Alobar Holoprosencephaly

Anterior midline brain, cranial, and facial malformations resulting from the failure of the embryonic prosencephalon to undergo segmentation and cleavage. Alobar prosencephaly is the most severe form and features anophthalmia; cyclopia; severe INTELLECTUAL DISABILITY; CLEFT LIP; CLEFT PALATE; SEIZURES; and microcephaly. Semilobar holoprosencepaly is characterized by hypotelorism, microphthalmia, coloboma, nasal malformations, and variable degrees of INTELLECTUAL DISABILITY. Lobar holoprosencephaly is associated with mild (or absent) facial malformations and intellectual abilities that range from mild INTELLECTUAL DISABILITY to normal. Holoprosencephaly is associated with CHROMOSOME ABNORMALITIES.

Synonym
Semilobar Holoprosencephaly
Lobar Holoprosencephaly
Alobar Holoprosencephaly
Arhinencephaly
Holoprosencephaly, Familial Alobar
Holoprosencephaly

Excerpt	Reference
"Holoprosencephaly is a congenital defect of the median structures of the brain and face."	( Hughes, JP; Olsen, CL; Sharpe-Stimac, M; Youngblood, LG, 1997)
"Holoprosencephaly is a common developmental anomaly of the forebrain and midface, that has been associated with mutations in the Sonic Hedgehog gene, and with perturbations of cholesterol synthesis and metabolism in mammalian embryos."	( Bourguignon, L; Gaoua, W; Gofflot, F; Picard, JJ; Roux, C, 2001)
"The pathogenesis of holoprosencephaly is multifactorial, and blockage of Sonic hedgehog signaling is one of the most important causative factors in animal models and human cases."	( Asato, H; Fukuda, S; Harii, K; Nagase, M; Nagase, T; Nakamura, S; Ohsaki, K; Osumi, N; Yoshimura, K, 2005)
"Holoprosencephaly is addressed under the following headings: alobar, semilobar, and lobar holoprosencephaly; arrhinencephaly; agenesis of the corpus callosum; pituitary abnormalities; hindbrain abnormalities; syntelencephaly; aprosencephaly/atelencephaly; neural tube defects; facial anomalies; median cleft lip; minor facial anomalies; single maxillary central incisor; holoprosencephaly-like phenotype; epidemiology; genetic causes of holoprosencephaly; teratogenic causes of holoprosencephaly; SHH mutations; ZIC2 mutations; SIX3 mutations; TGIF mutations; PTCH mutations; GLI2 mutations; FAST1 mutations; TDGF1 mutations; and DHCR7 mutations."	( Cohen, MM, 2006)
"Alobar holoprosencephaly is a rare and severe brain malformation due to early arrest in brain cleavage and rotation."	( Ambrosini, G; Andrisani, A; Capobianco, G; Cherchi, PL; Cosmi, E; Dessole, S, 2007)
"Holoprosencephaly is a developmental defect caused by incomplete cleavage of the embryonic forebrain structures during early embryogenesis."	( Athanassiadou, F; Economou, I; Kourti, M; Pavlou, E; Rousso, I, 2008)
"Holoprosencephaly is a rare disorder of embryological development that presents with midline clefting of the lip."	( Kimoto, N; Morita, N; Morita, Y; Ogawa, H; Oomata, T; Taenaka, Y, 2011)
"Holoprosencephaly is the most frequent congenital malformation of the forebrain in humans."	( Chandrasekharappa, S; Hu, P; Jones, M; Muenke, M; Pineda-Alvarez, DE; Ribeiro, LA; Richieri-Costa, A; Roessler, E; Zhou, N, 2012)
"Holoprosencephaly is a rare spectrum of cerebral and facial malformations resulting from incomplete division of the embryonic forebrain (prosencephalon) into distinct lateral cerebral hemisphere."	( Chaudhari, HD; Darji, P; Khokhani, P; Thakkar, G, 2012)
"Holoprosencephaly is a common developmental disorder in humans characterised by incomplete brain hemisphere separation and midface anomalies."	( Hoffmeister, M; Kovacevic, I; Küchler, P; Moser, M; Müller-Esterl, W; Oess, S; Prelle, C, 2014)
"Etiologically, holoprosencephaly is thought to arise from a complex combination of genetic and environmental factors."	( Hong, M; Krauss, RS, 2017)

Excerpt	Reference
"Other causes of holoprosencephaly have converged upon the Shh signaling pathway: genetic and pharmacologic impairment of cholesterol synthesis, and the action of the steroidal alkaloid cyclopamine."	( Incardona, JP; Roelink, H, 2000)

Excerpt	Reference
"D21 fetuses showed the holoprosencephaly spectrum of malformations and the treated dams low cholesterol and accumulation of 7DHC, 8DHC, and trienols, as in SLOS-affected children."	( Chevy, F; Kolf-Clauw, M; Mulliez, N; Roux, C; Siliart, B; Wolf, C, 1997)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	31 (15.35)	23.3326
1990's	47 (23.27)	12.5806
2000's	66 (32.67)	18.1394
2010's	46 (22.77)	28.8240
2020's	12 (5.94)	9.53

Drug	Relationship Strength	Studies
adenine	low	1
lactic acid	low	1
glycine	low	2
methanol	low	1
nitrous oxide	low	1
palmitic acid	low	1
phenytoin	low	2
aspirin	low	1
caffeine	low	2
chlordiazepoxide	low	1
amphetamine	low	1
fentanyl	low	1
halothane	low	1
imipramine	low	1
lorazepam	low	1
metformin	low	1
apnea	low	1
sulfasalazine	low	1
alanine	low	3
serine	low	1
glutamine	low	2
lysine	low	1
bromodeoxyuridine	low	1
tyrosine	low	1
caffeine citrate	low	1
asparagine	low	1
histidine	low	2
valine	low	1
threonine	low	1
tryptophan	low	1
triparanol	low	1
trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride	low	6
jervine	low	1
d-alpha tocopherol	low	1
dronabinol	low	1
manganese	low	1
uranium	low	1
phenyl acetate	low	1
glutamic acid	low	2
substance p	low	1
enkephalin, methionine	low	1
propiconazole	low	12
colforsin	low	1
lovastatin	low	1
mifepristone	low	1
glucose, (beta-d)-isomer	low	1
tomatidine	low	1
methotrexate	low	2
cholesta-5,8-dien-3 beta-ol	low	1
glycogen	low	1
7-dehydrocholesterol	low	4
inositol 3-phosphate	low	10
pancuronium	low	1
ochratoxin a	low	2
vicenin ii	low	1
cyclopamine	low	10
tretinoin	low	8
isomethyleugenol	low	1
arginine vasopressin	low	2
enclomiphene	low	1
lithium	low	1
formononetin	low	1
apigenin	low	1
7,3'-dihydroxy-4'-methoxyisoflavone	low	1
calcitriol	low	1
psi-baptigenin	low	1
misoprostol	low	1
phenylephrine hydrochloride	low	36
deamino arginine vasopressin	low	2
cysteine	low	1
bm 15766	low	1
pituitrin	low	4
acid phosphatase	low	1
jaw	low	3
gdc 0449	low	1
ascorbic acid	low	1
minocycline	low	22
epidermal growth factor	low	3
transforming growth factor beta	low	10
vitamin b 12	low	1
tomatine	low	1
guanine	low	1
folic acid	low	2
eye	low	14

Protein Targets (984)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Vitamin D3 receptor	0	1	2	5
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	10	0	0	10
Chain A, 2-oxoglutarate Oxygenase	13	0	0	13
Luciferase	7	0	0	7
BRCA1	3	0	0	3
ATAD5 protein, partial	11	0	0	11
Microtubule-associated protein tau	16	0	0	16
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
DNA polymerase beta	5	0	0	5
ras-related protein Rab-9A	1	0	0	1
DNA polymerase iota isoform a (long)	8	0	0	8
dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	0	1
DNA polymerase kappa isoform 1	8	0	0	8
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
RAR-related orphan receptor gamma	18	0	0	18
TDP1 protein	23	0	0	23
AR protein	30	0	0	30
nuclear receptor subfamily 1, group I, member 3	16	0	0	16
cytochrome P450 family 3 subfamily A polypeptide 4	15	0	0	15
glucocorticoid receptor [Homo sapiens]	23	0	0	23
estrogen-related nuclear receptor alpha	28	0	0	28
pregnane X nuclear receptor	15	0	0	15
estrogen nuclear receptor alpha	35	0	0	35
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	13	0	0	13
nuclear factor erythroid 2-related factor 2 isoform 2	10	0	0	10
heat shock protein beta-1	8	0	0	8
importin subunit beta-1 isoform 1	4	0	0	4
snurportin-1	4	0	0	4
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
lamin isoform A-delta10	16	0	0	16
Voltage-dependent calcium channel gamma-2 subunit	14	0	0	14
Bile salt export pump	0	17	0	17
Cyclin-dependent kinase 1	0	2	0	2
Heat shock protein HSP 90-beta	0	1	0	1
Glutamate receptor 2	14	2	2	18
Xanthine dehydrogenase/oxidase	0	3	0	3
TAR DNA-binding protein 43	3	0	0	3
Protein mono-ADP-ribosyltransferase PARP15	0	2	0	2
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	12	0	0	12
Ataxin-2	13	0	0	13
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	7	0	0	7
Carbonic anhydrase 1	0	8	0	16
Carbonic anhydrase 2	0	8	1	17
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	6	2	11
Proton-coupled amino acid transporter 1	0	3	0	3
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	2
glp-1 receptor, partial	9	0	0	9
thioredoxin reductase	14	0	0	14
GLS protein	13	0	0	13
regulator of G-protein signaling 4	8	0	0	8
NPYLR7B	0	0	1	1
arylsulfatase A	8	0	0	8
euchromatic histone-lysine N-methyltransferase 2	22	0	0	22
thyroid stimulating hormone receptor	10	0	0	10
flap endonuclease 1	7	0	0	7
peripheral myelin protein 22	13	0	0	13
ATP-binding cassette sub-family C member 3	0	14	0	14
Multidrug resistance-associated protein 4	0	14	0	16
Beta-2 adrenergic receptor	0	2	2	4
Beta-1 adrenergic receptor	0	0	2	2
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	2	0	2
Beta-3 adrenergic receptor	0	2	1	3
Delta-type opioid receptor	0	3	1	4
10 kDa heat shock protein, mitochondrial	0	2	0	2
Thiosulfate sulfurtransferase	0	2	0	2
Beta-2 adrenergic receptor	0	0	1	3
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
Beta-2 adrenergic receptor	0	2	2	4
Canalicular multispecific organic anion transporter 1	0	14	0	14
ATP-dependent phosphofructokinase	10	0	0	10
Solute carrier family 22 member 3	0	1	0	1
5-hydroxytryptamine receptor 2C	0	4	1	6
Phenylethanolamine N-methyltransferase	0	2	0	2
Cytochrome P450 2A6	0	1	0	1
Substance-P receptor	0	3	0	3
5-hydroxytryptamine receptor 2A	0	4	1	5
5-hydroxytryptamine receptor 1A	0	6	1	7
Cytochrome P450 2A5	0	1	0	1
Sodium-dependent dopamine transporter	0	3	0	3
5-hydroxytryptamine receptor 1B	0	2	1	3
5-hydroxytryptamine receptor 1D	0	2	1	3
5-hydroxytryptamine receptor 1F	0	2	1	3
5-hydroxytryptamine receptor 2B	0	3	1	4
5-hydroxytryptamine receptor 6	0	1	1	2
5-hydroxytryptamine receptor 7	0	1	1	2
5-hydroxytryptamine receptor 5A	0	1	1	2
5-hydroxytryptamine receptor 5B	0	1	1	2
5-hydroxytryptamine receptor 3A	0	1	1	2
Sigma non-opioid intracellular receptor 1	0	3	0	3
5-hydroxytryptamine receptor 4	0	1	1	2
5-hydroxytryptamine receptor 3B	0	1	1	2
Sigma non-opioid intracellular receptor 1	0	3	1	4
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
Chain A, HADH2 protein	6	0	0	6
Chain B, HADH2 protein	6	0	0	6
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain A, Cruzipain	7	0	0	7
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain B, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain B, Transthyretin	0	0	1	1
Chain A, Casein kinase II subunit alpha	0	1	0	1
Chain A, Casein kinase II subunit alpha	0	1	0	1
Chain A, Casein Kinase Ii Subunit Alpha	0	1	0	1
interleukin 8	3	0	0	3
endonuclease IV	2	0	0	2
RGS12	1	0	0	1
15-lipoxygenase, partial	4	0	0	4
phosphopantetheinyl transferase	11	0	0	11
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
USP1 protein, partial	12	0	0	12
NFKB1 protein, partial	1	0	0	1
PPM1D protein	2	0	0	2
GLI family zinc finger 3	18	0	0	18
Thrombopoietin	1	0	0	1
Smad3	3	0	0	3
apical membrane antigen 1, AMA1	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	15	0	0	15
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
thyroid stimulating hormone receptor	7	0	0	7
estrogen receptor 2 (ER beta)	11	0	0	11
progesterone receptor	9	0	0	9
EWS/FLI fusion protein	9	0	0	9
retinoic acid nuclear receptor alpha variant 1	21	0	0	21
retinoid X nuclear receptor alpha	16	0	0	16
farnesoid X nuclear receptor	14	0	0	14
G	8	0	0	8
cytochrome P450 2D6	8	0	0	8
Neuraminidase	0	3	0	3
67.9K protein	3	0	0	3
glucocerebrosidase	5	0	0	5
Parkin	4	0	0	4
peroxisome proliferator-activated receptor delta	12	0	0	12
peroxisome proliferator activated receptor gamma	15	0	0	15
vitamin D (1,25- dihydroxyvitamin D3) receptor	13	0	0	13
pyruvate kinase	1	0	0	1
IDH1	9	0	0	9
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
aryl hydrocarbon receptor	8	0	0	8
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	7	0	0	7
v-jun sarcoma virus 17 oncogene homolog (avian)	7	0	0	7
Histone H2A.x	5	0	0	5
Replicase polyprotein 1ab	0	1	2	3
cytochrome P450 2D6 isoform 1	3	0	0	3
peripheral myelin protein 22 isoform 1	5	0	0	5
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	5	0	0	5
cytochrome P450 2C19 precursor	2	0	0	2
cytochrome P450 2C9 precursor	4	0	0	4
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	8	0	0	8
thyroid hormone receptor beta isoform a	7	0	0	7
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
thyroid hormone receptor beta isoform 2	17	0	0	17
histone deacetylase 9 isoform 3	3	0	0	3
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
mitogen-activated protein kinase 1	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	21	0	0	21
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5	0	0	5
DNA polymerase eta isoform 1	3	0	0	3
nuclear receptor ROR-gamma isoform 1	12	0	0	12
geminin	20	0	0	20
survival motor neuron protein isoform d	8	0	0	8
cytochrome P450 3A4 isoform 1	5	0	0	5
M-phase phosphoprotein 8	5	0	0	5
pyruvate kinase PKM isoform b	1	0	0	1
neuropeptide S receptor isoform A	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	5	3	0	8
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Polyphenol oxidase 2	0	3	0	5
Aldo-keto reductase family 1 member B10	0	2	0	2
G2/mitotic-specific cyclin-B2	0	1	0	1
Poly [ADP-ribose] polymerase tankyrase-1	0	1	0	1
Lysozyme C-1	0	1	0	1
Cationic trypsin	0	1	0	1
Interferon beta	9	0	0	9
HLA class I histocompatibility antigen, B alpha chain	8	0	0	8
Transthyretin	0	0	1	1
Estrogen receptor	1	5	1	7
Glucocorticoid receptor	1	2	2	8
Cellular tumor antigen p53	20	0	0	20
Cytochrome P450 1A1	0	3	0	3
Amyloid-beta precursor protein	0	2	0	2
Integrin beta-3	4	1	1	6
Myeloperoxidase	0	3	0	3
Cytochrome P450 1A2	0	2	1	5
Beta-glucuronidase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	5	0	5
Seed linoleate 13S-lipoxygenase-1	0	2	0	4
ATP-dependent translocase ABCB1	0	3	2	5
Neutrophil elastase	0	3	0	3
Integrin alpha-IIb	4	1	1	6
Ornithine decarboxylase	1	0	0	2
Poly [ADP-ribose] polymerase 1	0	1	0	1
Replicase polyprotein 1a	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	2	1	3
Replicase polyprotein 1ab	0	3	1	4
Androgen receptor	1	4	1	7
Sialidase	0	1	0	1
Serine/threonine-protein kinase pim-1	0	1	0	2
Aromatase	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	1	1	2
17-beta-hydroxysteroid dehydrogenase type 1	0	1	0	1
Pyruvate kinase PKM	0	1	1	2
G2/mitotic-specific cyclin-B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	0	3
Urease subunit alpha	0	2	0	2
Aldo-keto reductase family 1 member B1	0	3	0	3
G2/mitotic-specific cyclin-B	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	5	3	0	8
Mucin-1	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	5	3	0	8
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	5	3	0	8
Casein kinase II subunit alpha'	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	5	3	0	8
Gamma-aminobutyric acid receptor subunit alpha-3	5	3	0	8
Amine oxidase [flavin-containing] A	0	4	0	4
Acetylcholinesterase	0	3	0	3
Carbonic anhydrase 4	0	2	0	5
Gamma-aminobutyric acid receptor subunit gamma-1	5	3	0	8
Gamma-aminobutyric acid receptor subunit alpha-2	5	3	0	8
Amine oxidase [flavin-containing] B	0	5	0	5
Dipeptidyl peptidase 4	0	2	0	2
Proteasome subunit beta type-5	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	5	3	0	8
Gamma-aminobutyric acid receptor subunit beta-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	5	3	0	8
Gamma-aminobutyric acid receptor subunit alpha-6	5	3	0	8
Substance-P receptor	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	0	3
Multidrug resistance-associated protein 1	0	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	0	3
Prostaglandin G/H synthase 2	0	5	0	5
Mu-type opioid receptor	0	4	1	6
Receptor-type tyrosine-protein kinase FLT3	0	1	0	1
Testosterone 17-beta-dehydrogenase 3	0	1	0	1
17-beta-hydroxysteroid dehydrogenase type 2	0	1	0	1
Acetylcholinesterase	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Delta-type opioid receptor	0	2	0	3
Kappa-type opioid receptor	0	4	0	5
Homeobox protein Nkx-2.5	0	1	0	1
Tyrosine-protein kinase SYK	0	1	1	2
Histamine H2 receptor	6	1	0	7
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Glycogen synthase kinase-3 alpha	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Estrogen receptor	0	0	1	1
Nuclear receptor ROR-gamma	4	1	1	6
Death-associated protein kinase 1	0	1	0	1
Mitogen-activated protein kinase 10	0	1	0	1
Beta-secretase 1	0	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	5	4	0	9
Gamma-aminobutyric acid receptor subunit beta-3	5	3	0	8
Gamma-aminobutyric acid receptor subunit beta-2	5	3	0	8
Casein kinase II subunit beta	0	1	0	1
Casein kinase II subunit alpha	0	2	0	2
Urease subunit beta	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Lactoperoxidase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	0	2
MO15-related protein kinase Pfmrk	0	1	0	1
Inositol monophosphatase 1	3	0	0	3
Cyclin-dependent kinase 6	0	1	0	1
Cyclin-dependent-like kinase 5	0	1	0	1
Cyclin homolog	0	1	0	1
Transcription factor GATA-4	0	1	0	1
Cyclin-dependent kinase 5 activator 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	0	2
Mitogen-activated protein kinase 14	0	3	0	3
Cytochrome P450 1B1	0	2	0	2
Carbonic anhydrase 3	0	1	0	1
Substance-K receptor	0	2	0	2
Reverse transcriptase/RNaseH	0	1	0	1
Integrase	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Casein kinase II subunit alpha 3	0	1	0	1
Inositol polyphosphate multikinase	0	1	0	1
G2/mitotic-specific cyclin-B3	0	1	0	1
GABA theta subunit	5	3	0	8
Inositol hexakisphosphate kinase 1	8	0	0	8
Estrogen receptor beta	1	3	1	5
Enoyl-acyl-carrier protein reductase	0	1	0	1
Aurora kinase B	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Myocilin	0	0	1	1
Cyclin-dependent kinase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	5	3	0	8
Prenyltransferase homolog	0	0	0	1
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
MAP kinase-interacting serine/threonine-protein kinase 2	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
NADPH oxidase 4	0	1	0	1
Dipeptidyl peptidase 3	0	1	0	1
Estrogen receptor beta	0	0	1	1
Inositol hexakisphosphate kinase 2	0	1	0	1
Short transient receptor potential channel 5	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	4	0	5
Sialidase-2	0	1	0	1
cytochrome P450 2C9, partial	8	0	0	8
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Bloom syndrome protein isoform 1	9	0	0	9
D(1A) dopamine receptor	3	0	0	3
vitamin D3 receptor isoform VDRA	9	0	0	9
Translocator protein	0	1	1	2
Vasopressin V2 receptor	0	3	2	6
Oxytocin receptor	0	1	2	3
Vasopressin V1a receptor	0	0	2	2
Vasopressin V1a receptor	0	2	2	4
Vasopressin V1b receptor	0	2	2	4
Vasopressin V2 receptor	0	0	1	1
Vasopressin V1b receptor	0	1	1	3
Translocator protein	0	2	0	3
Oxytocin receptor	0	1	0	1
Vasopressin V2 receptor	0	2	2	4
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	5	0	0	5
thioredoxin glutathione reductase	6	0	0	6
chromobox protein homolog 1	10	0	0	10
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
lethal factor (plasmid)	5	0	0	5
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	6	1	7
Spike glycoprotein	7	0	1	8
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Neutral amino acid transporter A	0	3	0	3
Neutral amino acid transporter B(0)	0	3	0	3
Carbonic anhydrase-like protein, putative	0	0	0	6
Amino acid transporter	0	3	0	3
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
hypothetical protein, conserved	2	0	0	2
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
muscarinic acetylcholine receptor M1	6	0	0	6
Prostaglandin-H2 D-isomerase	0	1	0	1
Solute carrier family 22 member 6	0	2	0	3
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Epidermal growth factor receptor	0	2	0	2
Fatty acid-binding protein, liver	0	2	0	2
Prostaglandin G/H synthase 1	0	3	0	3
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	5	0	5
Adenosine receptor A1	0	3	1	7
Adenosine receptor A2a	0	3	1	8
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	2	0	2
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	4	0	4
Solute carrier family 22 member 6	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	9	1	10
C-8 sterol isomerase	0	4	0	4
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	4	0	4
pregnane X receptor	6	0	0	6
bromodomain adjacent to zinc finger domain 2B	5	0	0	5
nuclear receptor subfamily 1, group I, member 2	5	0	0	5
Nuclear hormone receptor family member daf-12	0	0	1	1
serine/threonine-protein kinase mTOR isoform 1	5	0	0	5
oxysterols receptor LXR-beta isoform 1	0	0	1	1
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
Thymidine kinase, cytosolic	0	1	0	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
Potassium channel subfamily K member 2	0	0	1	1
Glycogen phosphorylase, muscle form	0	2	0	2
Renin	0	1	0	1
Cholinesterase	0	1	0	1
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Adenosine receptor A3	0	7	0	7
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	2	1	4
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	2	0	3
Adenosine receptor A1	0	3	1	6
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	1	1	3
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	2	3
Endochitinase B1	0	1	0	1
Muscarinic acetylcholine receptor	0	0	0	1
Phosphodiesterase	0	1	0	1
Guanine deaminase	0	1	0	2
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Chain A, Beta-lactamase	6	0	0	6
Chain A, Ferritin light chain	10	0	0	10
Vitamin D3 receptor	0	0	1	1
Vitamin D-binding protein	0	0	1	1
Cytochrome P450 3A4	0	6	1	10
Cytochrome P450 2D6	0	4	1	5
Cytochrome P450 2C9	0	7	1	10
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	2	3	5
Cytochrome P450 2C19	0	2	1	4
Kappa-type opioid receptor	0	2	1	3
Vitamin D3 receptor	0	0	1	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Vitamin D3 receptor A	0	0	2	2
potassium voltage-gated channel subfamily H member 2 isoform d	10	0	0	10
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Histamine H1 receptor	0	5	0	5
nuclear receptor subfamily 0 group B member 1	0	1	0	1
steroidogenic factor 1	0	1	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
relaxin receptor 1 isoform 1	1	0	0	1
relaxin receptor 2 isoform 1	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
Rap guanine nucleotide exchange factor 3	2	0	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
Solute carrier family 2, facilitated glucose transporter member 1	0	0	1	1
Adenylate cyclase type 2	0	0	1	1
Adenylate cyclase type 8	0	0	1	1
Relaxin receptor 1	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Integrin beta-1	0	1	0	1
Integrin alpha-4	0	1	0	1
Smoothened homolog	0	2	1	3
Sonic hedgehog protein	0	3	0	4
Sonic hedgehog protein	0	2	1	3
Smoothened homolog	0	4	3	7
activating transcription factor 6	8	0	0	8
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	0	1
L-lactate dehydrogenase A chain	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Glutamate receptor 1	0	2	2	4
Glutamate receptor 3	0	2	2	4
Glutamate receptor 4	0	2	2	4
Cannabinoid receptor 1	0	2	1	3
Cannabinoid receptor 1	0	2	1	4
Glycine receptor subunit alpha-1	0	0	2	2
Cannabinoid receptor 2	0	2	1	4
D(3) dopamine receptor	0	3	1	4
Cannabinoid receptor 1	0	1	0	1
Cannabinoid receptor 2	0	1	1	2
N-arachidonyl glycine receptor	0	0	1	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Lysophosphatidylserine lipase ABHD12	0	1	0	1
Monoglyceride lipase	0	1	0	1
Monoacylglycerol lipase ABHD6	0	1	0	1
Cannabinoid receptor 2	0	2	0	2
G-protein coupled receptor 55	0	1	1	2
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
ubiquitin-conjugating enzyme E2 N	0	1	0	1
protein AF-9 isoform a	0	0	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Tyrosine-protein kinase Fyn	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M1	0	2	0	2
Alpha-1B adrenergic receptor	0	8	0	8
Alpha-2C adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Substance-K receptor	0	6	0	6
Sodium-dependent noradrenaline transporter	0	6	0	6
5-hydroxytryptamine receptor 2A	0	4	0	4
5-hydroxytryptamine receptor 2C	0	3	0	3
Sodium-dependent serotonin transporter	0	4	0	4
Alpha-synuclein	2	1	0	3
5-hydroxytryptamine receptor 2B	0	6	0	6
Alpha-1A adrenergic receptor	0	8	0	8
5-hydroxytryptamine receptor 6	0	3	0	3
Sodium-dependent dopamine transporter	0	5	0	5
Solute carrier family 22 member 1	0	3	0	3
D(2) dopamine receptor	0	3	0	3
D(4) dopamine receptor	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	3	1	4
Kappa-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	4	0	4
Chain A, Dihydrofolate reductase	0	0	1	1
acid sphingomyelinase	2	0	0	2
alpha-galactosidase	3	0	0	3
lysosomal alpha-glucosidase preproprotein	4	0	0	4
Thymidylate synthase	0	4	0	4
Thymidylate synthase	0	3	0	3
Dihydrofolate reductase	0	2	3	5
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Solute carrier organic anion transporter family member 1A3	0	1	0	3
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Multidrug resistance associated protein	0	1	0	3
caspase 7, apoptosis-related cysteine protease	3	0	0	3
caspase-3	3	0	0	3
Interleukin-2	0	0	1	1
Amine oxidase [flavin-containing] A	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Albumin	0	2	2	4
Albumin	0	0	1	1
Sodium-dependent serotonin transporter	0	3	0	3
Glutamate receptor ionotropic, NMDA 2B	0	5	2	11
Asialoglycoprotein receptor 1	0	1	1	2
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	2	0	0	2
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	4	0	4
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	5	2	10
Glutamate receptor ionotropic, NMDA 2C	0	5	2	10
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	5	2	10
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	5	2	10
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	5	2	10
Chain A, Glutamine Binding Protein	0	0	1	1
Asc-type amino acid transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	5	0	5
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	1	2	3
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Purine nucleoside phosphorylase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Shiga toxin subunit A	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
histone acetyltransferase KAT2A isoform 1	6	0	0	6
Carbonic anhydrase 12	0	1	0	4
Plasma kallikrein	0	0	0	3
Carbonic anhydrase 3	0	1	0	4
Histidine-binding periplasmic protein	0	0	1	1
Carbonic anhydrase 6	0	1	0	4
Carbonic anhydrase 5A, mitochondrial	0	1	0	4
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase 7	0	1	0	4
Carbonic anhydrase	0	0	0	3
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	1	0	4
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase 13	0	0	0	1
Carbonic anhydrase 15	0	1	0	4
Carbonic anhydrase 13	0	1	0	3
Carbonic anhydrase 14	0	1	0	4
Carbonic anhydrase 5B, mitochondrial	0	1	0	4
Snq2p	0	0	0	1
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
Solute carrier family 22 member 2	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Sodium-dependent noradrenaline transporter	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Solute carrier family 22 member 3	0	1	0	1
Major prion protein	0	0	1	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Sphingomyelin phosphodiesterase	0	1	0	1
D	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	0	0	1
Alpha-2A adrenergic receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	3	0	3
D(1B) dopamine receptor	0	1	0	1
D(4) dopamine receptor	0	1	0	1
Histamine H1 receptor	0	1	0	1
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	2	0	3
UDP-glucuronosyltransferase 1A3	0	0	0	1
D(1A) dopamine receptor	2	0	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Cytochrome P450 2J2	0	3	0	3
D(2) dopamine receptor	0	1	0	1
D(2) dopamine receptor	0	1	1	2
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Envelope glycoprotein	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Solute carrier family 22 member 1	0	1	0	2
Multidrug and toxin extrusion protein 2	0	1	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
Solute carrier family 22 member 2	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Transporter	0	2	0	2
Sodium channel protein type 10 subunit alpha	0	1	0	1
Caspase-7	3	0	0	3
caspase-3	3	0	0	3
serine/threonine-protein kinase PLK1	1	0	0	1
Ornithine decarboxylase	0	0	0	2
Retinoic acid receptor alpha	0	2	2	4
Retinoic acid receptor gamma	0	2	2	4
Retinoic acid receptor beta	0	2	2	4
Cellular retinoic acid-binding protein 2	0	0	2	2
Mitogen-activated protein kinase 1	0	3	0	3
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	2	0	3
Cellular retinoic acid-binding protein 1	0	0	2	2
Rap guanine nucleotide exchange factor 4	2	0	0	2
Chymotrypsinogen A	0	1	0	1
Translocator protein	0	1	0	1
Chain A, Antigen Cd11a (p180)	0	1	0	1
SMAD family member 2	4	0	0	4
SMAD family member 3	4	0	0	4
PINK1	1	0	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
thyrotropin-releasing hormone receptor	2	0	0	2
bcl-2-related protein A1	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Integrin beta-2	0	1	0	1
Intercellular adhesion molecule 1	0	1	0	1
Insulin receptor	0	1	0	1
Androgen receptor	0	6	0	6
Integrin alpha-L	0	1	1	2
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Histone deacetylase 1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Histone deacetylase 2	0	1	0	1
Acyl-CoA:cholesterol acyltransferase	0	1	0	1
Histone deacetylase 6	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	3	0	3
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Cationic amino acid transporter 3	0	1	0	1
Dihydrofolate reductase	0	5	0	6
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
dopamine D1 receptor	2	0	0	2
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
transcriptional regulator ERG isoform 3	2	0	0	2
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Bile salt export pump	0	2	0	2
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	3	0	3
Reduced folate transporter	0	2	0	2
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	3
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	3
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Solute carrier family 22 member 11	0	0	0	2
Protein-arginine deiminase type-4	0	3	0	3
Chain A, PROGESTERONE RECEPTOR	0	1	0	1
Glucocorticoid receptor	0	1	0	1
Fumarate hydratase	2	0	0	2
nonstructural protein 1	3	0	0	3
polyprotein	2	0	0	2
huntingtin isoform 2	1	0	0	1
Progesterone receptor	0	2	1	5
Tegument protein VP16	0	0	1	1
Glucocorticoid receptor	0	1	1	3
Glucocorticoid receptor	0	1	0	1
Glycine receptor subunit alpha-1	0	2	0	2
Mineralocorticoid receptor	1	2	1	5
Coagulation factor VII	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Thyroid hormone receptor alpha	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Tissue factor	0	1	0	1
Glycine receptor subunit beta	0	2	0	2
ATP-dependent translocase ABCB1	0	0	1	1
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Guanine nucleotide-binding protein G	3	0	0	3
Progesterone receptor	0	0	1	1
Glucocorticoid receptor	0	1	0	1
Stromelysin-1	0	2	1	3
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase	0	1	0	1
Solute carrier family 22 member 19	0	0	0	1
Solute carrier family 22 member 8	0	0	0	1
Chain A, Fatty acid-binding protein, adipocyte	0	1	0	1
Acetylcholinesterase	0	2	0	2
Toll-like receptor 2	0	1	0	1
Fatty acid-binding protein, intestinal	0	1	0	1
Fatty acid-binding protein, adipocyte	0	2	1	3
Tyrosine-protein phosphatase non-receptor type 1	0	2	0	4
Fatty acid-binding protein 5	0	2	1	3
Peroxisome proliferator-activated receptor alpha	1	0	2	3
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
GALC protein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	2	0	0	2
Neuronal acetylcholine receptor subunit beta-2	2	0	0	2
Gamma-aminobutyric acid	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
heat shock protein 90, putative	0	0	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Peroxisome proliferator-activated receptor delta	0	0	1	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Cholinesterase	0	1	0	1
Neuromedin-K receptor	0	0	1	1
Substance-K receptor	0	1	1	2
Substance-P receptor	0	2	1	3
Neuromedin-K receptor	0	1	1	2
Substance-K receptor	0	1	0	1
Substance-K receptor	0	1	0	1
Growth hormone secretagogue receptor type 1	0	0	1	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Chain A, Glutathione S-transferase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Tumor necrosis factor	0	0	1	1
Interstitial collagenase	0	1	0	1
Fibroblast growth factor 1	0	0	1	1
Thromboxane-A synthase	0	1	0	1
Caspase-1	0	1	0	1
Flavin reductase (NADPH)	0	0	1	1
Sodium/bile acid cotransporter	0	1	0	1
Cystine/glutamate transporter	0	1	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Retinoic acid receptor alpha	0	2	2	7
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor gamma	0	2	2	7
Alpha-1A adrenergic receptor	0	1	0	1
Retinoic acid receptor RXR-beta	0	2	2	4
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nuclear receptor ROR-alpha	0	1	0	1
Retinoic acid receptor RXR-gamma	0	2	2	4
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
Spike glycoprotein	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Procathepsin L	0	0	1	1
Angiotensin-converting enzyme 2	0	0	1	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Tryptophan 2,3-dioxygenase	0	1	0	2
SLC16A10 protein	0	0	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Monocarboxylate transporter 10	0	0	0	2
Phospholipase A-2-activating protein	0	1	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Chain A, Arginase 1	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(6)

Research Excerpts

Overview

Context

Treatment

Research

Studies (202)

Protein Targets (984)

Alobar Holoprosencephaly

Synonyms(6)

Research Excerpts

Overview

Context

Treatment

Research

Studies (202)

Drugs Studied (99)

Protein Targets (984)