Page last updated: 2024-12-06

n-hydroxyphenacetin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

N-hydroxyphenacetin: RN given refers to parent cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID29539
SCHEMBL ID3279381
MeSH IDM0051617

Synonyms (24)

Synonym
nsc 229647
brn 2104196
n-(4-ethoxyphenyl)acetohydroxamic acid
acetohydroxamic acid, n-(p-ethoxyphenyl)-
n-hydroxyphenacetin
n-(4-ethoxyphenyl)-n-hydroxyacetamide
ccris 339
n-(p-ethoxyphenyl)acetohydroxamic acid
n-hydroxy-p-acetophenetidide
acetamide, n-(4-ethoxyphenyl)-n-hydroxy-
acetohydroxamic acid, n-(4-ethoxyphenyl)-
p-acetophenetidide, n-hydroxy-
nsc229647
19315-64-1
nsc-229647
AKOS006272871
bx808pyl73 ,
unii-bx808pyl73
SCHEMBL3279381
n-(4-ethoxyphenyl)-n-hydroxyacetamide #
GPMYDZBSYQUDJZ-UHFFFAOYSA-N
DTXSID80172916
4'-ethoxy-n-hydroxyacetanilide
hydroxyphenacetin, n-

Research Excerpts

Dosage Studied

N-Hydroxyphenacetin has been found in the urine of rats dosed with phenacetin.

ExcerptRelevanceReference
" Rats showed a considerable increase in N-hydroxyphenacetin excretion after chronic dosing with phenacetin at high dosage (500 mg/kg) for one month."( Formation of reactive metabolites of phenacetin in humans and rats.
D'Souza, CA; Davies, NW; McLean, S; Veronese, ME, 1985
)
0.54
"N-Hydroxyphenacetin has been found in the urine of rats dosed with phenacetin, extending previous reports that phenacetin is N-hydroxylated by liver microsomes in vitro."( N-hydroxyphenacetin, a new urinary metabolite of phenacetin in the rat.
Bignall, JC; Davies, NW; Favretto, WA; McLean, S; Watson, H,
)
3.02
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

TimeframeStudies, This Drug (%)All Drugs %
pre-199014 (87.50)18.7374
1990's1 (6.25)18.2507
2000's1 (6.25)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.39

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.39 (24.57)
Research Supply Index2.89 (2.92)
Research Growth Index4.28 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.39)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]