Roles > phytoestrogen
Page last updated: 2024-08-05 15:31:11

phytoestrogen

Any compound produced by a plant that happens to have estrogenic activity.

ChEBI ID: 76989

Members (14)

MemberDefinitionClass
biochanin aA member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone which is substituted by an additional hydroxy group at position 5 and a methoxy group at position 4'. A phytoestrogen, it has putative benefits in dietary cancer prophylaxis.biochanin A
coumestanA member of the class of coumestans that is 6H-[1]benzofuro[3,2-c]chromene substituted by an oxo group at position 6.coumestan
daidzeinA member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by an additional hydroxy group at position 4'.daidzein
ethyl-p-hydroxybenzoateAn ethyl ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with ethanol,ethylparaben
formononetinA member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by a methoxy group at position 4'.formononetin
genisteinA 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.genistein
glyciteinA methoxyisoflavone that is isoflavone substituted by a methoxy group at position 6 and hydroxy groups at positions 7 and 4'. It has been isolated from the mycelia of the fungus Cordyceps sinensis.glycitein
icariinA member of the class of flavonols that is kaempferol which is substituted at position 8 by a 3-methylbut-2-en-1-yl group and in which the hydroxy groups at positions 3, 4', and 7 have been converted to the corresponding 6-deoxy-alpha-L-mannopyranoside, methyl ether, and beta-D-glucopyranoside, respectively. A phoshphodiesterase-5 inhibitor, it is obtained from several species of plants in the genus Epimedium and is thought to be the main active ingredient of the Chinese herbal medicine Herba Epimedii (yinyanghuo).icariin
kwakhurinA member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone with additional hydroxy groups at positions 4' and 6', a methoxy group at position 3' and a prenyl group at position 2'. A characteristic estrogen-like isoflavonoid produced in Pueraria candollei var. mirifica (Leguminosae), which has long been used as a folk medicine for rejuvenation in Thailand.kwakhurin
matairesinolA lignan that is gamma-butyrolactone in which the 3 and 4 positions are substituted by 4-hydroxy-3-methoxybenzyl groups (the 3R,4R-diastereomer).(-)-matairesinol
notoginsenoside r1A ginsenoside found in Panax notoginseng that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside and beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position.notoginsenoside R1
pinoresinolAn enantiomer of pinoresinol having (+)-1S,3aR,4S,6aR-configuration.(+)-pinoresinol
quercetinA pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.quercetin
secoisolariciresinolAn enantiomer of secoisolariciresinol having (-)-(2R,3R)-configuration.(-)-secoisolariciresinol

Research

Studies (21,231)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-1990631 (2.97)18.7374
1990's2,577 (12.14)18.2507
2000's5,882 (27.70)29.6817
2010's8,512 (40.09)24.3611
2020's3,629 (17.09)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials624 (2.58%)5.53%
Reviews1,133 (4.68%)6.00%
Case Studies20 (0.08%)4.05%
Observational7 (0.03%)0.25%
Other22,410 (92.63%)84.16%

Protein Targets (467)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency24.6491115
15-lipoxygenase, partialHomo sapiens (human)Potency17.456613
67.9K proteinVaccinia virusPotency13.789727
acid sphingomyelinaseHomo sapiens (human)Potency562.341011
activating transcription factor 6Homo sapiens (human)Potency30.125525
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency32.8790118
AR proteinHomo sapiens (human)Potency17.30421273
aryl hydrocarbon receptorHomo sapiens (human)Potency17.8807320
arylsulfatase AHomo sapiens (human)Potency20.276712
ATAD5 protein, partialHomo sapiens (human)Potency13.4953611
Ataxin-2Homo sapiens (human)Potency8.967529
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency3.751212
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency9.4507214
Bloom syndrome protein isoform 1Homo sapiens (human)Potency15.129428
BRCA1Homo sapiens (human)Potency4.916913
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency7.110413
caspase-3Homo sapiens (human)Potency7.110413
Cellular tumor antigen p53Homo sapiens (human)Potency47.3865212
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency8.8498214
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency23.6751112
Chain A, ATP-DEPENDENT DNA HELICASE Q1Homo sapiens (human)Potency1.573328
Chain A, Beta-lactamaseEscherichia coli K-12Potency12.589311
Chain A, CruzipainTrypanosoma cruziPotency20.984524
Chain A, Ferritin light chainEquus caballus (horse)Potency37.081423
Chain A, HADH2 proteinHomo sapiens (human)Potency22.2960214
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency9.4924212
Chain A, Putative fructose-1,6-bisphosphate aldolaseGiardia intestinalisPotency15.811411
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency15.642514
Chain B, HADH2 proteinHomo sapiens (human)Potency22.2960214
chromobox protein homolog 1Homo sapiens (human)Potency44.668411
cytochrome P450 2C19 precursorHomo sapiens (human)Potency12.505317
cytochrome P450 2C9 precursorHomo sapiens (human)Potency6.169117
cytochrome P450 2C9, partialHomo sapiens (human)Potency7.508613
cytochrome P450 2D6Homo sapiens (human)Potency19.497111
cytochrome P450 2D6 isoform 1Homo sapiens (human)Potency25.781015
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency14.8715215
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency14.981612
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency11.3887111
D(1A) dopamine receptorHomo sapiens (human)Potency4.288022
Disintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)Potency31.622811
DNA polymerase betaHomo sapiens (human)Potency50.806813
DNA polymerase eta isoform 1Homo sapiens (human)Potency0.794311
DNA polymerase III, partialBacillus subtilisPotency10.621311
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency39.997512
DNA polymerase kappa isoform 1Homo sapiens (human)Potency0.859217
estrogen nuclear receptor alphaHomo sapiens (human)Potency15.34691299
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency10.4952323
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency14.02061070
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency31.593314
EWS/FLI fusion proteinHomo sapiens (human)Potency12.9225415
farnesoid X nuclear receptorHomo sapiens (human)Potency31.387127
flap endonuclease 1Homo sapiens (human)Potency12.472424
GVesicular stomatitis virusPotency7.508613
GABA theta subunitRattus norvegicus (Norway rat)Potency14.932618
galactokinaseHomo sapiens (human)Potency42.128511
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency14.932618
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency14.932618
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency14.932618
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency14.932618
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency14.932618
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency14.932618
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency14.932618
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency14.932618
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency14.932618
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency14.932618
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency14.932618
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency14.932618
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency14.932618
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency14.932618
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency14.932618
gemininHomo sapiens (human)Potency13.771324
GLI family zinc finger 3Homo sapiens (human)Potency13.0484321
glp-1 receptor, partialHomo sapiens (human)Potency9.068323
GLS proteinHomo sapiens (human)Potency13.664724
glucocerebrosidaseHomo sapiens (human)Potency18.286319
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency34.245239
glucokinase regulatory proteinHomo sapiens (human)Potency22.387211
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency8.7218110
GTP-binding nuclear protein Ran isoform 1Homo sapiens (human)Potency7.307811
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)Homo sapiens (human)Potency12.590227
hexokinase-4 isoform 1Homo sapiens (human)Potency22.387211
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency7.4571225
histone deacetylase 9 isoform 3Homo sapiens (human)Potency12.2963220
Histone H2A.xCricetulus griseus (Chinese hamster)Potency73.4538210
histone-lysine N-methyltransferase 2A isoform 2 precursorHomo sapiens (human)Potency22.387211
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency7.508613
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency52.825812
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency8.337326
importin subunit beta-1 isoform 1Homo sapiens (human)Potency7.307811
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency7.508616
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency8.577714
Integrin alpha-IIbHomo sapiens (human)Potency8.755816
Integrin beta-3Homo sapiens (human)Potency8.755816
Interferon betaHomo sapiens (human)Potency11.5558310
lamin isoform A-delta10Homo sapiens (human)Potency14.205426
lethal factor (plasmid)Bacillus anthracis str. A2012Potency18.933813
LuciferasePhotinus pyralis (common eastern firefly)Potency14.5573414
M-phase phosphoprotein 8Homo sapiens (human)Potency48.022412
Microtubule-associated protein tauHomo sapiens (human)Potency12.5185221
mitogen-activated protein kinase 1Homo sapiens (human)Potency18.488025
muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)Potency11.557422
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency28.183811
neuropeptide S receptor isoform AHomo sapiens (human)Potency0.158511
NFKB1 protein, partialHomo sapiens (human)Potency5.045124
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency5.427614
Nrf2Homo sapiens (human)Potency20.596211
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency18.8530424
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency16.360111
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency46.214813
Nuclear receptor ROR-gammaHomo sapiens (human)Potency1.188311
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency21.306523
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency22.0366333
Ornithine decarboxylaseRattus norvegicus (Norway rat)Potency25.118912
P53Homo sapiens (human)Potency29.373012
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency57.072114
ParkinHomo sapiens (human)Potency9.895325
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency2.685511
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency15.101422
peripheral myelin protein 22 isoform 1Homo sapiens (human)Potency37.484613
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency32.1823411
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency26.0915411
phosphoglycerate kinaseTrypanosoma brucei brucei TREU927Potency7.568611
phosphopantetheinyl transferaseBacillus subtilisPotency56.940216
plasminogen precursorMus musculus (house mouse)Potency6.023614
polyunsaturated fatty acid lipoxygenase ALOX12Homo sapiens (human)Potency5.990313
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Potency14.219112
PPM1D proteinHomo sapiens (human)Potency13.026814
pregnane X nuclear receptorHomo sapiens (human)Potency34.6109215
progesterone receptorHomo sapiens (human)Potency17.351919
pyruvate kinaseLeishmania mexicana mexicanaPotency12.589324
pyruvate kinase PKM isoform bHomo sapiens (human)Potency25.118924
RAR-related orphan receptor gammaMus musculus (house mouse)Potency14.1638224
ras-related protein Rab-9AHomo sapiens (human)Potency7.347214
regulator of G-protein signaling 4Homo sapiens (human)Potency6.431512
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency13.0466334
retinoid X nuclear receptor alphaHomo sapiens (human)Potency21.5677416
signal transducer and activator of transcription 6, interleukin-4 inducedHomo sapiens (human)Potency2.511922
SMAD family member 2Homo sapiens (human)Potency19.509624
SMAD family member 3Homo sapiens (human)Potency19.509624
Smad3Homo sapiens (human)Potency35.481311
snurportin-1Homo sapiens (human)Potency7.307811
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency39.810711
survival motor neuron protein isoform dHomo sapiens (human)Potency22.2666111
TAR DNA-binding protein 43Homo sapiens (human)Potency3.162311
TDP1 proteinHomo sapiens (human)Potency18.8434220
thioredoxin reductaseRattus norvegicus (Norway rat)Potency12.132335
ThrombopoietinHomo sapiens (human)Potency2.048424
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency43.7952315
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency22.352933
thyroid stimulating hormone receptorHomo sapiens (human)Potency27.3024410
tyrosine-protein kinase YesHomo sapiens (human)Potency23.078912
ubiquitin carboxyl-terminal hydrolase 2 isoform aHomo sapiens (human)Potency25.057822
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency6.023614
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency6.023614
USP1 protein, partialHomo sapiens (human)Potency56.234111
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency64.945113
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency4.795035
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency8.7218110

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
1-deoxy-D-xylulose 5-phosphate reductoisomeraseEscherichia coli K-12IC501.900011
17-beta-hydroxysteroid dehydrogenase type 1Homo sapiens (human)IC502.210011
17-beta-hydroxysteroid dehydrogenase type 2Homo sapiens (human)IC509.313326
3-oxoacyl-acyl-carrier protein reductase Plasmodium falciparum (malaria parasite P. falciparum)IC505.400011
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)IC504.000011
5-hydroxytryptamine receptor 2AHomo sapiens (human)IC5010.469011
5-hydroxytryptamine receptor 2AHomo sapiens (human)Ki2.991011
5-hydroxytryptamine receptor 2CHomo sapiens (human)IC5014.910011
5-hydroxytryptamine receptor 2CHomo sapiens (human)Ki7.806011
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)IC5014.910011
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)Ki7.806011
5'-nucleotidaseRattus norvegicus (Norway rat)Ki0.045311
72 kDa type IV collagenaseHomo sapiens (human)IC506.680011
AcetylcholinesteraseRattus norvegicus (Norway rat)IC5050.000011
AcetylcholinesteraseHomo sapiens (human)Ki38.300011
Adenosine receptor A1Homo sapiens (human)IC5019.904011
Adenosine receptor A1Homo sapiens (human)Ki11.611011
Adenosine receptor A1Rattus norvegicus (Norway rat)Ki8.900033
Adenosine receptor A2aHomo sapiens (human)IC5017.442011
Adenosine receptor A2aHomo sapiens (human)Ki9.792011
Adenosine receptor A2aRattus norvegicus (Norway rat)Ki15.416733
Adenosine receptor A3Homo sapiens (human)Ki30.000011
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1Homo sapiens (human)IC5037.900011
Aldehyde dehydrogenase, mitochondrialHomo sapiens (human)IC509.000022
Aldehyde oxidaseHomo sapiens (human)IC500.340011
Aldo-keto reductase family 1 member A1Rattus norvegicus (Norway rat)IC502.320011
Aldo-keto reductase family 1 member A1Sus scrofa (pig)IC5038.400011
Aldo-keto reductase family 1 member B1Bos taurus (cattle)IC5017.754055
Aldo-keto reductase family 1 member B1Homo sapiens (human)IC5035.787279
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)IC506.641756
Aldo-keto reductase family 1 member B1Sus scrofa (pig)IC5050.100011
Aldo-keto reductase family 1 member B10Homo sapiens (human)IC5034.150012
Aldo-keto reductase family 1 member C21Mus musculus (house mouse)IC506.900011
Aldo-keto reductase family 1 member C21Mus musculus (house mouse)Ki11.000011
ALK tyrosine kinase receptorHomo sapiens (human)IC503.320011
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)IC5039.900012
Alpha-amylase 1A Homo sapiens (human)IC5021.400022
Alpha-glucosidase MAL32Saccharomyces cerevisiae S288CIC5061.000012
Alpha-mannosidaseCanavalia ensiformis (jack bean)IC5049.000011
Alpha-synucleinHomo sapiens (human)IC5020.000011
Amine oxidase [flavin-containing] AHomo sapiens (human)IC507.7964811
Amine oxidase [flavin-containing] AMus musculus (house mouse)IC5021.200011
Amine oxidase [flavin-containing] A Bos taurus (cattle)IC5047.505022
Amine oxidase [flavin-containing] A Rattus norvegicus (Norway rat)IC5040.000011
Amine oxidase [flavin-containing] BBos taurus (cattle)IC5057.500022
Amine oxidase [flavin-containing] BHomo sapiens (human)IC5021.628969
Amine oxidase [flavin-containing] BMus musculus (house mouse)IC5011.000011
Amyloid-beta precursor proteinHomo sapiens (human)IC5040.785044
Androgen receptorHomo sapiens (human)IC501,450.000012
Androgen receptorRattus norvegicus (Norway rat)IC5085.113811
Anthrax toxin receptor 2Homo sapiens (human)IC50300.000011
Arginase Leishmania amazonensisIC504.000011
AromataseHomo sapiens (human)IC504,235,550,038.252868
AromataseHomo sapiens (human)Ki53.000057
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000011
ATP-dependent translocase ABCB1Homo sapiens (human)IC5052.500011
Aurora kinase BHomo sapiens (human)IC502.435022
B2 bradykinin receptorCavia porcellus (domestic guinea pig)IC504.000022
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)Plasmodium falciparum (malaria parasite P. falciparum)IC5011.625014
Beta-lactamaseEnterobacter cloacaeIC50269.666733
Beta-lactamaseEscherichia coli K-12IC5058.000044
Beta-secretase 1Homo sapiens (human)IC507.640033
Beta-secretase 1Homo sapiens (human)Ki14.000011
Bifunctional epoxide hydrolase 2Homo sapiens (human)IC5020.270022
Bile salt export pumpHomo sapiens (human)IC50134.000022
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)IC507.550024
C-C chemokine receptor type 4Homo sapiens (human)IC5047.240936
C-X-C chemokine receptor type 1Homo sapiens (human)IC5035.378024
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BRattus norvegicus (Norway rat)IC50275.000011
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CRattus norvegicus (Norway rat)IC50275.000011
Calcium/calmodulin-dependent protein kinase type II subunit betaHomo sapiens (human)IC503.000011
Calmodulin-1Homo sapiens (human)IC5012.970011
cAMP-dependent protein kinase catalytic subunit alphaHomo sapiens (human)IC5050.714317
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000011
Carbonic anhydrase 1Homo sapiens (human)Ki24.2918611
Carbonic anhydrase 12Homo sapiens (human)Ki4.524734
Carbonic anhydrase 13Mus musculus (house mouse)Ki9.030011
Carbonic anhydrase 14Homo sapiens (human)Ki6.555022
Carbonic anhydrase 2Homo sapiens (human)Ki23.9973611
Carbonic anhydrase 3Bos taurus (cattle)Ki6.526025
Carbonic anhydrase 3Homo sapiens (human)Ki8.100011
Carbonic anhydrase 4Homo sapiens (human)Ki6.039648
Carbonic anhydrase 5A, mitochondrialHomo sapiens (human)Ki6.810011
Carbonic anhydrase 5B, mitochondrialHomo sapiens (human)Ki11.900011
Carbonic anhydrase 6Homo sapiens (human)Ki4.950022
Carbonic anhydrase 7Homo sapiens (human)Ki3.478934
Carbonic anhydrase 9Homo sapiens (human)Ki7.600022
Carbonyl reductase [NADPH] 1Homo sapiens (human)IC5012.710011
Carbonyl reductase [NADPH] 1Homo sapiens (human)Ki2.030011
Carboxylic ester hydrolase Rattus norvegicus (Norway rat)IC5050.000011
Casein kinase II subunit alphaHomo sapiens (human)IC501.650055
Casein kinase II subunit alphaHomo sapiens (human)Ki1.180044
Casein kinase II subunit alpha 3Homo sapiens (human)IC500.550011
Casein kinase II subunit alpha 3Homo sapiens (human)Ki1.180011
Casein kinase II subunit alpha'Homo sapiens (human)IC501.650055
Casein kinase II subunit alpha'Homo sapiens (human)Ki1.180011
Casein kinase II subunit betaHomo sapiens (human)IC501.650055
Casein kinase II subunit betaHomo sapiens (human)Ki1.180011
Cationic trypsinBos taurus (cattle)IC5024.420025
cGMP-dependent 3',5'-cyclic phosphodiesteraseRattus norvegicus (Norway rat)IC5081.300011
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)IC505.900011
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydrataseHelicobacter pyloriKi12.700013
Chain A, APH(2')-IdEnterococcus casseliflavusKi25.100011
Chain A, Estrogen receptor 1 (alpha)Homo sapiens (human)IC500.009011
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydrataseHelicobacter pyloriKi12.700013
Chymotrypsin-CHomo sapiens (human)IC50100.000011
Chymotrypsin-like elastase family member 1Sus scrofa (pig)IC5028.750014
Chymotrypsinogen ABos taurus (cattle)IC50292.500022
Chymotrypsinogen BHomo sapiens (human)IC50100.000011
Collagenase 3Homo sapiens (human)IC508.460011
CruzipainTrypanosoma cruziIC50241.350022
Cyclin homologHerpesvirus saimiri (strain 11)IC5031.275014
Cyclin-dependent kinase 1Homo sapiens (human)IC5097.090045
Cyclin-dependent kinase 1Oryzias latipes (Japanese medaka)IC5031.275014
Cyclin-dependent kinase 2Homo sapiens (human)IC5040.000011
Cyclin-dependent kinase 4Homo sapiens (human)IC50155.500012
Cyclin-dependent kinase 5 activator 1Homo sapiens (human)IC5029.620025
Cyclin-dependent kinase 6Homo sapiens (human)IC5030.020025
Cyclin-dependent-like kinase 5 Homo sapiens (human)IC5029.620025
Cytochrome P450 11B1, mitochondrialRattus norvegicus (Norway rat)IC5050.000011
Cytochrome P450 1A1Homo sapiens (human)IC5023.697066
Cytochrome P450 1A1Homo sapiens (human)Ki0.660011
Cytochrome P450 1A2Homo sapiens (human)IC5014.699033
Cytochrome P450 1B1Homo sapiens (human)IC501.110855
Cytochrome P450 1B1Homo sapiens (human)Ki0.023022
Cytochrome P450 2C8Homo sapiens (human)IC5013.500022
Cytochrome P450 2C9 Homo sapiens (human)Ki27.000011
Cytochrome P450 2D6Homo sapiens (human)IC5046.666733
Cytochrome P450 3A4Homo sapiens (human)IC5023.575044
Cytoplasmic tyrosine-protein kinase BMXHomo sapiens (human)IC5067.990011
Cytosol aminopeptidaseSus scrofa (pig)IC5034.300011
D(4) dopamine receptorHomo sapiens (human)Ki7.846011
Death-associated protein kinase 1Homo sapiens (human)IC5053.450012
Dipeptidyl peptidase 3Homo sapiens (human)IC5055.350012
Dipeptidyl peptidase 4Homo sapiens (human)IC5044.466723
Dipeptidyl peptidase 4Rattus norvegicus (Norway rat)IC5039.000011
DNA (cytosine-5)-methyltransferase 1Homo sapiens (human)IC5030.000011
DNA (cytosine-5)-methyltransferase 3-likeHomo sapiens (human)IC50100.000011
DNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)IC50100.000011
Dual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)IC5010.000011
Dual specificity mitogen-activated protein kinase kinase 4Homo sapiens (human)IC500.400011
ELAV-like protein 1Homo sapiens (human)IC501.400011
ELAV-like protein 3Homo sapiens (human)IC501.800011
Enoyl-[acyl-carrier-protein] reductase [NADH] FabIEscherichia coli K-12IC5020.000011
Enoyl-acyl-carrier protein reductase Plasmodium falciparum (malaria parasite P. falciparum)IC501.833333
Enoyl-acyl-carrier protein reductase Plasmodium falciparum (malaria parasite P. falciparum)Ki0.528333
Epidermal growth factor receptorHomo sapiens (human)IC5037.00751016
Epoxide hydrolase 1 Homo sapiens (human)IC507.000011
Estrogen receptorHomo sapiens (human)IC5035.04042531
Estrogen receptorHomo sapiens (human)Ki0.736323
Estrogen receptor betaHomo sapiens (human)IC501.98412433
Estrogen receptor betaHomo sapiens (human)Ki0.108223
Focal adhesion kinase 1Homo sapiens (human)IC501.200011
G-protein coupled receptor 35Homo sapiens (human)IC5015.400011
G1/S-specific cyclin-D1Homo sapiens (human)IC50155.500012
G2/mitotic-specific cyclin-BMarthasterias glacialis (spiny starfish)IC5031.275014
G2/mitotic-specific cyclin-B1Homo sapiens (human)IC50121.250034
G2/mitotic-specific cyclin-B2Homo sapiens (human)IC5075.000011
G2/mitotic-specific cyclin-B3Homo sapiens (human)IC5075.000011
glucose-6-phosphate dehydrogenaseLeuconostoc mesenteroidesIC5025.000011
Glutathione reductaseSaccharomyces cerevisiae S288CIC5048.800011
Glutathione reductase, mitochondrialHomo sapiens (human)IC50218.000011
Glyceraldehyde-3-phosphate dehydrogenase, glycosomalTrypanosoma cruziIC50142.000011
Glycogen phosphorylase, liver formHomo sapiens (human)IC504.800011
Glycogen synthase kinase-3 alphaHomo sapiens (human)IC502.100011
Glycogen synthase kinase-3 betaHomo sapiens (human)IC502.100011
Glycogen synthase kinase-3 betaRattus norvegicus (Norway rat)IC5031.275014
Heat shock factor protein 1Homo sapiens (human)IC5050.000011
Hepatocyte growth factor receptorHomo sapiens (human)IC500.580011
hexokinaseTrypanosoma brucei brucei TREU927IC5022.378011
Hypoxia-inducible factor 1-alpha inhibitorHomo sapiens (human)IC5010.200011
Inositol hexakisphosphate kinase 2Homo sapiens (human)IC500.700011
Inositol polyphosphate multikinaseHomo sapiens (human)IC502.300011
Insulin-like growth factor 1 receptorHomo sapiens (human)IC500.300011
Integrase Human immunodeficiency virus 1IC5013.362558
Interstitial collagenaseHomo sapiens (human)IC5025.805022
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)IC501.000011
LactoperoxidaseBos taurus (cattle)IC506.100011
Lactoylglutathione lyaseHomo sapiens (human)IC503.200011
Lactoylglutathione lyaseHomo sapiens (human)Ki15.135611
Lysine-specific histone demethylase 1AHomo sapiens (human)IC507.310045
Lysosomal alpha-glucosidaseHomo sapiens (human)IC507.800011
Macrophage metalloelastaseHomo sapiens (human)IC5010.230011
Malate dehydrogenaseThermus thermophilusIC506.000011
Maltase-glucoamylase, intestinalHomo sapiens (human)IC507.902544
Maltase-glucoamylase, intestinalHomo sapiens (human)Ki10.400011
Matrix metalloproteinase-9Homo sapiens (human)IC500.891922
Mitogen-activated protein kinase 10Homo sapiens (human)IC5022.386713
Mitogen-activated protein kinase 14Homo sapiens (human)IC5022.386713
MO15-related protein kinase Pfmrk Plasmodium falciparum (malaria parasite P. falciparum)IC5093.000011
Monocarboxylate transporter 1Rattus norvegicus (Norway rat)IC5014.000011
Monocarboxylate transporter 2Rattus norvegicus (Norway rat)IC505.000011
Multidrug resistance-associated protein 1 Homo sapiens (human)Ki5.250022
Multidrug resistance-associated protein 4Homo sapiens (human)IC5020.800011
MyeloperoxidaseHomo sapiens (human)IC501.697544
NADPH oxidase 4Homo sapiens (human)IC500.680011
NeuraminidaseInfluenza A virus (A/Puerto Rico/8/1934(H1N1))IC507.750011
Neuraminidase Influenza A virus (A/Wilson-Smith/1933(H1N1))IC5055.0288817
Neuraminidase Influenza A virus (A/Wilson-Smith/1933(H1N1))Ki3.800011
Neutrophil elastaseHomo sapiens (human)IC5018.339022
Neutrophil elastaseHomo sapiens (human)Ki11.900011
Nitric oxide synthase, inducibleMus musculus (house mouse)IC5016.400011
NUAK family SNF1-like kinase 1Homo sapiens (human)IC505.090011
Oligo-1,6-glucosidase IMA1Saccharomyces cerevisiae S288CIC50530.000011
Ornithine decarboxylaseHomo sapiens (human)IC5026.000011
Oxysterols receptor LXR-alphaHomo sapiens (human)IC5046.000034
Oxysterols receptor LXR-betaHomo sapiens (human)IC5048.000023
Pancreatic triacylglycerol lipaseSus scrofa (pig)IC5090.000023
Phosphatidylinositol 3-kinase regulatory subunit alphaHomo sapiens (human)IC503.800011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (human)IC508.795022
Phosphodiesterase Rattus norvegicus (Norway rat)IC50275.000011
Phospholipase A2Homo sapiens (human)IC502.000011
Polyphenol oxidase 2Agaricus bisporusIC50135.500022
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)IC506.958055
Polyunsaturated fatty acid 5-lipoxygenaseRattus norvegicus (Norway rat)IC501.950066
Polyunsaturated fatty acid lipoxygenase ALOX12Homo sapiens (human)IC5066.813323
Polyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)IC5067.400023
Polyunsaturated fatty acid lipoxygenase ALOX15Oryctolagus cuniculus (rabbit)IC5015.487733
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)IC50100.000023
Probable maltase-glucoamylase 2Homo sapiens (human)IC507.800011
Prolyl endopeptidaseHomo sapiens (human)IC5013.000011
Prostaglandin G/H synthase 1Homo sapiens (human)IC5080.000011
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)IC5050.000022
Prostaglandin G/H synthase 2Homo sapiens (human)IC5028.600011
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)IC5050.000022
Proteasome subunit beta type-5Homo sapiens (human)IC5046.626746
Protein E6Human papillomavirus 16IC5020.000011
Protein kinase C alpha typeHomo sapiens (human)IC5056.875028
ProthrombinHomo sapiens (human)IC5015.750022
Prothrombin Bos taurus (cattle)IC5028.750014
Proto-oncogene tyrosine-protein kinase receptor RetHomo sapiens (human)IC5078.100011
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)IC5040.024055
rac GTPase-activating protein 1 isoform aHomo sapiens (human)IC5091.260011
RAC-alpha serine/threonine-protein kinaseHomo sapiens (human)IC5037.695022
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)IC500.590011
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2IC5023.800011
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirusIC5042.140055
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2Ki7.400011
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirusKi7.400011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1Oryctolagus cuniculus (rabbit)IC509.000011
Seed linoleate 13S-lipoxygenase-1Glycine max (soybean)IC50100.000011
Seed linoleate 13S-lipoxygenase-1Glycine max (soybean)Ki106.700011
Serine/threonine-protein kinase B-rafHomo sapiens (human)IC507.589011
Serine/threonine-protein kinase N1Homo sapiens (human)IC505.800011
Serine/threonine-protein kinase Nek2Homo sapiens (human)IC505.730011
Serine/threonine-protein kinase Nek6Homo sapiens (human)IC504.230011
Serine/threonine-protein kinase pim-1Homo sapiens (human)IC500.768655
Serine/threonine-protein kinase PLK1Homo sapiens (human)IC5034.875022
Sex hormone-binding globulinHomo sapiens (human)IC50141.000012
Short transient receptor potential channel 5Homo sapiens (human)IC506.500011
SialidaseClostridium perfringensIC5010.275066
Sialidase-2Homo sapiens (human)IC50270.000012
Signal transducer and activator of transcription 3Homo sapiens (human)IC5024.800011
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)IC5050.000011
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)IC5050.000011
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)IC5050.000011
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)IC5050.000011
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)IC5020.000011
Sodium-dependent dopamine transporter Homo sapiens (human)IC5016.918011
Sodium-dependent dopamine transporter Homo sapiens (human)Ki13.442011
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)IC500.697522
Solute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)Ki7.000033
Solute carrier family 2, facilitated glucose transporter member 2Homo sapiens (human)IC5012.000022
Solute carrier family 2, facilitated glucose transporter member 4Mus musculus (house mouse)IC5020.000011
Solute carrier family 2, facilitated glucose transporter member 4 Rattus norvegicus (Norway rat)Ki16.000011
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)IC509.120111
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)Ki5.000011
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)IC503.890411
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)Ki2.960011
Sorbitol dehydrogenaseHomo sapiens (human)IC50106.300022
Steroid hormone receptor ERR1Homo sapiens (human)IC500.010011
Steroid hormone receptor ERR2Homo sapiens (human)IC500.395011
Stromelysin-1Homo sapiens (human)IC505.570011
Substance-K receptorCavia porcellus (domestic guinea pig)IC5068.150014
Substance-P receptorCavia porcellus (domestic guinea pig)IC5068.150014
Sucrase-isomaltase, intestinalHomo sapiens (human)IC507.800011
Testosterone 17-beta-dehydrogenase 3Homo sapiens (human)IC5020.550012
Thromboxane-A synthase Homo sapiens (human)IC507.720011
Tissue alpha-L-fucosidaseBos taurus (cattle)IC5054.000011
TransporterRattus norvegicus (Norway rat)IC500.450011
TransthyretinHomo sapiens (human)IC5011.900012
Triosephosphate isomeraseOryctolagus cuniculus (rabbit)Ki67.500012
Trypsin-1Homo sapiens (human)IC5015.400011
Trypsin-2Homo sapiens (human)IC5015.400011
Trypsin-3Homo sapiens (human)IC5015.400011
Type-1 angiotensin II receptorOryctolagus cuniculus (rabbit)IC5047.300011
TyrosinaseHomo sapiens (human)IC5044.380011
TyrosinaseMus musculus (house mouse)IC50500.000013
Tyrosine-protein kinase ABL1Homo sapiens (human)IC5041.666739
Tyrosine-protein kinase ABL2Homo sapiens (human)IC5010.000011
Tyrosine-protein kinase CSKHomo sapiens (human)IC5050.714317
Tyrosine-protein kinase FynHomo sapiens (human)IC5058.180011
Tyrosine-protein kinase LckHomo sapiens (human)IC5013.000022
Tyrosine-protein kinase receptor UFOHomo sapiens (human)IC500.960011
Tyrosine-protein kinase SYKHomo sapiens (human)IC5029.500022
Tyrosine-protein kinase YesHomo sapiens (human)Ki0.472011
Tyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)IC5023.300022
UDP-glucuronosyltransferase 1A1 Homo sapiens (human)IC5063.650022
Urease subunit alphaHelicobacter pylori 26695IC50518.480035
Urease subunit alphaHelicobacter pylori 26695Ki9.340011
Urease subunit betaHelicobacter pylori 26695IC50518.480035
Urease subunit betaHelicobacter pylori 26695Ki9.340011
Urokinase-type plasminogen activatorHomo sapiens (human)IC5025.420025
Vascular endothelial growth factor receptor 2Homo sapiens (human)IC500.970022
Vasopressin V2 receptorHomo sapiens (human)IC5020.328236
Xanthine dehydrogenase/oxidaseBos taurus (cattle)IC5016.815022
Xanthine dehydrogenase/oxidaseHomo sapiens (human)IC50456.7020610
Xanthine dehydrogenase/oxidaseBos taurus (cattle)Ki1.200011
Xanthine dehydrogenase/oxidaseHomo sapiens (human)Ki0.280011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5-hydroxytryptamine receptor 1AHomo sapiens (human)EC50100.000011
Angiotensin-converting enzyme 2 Homo sapiens (human)EC5083.400011
ATP-dependent translocase ABCB1Homo sapiens (human)Kd16.691112
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)EC500.195333
Chain A, TransthyretinHomo sapiens (human)Kd2.150014
Cystic fibrosis transmembrane conductance regulatorHomo sapiens (human)EC508.290055
Cystic fibrosis transmembrane conductance regulatorHomo sapiens (human)Kd25.600011
Cystic fibrosis transmembrane conductance regulatorRattus norvegicus (Norway rat)Kd40.000011
Cytochrome P450 1A1Homo sapiens (human)EC508.800011
Cytochrome P450 1B1Homo sapiens (human)EC501.100011
Estrogen receptorHomo sapiens (human)EC506.312677
Estrogen receptorMus musculus (house mouse)EC5055.941012
Estrogen receptorOvis aries (sheep)Kd5.900011
Estrogen receptor betaHomo sapiens (human)EC500.33311010
Estrogen receptor betaMus musculus (house mouse)EC5055.941012
Estrogen receptor betaOvis aries (sheep)Kd5.900011
G-protein coupled receptor 35Homo sapiens (human)EC506.975022
glycogen synthase kinase-3 beta isoform 1Homo sapiens (human)EC50300.000011
Heterogeneous nuclear ribonucleoprotein A1Homo sapiens (human)Kd5.300012
Interleukin-2Homo sapiens (human)Kd5.470011
Interstitial collagenaseHomo sapiens (human)Kd51.800011
nuclear factor NF-kappa-B p105 subunit isoform 1Homo sapiens (human)EC5055.941011
Procathepsin LHomo sapiens (human)EC5083.400011
ProthrombinHomo sapiens (human)Kd0.038711
Replicase polyprotein 1aSevere acute respiratory syndrome-related coronavirusEC5083.400022
Replicase polyprotein 1abBetacoronavirus England 1EC5083.400011
Replicase polyprotein 1abHuman coronavirus 229EEC5083.400022
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2EC5083.400011
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirusEC5083.400022
Serine/threonine-protein kinase pim-1Homo sapiens (human)Kd0.025011
Sex hormone-binding globulinHomo sapiens (human)Kd20.059912
signal transducer and activator of transcription 1-alpha/beta isoform alphaHomo sapiens (human)EC502.060011
Spike glycoproteinBetacoronavirus England 1EC5083.400011
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusEC5083.400011
STAT3, partialHomo sapiens (human)EC5055.700011
transcription factor p65 isoform 1Homo sapiens (human)EC5055.941011
Transmembrane protease serine 2Homo sapiens (human)EC5083.400011
Tyrosine-protein kinase SYKHomo sapiens (human)EC5035.000011

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Androgen receptorHomo sapiens (human)EC1506.233313
AromataseHomo sapiens (human)Log IC500.004511
Glucocorticoid receptorHomo sapiens (human)EC1506.233313
interferon gamma precursorHomo sapiens (human)AC5016.690022
Polyphenol oxidase 2Agaricus bisporusID5070.000011
Prenyltransferase homologStreptomyces coelicolor A3(2)Km310.000022
Quinone oxidoreductaseMus musculus (house mouse)CD22.900011
Seed linoleate 13S-lipoxygenase-1Glycine max (soybean)Km114.800022
Seed linoleate 13S-lipoxygenase-1Glycine max (soybean)Vmax0.007022
UDP-glucuronosyltransferase 1A4Homo sapiens (human)Km400.000011
Xanthine dehydrogenase/oxidaseBos taurus (cattle)Km65.300044