Any protective agent counteracting or neutralizing the action of poisons.
| Member | Definition | Class |
|---|
| desferrioxamine b mesylate | A methanesulfonate salt obtained by reaction of desferrioxamine B with one molar equivalent of methanesulfonic acid. It is an iron-chelating medicine used to remove excess iron from the body. It binds to iron in the blood, which is then passed out in the urine. | desferrioxamine B mesylate |
| dimethyl sulfoxide | A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents. | dimethyl sulfoxide |
| edetic acid | | ethylenediaminetetraacetic acid |
| edrophonium | A quaternary ammonium ion that is N-ethyl-N,N-dimethylanilinium in which one of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals. | edrophonium |
| edrophonium chloride | The chloride salt of edrophonium. A reversible inhibitor of cholinesterase with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes), it is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals. | edrophonium chloride |
| fomepizole | A member of the class of pyrazoles that is 1H-pyrazole substituted by a methyl group at position 4. | fomepizole |
| niacin | A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group. | nicotinic acid |
| pinostrobin | A monohydroxyflavanone that is (2S)-flavanone substituted by a hydroxy group at position 5 and a methoxy group at position 7 respectively. | pinostrobin |
| thiazolidine-4-carboxylic acid | A sulfur-containing amino acid that is proline in which the methylene group at position 4 is replaced by a sulfur atom. | thioproline zwitterion; thioproline |
| thiazolidine-4-carboxylic acid | An alpha-amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of thioproline; major species at pH 7.3. | thioproline zwitterion; thioproline |
| varespladib | A member of the class of indoles that is 1H-indole substituted by benzyl, ethyl, oxamoyl, and carboxymethoxy groups at positions 1, 2, 3, and 4, respectively. It is an oral secretory phospholipase A2 inhibitor and exhibits anti-inflammatory effects. | varespladib |
| varespladib methyl | A methyl ester resulting from the formal condensation of the carboxy group of varespladib with methanol. It is a potential therapy for the treatment of snakebite envenomings in which toxicity depends on the action of PLA2s. | varespladib methyl |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 67.9K protein | Vaccinia virus | Potency | 28.1838 | 1 | 1 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 13.4481 | 4 | 4 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 18.0299 | 1 | 1 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 1.2589 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 2.5829 | 4 | 5 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 25.9290 | 1 | 1 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 19.3450 | 2 | 2 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.0025 | 2 | 2 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 1.9394 | 1 | 1 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 10.4029 | 1 | 3 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 3.1623 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 9.8344 | 1 | 2 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 0.4456 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 1.2589 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 13.4504 | 1 | 1 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 23.9185 | 1 | 1 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 2.3109 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 24.7474 | 3 | 4 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 14.2938 | 6 | 10 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 18.9517 | 1 | 3 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 9.8759 | 4 | 8 |
| G | Vesicular stomatitis virus | Potency | 13.4504 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 0.9340 | 2 | 3 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 52.0043 | 2 | 3 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 12.6950 | 2 | 3 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 3.8697 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 3.5481 | 1 | 2 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 26.8546 | 1 | 2 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 13.4504 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 3.1006 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 13.4504 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 13.4504 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 5.6987 | 3 | 3 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 22.9833 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 3.5481 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 3.5481 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 21.8963 | 3 | 4 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 10.3225 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 13.4166 | 1 | 2 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 1.9394 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 38.1456 | 1 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 3.5481 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 0.0097 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 16.8970 | 2 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 28.6323 | 3 | 7 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 19,952.6000 | 1 | 1 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 26.6795 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 12.8415 | 1 | 3 |
| TDP1 protein | Homo sapiens (human) | Potency | 24.2556 | 2 | 3 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 4.7444 | 2 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 39.8107 | 2 | 2 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 43.5774 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 12.5384 | 2 | 3 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 13.4232 | 1 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 3.8697 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 85/88 kDa calcium-independent phospholipase A2 | Homo sapiens (human) | IC50 | 3.0076 | 8 | 8 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 3.2080 | 5 | 5 |
| Acetylcholinesterase | Homo sapiens (human) | Ki | 21.5650 | 8 | 10 |
| Acetylcholinesterase | Mus musculus (house mouse) | Ki | 0.2500 | 1 | 1 |
| Acetylcholinesterase | Bos taurus (cattle) | IC50 | 0.0500 | 1 | 1 |
| Alcohol dehydrogenase E chain | Equus caballus (horse) | Ki | 0.1412 | 1 | 1 |
| Alcohol dehydrogenase S chain | Equus caballus (horse) | Ki | 0.1412 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 23.2250 | 2 | 4 |
| Angiotensin-converting enzyme | Homo sapiens (human) | IC50 | 14.0000 | 1 | 1 |
| Beta-lactamase | Bacillus anthracis | IC50 | 1,060.0000 | 1 | 1 |
| Beta-lactamase | Pseudomonas aeruginosa | IC50 | 27.9000 | 1 | 1 |
| Beta-lactamase VIM-1 | Pseudomonas aeruginosa | IC50 | 9.3000 | 1 | 1 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 19.9500 | 2 | 2 |
| Cereblon isoform 4 | Magnetospirillum gryphiswaldense | IC50 | 20.8000 | 1 | 1 |
| Cereblon isoform 4 | Magnetospirillum gryphiswaldense | Ki | 5,570.2333 | 3 | 3 |
| Cholesteryl ester transfer protein | Homo sapiens (human) | IC50 | 0.1400 | 1 | 1 |
| Choline O-acetyltransferase | Rattus norvegicus (Norway rat) | Ki | 25,000.0000 | 1 | 1 |
| Cholinesterase | Homo sapiens (human) | Ki | 99.5050 | 1 | 2 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 0.1400 | 1 | 1 |
| D-amino-acid oxidase | Homo sapiens (human) | IC50 | 1,125.0000 | 1 | 1 |
| D-aspartate oxidase | Homo sapiens (human) | IC50 | 2,778.0000 | 1 | 1 |
| Eyes absent homolog 2 | Homo sapiens (human) | IC50 | 386.2500 | 4 | 4 |
| Genome polyprotein | Dengue virus 2 Thailand/16681/84 | Ki | 345.0000 | 1 | 1 |
| Group 10 secretory phospholipase A2 | Homo sapiens (human) | IC50 | 0.0918 | 8 | 8 |
| Group 10 secretory phospholipase A2 | Mus musculus (house mouse) | IC50 | 0.0750 | 2 | 2 |
| Group 3 secretory phospholipase A2 | Homo sapiens (human) | IC50 | 0.1225 | 2 | 2 |
| Group IID secretory phospholipase A2 | Homo sapiens (human) | IC50 | 0.1017 | 3 | 3 |
| Group IID secretory phospholipase A2 | Mus musculus (house mouse) | IC50 | 0.4300 | 1 | 1 |
| Group IIE secretory phospholipase A2 | Homo sapiens (human) | IC50 | 0.0863 | 4 | 4 |
| Group IIE secretory phospholipase A2 | Mus musculus (house mouse) | IC50 | 0.0750 | 2 | 2 |
| Group IIF secretory phospholipase A2 | Homo sapiens (human) | IC50 | 0.1250 | 3 | 3 |
| Group IIF secretory phospholipase A2 | Mus musculus (house mouse) | IC50 | 1.6000 | 1 | 1 |
| Group XIIA secretory phospholipase A2 | Homo sapiens (human) | IC50 | 0.1225 | 2 | 2 |
| Group XIIB secretory phospholipase A2-like protein | Homo sapiens (human) | IC50 | 0.1225 | 2 | 2 |
| Hydroxycarboxylic acid receptor 2 | Homo sapiens (human) | IC50 | 4.3681 | 16 | 16 |
| Hydroxycarboxylic acid receptor 2 | Mus musculus (house mouse) | IC50 | 0.1400 | 3 | 3 |
| Hydroxycarboxylic acid receptor 2 | Homo sapiens (human) | Ki | 0.0787 | 3 | 3 |
| Metallo-beta-lactamase VIM-13 | Pseudomonas aeruginosa | IC50 | 252.6000 | 1 | 1 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| Nicotinamidase | Saccharomyces cerevisiae S288C | Ki | 2,000.0000 | 1 | 1 |
| Phospholipase A2 | Homo sapiens (human) | IC50 | 0.3668 | 6 | 6 |
| Phospholipase A2 | Mus musculus (house mouse) | IC50 | 0.1400 | 2 | 2 |
| Phospholipase A2 group V | Homo sapiens (human) | IC50 | 0.2738 | 5 | 5 |
| Phospholipase A2 group V | Mus musculus (house mouse) | IC50 | 0.7500 | 2 | 2 |
| Phospholipase A2, major isoenzyme | Sus scrofa (pig) | IC50 | 0.0480 | 2 | 2 |
| Phospholipase A2, membrane associated | Homo sapiens (human) | IC50 | 0.0527 | 11 | 11 |
| Phospholipase A2, membrane associated | Mus musculus (house mouse) | IC50 | 0.0700 | 2 | 2 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 1,000.0000 | 1 | 1 |
| Protein cereblon | Homo sapiens (human) | IC50 | 264.0000 | 1 | 1 |
| Protein cereblon | Homo sapiens (human) | Ki | 68,568.5000 | 2 | 2 |
| Putative inactive group IIC secretory phospholipase A2 | Homo sapiens (human) | IC50 | 0.1225 | 2 | 2 |
| Sterol O-acyltransferase 1 | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| Sterol O-acyltransferase 1 | Rattus norvegicus (Norway rat) | IC50 | 0.5000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | IC50 | 518.2300 | 1 | 1 |