Target type: molecularfunction
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-ascorbate(out) + Na+(out) = L-ascorbate(in) + Na+(in). [GOC:mah, GOC:yaf, PMID:18094143]
L-ascorbate:sodium symporter activity refers to the transmembrane transport of both L-ascorbate (vitamin C) and sodium ions across a cell membrane. This process is facilitated by a specific protein known as the L-ascorbate:sodium symporter. The symporter utilizes the electrochemical gradient of sodium ions to drive the uptake of L-ascorbate against its concentration gradient. This means that L-ascorbate is transported into the cell even when its concentration inside the cell is higher than outside. The symporter binds both L-ascorbate and sodium ions simultaneously, and the binding of one molecule increases the affinity of the symporter for the other. This coupled transport mechanism ensures that both L-ascorbate and sodium ions are transported together. The L-ascorbate:sodium symporter is crucial for maintaining intracellular levels of L-ascorbate, which is an essential antioxidant and cofactor for various enzymatic reactions. The activity of this symporter is influenced by factors such as the concentration of sodium ions, the pH gradient across the membrane, and the availability of L-ascorbate.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Solute carrier family 23 member 1 | A solute carrier family 23 member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UHI7] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| ascorbic acid | Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms. | ascorbic acid; vitamin C | coenzyme; cofactor; flour treatment agent; food antioxidant; food colour retention agent; geroprotector; plant metabolite; skin lightening agent |