Goiter, Nodular

An enlarged THYROID GLAND containing multiple nodules (THYROID NODULE), usually resulting from recurrent thyroid HYPERPLASIA and involution over many years to produce the irregular enlargement. Multinodular goiters may be nontoxic or may induce THYROTOXICOSIS.

Synonym
Goiter, Nodular

Excerpt	Reference
"Since toxic multinodular goiter is usually a diffuse process involving the whole gland, this case is unique and underlines the wide variability in the manifestation of this disorder."	( Kern, PA; Robbins, RJ, 1983)
"Toxic multinodular goiter is a cause of nonautoimmune hyperthyroidism and is believed to differ in its nature and pathogenesis from toxic adenoma."	( Agretti, P; Cetani, F; Chiovato, L; Fiore, E; Miccoli, P; Pinchera, A; Rocchi, R; Tonacchera, M; Viacava, P; Vitti, P, 1998)
"Multinodular goiter is a worldwide-distributed disease, but yet its pathology and genetic etiology are not clear."	( Chu, J; Du, L; Liu, X; Luo, Z; Peng, Z; Tao, S; Zhang, R, 2000)
"Hypothyroidism and nodular goiter are two frequent endocrine diseases which respectively require substitutive and suppressive treatment with L-Thyroxine."	( Dazzi, D; Negro, R; Pezzarossa, A, 2000)
"Hypothyroidism and nodular goiter are two frequent endocrine diseases which respectively require substitutive and suppressive treatment with L-Thyroxine."	( Dazzi, D; Negro, R; Pezzarossa, A, 2000)
"Nodular goiters are more prevalent in iodine-deficient areas."	( Chen, Y; Chong, W; Dai, H; Fan, C; Gao, T; Gu, X; Guan, H; Hu, F; Jin, Y; Li, C; Li, J; Li, Y; Mao, J; Shan, Z; Shi, X; Teng, D; Teng, W; Teng, X; Tong, Y; Wang, W; Yang, F; Yang, R; Yu, X; Yu, Y; Zhao, D, 2008)
"Nodular goiter is the most common disorder of the thyroid gland."	( Alexandraki, K; Boutzios, G; Garoufalia, Z; Kouraklis, G; Tsourouflis, G, 2019)
"Toxic multinodular goiter is a heterogeneous disease associated with hyperthyroidism frequently detected in areas with deficient iodine intake, and functioning and non-functioning nodules, characterized by increased proliferation but opposite functional activity, may coexist in the same gland."	( Agretti, P; Bagattini, B; Chiovato, L; De Marco, G; Di Cosmo, C; Ferrarini, E; Montanelli, L; Tonacchera, M, 2022)

Excerpt	Reference
"Patients with toxic nodular goiter have only a slight chance for spontaneous remission."	( Reinwein, D, 1978)

Excerpt	Reference
"To diagnose and treat patients with nodular goiters cost-effectively is often challenging because many thyroid illnesses present with a nodule; often the patient is unaware of its presence."	( Petrone, LR, 1996)
"This patient as well had been treated for a multinodular goiter originally."	( Friedrich, J; Hörmann, R; Krause, U; Reichmann, I; Zander, C, 1998)
"We described four patients treated for nodular goiter, where clinical and biochemical studies before and after triiodothyronine treatment (by increasing doses from 20 micrograms to 100 micrograms daily for 10 days) have made it possible to diagnose the Refetoff syndrome."	( Gradecka-Kubik, I; Lacka, K, 1998)
"The findings show that untreated toxic multinodular goiter causes profound alterations in components of the antioxidant system in erythrocytes indicative of increased oxidative stress."	( Alicigüzel, Y; Karayalçin, U; Ozdem, SN; Ozdem, SS; Perry, G; Siedlak, SL; Smith, MA, 2001)
"It is only partially effective in the treatment of multinodular goiters."	( CATZ, B; FAWELL, WN, 1963)
"Medical treatment of nodular goiter is aimed at achieving a reduction in size or preservation of the status quo."	( Meng, W, 2004)
"The use of 131I in the treatment of multinodular goiters (MNG) is well established."	( Albino, CC; Goedert, CA; Graf, H; Mesa, CO; Olandoski, M; Souza, AM; Ueda, CE; Woellner, LC, 2005)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	415 (40.49)	23.3326
1990's	181 (17.66)	12.5806
2000's	228 (22.24)	18.1394
2010's	170 (16.59)	28.8240
2020's	31 (3.02)	9.53

Drug	Relationship Strength	Studies	Trials
2,3-dihydroxybenzoic acid	low	1	0
protocatechuic acid	low	1	0
5-hydroxytryptophan	low	1	0
acetic acid	low	1	0
ammonium hydroxide	low	1	0
anthranilic acid	low	1	0
choline	low	1	0
chlorine	low	2	0
salicylic acid	low	2	0
guaiacol	low	1	0
n(g),n(g')-dimethyl-l-arginine	low	1	0
lactic acid	low	2	0
formaldehyde	low	2	0
hydrogen carbonate	low	1	0
histamine	low	1	0
iodine	medium	220	9
malonic acid	low	1	0
methanol	low	1	0
niacinamide	low	1	0
pyruvic acid	low	2	0
thiamine	low	1	0
urea	low	1	0
vanilmandelic acid	low	1	0
phenytoin	low	1	0
amiodarone	low	11	0
anastrozole	medium	1	1
aspirin	low	2	0
atenolol	low	1	0
diazepam	low	1	0
pentetic acid	low	1	0
valproic acid	low	1	0
ether	low	1	0
etidronate	low	1	0
2,5-dihydroxybenzoic acid	low	1	0
p-hydroxyamphetamine	low	1	0
hydroxychloroquine	low	1	0
iopanoic acid	low	1	0
iodipamide	low	1	0
isoniazid	low	1	0
mechlorethamine	low	1	0
mesalamine	low	1	0
metformin	low	5	0
mitoxantrone	low	1	0
activins	low	1	0
potassium iodide	low	9	0
procaine	low	1	0
procarbazine	low	1	0
propofol	medium	1	1
propranolol	low	7	0
salicyl alcohol	low	1	0
sevoflurane	medium	1	1
sodium fluoride	low	1	0
sodium iodide	low	5	0
ipodate	medium	1	1
risedronic acid	low	1	0
sulfamethoxazole	low	1	0
2-thiosalicylic acid	low	1	0
ticlopidine	low	1	0
trimethoprim	low	1	0
prednisolone	low	1	0
estriol	medium	1	1
thymidine	low	5	0
3,3',5-triiodothyroacetic acid	low	1	0
hydroxyproline	low	1	0
thyroxine	medium	363	24
aldosterone	low	3	0
tetrahydrocortisol	low	1	0
prednisone	low	13	0
tetrahydrocortisone	low	1	0
dehydroepiandrosterone	low	2	0
triiodothyronine	medium	228	12
alanine	low	1	0
desoxycorticosterone acetate	low	1	0
chlorobutanol	low	1	0
bromodeoxyuridine	low	1	0
tyrosine	low	3	0
leucine	low	1	0
methionine	low	2	0
phenylalanine	low	2	0
barbituric acid	low	1	0
4-hydroxypropiophenone	low	1	0
valine	low	2	0
threonine	low	2	0
arginine	low	2	0
tetramethylammonium	low	1	0
triamcinolone acetonide	low	1	0
bisphenol a	medium	1	1
methylprednisolone	low	1	0
5-methylsalicylic acid	low	1	0
5-nitrosalicylic acid	low	1	0
iodohippuric acid	low	1	0
quinazolines	low	1	0
nitroblue tetrazolium	low	1	0
calcium gluconate	low	1	0
diiodotyrosine	low	9	0
gamma-resorcylic acid	low	1	0
betamethasone	low	1	0
malondialdehyde	low	3	0
lithium carbonate	low	6	0
2-hydroxyphenylacetic acid	low	1	0
acetylcysteine	low	1	0
d-alpha tocopherol	low	1	0
selenomethionine	low	2	0
sulfur hexafluoride	low	1	0
fluorescein-5-isothiocyanate	low	1	0
dithiothreitol	low	1	0
metanephrine	low	2	0
2-aminobenzyl alcohol	low	1	0
mercury	low	1	0
molybdenum	low	1	0
niobium	low	1	0
platinum	medium	1	1
silver	low	1	0
technetium	low	47	0
perchloric acid	low	2	0
fluorine	low	1	0
thallium chloride	low	2	0
galactose	low	1	0
sodium selenite	low	1	0
trolamine salicylate	low	2	0
tetradecanoylphorbol acetate	low	1	0
iodine	medium	50	1
carbimazole	low	25	0
bromocriptine	low	1	0
phenyl acetate	low	1	0
cetylpyridinium chloride anhydrous	low	1	0
fludrocortisone	low	1	0
transferrin	medium	2	2
calcium oxalate	low	1	0
dobutamine	low	1	0
ribavirin	low	1	0
propiconazole	low	1	0
colforsin	low	2	0
fomesafen	low	1	0
clopidogrel	low	1	0
3-iodobenzylguanidine	low	1	0
colestipol	medium	1	1
triazoles	medium	1	1
fluorodeoxyglucose f18	low	7	0
4-aminobenzyl alcohol	low	1	0
rosiglitazone	low	1	0
fibrinogen	low	2	0
homocysteine	low	2	0
cobalt	low	3	0
pyridinoline	low	1	0
deoxypyridinoline	low	1	0
deoxyglucose	low	1	0
n,n-dimethylarginine	low	1	0
methotrexate	low	3	0
thyroxine sulfate	medium	1	1
omega-n-methylarginine	low	1	0
cinacalcet	low	1	0
symmetric dimethylarginine	low	1	0
erlotinib hydrochloride	low	1	0
sorafenib	low	1	0
alanyl-glutamyl-aspartyl-glycine	low	1	0
cortisone	low	1	0
povidone-iodine	low	2	0
glycogen	low	1	0
n-acetylneuraminic acid	low	1	0
glucosamine	low	1	0
monoiodotyrosine	low	5	0
inositol 3-phosphate	low	1	0
cocaine	low	1	0
potassium perchlorate	low	1	0
sodium perchlorate	low	2	0
bromochloroacetic acid	low	7	0
isomethyleugenol	low	1	0
polidocanol	low	1	0
propylthiouracil	medium	21	2
phenylthiourea	low	3	0
thiouracil	low	2	0
methimazole	medium	55	14
nadp	low	4	0
lithium	medium	7	1
17-ketosteroids	low	1	0
methanethiosulfonate	low	1	0
dinoprostone	low	1	0
calcitriol	medium	5	1
alprostadil	low	1	0
cholecalciferol	medium	2	2
sirolimus	medium	2	1
casein kinase ii	low	1	0
lead	low	2	0
rubidium	low	1	0
bismuth	low	1	0
thallium	low	6	0
indium	low	3	0
gallium	low	2	0
sulfur	low	1	0
cysteine	medium	1	1
thyronines	low	1	0
phosphorus	medium	6	1
4,4'-diisothiocyanostilbene-2,2'-disulfonic acid	low	1	0
selenium	low	7	0
pregnanediol	low	1	0
lactacystin	low	1	0
pentagastrin	low	5	0
mocetinostat	low	2	0
atrial natriuretic factor	low	1	0
gastrins	low	1	0
neuropeptide y	low	1	0
oligonucleotides	low	1	0
endothelin-1	low	2	0
technetium tc 99m sestamibi	medium	24	2
letter	low	1	0
sodium pertechnetate tc 99m	medium	33	1
sodium ethylxanthate	low	1	0
quetiapine fumarate	low	1	0
cardiovascular agents	low	1	0
triiodothyronine, reverse	medium	2	1
thymosin	low	1	0
interleukin-8	low	2	0
heme	low	1	0
ascorbic acid	low	3	0
tetracycline	low	1	0
salicylates	low	1	0
epidermal growth factor	low	3	0
transforming growth factor beta	low	4	0
cyclin d1	low	6	0
caseins	low	2	0
lewis x antigen	low	1	0
hyaluronoglucosaminidase	low	1	0
vitamin b 12	low	1	0
gallium ga 68 dotatate	low	3	0
technetium tc 99m medronate	low	1	0
technetium tc-99m tetrofosmin	low	3	0
thromboplastin	low	1	0
muramidase	low	1	0
lutetium lu 177 dotatate	low	1	0
exudates	low	3	0
cyclic gmp	low	1	0
guanosine triphosphate	low	1	0
guanosine 5'-o-(3-thiotriphosphate)	low	1	0
neopterin	low	1	0
dacarbazine	low	1	0
olanzapine	low	1	0
guanylyl imidodiphosphate	low	1	0
capromab pendetide	low	1	0
cholestyramine resin	low	1	0
eye	low	1	0
technetium tc 99m bicisate	medium	1	1
metallothionein	low	2	0
phosphorus radioisotopes	low	2	0

Protein Targets (1,774)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Complement Factor D	0	1	0	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	2	0	2
Aldo-keto reductase family 1 member B1	0	3	0	3
phosphopantetheinyl transferase	20	0	0	20
Microtubule-associated protein tau	15	0	0	15
cytochrome P450 2D6	18	0	0	18
euchromatic histone-lysine N-methyltransferase 2	45	0	0	45
muscleblind-like protein 1 isoform 1	5	0	0	5
Bile salt export pump	0	46	0	46
Histone deacetylase 8	0	4	1	5
Chain A, Neutrophil gelatinase-associated lipocalin	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	7	0	0	7
72 kDa type IV collagenase	0	4	0	4
Matrilysin	0	3	0	3
Prolyl 4-hydroxylase subunit alpha-1	0	5	0	5
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6	0	3	0	3
Alpha-(1,3)-fucosyltransferase 7	0	3	0	3
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1	0	3	0	3
thioredoxin reductase	20	0	0	20
chromobox protein homolog 1	26	0	0	26
DNA polymerase iota isoform a (long)	15	0	0	15
Carbonic anhydrase 12	0	5	0	8
Carbonic anhydrase 1	0	21	0	25
Carbonic anhydrase 2	0	23	1	29
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Aminopeptidase N	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	3	0	5
Carbonic anhydrase 7	0	6	0	9
Carbonic anhydrase 9	0	9	0	12
Carbonic anhydrase 14	0	5	0	8
dopamine D1 receptor	9	0	0	9
GLS protein	18	0	0	18
Thrombopoietin	6	0	0	6
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	9	0	0	9
cytochrome P450 2D6 isoform 1	6	0	0	6
cytochrome P450 2C19 precursor	10	0	0	10
ras-related protein Rab-9A	3	0	0	3
histone acetyltransferase KAT2A isoform 1	13	0	0	13
lethal factor (plasmid)	9	0	0	9
POU domain, class 2, transcription factor 1	0	0	0	2
Spike glycoprotein	17	0	2	19
ATP-dependent phosphofructokinase	13	0	0	13
Chain A, HADH2 protein	13	0	0	13
Chain B, HADH2 protein	13	0	0	13
hypoxia-inducible factor 1 alpha subunit	15	0	0	15
SMAD family member 2	8	0	0	8
USP1 protein, partial	26	0	0	26
SMAD family member 3	8	0	0	8
AR protein	56	0	0	56
estrogen receptor 2 (ER beta)	25	0	0	25
nuclear receptor subfamily 1, group I, member 3	33	0	0	33
progesterone receptor	34	0	0	34
glucocorticoid receptor [Homo sapiens]	51	0	0	51
retinoid X nuclear receptor alpha	33	0	0	33
estrogen-related nuclear receptor alpha	50	0	0	50
farnesoid X nuclear receptor	27	0	0	27
estrogen nuclear receptor alpha	74	0	0	74
peroxisome proliferator-activated receptor delta	22	0	0	22
peroxisome proliferator activated receptor gamma	32	0	0	32
vitamin D (1,25- dihydroxyvitamin D3) receptor	25	0	0	25
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	29	0	0	29
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	12	0	0	12
v-jun sarcoma virus 17 oncogene homolog (avian)	22	0	0	22
cytochrome P450 2C9 precursor	4	0	0	4
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	10	0	0	10
vitamin D3 receptor isoform VDRA	16	0	0	16
thyroid hormone receptor beta isoform 2	42	0	0	42
heat shock protein beta-1	15	0	0	15
DNA polymerase beta	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	43	0	0	43
geminin	47	0	0	47
survival motor neuron protein isoform d	17	0	0	17
lamin isoform A-delta10	32	0	0	32
Cellular tumor antigen p53	38	0	0	38
Androgen receptor	0	6	0	6
Thyroid hormone receptor alpha	0	4	3	7
Thyroid hormone receptor beta	0	4	3	7
Proliferating cell nuclear antigen	0	3	0	3
Thyroid hormone receptor beta	0	3	0	3
Retinoic acid receptor RXR-alpha	0	0	5	5
Peroxisome proliferator-activated receptor gamma	0	2	8	11
Histamine H2 receptor	7	0	1	8
Sodium/bile acid cotransporter	0	3	0	3
Solute carrier organic anion transporter family member 1C1	0	2	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	17	0	0	17
thioredoxin glutathione reductase	6	0	0	6
nonstructural protein 1	5	0	0	5
G	21	0	0	21
IDH1	11	0	0	11
peripheral myelin protein 22	20	0	0	20
Rap guanine nucleotide exchange factor 3	7	0	0	7
Interferon beta	27	0	0	27
HLA class I histocompatibility antigen, B alpha chain	21	0	0	21
Testosterone 17-beta-dehydrogenase 3	0	1	0	1
Succinate-semialdehyde dehydrogenase, mitochondrial	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	2	0	2
Inositol hexakisphosphate kinase 1	21	0	0	21
cytochrome P450 2C9, partial	21	0	0	21
Casein kinase II subunit alpha	0	3	3	7
Sigma intracellular receptor 2	0	0	0	1
Free fatty acid receptor 3	0	0	1	1
Free fatty acid receptor 2	0	1	1	2
Tyrosine-protein kinase Lck	0	2	5	7
Tyrosine-protein kinase Fyn	0	3	5	8
Fibrinogen C domain-containing protein 1	0	1	0	1
Chain A, 2-oxoglutarate Oxygenase	10	0	0	10
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
acetylcholinesterase	13	0	0	13
15-lipoxygenase, partial	7	0	0	7
pregnane X receptor	10	0	0	10
RAR-related orphan receptor gamma	36	0	0	36
NFKB1 protein, partial	7	0	0	7
regulator of G-protein signaling 4	9	0	0	9
retinoic acid nuclear receptor alpha variant 1	43	0	0	43
arylsulfatase A	9	0	0	9
Bloom syndrome protein isoform 1	11	0	0	11
D(1A) dopamine receptor	7	0	0	7
thyroid hormone receptor beta isoform a	15	0	0	15
flap endonuclease 1	11	0	0	11
muscarinic acetylcholine receptor M1	13	0	0	13
Histone deacetylase 3	0	5	0	5
Solute carrier family 22 member 6	0	3	0	3
Histone deacetylase 4	0	4	0	4
Guanine nucleotide-binding protein G	4	0	0	4
Histone deacetylase 1	0	5	0	5
Histone deacetylase 7	0	4	0	4
Histone deacetylase 2	0	5	0	5
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	4	0	4
Ataxin-2	23	0	0	23
Histone deacetylase 6	0	4	0	4
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	4	0	4
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	13	0	0	13
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	2	1	6
Proton-coupled amino acid transporter 1	0	3	0	4
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	12	0	0	12
Sex hormone-binding globulin	0	0	4	4
Corticosteroid-binding globulin	0	5	0	5
Mineralocorticoid receptor	0	3	3	6
Androgen receptor	0	11	0	11
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	2
TDP1 protein	41	0	0	41
ATP-binding cassette sub-family C member 3	0	28	0	28
Multidrug resistance-associated protein 4	0	28	0	32
Thromboxane-A synthase	0	2	0	2
Prostaglandin E2 receptor EP3 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	2	0	2
Prostacyclin receptor	0	3	2	5
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Solute carrier organic anion transporter family member 2A1	0	0	0	2
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Canalicular multispecific organic anion transporter 1	0	26	0	26
Solute carrier organic anion transporter family member 2A1	0	1	0	3
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier organic anion transporter family member 3A1	0	0	0	1
ATAD5 protein, partial	12	0	0	12
Fumarate hydratase	7	0	0	7
PPM1D protein	9	0	0	9
caspase 7, apoptosis-related cysteine protease	7	0	0	7
aldehyde dehydrogenase 1 family, member A1	25	0	0	25
thyroid stimulating hormone receptor	18	0	0	18
EWS/FLI fusion protein	21	0	0	21
pregnane X nuclear receptor	39	0	0	39
polyprotein	7	0	0	7
caspase-3	7	0	0	7
thyroid stimulating hormone receptor	12	0	0	12
Histone H2A.x	16	0	0	16
cellular tumor antigen p53 isoform a	8	0	0	8
potassium voltage-gated channel subfamily H member 2 isoform d	8	0	0	8
huntingtin isoform 2	5	0	0	5
mitogen-activated protein kinase 1	8	0	0	8
serine/threonine-protein kinase mTOR isoform 1	5	0	0	5
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5	0	0	5
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
nuclear receptor ROR-gamma isoform 1	19	0	0	19
cytochrome P450 3A4 isoform 1	13	0	0	13
Gamma-aminobutyric acid receptor subunit pi	13	5	5	23
Polyunsaturated fatty acid lipoxygenase ALOX15B	4	0	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Solute carrier organic anion transporter family member 1A4	0	2	0	4
Voltage-dependent L-type calcium channel subunit alpha-1F	0	5	0	5
5-hydroxytryptamine receptor 4	0	12	0	12
Lysine-specific demethylase PHF2	0	1	0	1
Thyroid hormone receptor alpha	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	4	2	6
Integrin beta-3	6	1	0	7
ATP-dependent translocase ABCB1	0	2	0	2
Aldo-keto reductase family 1 member B1	0	11	0	11
Muscarinic acetylcholine receptor M2	0	9	1	10
Muscarinic acetylcholine receptor M4	0	7	0	7
ATP-dependent translocase ABCB1	0	8	1	11
Integrin alpha-IIb	6	1	0	7
Beta-1 adrenergic receptor	0	10	2	12
Muscarinic acetylcholine receptor M5	0	5	0	5
Alpha-2A adrenergic receptor	0	10	2	13
Adenosine receptor A3	0	4	1	5
Cytochrome P450 2C8	0	5	0	5
Muscarinic acetylcholine receptor M1	0	7	2	9
Beta-3 adrenergic receptor	0	4	2	6
D(2) dopamine receptor	0	7	2	9
Gamma-aminobutyric acid receptor subunit beta-1	13	5	5	23
Alpha-1B adrenergic receptor	0	5	1	6
Lethal factor	0	1	0	1
Alpha-2B adrenergic receptor	0	11	2	14
Gamma-aminobutyric acid receptor subunit delta	13	5	5	23
Gamma-aminobutyric acid receptor subunit gamma-2	13	5	5	23
Gamma-aminobutyric acid receptor subunit alpha-5	13	5	5	23
Gamma-aminobutyric acid receptor subunit alpha-3	13	5	5	23
Muscarinic acetylcholine receptor M3	0	6	1	7
ATP-dependent translocase ABCB1	0	2	0	2
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	7	1	8
D(4) dopamine receptor	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	13	5	5	23
Gamma-aminobutyric acid receptor subunit alpha-2	13	5	5	23
Carnitine O-palmitoyltransferase 2, mitochondrial	0	2	0	2
Sodium-dependent noradrenaline transporter	0	13	0	13
Histamine H2 receptor	0	3	2	5
Endothelin-1 receptor	0	4	1	5
5-hydroxytryptamine receptor 2A	0	9	2	11
5-hydroxytryptamine receptor 2C	0	13	2	15
Gamma-aminobutyric acid receptor subunit alpha-4	13	5	5	23
Gamma-aminobutyric acid receptor subunit gamma-3	13	5	5	23
Lysine-specific demethylase 5A	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	13	5	5	23
B2 bradykinin receptor	0	2	0	2
Sodium-dependent serotonin transporter	0	16	0	16
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Mu-type opioid receptor	0	3	1	4
D(3) dopamine receptor	0	8	0	8
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	2	0	3
Squalene synthase	0	1	0	1
Delta-type opioid receptor	0	3	1	4
Kappa-type opioid receptor	0	3	1	4
5-hydroxytryptamine receptor 2B	0	11	1	12
C-C chemokine receptor type 2	0	3	0	3
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	5	1	6
D(1A) dopamine receptor	2	0	0	2
5-hydroxytryptamine receptor 6	0	11	1	12
Carnitine O-palmitoyltransferase 1, liver isoform	0	2	0	2
C-C chemokine receptor type 4	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	13	6	5	24
Gamma-aminobutyric acid receptor subunit beta-3	13	5	5	23
Gamma-aminobutyric acid receptor subunit beta-2	13	5	5	23
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	5	0	5
Sodium-dependent dopamine transporter	0	8	0	8
Potassium voltage-gated channel subfamily H member 2	0	14	0	14
Voltage-dependent L-type calcium channel subunit alpha-1S	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1C	0	8	0	8
Sodium channel protein type 5 subunit alpha	0	4	0	4
Squalene monooxygenase	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	2	0	2
Lysine-specific demethylase 7A	0	1	0	1
GABA theta subunit	13	5	5	23
Carnitine O-palmitoyltransferase 1, muscle isoform	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	11	1	12
Gamma-aminobutyric acid receptor subunit epsilon	13	5	5	23
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	1	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
Sodium channel protein type 11 subunit alpha	0	1	0	1
Histone lysine demethylase PHF8	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	31	0	0	31
Aromatase	0	3	0	3
Cytochrome P450 2C9	0	8	1	10
Amine oxidase [flavin-containing] A	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	1	0	2
GLI family zinc finger 3	39	0	0	39
Nuclear receptor ROR-gamma	11	0	0	11
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
alpha-galactosidase	3	0	0	3
Cytochrome P450 3A4	0	11	2	15
Nitric oxide synthase, endothelial	0	1	0	3
Nitric oxide synthase, brain	0	4	0	5
Nitric oxide synthase, brain	0	3	0	4
Nitric oxide synthase, inducible	0	1	0	2
Nitric oxide synthase, inducible	0	2	1	5
Cationic amino acid transporter 3	0	1	0	1
Chain A, Hyaluronidase, phage associated	0	1	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
Polyphenol oxidase 2	0	9	0	12
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	2	0	2
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	3	0	3
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	9	0	0	9
hypothetical protein, conserved	3	0	0	3
glucocerebrosidase	2	0	0	2
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
DNA polymerase kappa isoform 1	9	0	0	9
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Epidermal growth factor receptor	0	6	4	10
Fatty acid-binding protein, liver	0	4	0	4
Myeloperoxidase	0	3	0	3
Prostaglandin G/H synthase 1	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	4	0	4
Adenosine receptor A1	0	2	0	5
Adenosine receptor A2a	0	1	0	4
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	5	2	7
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	5	0	5
Solute carrier family 22 member 6	0	5	0	5
Sigma non-opioid intracellular receptor 1	0	0	1	1
Beta-1 adrenergic receptor	0	1	2	4
Beta-2 adrenergic receptor	0	6	2	8
5-hydroxytryptamine receptor 1A	0	10	3	14
Alpha-1D adrenergic receptor	0	9	1	11
Alpha-1A adrenergic receptor	0	3	2	6
Alpha-1B adrenergic receptor	0	2	1	4
TAR DNA-binding protein 43	7	1	0	8
Beta-2 adrenergic receptor	0	1	2	4
Atrial natriuretic peptide receptor 1	0	0	1	1
Atrial natriuretic peptide receptor 1	0	0	1	1
aryl hydrocarbon receptor	20	0	0	20
nuclear receptor subfamily 1, group I, member 2	8	0	0	8
galanin receptor type 3	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	19	0	0	19
Glucocorticoid receptor	0	14	2	21
Glycine receptor subunit alpha-1	0	14	0	14
Glutamate receptor 2	19	0	0	19
Glycine receptor subunit beta	0	14	0	14
Glycine receptor subunit alpha-2	0	14	0	14
Glycine receptor subunit alpha-3	0	14	0	14
ORF73	0	0	1	1
Chain A, Estrogen-related receptor gamma	0	0	1	1
Chain A, Estrogen-related receptor gamma	0	0	1	1
Chain A, Estrogen-related receptor gamma	0	0	1	1
Chain A, Estrogen-related receptor gamma	0	0	1	1
Luciferase	18	0	0	18
glp-1 receptor, partial	9	0	0	9
GALC protein	5	0	0	5
importin subunit beta-1 isoform 1	4	0	0	4
snurportin-1	4	0	0	4
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
GTPase KRas	0	0	1	1
Estrogen receptor	0	6	1	7
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	6	0	6
Estrogen-related receptor gamma	0	1	0	1
GTP-binding protein Rheb	0	0	1	1
Estrogen receptor beta	0	3	1	4
Carbonic anhydrase 4	0	10	0	13
Carbonic anhydrase	0	6	0	9
Carbonic anhydrase 15	0	6	0	9
Genome polyprotein	0	2	1	3
5-hydroxytryptamine receptor 1A	0	5	1	6
Alpha-2C adrenergic receptor	0	8	2	11
D	0	3	0	3
D(3) dopamine receptor	0	3	0	3
Alpha-2B adrenergic receptor	0	3	1	4
Alpha-2C adrenergic receptor	0	3	1	4
Alpha-2A adrenergic receptor	0	3	1	4
D(1B) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1B	0	5	0	5
D(4) dopamine receptor	0	2	0	2
Alpha-synuclein	3	3	0	6
D(2) dopamine receptor	0	4	1	5
ATPase family AAA domain-containing protein 5	17	0	0	17
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
Nuclear hormone receptor family member daf-12	0	0	1	1
oxysterols receptor LXR-beta isoform 1	0	0	1	1
Thymidine kinase, cytosolic	0	3	0	5
Thymidine phosphorylase	0	0	0	2
Thymidylate kinase	0	2	0	2
Thymidine kinase	0	0	0	2
Thymidylate kinase	0	2	0	2
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Chain A, Beta-lactamase	6	0	0	6
Chain A, Ferritin light chain	10	0	0	10
Vitamin D3 receptor	0	0	1	1
Vitamin D-binding protein	0	0	1	1
Cytochrome P450 1A2	0	2	0	3
Cytochrome P450 2D6	0	6	0	6
Vitamin D3 receptor	0	2	3	8
Vitamin D3 receptor	0	1	1	3
Cytochrome P450 2C19	0	8	0	8
Kappa-type opioid receptor	0	0	1	1
Vitamin D3 receptor	0	0	2	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	2	0	2
Vitamin D3 receptor A	0	0	2	2
Lactoperoxidase	0	2	0	2
Chain A, Protein kinase CK2, alpha Subunit	0	1	0	1
Chain A, PROTEIN KINASE CK2, alpha SUBUNIT	0	1	0	1
Chain A, Protein Kinase Ck2, Alpha Subunit	0	1	0	1
endonuclease IV	5	0	0	5
Parkin	3	0	0	3
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
peripheral myelin protein 22 isoform 1	5	0	0	5
Serine/threonine-protein kinase Sgk1	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	5	6
Casein kinase II subunit alpha	0	1	0	1
Casein kinase II subunit alpha'	0	3	4	7
Cyclin-A2	0	2	0	2
Cyclin-dependent kinase 2	0	3	5	8
Casein kinase II subunit beta	0	3	0	3
Casein kinase II subunit beta	0	1	0	1
Cyclin-A1	0	2	0	2
Dual specificity mitogen-activated protein kinase kinase 1	0	2	4	6
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	4	5
Ribosomal protein S6 kinase alpha-1	0	1	4	5
Casein kinase II subunit alpha 3	0	3	0	3
Single-stranded DNA cytosine deaminase	2	0	0	2
67.9K protein	9	0	0	9
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	6	0	0	6
activating transcription factor 6	14	0	0	14
thyrotropin-releasing hormone receptor	3	0	0	3
Caspase-2	0	0	1	1
Inositol monophosphatase 1	5	0	0	5
Chain A, Cruzipain	4	0	0	4
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	2	0	2
Glycine receptor subunit alpha-1	0	0	2	2
10 kDa heat shock protein, mitochondrial	0	2	0	2
Thiosulfate sulfurtransferase	0	2	0	2
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	2	0	5
Solute carrier family 22 member 1	0	6	0	10
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Acetylcholinesterase	0	3	0	3
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Solute carrier family 22 member 1	0	3	0	6
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	3	0	5
Smad3	4	0	0	4
PINK1	1	0	0	1
Extracellular calcium-sensing receptor	0	0	1	1
Angiotensin-converting enzyme 2	0	1	2	3
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
Cytochrome P450 2B6	0	3	0	3
Liver carboxylesterase 1	0	1	0	3
Rap guanine nucleotide exchange factor 4	2	0	0	2
P2Y purinoceptor 12	0	3	0	3
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	5	0	5
Gamma-aminobutyric acid receptor subunit delta	0	5	0	5
Amyloid-beta precursor protein	1	1	0	2
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	1	2
5-hydroxytryptamine receptor 2C	0	5	0	6
Tryptophan 5-hydroxylase 1	0	1	0	1
5-hydroxytryptamine receptor 2A	0	7	0	7
Gamma-aminobutyric acid receptor subunit alpha-1	0	6	3	9
Gamma-aminobutyric acid receptor subunit beta-1	0	5	1	6
Gamma-aminobutyric acid receptor subunit gamma-2	0	6	2	8
Sodium-dependent dopamine transporter	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	6	2	8
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	5	0	5
5-hydroxytryptamine receptor 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	5	3	8
Sodium-dependent serotonin transporter	0	3	0	4
5-hydroxytryptamine receptor 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	5	2	7
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	5	2	7
Gamma-aminobutyric acid receptor subunit beta-2	0	5	2	7
Gamma-aminobutyric acid receptor subunit alpha-4	0	5	1	6
Gamma-aminobutyric acid receptor subunit epsilon	0	5	0	5
Glutamate receptor ionotropic, NMDA 2A	0	1	0	4
Glutamate receptor ionotropic, NMDA 2B	0	1	0	4
Glutamate receptor ionotropic, NMDA 2C	0	1	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	5	1	6
Sodium-dependent dopamine transporter	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	4
5-hydroxytryptamine receptor 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	5	0	5
Glutamate receptor ionotropic, NMDA 3B	0	1	0	4
Gamma-aminobutyric acid receptor subunit gamma-3	0	5	0	5
5-hydroxytryptamine receptor 3B	0	1	0	1
Leukotriene B4 receptor 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	4
Gamma-aminobutyric acid receptor subunit theta	0	5	0	5
Transporter	0	3	0	3
nuclear receptor subfamily 0 group B member 1	0	1	0	1
steroidogenic factor 1	0	1	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
relaxin receptor 1 isoform 1	1	0	0	1
relaxin receptor 2 isoform 1	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	4	4
Solute carrier family 2, facilitated glucose transporter member 1	0	0	1	1
Adenylate cyclase type 2	0	0	1	1
Adenylate cyclase type 8	0	0	1	1
Adenylate cyclase type 1	0	1	1	2
Relaxin receptor 1	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
atrial natriuretic peptide receptor 1 precursor	4	0	0	4
M-phase phosphoprotein 8	4	0	0	4
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
Multidrug and toxin extrusion protein 1	0	3	0	3
Phosphodiesterase	0	1	0	1
Multidrug resistance-associated protein 5	0	0	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Matrix metalloproteinase-9	0	1	0	1
Isocitrate lyase	0	2	0	2
Beta-glucuronidase	0	1	0	1
Beta-glucuronidase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	5	0	5
G-protein coupled bile acid receptor 1	0	0	1	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
Hsf1 protein	0	0	1	1
Gamma-aminobutyric acid	0	2	0	2
Alpha-1-acid glycoprotein 1	0	0	0	1
Albumin	0	2	2	5
Albumin	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	3
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	3
Translocator protein	0	1	1	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	2	0	2
Gastrin/cholecystokinin type B receptor	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
RGS12	1	0	0	1
WRN	2	0	0	2
transcriptional regulator ERG isoform 3	3	0	0	3
eyes absent homolog 2 isoform a	1	0	0	1
DNA polymerase eta isoform 1	4	0	0	4
C-terminal-binding protein 1	1	0	0	1
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	3
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Solute carrier family 22 member 6	0	1	0	3
Solute carrier family 22 member 7	0	0	0	2
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 8	0	1	0	4
Solute carrier family 22 member 7	0	0	0	1
Solute carrier family 22 member 11	0	0	0	3
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 7	0	0	0	2
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Carbonic anhydrase 3	0	2	0	5
Carbonic anhydrase 6	0	5	0	8
Carbonic anhydrase 5A, mitochondrial	0	4	0	7
Carbonic anhydrase 13	0	1	0	3
Carbonic anhydrase 5B, mitochondrial	0	2	0	5
Serine/threonine-protein kinase B-raf	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	1	0	3
Lanosterol 14-alpha demethylase	0	0	1	1
Olfactory receptor 51E2	0	0	2	2
UDP-glucuronosyltransferase 1A10	0	0	0	1
acid sphingomyelinase	2	0	0	2
apical membrane antigen 1, AMA1	5	0	0	5
Type IV secretion-like conjugative transfer relaxase protein TraI	0	1	0	1
Bone morphogenetic protein receptor type-1B	0	0	4	4
Cell division cycle 7-related protein kinase	0	0	3	3
Serine/threonine-protein kinase PLK4	0	1	4	5
ATP-dependent RNA helicase DDX3X	0	0	4	4
Pyridoxal kinase	0	0	4	4
Citron Rho-interacting kinase	0	0	4	4
Serine/threonine-protein kinase Chk1	0	0	4	4
Aurora kinase A	0	1	4	5
Cyclin-G-associated kinase	0	0	4	4
Ephrin type-B receptor 6	0	0	4	4
Peroxisomal acyl-coenzyme A oxidase 3	0	0	4	4
Receptor-interacting serine/threonine-protein kinase 2	0	1	4	5
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	4	4
Dynamin-like 120 kDa protein, mitochondrial	0	0	4	4
Eukaryotic translation initiation factor 5B	0	0	2	2
Rho-associated protein kinase 2	0	0	4	4
Serine/threonine-protein kinase ULK1	0	0	4	4
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	4	4
Ribosomal protein S6 kinase alpha-5	0	0	4	4
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	4	4
Ribosomal protein S6 kinase alpha-4	0	0	4	4
Serine/threonine-protein kinase 16	0	0	4	4
Serine/threonine-protein kinase 10	0	0	4	4
Serine/threonine-protein kinase D3	0	0	5	5
Structural maintenance of chromosomes protein 2	0	0	4	4
Mitogen-activated protein kinase kinase kinase 6	0	0	4	4
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	4	4
Serine/threonine-protein kinase LATS1	0	0	4	4
Serine/threonine-protein kinase PAK 4	0	0	4	4
Tyrosine-protein kinase ABL1	0	3	5	8
High affinity nerve growth factor receptor	0	0	4	4
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	2	2
ADP/ATP translocase 2	0	0	4	4
Protein kinase C beta type	0	1	5	6
Insulin receptor	0	1	4	5
Cyclin-dependent kinase 1	0	1	4	5
Glycogen phosphorylase, liver form	0	0	4	4
Tyrosine-protein kinase Fes/Fps	0	0	4	4
Adenine phosphoribosyltransferase	0	0	3	3
Tyrosine-protein kinase Yes	0	0	4	4
Tyrosine-protein kinase Lyn	0	0	4	4
Proto-oncogene tyrosine-protein kinase receptor Ret	0	2	4	6
Insulin-like growth factor 1 receptor	0	0	4	4
Signal recognition particle receptor subunit alpha	0	0	3	3
Cytochrome c1, heme protein, mitochondrial	0	0	4	4
Hepatocyte growth factor receptor	0	1	4	5
Tyrosine-protein kinase HCK	0	1	4	5
Platelet-derived growth factor receptor beta	0	2	4	6
Tyrosine-protein kinase Fgr	0	0	4	4
Serine/threonine-protein kinase A-Raf	0	1	4	5
Glycogen phosphorylase, brain form	0	0	4	4
Breakpoint cluster region protein	0	1	4	5
Serine/threonine-protein kinase pim-1	0	0	4	4
Fibroblast growth factor receptor 1	0	2	4	6
DNA topoisomerase 2-alpha	0	1	4	6
Cyclin-dependent kinase 4	0	1	4	5
ADP/ATP translocase 3	0	0	4	4
Inosine-5'-monophosphate dehydrogenase 2	0	0	4	4
Proto-oncogene tyrosine-protein kinase Src	0	2	4	6
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	4	4
Serine/threonine-protein kinase B-raf	0	3	5	8
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	4	4
Tyrosine-protein kinase Fer	0	0	4	4
Protein kinase C alpha type	0	1	5	6
cAMP-dependent protein kinase catalytic subunit alpha	0	0	4	4
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	4	4
Ras-related protein Rab-6A	0	0	3	3
Ephrin type-A receptor 1	0	0	4	4
Multifunctional protein ADE2	0	0	4	4
cAMP-dependent protein kinase catalytic subunit gamma	0	0	3	3
cAMP-dependent protein kinase catalytic subunit beta	0	0	4	4
Ferrochelatase, mitochondrial	0	0	4	4
Ribosomal protein S6 kinase beta-1	0	0	4	4
Tyrosine-protein kinase JAK1	0	0	4	4
Beta-adrenergic receptor kinase 1	0	0	4	4
Probable ATP-dependent RNA helicase DDX6	0	0	4	4
Mitogen-activated protein kinase 3	0	1	4	5
MAP/microtubule affinity-regulating kinase 3	0	0	4	4
Deoxycytidine kinase	0	0	4	4
Mitogen-activated protein kinase 1	0	1	4	5
Ephrin type-A receptor 2	0	0	4	4
Ephrin type-B receptor 2	0	0	4	4
Non-receptor tyrosine-protein kinase TYK2	0	0	4	4
UMP-CMP kinase	0	0	2	2
Phosphatidylethanolamine-binding protein 1	0	0	3	3
Wee1-like protein kinase	0	0	4	4
Heme oxygenase 2	0	0	4	4
S-adenosylmethionine synthase isoform type-2	0	0	4	4
DnaJ homolog subfamily A member 1	0	0	4	4
RAC-alpha serine/threonine-protein kinase	0	1	4	5
RAC-beta serine/threonine-protein kinase	0	0	4	4
Dual specificity protein kinase TTK	0	0	4	4
DNA replication licensing factor MCM4	0	0	4	4
Myosin-10	0	0	3	3
Dual specificity mitogen-activated protein kinase kinase 2	0	0	4	4
Receptor-type tyrosine-protein kinase FLT3	0	2	4	6
Bone morphogenetic protein receptor type-1A	0	0	4	4
Activin receptor type-1B	0	0	4	4
TGF-beta receptor type-1	0	0	4	4
TGF-beta receptor type-2	0	0	4	4
Electron transfer flavoprotein subunit beta	0	0	3	3
Tyrosine-protein kinase CSK	0	0	4	4
Glycine--tRNA ligase	0	0	4	4
Protein kinase C iota type	0	0	5	5
Exosome RNA helicase MTR4	0	0	4	4
Serine/threonine-protein kinase mTOR	0	3	4	7
Tyrosine-protein kinase Tec	0	0	4	4
Tyrosine-protein kinase ABL2	0	0	4	4
Tyrosine-protein kinase FRK	0	0	4	4
G protein-coupled receptor kinase 6	0	0	4	4
Tyrosine-protein kinase SYK	0	0	4	4
26S proteasome regulatory subunit 6B	0	0	4	4
Mitogen-activated protein kinase 8	0	0	4	4
Mitogen-activated protein kinase 9	0	0	4	4
Dual specificity mitogen-activated protein kinase kinase 3	0	0	4	4
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	4	4
Casein kinase I isoform alpha	0	1	4	5
Casein kinase I isoform delta	0	0	4	4
MAP kinase-activated protein kinase 2	0	0	4	4
Elongation factor Tu, mitochondrial	0	0	4	4
Choline-phosphate cytidylyltransferase A	0	0	2	2
Cysteine--tRNA ligase, cytoplasmic	0	0	4	4
Casein kinase I isoform epsilon	0	0	4	4
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	4	4
Dual specificity protein kinase CLK1	0	0	4	4
Dual specificity protein kinase CLK2	0	0	4	4
Dual specificity protein kinase CLK3	0	0	4	4
Glycogen synthase kinase-3 alpha	0	0	4	4
Glycogen synthase kinase-3 beta	0	1	4	5
Cyclin-dependent kinase 7	0	0	4	4
Cyclin-dependent kinase 9	0	0	4	4
Ras-related protein Rab-27A	0	0	4	4
Interleukin-1 receptor-associated kinase 1	0	0	4	4
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Ribosomal protein S6 kinase alpha-3	0	0	4	4
Serine/threonine-protein kinase Nek2	0	0	4	4
Serine/threonine-protein kinase Nek3	0	0	4	4
Dual specificity mitogen-activated protein kinase kinase 6	0	0	4	4
Serine/threonine-protein kinase PLK1	0	1	4	5
LIM domain kinase 1	0	0	4	4
LIM domain kinase 2	0	0	4	4
Mitogen-activated protein kinase 10	0	0	4	4
Tyrosine--tRNA ligase, cytoplasmic	0	0	4	4
5'-AMP-activated protein kinase subunit gamma-1	0	0	4	5
Ephrin type-B receptor 3	0	0	4	4
Ephrin type-A receptor 5	0	0	4	4
Ephrin type-B receptor 4	0	1	4	5
Ephrin type-A receptor 4	0	0	4	4
Adenylate kinase 2, mitochondrial	0	0	4	4
Adenosine kinase	0	0	4	4
Ras-related protein Rab-10	0	0	4	4
Actin-related protein 3	0	0	4	4
Actin-related protein 2	0	0	4	4
GTP-binding nuclear protein Ran	0	0	4	4
Casein kinase I isoform gamma-2	0	0	4	4
Cyclin-dependent kinase 3	0	0	3	3
Cyclin-dependent kinase 6	0	1	4	5
Cyclin-dependent-like kinase 5	0	0	4	4
Cyclin-dependent kinase 16	0	0	4	4
Cyclin-dependent kinase 17	0	0	4	4
ATP-dependent 6-phosphofructokinase, platelet type	0	0	4	4
DNA topoisomerase 2-beta	0	0	4	5
Protein kinase C theta type	0	0	5	5
Activin receptor type-1	0	0	4	4
Macrophage-stimulating protein receptor	0	0	4	4
Focal adhesion kinase 1	0	0	4	4
Protein kinase C delta type	0	1	5	6
Tyrosine-protein kinase BTK	0	1	4	5
Activated CDC42 kinase 1	0	0	4	4
Epithelial discoidin domain-containing receptor 1	0	0	4	4
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	4	4
Serine/threonine-protein kinase 4	0	0	4	4
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	4	5
Dual specificity mitogen-activated protein kinase kinase 5	0	0	4	4
Mitogen-activated protein kinase 7	0	0	4	4
Serine/threonine-protein kinase PAK 2	0	0	4	4
Serine/threonine-protein kinase 3	0	0	4	4
Mitogen-activated protein kinase kinase kinase 1	0	0	4	4
Integrin-linked protein kinase	0	0	4	4
Rho-associated protein kinase 1	0	0	4	4
Non-receptor tyrosine-protein kinase TNK1	0	0	4	4
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	4	4
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	4	4
Activin receptor type-2B	0	0	4	4
Bone morphogenetic protein receptor type-2	0	0	4	4
Protein-tyrosine kinase 6	0	0	4	4
cGMP-dependent protein kinase 1	0	0	4	4
Cyclin-dependent kinase 13	0	0	4	4
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	4	4
Protein-tyrosine kinase 2-beta	0	0	4	4
Maternal embryonic leucine zipper kinase	0	0	4	4
Structural maintenance of chromosomes protein 1A	0	0	4	4
Chromodomain-helicase-DNA-binding protein 4	0	0	4	4
Peroxisomal acyl-coenzyme A oxidase 1	0	0	4	4
Ephrin type-A receptor 7	0	0	3	3
Delta(24)-sterol reductase	0	0	4	4
Dual specificity testis-specific protein kinase 1	0	0	4	4
Myosin light chain kinase, smooth muscle	0	0	4	4
Mitogen-activated protein kinase 11	0	0	4	4
Serine/threonine-protein kinase STK11	0	0	4	4
Serine/threonine-protein kinase N1	0	0	4	4
Serine/threonine-protein kinase N2	0	0	4	4
Mitogen-activated protein kinase 14	0	1	4	5
Calcium/calmodulin-dependent protein kinase type IV	0	0	4	4
Mitogen-activated protein kinase kinase kinase 11	0	0	4	4
Discoidin domain-containing receptor 2	0	2	4	6
AP2-associated protein kinase 1	0	0	4	4
Myosin light chain kinase 3	0	0	4	4
Putative heat shock protein HSP 90-beta 2	0	0	4	4
Serine/threonine-protein kinase MRCK alpha	0	0	4	4
Serine/threonine-protein kinase MRCK gamma	0	0	4	4
Acyl-CoA dehydrogenase family member 10	0	0	4	4
Serine/threonine-protein kinase N3	0	0	4	4
Serine/threonine-protein kinase ULK3	0	0	4	4
Uncharacterized protein FLJ45252	0	0	4	4
Acyl-CoA dehydrogenase family member 11	0	0	4	4
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	3	3
Serine/threonine-protein kinase MARK2	0	0	4	4
ATP-dependent RNA helicase DHX30	0	0	4	4
Serine/threonine-protein kinase TAO1	0	0	4	4
STE20-related kinase adapter protein alpha	0	0	4	4
Myosin-14	0	0	4	4
AarF domain-containing protein kinase 1	0	0	4	4
ATP-dependent RNA helicase DDX42	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	4	4
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	1	1
Regulatory-associated protein of mTOR	0	2	0	2
Atypical kinase COQ8A, mitochondrial	0	0	4	4
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	4	4
Mitogen-activated protein kinase 15	0	0	4	4
Serine/threonine-protein kinase Nek9	0	0	4	4
Serine/threonine-protein kinase Nek7	0	0	3	3
ATP-dependent RNA helicase DDX1	0	0	4	4
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	4	4
Aurora kinase B	0	0	4	4
MAP/microtubule affinity-regulating kinase 4	0	0	4	4
Serine/threonine-protein kinase Nek1	0	0	4	4
PAS domain-containing serine/threonine-protein kinase	0	0	3	3
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	4	4
EKC/KEOPS complex subunit TP53RK	0	0	4	4
Dual specificity testis-specific protein kinase 2	0	0	3	3
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	4	4
Mitogen-activated protein kinase kinase kinase 5	0	0	4	4
Mitogen-activated protein kinase kinase kinase 3	0	0	4	4
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	4	4
Target of rapamycin complex subunit LST8	0	2	0	2
Nucleolar GTP-binding protein 1	0	0	4	4
Serine/threonine-protein kinase D2	0	0	4	4
NUAK family SNF1-like kinase 2	0	0	3	3
RNA cytidine acetyltransferase	0	0	4	4
Serine/threonine-protein kinase SIK2	0	0	4	4
STE20-like serine/threonine-protein kinase	0	0	4	4
Serine/threonine-protein kinase TAO3	0	0	4	4
dCTP pyrophosphatase 1	0	0	4	4
Dual specificity protein kinase CLK4	0	0	4	4
Casein kinase I isoform gamma-1	0	0	4	4
Phenylalanine--tRNA ligase beta subunit	0	0	4	4
BMP-2-inducible protein kinase	0	0	4	4
Obg-like ATPase 1	0	0	4	4
Midasin	0	0	4	4
Interleukin-1 receptor-associated kinase 4	0	0	4	4
Mitogen-activated protein kinase kinase kinase 20	0	0	4	4
Cyclin-dependent kinase 12	0	0	4	4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	3	3
Serine/threonine-protein kinase 26	0	0	4	4
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	4	4
Serine/threonine-protein kinase NLK	0	0	4	4
5'-AMP-activated protein kinase subunit gamma-2	0	0	4	5
Serine/threonine-protein kinase TBK1	0	0	4	4
Septin-9	0	0	4	4
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
Ribosomal protein S6 kinase alpha-6	0	0	4	4
TRAF2 and NCK-interacting protein kinase	0	0	4	4
Serine/threonine-protein kinase TAO2	0	0	4	4
Long-chain-fatty-acid--CoA ligase 5	0	0	3	3
RAC-gamma serine/threonine-protein kinase	0	0	4	4
Serine/threonine-protein kinase SIK3	0	0	4	4
Mitogen-activated protein kinase kinase kinase 2	0	0	4	4
Thyroid hormone receptor-associated protein 3	0	0	3	3
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	4	4
Receptor-interacting serine/threonine-protein kinase 3	0	1	4	5
Serine/threonine-protein kinase MRCK beta	0	0	4	4
Interleukin-1 receptor-associated kinase 3	0	0	4	4
Casein kinase I isoform gamma-3	0	0	4	4
Mitogen-activated protein kinase kinase kinase 4	0	0	4	4
Chain A, Probable hydrogenase nickel incorporation protein hypB	0	0	1	1
Chain B, Probable hydrogenase nickel incorporation protein hypB	0	0	1	1
Chain A, Uracil Phosphoribosyltransferase	0	0	1	1
Chain B, Uracil Phosphoribosyltransferase	0	0	1	1
Chain C, Uracil Phosphoribosyltransferase	0	0	1	1
2-dehydropantoate 2-reductase	0	0	1	1
Ras-related protein Rab-7a	0	0	1	1
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9	0	2	0	2
Chain A, ras-related C3 botulinum toxin substrate 1 isoform Rac1b	0	0	1	1
Chain A, ras-related C3 botulinum toxin substrate 1 isoform Rac1b	0	0	1	1
Protein-glutamine gamma-glutamyltransferase 2	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Solute carrier family 22 member 3	0	2	0	3
Plasma kallikrein	0	0	0	3
Macrophage migration inhibitory factor	0	3	0	3
Histamine H1 receptor	0	2	3	5
Histamine H1 receptor	0	2	1	3
Metabotropic glutamate receptor 5	0	2	1	3
Histamine H1 receptor	0	4	3	7
Carbonic anhydrase	0	0	0	4
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase-like protein, putative	0	0	0	3
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase	0	0	0	4
Equilibrative nucleoside transporter 4	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 13	0	1	0	3
Histamine H4 receptor	0	1	2	3
Histamine H3 receptor	0	1	0	1
Carboxylic ester hydrolase	0	0	0	1
Histamine H3 receptor	0	1	2	3
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	3	0	5
Spike glycoprotein	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Transmembrane protease serine 2	0	0	2	2
Procathepsin L	0	0	2	2
Replicase polyprotein 1a	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Replicase polyprotein 1ab	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
Sigma intracellular receptor 2	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
DNA repair and recombination protein RadA	0	0	1	1
Heat shock protein HSP 90-alpha	0	0	1	1
G2/mitotic-specific cyclin-B1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	0	1	1
histone deacetylase 9 isoform 3	1	0	0	1
Peptidylglycine alpha-amidating monooxygenase	0	0	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
N-glycosylase/DNA lyase	0	1	0	1
Bile salt export pump	0	8	0	8
Formamidopyrimidine-DNA glycosylase	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Cytochrome P450 2A6	0	2	0	2
Endonuclease III-like protein 1	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	2
Pantothenate synthetase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	3	0	3
Endonuclease 8-like 1	0	1	0	1
Proteasome subunit beta type-11	0	1	0	1
Proteasome subunit alpha type-7	0	1	0	1
Proteasome subunit beta type-1	0	1	0	1
Proteasome subunit alpha type-1	0	1	0	1
Proteasome subunit alpha type-2	0	1	0	1
Proteasome subunit alpha type-3	0	1	0	1
Proteasome subunit alpha type-4	0	1	0	1
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-9	0	1	0	1
Proteasome subunit alpha type-5	0	1	0	1
Proteasome subunit beta type-4	0	1	0	1
Proteasome subunit beta type-6	0	1	0	1
Proteasome subunit beta type-5	0	1	0	1
Proteasome subunit beta type-10	0	1	0	1
Proteasome subunit beta type-3	0	1	0	1
Proteasome subunit beta type-2	0	1	0	1
Proteasome subunit alpha type-6	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Proteasome subunit alpha-type 8	0	1	0	1
Proteasome subunit beta type-7	0	1	0	1
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	2	0	2
Large neutral amino acids transporter small subunit 1	0	5	0	6
Phospholipase A-2-activating protein	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Phosphoenolpyruvate carboxykinase	0	1	0	1
D-aspartate oxidase	0	1	0	1
L-lactate dehydrogenase A chain	0	0	1	1
D-amino-acid oxidase	0	1	0	1
D-aspartate oxidase	0	1	0	1
D-aspartate oxidase	0	2	0	2
Serine racemase	0	2	0	2
Serine racemase	0	2	0	2
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	7	0	0	7
microphthalmia-associated transcription factor isoform 9	0	1	0	1
caspase-1 isoform alpha precursor	2	0	0	2
Solute carrier organic anion transporter family member 2B1	0	0	0	1
Tumor necrosis factor	0	1	0	1
Neuraminidase	0	1	0	1
Platelet-activating factor receptor	1	0	0	1
Cystathionine gamma-lyase	0	2	0	2
Caspase-7	2	0	0	2
Solute carrier organic anion transporter family member 1B3	0	2	0	5
Protein-arginine deiminase type-4	0	5	0	5
Cystine/glutamate transporter	0	1	0	1
Hydroxyacid oxidase 1	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	1	0	4
large T antigen	0	1	0	1
Dihydrofolate reductase	0	5	0	6
Dipeptidyl peptidase 4	0	2	0	2
Dopamine beta-hydroxylase	0	2	0	2
Lanosterol 14-alpha demethylase	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	3	0	4
Dihydrofolate reductase	0	3	0	3
Dihydrofolate reductase	0	3	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	4	0	5
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	3	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	3	0	3
Thymidylate synthase	0	2	0	3
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	3	0	3
Thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	4	2	6
Bifunctional dihydrofolate reductase-thymidylate synthase	0	3	0	3
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	5	0	6
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	1	0	2
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	4	0	4
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	3
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	3	0	3
Dihydrofolate reductase	0	2	0	3
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	5
Chain A, Probable serine/threonine-protein kinase pknB	0	1	0	1
DNA polymerase III, partial	1	0	0	1
nonstructural protein 1	0	1	0	1
LANA	0	0	0	1
pyruvate kinase	1	0	0	1
phospholipase A2, group III	0	1	0	1
interferon gamma precursor	0	0	0	1
histone-lysine N-methyltransferase NSD2 isoform 1	0	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	4	0	0	4
protein AF-9 isoform a	0	0	0	1
tyrosine-protein kinase Yes	3	0	0	3
dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	0	1
rac GTPase-activating protein 1 isoform a	0	1	0	1
Vpr	1	0	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
pyruvate kinase PKM isoform b	1	0	0	1
Glycoprotein hormones alpha chain	1	0	0	1
Proto-oncogene tyrosine-protein kinase ROS	0	1	2	3
Ornithine decarboxylase	1	0	0	1
Angiotensin-converting enzyme	0	3	0	3
DNA topoisomerase 2	0	0	0	1
NEDD8-activating enzyme E1 regulatory subunit	0	0	1	1
Nuclear receptor subfamily 3 group C member 3	0	3	0	3
Integrase	0	2	0	2
Multidrug and toxin extrusion protein 2	0	1	0	1
NEDD8-activating enzyme E1 catalytic subunit	0	0	1	1
phosphoglycerate kinase	1	0	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Integrin alpha-4	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Iodotyrosine deiodinase	0	0	1	1
fMet-Leu-Phe receptor	0	1	0	1
Tyrosine 3-monooxygenase	0	1	0	1
Tyrosine 3-monooxygenase	0	1	0	1
Iodotyrosine deiodinase 1	0	0	1	1
Sialidase-4	0	1	0	1
Sialidase-1	0	1	0	1
Sialidase-3	0	1	0	1
Sialidase-2	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	0	0	2
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	0	0	1
Neuropeptide Y receptor type 1	0	2	0	2
Neuropeptide Y receptor type 2	0	2	0	2
Chain A, NAD-dependent deacetylase	0	1	0	1
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Tissue factor	0	2	0	2
Cytochrome P450 3A5	0	1	1	2
NAD-dependent protein deacetylase HST2	0	1	0	1
Fatty-acid amide hydrolase 1	0	3	0	3
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	2	0	2
NAD-dependent protein deacetylase	0	1	0	1
5-hydroxytryptamine receptor 3E	0	1	0	1
lysosomal alpha-glucosidase preproprotein	2	0	0	2
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Alpha-1D adrenergic receptor	0	3	1	4
5-hydroxytryptamine receptor 7	0	3	1	4
5-hydroxytryptamine receptor 3A	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Sigma non-opioid intracellular receptor 1	0	2	1	3
5-hydroxytryptamine receptor 3D	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
Neutrophil elastase	0	1	0	1
Proteinase-activated receptor 1	0	1	0	1
Nitric oxide synthase, endothelial	0	2	0	2
Collagenase 3	0	2	0	2
Nitric oxide synthase, brain	0	1	0	1
Beta-secretase 1	0	1	1	2
Trace amine-associated receptor 1	0	0	1	1
Leukotriene C4 synthase	0	0	2	2
Membrane-associated progesterone receptor component 1	0	0	2	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	1	2	3
Serine/threonine-protein kinase 25	0	0	2	2
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	2	2
Serine/threonine-protein kinase RIO3	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 7	0	0	2	2
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	2	3
Peripheral plasma membrane protein CASK	0	0	2	2
Serine/threonine-protein kinase DCLK1	0	0	2	2
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	2	2
Muscle, skeletal receptor tyrosine-protein kinase	0	0	2	2
Mitogen-activated protein kinase 13	0	0	2	2
3-phosphoinositide-dependent protein kinase 1	0	0	2	2
Mitogen-activated protein kinase kinase kinase 13	0	0	2	2
Death-associated protein kinase 3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 7	0	0	2	2
NUAK family SNF1-like kinase 1	0	0	2	2
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	2	2
Tyrosine-protein kinase JAK2	0	0	3	3
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	2	2
Serine/threonine-protein kinase PAK 3	0	0	2	2
Cyclin-dependent kinase-like 5	0	0	3	3
Serine/threonine-protein kinase 17B	0	0	2	2
Cyclin-dependent kinase 14	0	0	2	2
Serine/threonine-protein kinase OSR1	0	0	2	2
Serine/threonine-protein kinase Chk2	0	0	2	2
RAF proto-oncogene serine/threonine-protein kinase	0	2	2	4
Macrophage colony-stimulating factor 1 receptor	0	2	2	4
Wee1-like protein kinase 2	0	0	2	2
Uncharacterized serine/threonine-protein kinase SBK3	0	0	2	2
Mast/stem cell growth factor receptor Kit	0	2	2	4
Myosin light chain kinase, smooth muscle	0	0	2	2
Insulin receptor-related protein	0	0	2	2
Platelet-derived growth factor receptor alpha	0	2	2	4
Vascular endothelial growth factor receptor 1	0	2	2	4
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	2	2
Serine/threonine-protein kinase MAK	0	0	2	2
Cyclin-dependent kinase 11B	0	0	2	2
Fibroblast growth factor receptor 2	0	1	2	3
Receptor tyrosine-protein kinase erbB-3	0	0	2	2
Fibroblast growth factor receptor 4	0	0	2	2
Fibroblast growth factor receptor 3	0	0	2	2
Protein kinase C eta type	0	0	3	3
Activin receptor type-2A	0	0	2	2
Ephrin type-A receptor 3	0	0	2	2
Ephrin type-A receptor 8	0	0	2	2
Leukocyte tyrosine kinase receptor	0	0	2	2
Tyrosine-protein kinase receptor UFO	0	0	2	2
Mitogen-activated protein kinase 4	0	0	2	2
G protein-coupled receptor kinase 4	0	0	2	2
Tyrosine-protein kinase receptor Tie-1	0	0	2	2
Vascular endothelial growth factor receptor 3	0	2	2	4
Vascular endothelial growth factor receptor 2	0	3	3	7
Serine/threonine-protein kinase receptor R3	0	0	3	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	1	2	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	1	2	3
Megakaryocyte-associated tyrosine-protein kinase	0	0	2	2
Tyrosine-protein kinase TXK	0	0	2	2
Tyrosine-protein kinase ZAP-70	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 4	0	0	2	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	2	3
Cyclin-dependent kinase 8	0	1	2	3
Tyrosine-protein kinase Blk	0	0	2	2
Cytoplasmic tyrosine-protein kinase BMX	0	0	2	2
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	2	2
Serine/threonine-protein kinase Nek4	0	0	2	2
Tyrosine-protein kinase JAK3	0	0	2	2
Death-associated protein kinase 1	0	0	2	2
Mitogen-activated protein kinase 12	0	0	2	2
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	2	3
Ephrin type-B receptor 1	0	0	2	2
Hormonally up-regulated neu tumor-associated kinase	0	0	2	2
Serine/threonine-protein kinase SIK1	0	0	2	2
Receptor-interacting serine/threonine-protein kinase 4	0	0	2	2
Cell division control protein 2 homolog	0	0	2	2
Calcium-dependent protein kinase 1	0	0	2	2
Tubulin alpha-1A chain	0	0	2	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	2	2
SRSF protein kinase 2	0	0	2	2
Mitogen-activated protein kinase kinase kinase 9	0	0	2	2
Serine/threonine-protein kinase PknB	0	0	2	2
Cyclin-dependent kinase-like 1	0	0	2	2
Protein kinase C epsilon type	0	1	3	4
Angiopoietin-1 receptor	0	1	2	3
Mitogen-activated protein kinase kinase kinase 10	0	0	2	2
Tyrosine-protein kinase receptor TYRO3	0	0	2	2
Cyclin-dependent kinase 18	0	0	3	3
Tyrosine-protein kinase ITK/TSK	0	0	2	2
Myotonin-protein kinase	0	0	2	2
Mitogen-activated protein kinase kinase kinase 12	0	0	2	2
Tyrosine-protein kinase Mer	0	1	3	4
Serine/threonine-protein kinase PAK 1	0	0	2	2
cGMP-dependent protein kinase 2	0	0	2	2
Serine/threonine-protein kinase PRP4 homolog	0	0	2	2
Receptor-interacting serine/threonine-protein kinase 1	0	2	2	4
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	2	2
Calcium/calmodulin-dependent protein kinase type 1	0	0	2	2
Serine/threonine-protein kinase D1	0	0	3	3
Serine/threonine-protein kinase 38	0	0	2	2
Receptor tyrosine-protein kinase erbB-4	0	0	2	2
Ribosomal protein S6 kinase alpha-2	0	0	2	2
Rhodopsin kinase GRK1	0	0	2	2
NT-3 growth factor receptor	0	0	2	2
BDNF/NT-3 growth factors receptor	0	0	2	2
Mitogen-activated protein kinase 6	0	0	2	2
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	2	2
Receptor protein-tyrosine kinase	0	1	0	1
Serine/threonine-protein kinase SBK1	0	0	2	2
Mitogen-activated protein kinase kinase kinase 19	0	0	2	2
Serine/threonine-protein kinase TNNI3K	0	1	2	3
Rab-like protein 3	0	0	2	2
Leucine-rich repeat serine/threonine-protein kinase 2	0	0	2	2
Serine/threonine-protein kinase Nek5	0	0	2	2
Dual serine/threonine and tyrosine protein kinase	0	0	2	2
Mitogen-activated protein kinase kinase kinase 15	0	0	2	2
Serine/threonine-protein kinase tousled-like 2	0	0	2	2
Serine/threonine-protein kinase 32C	0	0	2	2
Serine/threonine-protein kinase pim-3	0	0	2	2
Serine/threonine-protein kinase VRK2	0	0	2	2
Myosin light chain kinase family member 4	0	0	2	2
Homeodomain-interacting protein kinase 1	0	1	2	3
Calcium/calmodulin-dependent protein kinase type 1D	0	0	2	2
Cyclin-dependent kinase-like 3	0	0	2	2
MAP kinase-activated protein kinase 5	0	0	3	3
Serine/threonine-protein kinase BRSK2	0	0	2	2
Serine/threonine-protein kinase NIM1	0	0	2	2
Serine/threonine-protein kinase ULK2	0	0	2	2
Misshapen-like kinase 1	0	0	3	3
Serine/threonine-protein kinase DCLK2	0	0	2	2
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	2	2
Casein kinase I isoform alpha-like	0	0	2	2
Homeodomain-interacting protein kinase 4	0	1	2	3
Myosin-IIIa	0	0	2	2
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	2	2
Serine/threonine-protein kinase Nek11	0	0	2	2
Serine/threonine-protein kinase BRSK1	0	0	2	2
Serine/threonine-protein kinase 35	0	0	2	2
Rhodopsin kinase GRK7	0	0	2	2
Serine/threonine-protein kinase 32A	0	0	2	2
Myosin-IIIb	0	0	2	2
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	2	2
Cyclin-dependent kinase-like 2	0	0	2	2
Serine/threonine-protein kinase Sgk3	0	0	2	2
Atypical kinase COQ8B, mitochondrial	0	0	2	2
Calcium/calmodulin-dependent protein kinase type 1G	0	0	3	3
Cyclin-dependent kinase 15	0	0	2	2
SRSF protein kinase 1	0	0	2	2
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	2	2
Serine/threonine-protein kinase RIO1	0	0	2	2
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	2	2
Serine/threonine-protein kinase RIO2	0	0	2	2
Cyclin-dependent kinase 19	0	1	2	3
Transient receptor potential cation channel subfamily M member 6	0	0	2	2
Testis-specific serine/threonine-protein kinase 1	0	0	2	2
Serine/threonine-protein kinase 33	0	0	2	2
Serine/threonine-protein kinase DCLK3	0	0	2	2
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	2	2
Homeodomain-interacting protein kinase 2	0	1	2	3
Tyrosine-protein kinase Srms	0	0	2	2
Homeodomain-interacting protein kinase 3	0	1	2	3
Serine/threonine-protein kinase PLK3	0	1	2	3
MAP kinase-interacting serine/threonine-protein kinase 2	0	1	2	3
Serine/threonine-protein kinase Nek6	0	0	2	2
Serine/threonine-protein kinase PAK 6	0	0	2	2
SNF-related serine/threonine-protein kinase	0	0	2	2
Serine/threonine-protein kinase LATS2	0	0	2	2
Serine/threonine-protein kinase 36	0	0	2	2
Isoleucine--tRNA ligase, mitochondrial	0	0	3	3
Serine/threonine-protein kinase 32B	0	0	2	2
Serine/threonine-protein kinase PLK2	0	1	2	3
Serine/threonine-protein kinase MARK1	0	0	2	2
Serine/threonine-protein kinase pim-2	0	0	2	2
Serine/threonine-protein kinase PAK 5	0	0	2	2
eIF-2-alpha kinase GCN2	0	0	2	2
Phosphatidylinositol 4-kinase beta	0	0	2	2
Serine/threonine-protein kinase 17A	0	0	2	2
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	2	2
Ephrin type-A receptor 6	0	0	2	2
Death-associated protein kinase 2	0	0	2	2
Serine/threonine-protein kinase tousled-like 1	0	0	2	2
ALK tyrosine kinase receptor	0	0	2	2
SRSF protein kinase 3	0	0	2	2
Serine/threonine-protein kinase ICK	0	0	3	3
Cyclin-dependent kinase 11A	0	0	2	2
Aurora kinase C	0	0	2	2
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	2	2
Serine/threonine-protein kinase 38-like	0	0	2	2
Microtubule-associated serine/threonine-protein kinase 1	0	0	2	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	3	3
Serine/threonine-protein kinase 24	0	0	3	3
Gastrin/cholecystokinin type B receptor	0	1	1	2
Sodium/iodide cotransporter	0	2	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
SLC16A10 protein	0	0	0	2
Large neutral amino acids transporter small subunit 1	0	1	0	1
Monocarboxylate transporter 10	0	0	0	2
Chain A, PROTEIN (CATECHOL OXIDASE)	0	1	0	1
Tyrosinase	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	1	0	1
Taste receptor type 2 member 38	0	0	3	6
Sodium channel protein type 2 subunit alpha	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
luciferase	0	0	0	1
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Cytochrome P450 2J2	0	4	0	4
heat shock protein HSP 90-alpha isoform 2	0	1	0	2
heat shock protein 90, putative	0	0	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Beta-2 adrenergic receptor	0	2	0	3
Beta-1 adrenergic receptor	0	3	1	5
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
Adenosine receptor A2a	0	2	1	3
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Vasopressin V1a receptor	0	1	1	2
5-hydroxytryptamine receptor 7	0	2	0	2
Beta-2 adrenergic receptor	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
NADH-cytochrome b5 reductase 3	0	1	0	1
Thyroid peroxidase	0	1	0	1
Chain A, Protocatechuate 3,4-dioxygenase alpha chain	0	0	1	1
Chain B, Protocatechuate 3,4-dioxygenase beta chain	0	0	1	1
M18 aspartyl aminopeptidase	0	1	0	1
cathepsin L1	0	1	0	1
3-dehydroquinate synthase	0	1	0	1
Alpha-glucosidase MAL12	0	1	0	1
Anthrax toxin receptor 2	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Dihydroorotate dehydrogenase	0	1	0	1
Monocarboxylate transporter 4	0	0	0	1
Monocarboxylate transporter 2	0	0	0	1
Monocarboxylate transporter 1	0	0	0	1
C-terminal-binding protein 2	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
NS5	0	0	1	1
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
Polymerase basic protein 2	0	0	1	1
RNA-directed RNA polymerase catalytic subunit	0	0	1	1
Polymerase acidic protein	0	0	2	2
Adenosylhomocysteinase	0	0	0	2
Adenosine receptor A1	0	3	0	3
Adenosine receptor A1	0	1	0	1
Genome polyprotein	0	0	1	1
Butyrophilin subfamily 3 member A1	0	0	1	1
4-hydroxy-3-methylbut-2-enyl diphosphate reductase	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	2	0	2
Farnesyl pyrophosphate synthase	0	2	0	2
Farnesyl pyrophosphate synthase	0	2	0	2
Farnesyl diphosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
H	0	1	0	1
Phosphotransferase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	1	0	1
Free fatty acid receptor 1	0	0	1	1
Glutamate receptor ionotropic, NMDA 2D	0	0	1	1
Glutamate receptor ionotropic, NMDA 3B	0	0	1	1
Muscarinic acetylcholine receptor M3	0	0	1	1
Muscarinic acetylcholine receptor M4	0	0	1	1
Muscarinic acetylcholine receptor M5	0	0	1	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Catechol O-methyltransferase	0	0	1	1
Peroxisome proliferator-activated receptor alpha	0	1	1	2
Amine oxidase [flavin-containing] B	0	2	0	2
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Cannabinoid receptor 2	0	0	1	1
Mu-type opioid receptor	0	2	0	2
Peroxisome proliferator-activated receptor delta	0	2	1	3
Glutamate receptor ionotropic, NMDA 1	0	0	1	1
Peroxisome proliferator-activated receptor alpha	0	2	1	3
ATP-binding cassette sub-family C member 8	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	1	1
Glutamate receptor ionotropic, NMDA 2B	0	0	1	1
ATP-sensitive inward rectifier potassium channel 11	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	0	1	1
Thrombin	0	0	1	1
CDGSH iron-sulfur domain-containing protein 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	0	1	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Stromelysin-1	0	1	1	2
Tyrosine-protein phosphatase YopH	0	1	0	1
Estrogen receptor	0	0	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Eukaryotic translation initiation factor 4E	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Protein kinase C zeta type	0	0	3	3
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Uncharacterized aarF domain-containing protein kinase 5	0	0	1	1
Programmed cell death protein 4	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Carbonic anhydrase	0	3	0	3
Eyes absent homolog 2	0	1	0	1
Carbonic anhydrase	0	3	0	3
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
melanocortin receptor 4	0	1	1	2
Tyrosine-protein kinase ABL1	0	1	0	1
Platelet-derived growth factor receptor beta	0	1	0	1
G1/S-specific cyclin-D1	0	1	0	1
Cyclin-C	0	1	1	2
Delta-type opioid receptor	0	0	1	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Vascular endothelial growth factor receptor 3	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Protein delta homolog 1	0	0	1	1
Serine/threonine-protein kinase ATR	0	0	1	1
MAP kinase-activated protein kinase 3	0	0	1	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Poly [ADP-ribose] polymerase tankyrase-2	0	0	1	1
RuvB-like 2	0	1	1	2
RuvB-like 1	0	1	0	1
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
ATP-dependent 6-phosphofructokinase	0	1	0	1
Dihydropteroate synthase	0	1	0	1
Endothelin-1 receptor	0	1	0	1
Protease	0	1	1	2
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Neutrophil collagenase	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Protein kinase C gamma type	0	1	1	2
Luciferin 4-monooxygenase	0	0	1	1
Ras guanyl-releasing protein 3	0	0	1	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Thymidine kinase	0	1	0	2
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
serine/threonine-protein kinase PLK1	1	0	0	1
Transthyretin	0	1	0	3
UDP-glucuronosyltransferase 1A1	0	1	0	1
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	2
Solute carrier organic anion transporter family member 4C1	0	1	0	2
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
neuropeptide S receptor isoform A	2	0	0	2
Prothrombin	0	0	1	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Chain A, Dihydrofolate Reductase	0	0	1	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, dihydrofolate reductase (DHFR)	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase type 1	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Dihydrofolate reductase type 1 from Tn4003	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Chain A, Arginase 1	0	1	0	1
Cocaine esterase	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	0	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (1,025)

Protein Targets (1,774)

Goiter, Nodular

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (1,025)

Drugs Studied (284)

Protein Targets (1,774)