid intracellular receptor 10707
Angiotensin-converting enzyme 2 0123
Sodium channel protein type 3 subunit alpha0202
Sodium channel protein type 11 subunit alpha0202
Sodium channel protein type 8 subunit alpha0202
Histamine H3 receptor0325
Sodium channel protein type 10 subunit alpha0202
Chain A, HADH2 protein8008
Chain B, HADH2 protein8008
Chain A, 2-oxoglutarate Oxygenase130013
Chain A, Cruzipain2002
cytochrome P450 2C9 precursor8008
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 19009
DNA gyrase subunit B0101
DNA gyrase subunit A0101
DNA gyrase subunit B0102
DNA gyrase subunit A0103
DNA gyrase subunit B0103
DNA topoisomerase 4 subunit A0101
DNA topoisomerase 4 subunit B0102
DNA topoisomerase 4 subunit A0102
DNA topoisomerase 2-alpha0104
DNA gyrase subunit A0102
Cytochrome P450 2C190607
Multidrug resistance protein MdtK0011
DNA gyrase subunit B0101
DNA gyrase subunit A0101
Enoyl-[acyl-carrier-protein] reductase [NADH]0001
DNA topoisomerase 4 subunit A0101
DNA topoisomerase 4 subunit B0101
Integrase 0101
Chain A, Beta-lactamase3003
endonuclease IV3003
PAX80001
pregnane X receptor2002
PPM1D protein3003
nuclear receptor subfamily 1, group I, member 26006
nuclear receptor subfamily 0 group B member 10101
cytochrome P450 2C19 precursor6006
thyroid hormone receptor beta isoform a3003
flap endonuclease 16006
steroidogenic factor 10101
caspase-1 isoform alpha precursor2002
neuropeptide S receptor isoform A4004
Solute carrier family 22 member 30203
Tubulin alpha-1A chain0213
Tubulin beta chain0213
Plasma kallikrein0004
Tubulin beta-4A chain0225
ATP-dependent translocase ABCB10101
Tubulin beta chain0225
Tubulin alpha-3C chain0225
Serine/threonine-protein kinase pim-10101
ATP-dependent translocase ABCB10101
Tubulin alpha-1B chain0225
Tubulin alpha-4A chain0225
Tubulin beta-4B chain0225
Vesicular acetylcholine transporter0101
Tubulin beta-3 chain0225
Tubulin beta-2A chain0225
Tubulin polymerization-promoting protein0011
Tubulin beta-8 chain0225
Tubulin beta-2B chain0202
Tubulin alpha-3E chain0225
Tubulin alpha-1A chain0225
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
CREB-binding protein1001
Tubulin alpha-1C chain0225
Tubulin beta-6 chain0225
Tubulin beta-2B chain0225
Tubulin beta-1 chain0225
ATP-dependent phosphofructokinase100010
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase 0101
bromodomain adjacent to zinc finger domain 2B8008
Myeloperoxidase0404
Dihydrofolate reductase0303
Cytochrome P450 2D10101
Cytochrome P450 2D260101
Cytochrome P450 2D30101
Cytochrome P450 2D40101
GLS protein9009
Sodium-dependent serotonin transporter0213
glp-1 receptor, partial3003
15-lipoxygenase, partial5005
nonstructural protein 12002
nuclear receptor ROR-gamma isoform 18008
transient receptor potential cation channel subfamily V member 11001
Cocaine esterase0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
UDP-glucuronosyltransferase 1A90102
Vitamin D-binding protein0101
HLA class I histocompatibility antigen, A alpha chain 0011
Integrin beta-10101
Beta-2 adrenergic receptor0202
Integrin alpha-40101
Carbonyl reductase [NADPH] 10001
UDP-glucuronosyltransferase 2B70203
Beta-1 adrenergic receptor0101
5-hydroxytryptamine receptor 3A0303
Adenosine receptor A10204
Beta-3 adrenergic receptor0101
5-hydroxytryptamine receptor 1D0303
5-hydroxytryptamine receptor 1F0303
Histamine H1 receptor0516
C-8 sterol isomerase0101
Delta-type opioid receptor0202
Mu-type opioid receptor0303
5-hydroxytryptamine receptor 2C 0101
Kappa-type opioid receptor0202
Alpha-1A adrenergic receptor0202
5-hydroxytryptamine receptor 2A0101
Alpha-1B adrenergic receptor0101
Kappa-type opioid receptor0101
5-hydroxytryptamine receptor 2A0101
D(2) dopamine receptor0101
D(3) dopamine receptor0101
AP-2 complex subunit sigma0101
N-acetyltransferase Eis0202
5-hydroxytryptamine receptor 2B0101
TAR DNA-binding protein 433003
5-hydroxytryptamine receptor 40101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Calcitonin gene-related peptide type 1 receptor0101
Genome polyprotein 0202
Sigma intracellular receptor 20202
Sigma intracellular receptor 20202
Sigma non-opioid intracellular receptor 10101
Zinc finger protein 6640101
Vesicular acetylcholine transporter0101
Transporter0101
Cholecystokinin receptor type A0101
Protease 0202
Transient receptor potential cation channel subfamily V member 40101
Sigma non-opioid intracellular receptor 10202
Transient receptor potential cation channel subfamily V member 20101
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Protein (female-specific Histamine Binding Protein 2)0011
aryl hydrocarbon receptor nuclear translocator0001
GALC protein3003
transforming acidic coiled-coil-containing protein 30001
Solute carrier family 22 member 20001
Carbonic anhydrase 120003
Carbonic anhydrase 30003
Macrophage migration inhibitory factor0202
Carbonic anhydrase 40003
Carbonic anhydrase 60003
Adenosine receptor A2a0103
Metabotropic glutamate receptor 50112
Carbonic anhydrase 5A, mitochondrial0003
Carbonic anhydrase0003
Carbonic anhydrase 70003
Carbonic anhydrase0004
Histamine H3 receptor0101
Histamine N-methyltransferase 0101
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 90003
Carbonic anhydrase 0004
Carbonic anhydrase-like protein, putative0003
Carbonic anhydrase0004
Carbonic anhydrase0004
Solute carrier family 22 member 10102
Carbonic anhydrase 0004
Equilibrative nucleoside transporter 40001
Carbonic anhydrase 130002
Histamine H4 receptor0123
Histamine H4 receptor0123
Histamine H4 receptor 0101
Carbonic anhydrase 150003
Carbonic anhydrase 130003
Histamine H4 receptor0123
Histamine H3 receptor0101
Carboxylic ester hydrolase 0001
Solute carrier family 22 member 20102
Carbonic anhydrase 140003
Carbonic anhydrase 5B, mitochondrial0003
Parkin4004
pyruvate kinase2002
NPC intracellular cholesterol transporter 1 precursor3003
pyruvate kinase PKM isoform b2002
N-glycosylase/DNA lyase0101
Ornithine decarboxylase2002
Aspartate aminotransferase, cytoplasmic0101
Lactoperoxidase0101
Single-stranded DNA cytosine deaminase2002
Genome polyprotein 0101
Cyclic GMP-AMP synthase0101
Toll-like receptor 90101
Toll-like receptor 70101
hypothetical protein, conserved1001
alpha-galactosidase3003
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Uracil nucleotide/cysteinyl leukotriene receptor0303
Chain A, membrane-associated prostaglandin E synthase-20101
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)6006
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)3003
Prostaglandin-H2 D-isomerase0101
Prostaglandin E synthase0101
Prostaglandin G/H synthase 1 0102
Prostaglandin G/H synthase 2 0102
3',5'-cyclic-AMP phosphodiesterase 0101
Solute carrier organic anion transporter family member 2B1 0202
Cytochrome c oxidase subunit 20101
Phospholipase A2, major isoenzyme0101
Prostaglandin G/H synthase 10203
Neuronal acetylcholine receptor subunit alpha-41102
Interleukin-80101
Androgen receptor0213
Neuronal acetylcholine receptor subunit beta-21102
Polyunsaturated fatty acid 5-lipoxygenase0102
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member C40101
Prostaglandin G/H synthase 10101
Prostaglandin G/H synthase 10101
Sodium- and chloride-dependent GABA transporter 10101
Thromboxane-A synthase 0101
Serum paraoxonase/arylesterase 10101
Indoleamine 2,3-dioxygenase 10202
Caspase-10001
Nitric oxide synthase, inducible0101
Substance-P receptor0202
Prostaglandin E2 receptor EP3 subtype0101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Prostaglandin E2 receptor EP4 subtype0101
Multidrug resistance-associated protein 1 0102
Bifunctional epoxide hydrolase 20101
Prostaglandin G/H synthase 20314
Prostaglandin G/H synthase 2 0101
Prostaglandin E2 receptor EP1 subtype0101
Peroxisome proliferator-activated receptor gamma0011
Aldo-keto reductase family 1 member C30202
Sodium- and chloride-dependent betaine transporter0101
C-X-C chemokine receptor type 30101
Aldo-keto reductase family 1 member C2 0101
Guanine nucleotide-binding protein G1001
Prostaglandin D2 receptor 0202
Solute carrier organic anion transporter family member 1A30102
Prostaglandin G/H synthase 20202
Lactoylglutathione lyase0101
Aldo-keto reductase family 1 member C10101
Prostaglandin G/H synthase 20102
Solute carrier family 22 member 70001
Prostaglandin E2 receptor EP2 subtype0101
Rho-associated protein kinase 20101
Prostaglandin G/H synthase 1 0101
Nicotinate phosphoribosyltransferase0101
Multidrug and toxin extrusion protein 10101
Dehydrogenase/reductase SDR family member 90101
P2Y purinoceptor 120101
Solute carrier organic anion transporter family member 1B30203
Cytosolic phospholipase A2 gamma0101
Prostaglandin D2 receptor 20112
Solute carrier organic anion transporter family member 1B10202
hepatocyte nuclear factor 4-alpha isoform 20101
perilipin-50101
perilipin-10101
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
Glutathione reductase, mitochondrial0303
Polyunsaturated fatty acid 5-lipoxygenase0101
Glucose-6-phosphate 1-dehydrogenase0202
UDP-glucuronosyltransferase 1A30001
6-phosphogluconate dehydrogenase, decarboxylating0202
Inositol monophosphatase 13003
importin subunit beta-1 isoform 13003
snurportin-13003
GTP-binding nuclear protein Ran isoform 12002
Cytochrome P450 1A10303
Cytochrome P450 1B10202
lysosomal alpha-glucosidase preproprotein1001
atrial natriuretic peptide receptor 1 precursor2002
phosphoethanolamine/phosphocholine phosphatase isoform 10101
serine/threonine-protein kinase PLK12002
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10202
Sodium/potassium-transporting ATPase subunit alpha-1 0202
Sodium/potassium-transporting ATPase subunit beta-10202
Amyloid-beta precursor protein1001
Microtubule-associated protein tau0101
Sodium/potassium-transporting ATPase subunit alpha-30202
Sodium/potassium-transporting ATPase subunit beta-20202
Alpha-synuclein2002
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha1001
Fatty acid synthase0404
Sodium/potassium-transporting ATPase subunit alpha-20202
Sodium/potassium-transporting ATPase subunit beta-30202
Sodium/potassium-transporting ATPase subunit gamma0202
WD repeat-containing protein 50202
Histone-lysine N-methyltransferase 2A0202
Sodium/potassium-transporting ATPase subunit alpha-40202
Cytosolic endo-beta-N-acetylglucosaminidase0202
Indoleamine 2,3-dioxygenase 20101
Broad substrate specificity ATP-binding cassette transporter ABCG20203
Chain A, AMINOPEPTIDASE0202
Chain A, AMINOPEPTIDASE0202
Chain A, Leucine Aminopeptidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0303
Intestinal-type alkaline phosphatase0303
Large neutral amino acids transporter small subunit 10304
Phospholipase A-2-activating protein0303
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Cationic amino acid transporter 30101
ClpP3003
Cytochrome P450 1A2 0101
Cholinesterase0202
Cytochrome P450 2C11 0101
Aromatase0202
Ribosyldihydronicotinamide dehydrogenase [quinone]0202
Acetylcholinesterase0202
Metabotropic glutamate receptor 10101
Acetylcholinesterase 0101
Nociceptin receptor0101
Melatonin receptor type 1A0213
Melatonin receptor type 1C0011
Melatonin receptor type 1A0112
Melatonin receptor type 1B0213
Melatonin receptor type 1C0112
Melatonin receptor type 1B0112
Nuclear factor erythroid 2-related factor 20001
Palmitoleoyl-protein carboxylesterase NOTUM0101
Carboxylic ester hydrolase 0101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
acid sphingomyelinase1001
dopamine D1 receptor2002
Thymidylate synthase 0101
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX122002
transcriptional regulator ERG isoform 31001
DNA polymerase beta1001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
DNA polymerase eta isoform 11001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0405
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Thymidylate synthase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
Cytochrome P450 11B1, mitochondrial 0202
Folate receptor alpha0101
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
Caspase-71001
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200101
Dihydrofolate reductase 0101
Solute carrier family 22 member 60101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Nuclear receptor subfamily 1 group I member 20011
Glucocorticoid receptor06213
Glycine receptor subunit alpha-10606
Androgen receptor0303
Glycine receptor subunit beta0606
Glycine receptor subunit alpha-20606
Glycine receptor subunit alpha-30606
Nuclear receptor subfamily 1 group I member 20011
Steroid 17-alpha-hydroxylase/17,20 lyase0101
Cytochrome P450 2C80101
Cytochrome P450 11B1, mitochondrial0101
Cytochrome P450 11B1, mitochondrial0101
Cytochrome P450 11B2, mitochondrial0101
5-hydroxytryptamine receptor 3E0101
huntingtin isoform 23003
5-hydroxytryptamine receptor 3B0101
Endothelin receptor type B0101
Endothelin receptor type B0101
Endothelin-1 receptor0101
5-hydroxytryptamine receptor 60101
Type-2 angiotensin II receptor0202
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 5B0101
5-hydroxytryptamine receptor 3A0202
5-hydroxytryptamine receptor 3A0101
Angiotensin-converting enzyme0101
5-hydroxytryptamine receptor 4 0101
5-hydroxytryptamine receptor 3D0101
5-hydroxytryptamine receptor 3C0101
5-hydroxytryptamine receptor 3B0202
5-hydroxytryptamine receptor 3B0202
G-protein coupled receptor 0101
Transporter0202
Mcl-10101
pyruvate kinase PKM isoform a1001
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Bifunctional cytochrome P450/NADPH--P450 reductase0011
Potassium-transporting ATPase subunit beta0101
Potassium-transporting ATPase alpha chain 10101
UDP-glucuronosyltransferase 1-60101
Potassium-transporting ATPase alpha chain 10101
UDP-glucuronosyltransferase 1A1 0101
Bombesin receptor subtype-30011
UDP-glucuronosyltransferase 2B10 0101
Potassium-transporting ATPase subunit beta0101
Potassium-transporting ATPase alpha chain 20001
Glutathione S-transferase omega-10101
Muscarinic acetylcholine receptor0101
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Alkaline phosphatase, tissue-nonspecific isozyme 0101
Intestinal-type alkaline phosphatase0101
5'-nucleotidase0101
E3 ubiquitin-protein ligase XIAP0101
SLC16A10 protein0002
Large neutral amino acids transporter small subunit 1 0101
Monocarboxylate transporter 100002
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Glutamine synthetase0011
Nociceptin receptor0011
Estrogen receptor beta0202
Pyridoxal kinase0001
Lysine-specific demethylase 4E0101
runt-related transcription factor 1 isoform AML1b1001
core-binding factor subunit beta isoform 21001
Glutamate receptor 10101
Glutamate receptor 30101
Glutamate receptor 40101
Advanced glycosylation end product-specific receptor0011
Beta-lactamase 0101
Advanced glycosylation end product-specific receptor0011
Chain E, Fibrin beta chain0101
RGS121001
signal transducer and activator of transcription 6, interleukin-4 induced1001
DNA polymerase III, partial1001
phospholipase A2, group III0101
hexokinase-4 isoform 11001
glucokinase regulatory protein1001
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 11001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
tumor susceptibility gene 101 protein1001
DNA dC->dU-editing enzyme APOBEC-3G isoform 11102
Nuclear factor NF-kappa-B p105 subunit0101
Alanine aminotransferase 10002
Disintegrin and metalloproteinase domain-containing protein 171001
Nuclear factor NF-kappa-B p100 subunit 0101
Transcription factor p650101
Bcl-2-like protein 10101
Bcl2-associated agonist of cell death 0101
Regulator of G-protein signaling 170112
Vif0101
Acetylcholinesterase0101
Amine oxidase [flavin-containing] B0001
Amine oxidase [flavin-containing] A 0001
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 5A0101
Nischarin0101
Nuclear receptor subfamily 2 group E member 10011
Chain A, Trp Rna-binding Attenuation Protein0011
Chain K, Trp Rna-binding Attenuation Protein0011
Chain B, tryptophanyl-tRNA synthetase0011
Chain C, Tryptophanyl-tRNA synthetase II0011
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
Stromelysin-10101
Indoleamine 2,3-dioxygenase 10102
Tryptophan 2,3-dioxygenase0102
Tryprostatin B synthase0001
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
streptokinase A precursor0011
twin arginine protein translocation system - TatA protein0001
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]