Page last updated: 2024-08-05 14:59:56
fluorochrome
A fluorescent dye used to stain biological specimens.
ChEBI ID: 51217
Members (120)
| Member | Definition | Class |
|---|---|---|
| 1,1'-((4,4,7,7-tetramethyl)-4,7-diazaundecamethylene)bis-4-(3-methyl-2,3-dihydro(benzo-1,3-oxazole)-2-methylidine)quinolinium, tetraiodide | YoYo-1 | |
| 1,1'-(4,4,7,7-tetramethyl-4,7-diazaundecamethylene)bis-4-(3-methyl-2,3-dihydro(benzo-1,3-thiazole)-2-methylidene)quinolinium | ToTo-1 | |
| 2-(4-(dimethylamino)styryl)-1-methylpyridinium | 2-[4-(dimethylamino)styryl]-1-methylpyridinium iodide | |
| 2-(5'-chloro-2'-phosphoryloxyphenyl)-6-chloro-4-(3h)-quinazolinone | 2-(5'-chloro-2'-phosphoryloxyphenyl)-6-chloro-4-(3H)-quinazolinone | |
| 2',7'-dichlorofluorescein | 2',7'-dichlorofluorescein | |
| 3-(4-carboxybenzoyl)-2-quinolinecarboxaldehyde | CBQCA reagent | |
| 3,3'-diethyloxacarbocyanine | The cationic form of a C3 cyanine dye having 3-ethyl-1,3-benzoxazol-2(3H)-yl units at each end. | C3-oxacyanine cation |
| 3,3'-diethylthiacarbocyanine iodide | C3-thiacarbocyanine | |
| 3,3'-diethylthiacarbocyanine iodide | C3-thiacarbocyanine | |
| 3,3'-dioctadecylindocarbocyanine | The cationic form of a C3 cyanine dye having 3,3-dimethyl-1-octadecylindoleinine units at each end. | dilC18(3)(1+) |
| 3,3'-dipentyl-2,2'-oxacarbocyanine | The cationic form of a C3 cyanine dye having 3-pentyl-1,3-benzoxazol-2(3H)-yl units at each end. A fluorescent compound that preferentially stains chronic myelogenic leukemia cells. | 3,3'-dipentyloxacarbocyanine |
| 4-(4-diethylaminostyryl)-n-methylpyridinium | An organic iodide salt consisting of pyridinium iodide having a methyl substituent at the 1-position and a 4-diethylaminostyryl substituent at the 4-position. | 4-(4-diethylaminostyryl)-1-methylpyridinium iodide |
| 4-(4-dihexadecylaminostyryl)-n-methylpyridium | A pyridinium cation with a methyl substituent at the 1-position and a 4-(dihexadecylamino)styryl substituent at the 4-position. | 4-(4-dihexadecylaminostyryl)-N-methylpyridium |
| 4-carboxyfluorescein | 5-carboxyfluorescein | |
| 4-chloro-7-nitrobenzofurazan | A benzoxadiazole that is 2,1,3-benzoxadiazole which is substituted at position 4 by chlorine and at position 7 by a nitro group. | 4-chloro-7-nitrobenzofurazan |
| 5-carboxytetramethylrhodamine | A tetramethylrhodamine compound having a carboxy substituent at the 5-position | 5-carboxytetramethylrhodamine |
| 5-chloromethylfluorescein diacetate | 5-chloromethylfluorescein diacetate | |
| 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine | The cationic form of a C3 cyanine dye having 1,3-diethyl-5,6-dichloroindoleinine units at each end. | 1,1',3,3'-tetraethyl-5,5',6,6'-tetrachloroimidacarbocyanine |
| 7-amino-4-methylcoumarin | coumarin 120 | |
| 7-amino-4-trifluoromethylcoumarin | 7-amino-4-(trifluoromethyl)coumarin | |
| 7-methoxycoumarin-4-acetic acid | 7-methoxycoumarin-4-acetic acid | |
| 7-nitrobenzoxadiazole-6-aminohexanoic acid | A benzoxadiazole that is 2,1,3-benzoxadiazole which is substituted at positions 4 and 7 by (5-carboxypentyl)amino and nitro groups, respectively. | 7-nitrobenzoxadiazole-6-aminohexanoic acid |
| 9,10-bis(phenylethynyl)anthracene | 9,10-bis(phenylethynyl)anthracene | |
| 9,10-diphenylanthracene | A member of the class of anthracenes that is anthracene in which both of the hydrogens on the central ring are substituted by phenyl groups. | 9,10-diphenylanthracene |
| acridine orange | A member of the class of aminoacridines that is acridine carrying two dimethylamino substituents at positions 3 and 6. The hydrochloride salt is the fluorescent dye 'acridine orange', used for cell cycle determination. | acridine orange free base |
| acridine yellow | acridine yellow | |
| alcian yellow | An organic chloride salt composed of {diazenediylbis[(4,1-phenylene)(6-methyl-1,3-benzothiazole-2,5-diyl)methylenesulfanediyl]}bis[(dimethylamino)-N,N-dimethylmethaniminium] and chloride ions in a 1:2 ratio. | alcian yellow |
| alexa fluor 546 | Alexa Fluor 546 | |
| Alexa Fluor 555 | A fluorescent dye of absorption wavelength 555 nm and emission wavelength 565 nm, derived from a 3,6-diaminoxanthene-4,5-disulfate. | Alexa Fluor 555 |
| aurintricarboxylic acid | A member of the class of quinomethanes that is 3-methylidene-6-oxocyclohexa-1,4-diene-1-carboxylic acid in which the methylidene hydrogens are replaced by 4-carboxy-3-hydroxyphenyl groups. The trisodium salt is the biological stain 'chrome violet CG' while the triammonium salt is 'aluminon'. | aurintricarboxylic acid |
| basic blue k | An iminium salt composed of 4-{[4-(dimethylamino)phenyl][4-(ethylamino)naphthalen-1-yl]methylidene}-N,N-dimethylcyclohexa-2,5-dien-1-iminium and chloride ions in a 1:1 ratio. | victoria blue R |
| benzophenoneidum | A hydrochloride obtained by combining 4,4'-carbonimidoylbis(N,N-dimethylaniline) with one molar equivalent of hydrogen chloride. A fluorescent stain for demonstrating acid fast organisms in a method similar to the Ziehl Neelsen. It also can be used to make a fluorescent Schiff reagent. | auramine O |
| biphenylacetylene | An arylacetylene that is acetylene in which the hydrogens are replaced by phenyl groups. | biphenylacetylene |
| bisbenzimidazole | pibenzimol | |
| bobo 3 | BoBo-3 | |
| brilliant green | An organic hydrogensulfate salt having 4-{[4-(diethylamino)phenyl](phenyl)methylidene}-N,N-diethylcyclohexa-2,5-dien-1-iminium as the counterion. | brilliant green |
| c.i. direct red 80 | An organic sodium salt resulting from the formal condensation of Sirius red F3B (acid form) with six equivalents of sodium hydroxide. A polyazo dye used principally in staining methods for collagen and amyloid. | Sirius red F3B |
| calcein am | An organic heteropentacyclic compound that is calcein in which all four carboxy group hydrogens have been substituted by (acetyloxy)methoxy groups and the hyrodgens of the two hydroxy groups have been substituted by acetyl groups. It is a a non-fluorescent probe cleaved to a fluorescent probe by non-specific intracellular esterases. | calcein am |
| calcium crimson | calcium crimson | |
| calcium orange | A xanthene dye-based thiourea conjugate. | calcium orange |
| carbocyanines | pinacyanol iodide | |
| cascade blue | cascade blue | |
| clomipramine | A quaternary ammonium salt that is the tetrakis(N,N,N-trimethylmethammonium) salt of 5-({[4-(13-{4-[({3-carboxy-4-[(2,7-dichloro-6-hydroxy-3-oxo-3H-xanthen-9-yl)methyl]phenyl}carbonyl)amino]-2,5-bis(methyloxy)phenyl}-1,4,10-trioxa-7,13-diazacyclopentadecan-7-yl)-2-hydroxy-5-(methyloxy)phenyl]amino}carbonyl)-2-(2,7-dichloro-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid. | sodium green |
| coumarin 153 | coumarin 153 | |
| coumarin 314 | coumarin 504 | |
| coumarin 343 | coumarin 343 | |
| coumarin 480 | coumarin 480 | |
| coumarin 6 | coumarin 6 | |
| dapi | DAPI | |
| dibromobimane | A pyrazolopyrazole that consists of 1H,7H-pyrazolo[1,2-a]pyrazole-1,7-dione bearing two methyl substituents at positions 2 and 6 as well as two bromomethyl substituents at positions 3 and 5. | dibromobimane |
| diphenylhexatriene | 1,6-diphenylhexatriene | |
| dithiazanine | A cationic C3-cyanine dye with 3-ethylbenzothiazol-2-yl groups at both ends. | dithiazanine |
| dithiazanine iodide | dithiazanine iodide | |
| DND-167 dye | DND-167 dye | |
| dy-676 | DY-676 | |
| eosine yellowish-(ys) | An organic sodium salt that is 2',4',5',7'-tetrabromofluorescein in which the carboxy group and the phenolic hydroxy group have been deprotonated and the resulting charge is neutralised by two sodium ions. | eosin YS dye |
| epicocconone | A natural cell-permeable fluorescent compound isolated from the fungus Epicoccum nigrum. | epicocconone |
| ethidium | The fluorescent compound widely used in experimental cell biology and biochemistry to reveal double-stranded DNA and RNA. | ethidium |
| ethyl violet | An organic chloride salt that is the monochloride salt of ethyl violet cation. Used for inclusion in mixed dye solutions of the iron resorcin fuchsin type for demonstrating elastic fibres. | ethyl violet |
| evans blue | An organic sodium salt that is the tetrasodium salt of 6,6'-{(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis[diazene-2,1-diyl]}bis(4-amino-5-hydroxynaphthalene-1,3-disulfonate). It is sometimes used as a counterstain, especially in fluorescent methods to suppress background autofluorescence. | Evans blue |
| fast green fcf | An organic sodium salt having 2-{(4-{ethyl[(3-sulfonatophenyl)methyl]amino}phenyl)[4-{ethyl[(3-sulfonatophenyl)methyl]iminio}cyclohexa-2,5-dien-1-ylidene]methyl}-5-hydroxybenzene-1-sulfonate as the counterion. Used as a substitute for Light green SF yellowish in Masson's trichrome as it is less likely to fade, and is more brilliant in colour. Also used as a food colouring agent. | Fast green FCF |
| fluo-3 | Fluo-3 | |
| fluorexon | calcein | |
| fm1 43 | FM 1-43 dye | |
| gallein | A xanthene dye that is fluoran carrying four hydroxy substituents at positions 3', 4', 5' and 6'. | gallein |
| herniarin | A member of the class of coumarins that is coumarin substituted by a methoxy group at position 7. | herniarin |
| hoe 33342 | 2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole | |
| hydromethylthionine | A member of the class of phenothiazines that is 10H-phenothiazine in which the ring hydrogens at positions 3 and 7 have been replaced by dimethylamino groups. | leucomethylene blue |
| indo-1 | Indo-1 dye | |
| lissamine rhodamine b | An organic sodium salt having 4-[3,6-bis(diethylamino)xanthenium-9-yl]benzene-1,3-disulfonate as the counterion. | lissamine rhodamine |
| lucifer yellow | lucifer yellow dye | |
| magnesium green | magnesium green | |
| malachite green | An organic chloride salt that is the monochloride salt of malachite green cation. Used as a green-coloured dye, as a counter-stain in histology, and for its anti-fungal properties in aquaculture. | malachite green |
| methylene blue | An organic chloride salt having 3,7-bis(dimethylamino)phenothiazin-5-ium as the counterion. A commonly used dye that also exhibits antioxidant, antimalarial, antidepressant and cardioprotective properties. | methylene blue |
| methylene green | An organic chloride salt having 3,7-bis(dimethylamino)-4-nitrophenothiazin-5-ium as the counterion. It stains nuclei green and is sometimes used as a counterstain to red or purple primary stains. | methylene green |
| mitotracker orange | mitoTracker Orange | |
| monobromobimane | A pyrazolopyrazole that consists of 1H,7H-pyrazolo[1,2-a]pyrazole-1,7-dione bearing three methyl substituents at positions 2, 5 and 6 as well as a bromomethyl substituent at the 3-position. | monobromobimane |
| monochlorobimane | monochlorobimane | |
| monodansylcadaverine | A sulfonamide obtained by formal condensation of the sulfo group of 5-(dimethylamino)naphthalene-1-sulfonic acid with one of the amino groups of cadaverine. | monodansylcadaverine |
| new fuchsin | A hydrochloride that is the monohydrochloride of 4-[(4-aminophenyl)(4-iminocyclohexa-2,5-dien-1-ylidene)methyl]-2-methylaniline. One of the minor constituents of Basic fuchsin, together with pararosanilin, rosanilin and magenta II. | new fuchsin |
| nile red | An organic heterotetracyclic compound that is 5H-benzo[a]phenoxazin-5-one substituted at position 9 by a diethylamino group. | nile red |
| nk 5 | cryptocyanin | |
| nuclear fast red | An organic sodium salt that is the monosodium salt of 4-amino-1,3-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid. It forms bright red lakes with calcium and is a useful red nuclear staining lake with aluminum. | nuclear fast red |
| oregon green 488 carboxylic acid | A xanthene dye having two fluoro substituents at the 2- and 7-positions and a 2,4-dicarboxyphenyl group at the 9-position. | oregon green 488 |
| oregon green 514 | OG-514 dye | |
| oxazine 1 | oxazine-1 | |
| pacific blue succinimidyl ester | An N-hydroxysuccinimide ester derived from 6,8-difluoro-7-hydroxycoumarin-3-carboxylic acid (pacific blue). A fluorescent dye of excitation wavelength 403 nm and emission wavelength 455 nm. | pacific blue succinimidyl ester |
| perylenediimide | The 3,4,9,10-tetracarboxylic diimide derivative of perylene. | perylenediimide |
| phenosafranine | An organic chloride salt having 3,7-diamino-5-phenylphenazin-5-ium as the counterion. It is commonly used for staining Gram negative bacteria red in smears to contrast with the blue Gram positive organisms. | phenosafranine |
| ponceau s | An organic sodium salt that is the tetrasodium salt of 3-hydroxy-4-({2-sulfo-4-[(4-sulfophenyl)diazenyl]phenyl}diazenyl)naphthalene-2,7-disulfonic acid. | Ponceau S |
| popop | POPOP | |
| primuline | An organic sodium salt having 2'-(4-aminophenyl)-6-methyl[2,6'-bi-1,3-benzothiazole]-7-sulfonate as the counterion. | primuline |
| propidium | propidium | |
| pyranine | pyranine | |
| quinaldine blue | pinacyanol iodide | |
| rhodamine 123 | rhodamine 123 | |
| rhodamine 123 | A cationic fluorescent dye derived from 9-phenylxanthene. | rhodamine 123(1+) |
| rhodamine 123 | rhodamine 123 | |
| rhodamine b | An organic chloride salt having N-[9-(2-carboxyphenyl)-6-(diethylamino)-3H-xanthen-3-ylidene]-N-ethylethanaminium as the counterion. An amphoteric dye commonly used as a fluorochrome. | rhodamine B |
| rose bengal(2-) | The anionic form of a fluorescent dye derived from a polyhalogenated fluorescin. | rose bengal(2-) |
| safranine t | An organic chloride salt having 3,7-diamino-2,8-dimethyl-5-phenylphenazin-5-ium as the counterion. It is commonly used for staining Gram negative bacteria. | safranin O |
| scarlet red | A bis(azo) compound that is 2-naphthol substituted at position 1 by a {2-methyl-4-[(2-methylphenyl)diazenyl]phenyl}diazenyl group. A fat-soluble dye predominantly used for demonstrating triglycerides in frozen sections, but which may also stain some protein bound lipids in paraffin sections. | Sudan IV |
| sodium-binding benzofuran isophthalate | A crown compound that is 1,4,10-trioxa-7,13-diazacyclopentadecane in which the hydrogens of the amino groups at position 7 and 13 are replaced by 2-(2,4-dicarboxyphenyl)-5-methoxy-1-benzofuran-6-yl groups. It is a cell-impermeant fluorescent sodium indicator. | sodium-binding benzofuran isophthalate |
| stains-all | carbocyanin DBTC | |
| succinyl-leucyl-leucyl-valyl-tyrosyl-methylcoumarinamide | A tetrapeptide compound with a succinyl group at the N-terminal and a 7-amino-4-methylcoumarin group at the C-terminal. | succinyl-Leu-Leu-Val-Tyr-7-amino-4-methylcoumarin |
| sudan iii | A bis(azo) compound that is 2-naphthol substituted at position 1 by a 4-{[(2-methylphenyl)diazenyl]phenyl}diazenyl group. A fat-soluble dye predominantly used for demonstrating triglycerides in frozen sections, but which may also stain some protein bound lipids in paraffin sections. | Sudan III |
| sulforhodamine 101 | sulforhodamine 101 | |
| texas red | texas red | |
| thiazole orange | A cyanine dye comprising the thiazole orange cation [1-methyl-4-[(3-methyl-1,3-benzothiazol-2(3H)-ylidene)methyl]quinolinium] with the p-tosylate counterion. | thiazole orange |
| thioflavin t | An organic chloride salt having 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium as the counterion. It is widely used to visualise and quantify the presence of amyloids, both in vitro and in vivo. | thioflavine T |
| to-pro-1 | A C1 cyanine dye having benzothiazolium-2-yl and quinolinium-4-yl substituents. | To-Pro-1 |
| to-pro-3 | An unsymmetrical C3 cyanine dye having benzothiazolium-2-yl and quinolinium-4-yl substituents. | To-Pro-3 |
| tris(2,2'-bipyridine)ruthenium(II) | A ruthenium coordination entity consisting of ruthenium(II) bound to three 2,2'-bipyridine units. | tris(2,2'-bipyridine)ruthenium(II) |
| tris(4,7-diphenyl-1,10-phenanthroline)ruthenium (ii) | A ruthenium coordination entity consisting of ruthenium(II) bound to three 4,7-diphenyl-1,10-phenanthroline units. | tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) |
| uvitex swn | coumarin 460 | |
| victoria blue 4r | An iminium salt composed of 4-([4-(dimethylamino)phenyl]{4-[methyl(phenyl)amino]naphthalen-1-yl}methylidene)-N,N-dimethylcyclohexa-2,5-dien-1-iminium and chloride ions in a 1:1 ratio. It binds to nucleic acids and can be used in standardised staining techniques suitable for automated cell-pattern recognition. | victoria blue 4R |
| victoria blue b | An iminium salt composed of 4-{(4-anilinonaphthalen-1-yl)[4-(dimethylamino)phenyl]methylidene}-N,N-dimethylcyclohexa-2,5-dien-1-iminium and chloride ions in a 1:1 ratio. It binds to nucleic acids and can be used in standardised staining techniques suitable for automated cell-pattern recognition. | victoria blue B |
| yo-pro 1 | An unsymmetrical C1 cyanine dye having 1,3-benzoxazol-2-yl and quinolinium-4-yl substituents. | Yo-Pro-1 |
| yoyo-3 | YoYo-3 | |
| zn(ii)-phthalocyanine | zinc phthalocyanine |
Research
Studies (51,307)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 9,053 (17.64) | 18.7374 |
| 1990's | 9,927 (19.35) | 18.2507 |
| 2000's | 13,583 (26.47) | 29.6817 |
| 2010's | 14,653 (28.56) | 24.3611 |
| 2020's | 4,091 (7.97) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 578 (1.00%) | 5.53% |
| Reviews | 945 (1.64%) | 6.00% |
| Case Studies | 1,088 (1.89%) | 4.05% |
| Observational | 25 (0.04%) | 0.25% |
| Other | 54,907 (95.42%) | 84.16% |
Protein Targets (386)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 18.0454 | 1 | 10 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 5.9289 | 1 | 4 |
| 2,3-bisphosphoglycerate-independent phosphoglycerate mutase | Leishmania major strain Friedlin | Potency | 30.1313 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 11.7819 | 2 | 6 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 21.3645 | 4 | 24 |
| acid sphingomyelinase | Homo sapiens (human) | Potency | 26.9262 | 1 | 3 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 28.4184 | 2 | 6 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 20.2039 | 1 | 13 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 35.3688 | 2 | 7 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 8.0827 | 1 | 5 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 18.2303 | 1 | 5 |
| AR protein | Homo sapiens (human) | Potency | 18.3167 | 12 | 87 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 11.3049 | 2 | 19 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 13.1092 | 3 | 8 |
| Ataxin-2 | Homo sapiens (human) | Potency | 9.2888 | 1 | 6 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 16.2214 | 2 | 4 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 7.0640 | 2 | 9 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 15.4001 | 3 | 13 |
| BRCA1 | Homo sapiens (human) | Potency | 0.8913 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 17.5530 | 1 | 7 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 11.8960 | 1 | 5 |
| caspase-1 isoform alpha precursor | Homo sapiens (human) | Potency | 10.1022 | 1 | 5 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 7.6162 | 1 | 2 |
| caspase-3 | Homo sapiens (human) | Potency | 11.8960 | 1 | 5 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 7.6162 | 1 | 2 |
| Caspase-7 | Homo sapiens (human) | Potency | 11.0503 | 1 | 4 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 19.6057 | 3 | 19 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 24.1773 | 1 | 10 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 19.3167 | 4 | 17 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 30.3058 | 2 | 6 |
| Chain A, Breast cancer type 1 susceptibility protein | Homo sapiens (human) | Potency | 14.2191 | 1 | 2 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 22.9120 | 2 | 8 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 29.4350 | 2 | 9 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 16.5439 | 2 | 11 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 35.8947 | 1 | 7 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 16.6558 | 3 | 16 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 20.4575 | 1 | 5 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 13.0874 | 2 | 14 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 16.5439 | 2 | 11 |
| chaperonin-containing TCP-1 beta subunit homolog | Homo sapiens (human) | Potency | 51.0594 | 1 | 4 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 28.9804 | 2 | 5 |
| ClpP | Bacillus subtilis | Potency | 30.7410 | 2 | 2 |
| core-binding factor subunit beta isoform 2 | Homo sapiens (human) | Potency | 2.9317 | 2 | 4 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 13.3519 | 1 | 2 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 14.2191 | 1 | 2 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 8.6752 | 1 | 4 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 9.9132 | 1 | 5 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 23.0602 | 1 | 2 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 17.2168 | 2 | 6 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 5.0946 | 2 | 6 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 24.7750 | 1 | 14 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3F isoform a | Homo sapiens (human) | Potency | 3.9562 | 1 | 3 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 11.2004 | 1 | 5 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 32.0569 | 1 | 3 |
| DNA polymerase III, partial | Bacillus subtilis | Potency | 3.3587 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 45.6226 | 1 | 7 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 11.0336 | 1 | 12 |
| endonuclease IV | Escherichia coli | Potency | 1.4733 | 2 | 2 |
| Endothelin receptor type B | Rattus norvegicus (Norway rat) | Potency | 19.1180 | 1 | 2 |
| Endothelin-1 receptor | Rattus norvegicus (Norway rat) | Potency | 19.1180 | 1 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 21.3020 | 11 | 88 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 32.0712 | 3 | 13 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 17.3019 | 7 | 70 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 18.8114 | 1 | 15 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 15.8264 | 4 | 4 |
| eyes absent homolog 2 isoform a | Homo sapiens (human) | Potency | 41.2814 | 1 | 4 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 24.8871 | 4 | 15 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 19.8428 | 2 | 8 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 10.6654 | 1 | 2 |
| G | Vesicular stomatitis virus | Potency | 8.6752 | 1 | 4 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 17.2168 | 1 | 3 |
| galactokinase | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 17.2168 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 17.2168 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 17.2168 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 17.2168 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 17.2168 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 17.2168 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 17.2168 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 17.2168 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 17.2168 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 17.2168 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 17.2168 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 17.2168 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 17.2168 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 17.2168 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 17.2168 | 1 | 3 |
| geminin | Homo sapiens (human) | Potency | 17.4545 | 3 | 10 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 12.1759 | 2 | 21 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 12.4277 | 1 | 4 |
| GLS protein | Homo sapiens (human) | Potency | 6.8788 | 2 | 4 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 35.7168 | 1 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 27.5010 | 5 | 18 |
| glucokinase regulatory protein | Homo sapiens (human) | Potency | 10.6992 | 3 | 3 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | Potency | 0.0562 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 16.6913 | 2 | 11 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | Potency | 0.0562 | 1 | 1 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | Potency | 0.0562 | 1 | 1 |
| Glycoprotein hormones alpha chain | Homo sapiens (human) | Potency | 22.9826 | 1 | 4 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 29.2168 | 1 | 5 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 17.6335 | 2 | 8 |
| guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 34.6061 | 2 | 8 |
| hemoglobin subunit beta | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| hexokinase-4 isoform 1 | Homo sapiens (human) | Potency | 10.6992 | 3 | 3 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 11.7825 | 2 | 14 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 14.9171 | 1 | 12 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 15.8871 | 2 | 11 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 30.7562 | 2 | 18 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 17.1767 | 1 | 6 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 8.6752 | 1 | 4 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 9.5756 | 1 | 3 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 28.4433 | 2 | 4 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 33.3931 | 2 | 11 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 23.2823 | 3 | 3 |
| IDH1 | Homo sapiens (human) | Potency | 7.7082 | 1 | 4 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 43.1883 | 2 | 7 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 8.6752 | 1 | 8 |
| inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 15.6405 | 3 | 9 |
| Interferon beta | Homo sapiens (human) | Potency | 13.5030 | 3 | 11 |
| interleukin 8 | Homo sapiens (human) | Potency | 66.8242 | 1 | 2 |
| isocitrate dehydrogenase 1, partial | Homo sapiens (human) | Potency | 33.0088 | 1 | 3 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 9.0840 | 1 | 3 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 14.2191 | 1 | 4 |
| lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 18.8010 | 1 | 3 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 21.4016 | 4 | 21 |
| luciferase | Photuris pensylvanica (Pennsylania firefly) | Potency | 10.8631 | 1 | 3 |
| luteinizing hormone receptor | Homo sapiens (human) | Potency | 84.9214 | 1 | 1 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 27.7209 | 4 | 6 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 0.2078 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 13.8921 | 2 | 14 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 16.0158 | 2 | 3 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 6.9020 | 1 | 6 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 25.6651 | 1 | 2 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 25.6651 | 1 | 2 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 6.0159 | 3 | 5 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 2.7944 | 1 | 2 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 1.6084 | 1 | 3 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 20.0136 | 4 | 20 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 6.0820 | 2 | 7 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 34.9598 | 2 | 8 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 11.0468 | 1 | 2 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 11.4807 | 2 | 12 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 8.3186 | 1 | 2 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 24.0535 | 3 | 36 |
| Ornithine decarboxylase | Rattus norvegicus (Norway rat) | Potency | 0.1585 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 11.0957 | 1 | 2 |
| Parkin | Homo sapiens (human) | Potency | 1.5849 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 40.8887 | 2 | 6 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 28.6954 | 1 | 1 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 67.4555 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 31.5857 | 5 | 15 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 30.8128 | 5 | 16 |
| phosphoglycerate kinase | Trypanosoma brucei brucei TREU927 | Potency | 13.8596 | 3 | 6 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 46.0230 | 3 | 10 |
| Photinus pyralis luciferase | Shuttle vector pANFluc | Potency | 16.9441 | 1 | 1 |
| PINK1 | Homo sapiens (human) | Potency | 1.5849 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 1.7488 | 1 | 2 |
| polyprotein | Zika virus | Potency | 10.6654 | 1 | 2 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 18.9895 | 1 | 3 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 9.9551 | 1 | 4 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 9.4939 | 1 | 3 |
| PPM1D protein | Homo sapiens (human) | Potency | 13.4230 | 1 | 4 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 15.6340 | 3 | 11 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 29.3969 | 1 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 31.7533 | 3 | 14 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 19.1180 | 2 | 4 |
| pyruvate kinase PKM isoform a | Homo sapiens (human) | Potency | 32.4648 | 2 | 4 |
| pyruvate kinase PKM isoform b | Homo sapiens (human) | Potency | 0.1585 | 2 | 2 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 59.5833 | 2 | 4 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 81.9985 | 2 | 3 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 18.1632 | 2 | 23 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 1.3167 | 1 | 3 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 40.5590 | 1 | 3 |
| relaxin receptor 1 isoform 1 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 14.5383 | 3 | 29 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 19.3760 | 3 | 19 |
| RGS12 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| runt-related transcription factor 1 isoform AML1b | Homo sapiens (human) | Potency | 2.9317 | 2 | 4 |
| serine-protein kinase ATM isoform a | Homo sapiens (human) | Potency | 19.0188 | 4 | 7 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 12.6094 | 1 | 3 |
| Single-stranded DNA cytosine deaminase | Homo sapiens (human) | Potency | 79.3735 | 2 | 4 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 25.8436 | 3 | 15 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 25.8436 | 3 | 15 |
| Smad3 | Homo sapiens (human) | Potency | 11.7138 | 1 | 6 |
| snurportin-1 | Homo sapiens (human) | Potency | 43.1883 | 2 | 7 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 39.8107 | 1 | 2 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 5.8896 | 1 | 5 |
| T cell receptor, partial | Homo sapiens (human) | Potency | 4.0276 | 1 | 2 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 10.6192 | 1 | 4 |
| TDP1 protein | Homo sapiens (human) | Potency | 7.1767 | 2 | 28 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 45.9919 | 1 | 3 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 45.7179 | 2 | 12 |
| Thrombopoietin | Homo sapiens (human) | Potency | 3.1623 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 17.4691 | 3 | 28 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 24.7864 | 4 | 17 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 17.2215 | 7 | 38 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 21.7893 | 2 | 4 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 4.9288 | 1 | 2 |
| TSHR protein | Homo sapiens (human) | Potency | 15.5035 | 2 | 2 |
| tumor susceptibility gene 101 protein | Homo sapiens (human) | Potency | 14.2763 | 3 | 5 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 9.9505 | 3 | 6 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 1.7488 | 1 | 2 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 1.7488 | 1 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 26.2191 | 2 | 7 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 21.0396 | 2 | 17 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 24.4790 | 5 | 17 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 21.4924 | 1 | 10 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 18.3549 | 1 | 10 |
| Vpr | Human immunodeficiency virus 1 | Potency | 16.7921 | 1 | 4 |
| WRN | Homo sapiens (human) | Potency | 52.7968 | 1 | 4 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 10 kDa chaperonin | Escherichia coli | IC50 | 0.3990 | 2 | 4 |
| 10 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 1.6850 | 1 | 2 |
| 60 kDa chaperonin | Escherichia coli K-12 | IC50 | 205.5000 | 1 | 2 |
| 60 kDa chaperonin | Escherichia coli | IC50 | 0.3990 | 2 | 4 |
| 60 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 1.6850 | 1 | 2 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 17.2630 | 1 | 3 |
| Acetylcholinesterase | Homo sapiens (human) | Ki | 4.1400 | 2 | 3 |
| Acetylcholinesterase | Mus musculus (house mouse) | Ki | 0.6600 | 1 | 1 |
| Acetylcholinesterase | Bos taurus (cattle) | IC50 | 17.2630 | 1 | 3 |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | IC50 | 99.2500 | 2 | 2 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 0.3700 | 1 | 1 |
| alkaline phosphatase, germ cell type preproprotein | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| alkaline phosphatase, intestinal | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein | Homo sapiens (human) | IC50 | 74.8000 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.5000 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.5000 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.5000 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 0.0700 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 0.5500 | 2 | 2 |
| Amyloid-beta precursor protein | Homo sapiens (human) | Ki | 0.9633 | 6 | 6 |
| Apoptotic peptidase activating factor 1 | Homo sapiens (human) | IC50 | 59.0750 | 2 | 4 |
| Aromatase | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| B1 bradykinin receptor | Homo sapiens (human) | IC50 | 68.9255 | 1 | 2 |
| Bcl-2-like protein 1 | Homo sapiens (human) | Ki | 0.0009 | 1 | 1 |
| bcr | Homo sapiens (human) | IC50 | 35.0700 | 1 | 1 |
| Beta lactamase (plasmid) | Pseudomonas aeruginosa | IC50 | 20.1962 | 3 | 4 |
| Beta-secretase 1 | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| BZLF2 | Human herpesvirus 4 type 2 (Epstein-Barr virus type 2) | IC50 | 0.4200 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 5.7300 | 2 | 2 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 9.4150 | 2 | 2 |
| Carbonic anhydrase 13 | Mus musculus (house mouse) | Ki | 8.9000 | 1 | 1 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 9.0000 | 1 | 1 |
| Carbonic anhydrase 15 | Mus musculus (house mouse) | Ki | 8.4000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 350.0000 | 2 | 2 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 96.0000 | 1 | 1 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 8.3000 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 5.1000 | 1 | 1 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 500.0000 | 1 | 1 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 5.5000 | 1 | 1 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 8.7200 | 2 | 2 |
| caspase recruitment domain family, member 15 | Homo sapiens (human) | IC50 | 10.8950 | 1 | 1 |
| caspase-1 isoform alpha precursor | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| caspase-3 isoform a preproprotein | Homo sapiens (human) | IC50 | 34.9000 | 1 | 2 |
| caspase-9 isoform alpha precursor | Homo sapiens (human) | IC50 | 34.9000 | 1 | 2 |
| catenin beta-1 isoform 1 | Homo sapiens (human) | IC50 | 3.7300 | 1 | 1 |
| Chain A, Acetylcholinesterase | Tetronarce californica (Pacific electric ray) | Ki | 0.0331 | 1 | 1 |
| Chain E, Fibrin beta chain | Homo sapiens (human) | IC50 | 46.2655 | 2 | 2 |
| Cholinesterase | Homo sapiens (human) | IC50 | 17.2630 | 1 | 3 |
| Cholinesterase | Homo sapiens (human) | Ki | 3.2475 | 2 | 4 |
| Complement component C9 | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| core protein, partial | IC50 | 49.7510 | 1 | 1 | |
| Cruzipain | Trypanosoma cruzi | IC50 | 55.2500 | 4 | 4 |
| Cystathionine beta-synthase | Homo sapiens (human) | IC50 | 181.8000 | 4 | 4 |
| Cystathionine gamma-lyase | Homo sapiens (human) | IC50 | 94.5000 | 10 | 10 |
| Cystathionine gamma-lyase | Mus musculus (house mouse) | IC50 | 43.2000 | 1 | 1 |
| Cystathionine gamma-lyase | Homo sapiens (human) | Ki | 0.6000 | 1 | 1 |
| Cysteine protease ATG4B | Homo sapiens (human) | IC50 | 10.4750 | 4 | 4 |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | IC50 | 1.8000 | 1 | 1 |
| Dihydrolipoyl dehydrogenase | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 1,000.0000 | 1 | 1 |
| Dihydrolipoyl dehydrogenase, mitochondrial | Sus scrofa (pig) | IC50 | 1,000.0000 | 1 | 1 |
| DNA damage-inducible transcript 3 protein | Mus musculus (house mouse) | IC50 | 0.8700 | 1 | 1 |
| DNA polymerase eta | Homo sapiens (human) | IC50 | 0.0750 | 1 | 1 |
| DNA polymerase iota | Homo sapiens (human) | IC50 | 0.0750 | 1 | 1 |
| DNA repair protein RAD52 homolog | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| DNA topoisomerase 1 | Homo sapiens (human) | IC50 | 36.4300 | 1 | 2 |
| DNA topoisomerase 2-alpha | Homo sapiens (human) | IC50 | 28.9200 | 1 | 1 |
| DNA-(apurinic or apyrimidinic site) endonuclease | Homo sapiens (human) | IC50 | 3.3700 | 3 | 3 |
| DNA-3-methyladenine glycosylase | Homo sapiens (human) | IC50 | 0.2000 | 1 | 1 |
| Dual specificity mitogen-activated protein kinase kinase 3 | Homo sapiens (human) | IC50 | 14.0600 | 1 | 1 |
| Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | Homo sapiens (human) | IC50 | 0.9220 | 1 | 1 |
| Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | Homo sapiens (human) | Ki | 0.8240 | 1 | 1 |
| exodeoxyribonuclease V subunit RecB | Escherichia coli str. K-12 substr. MG1655 | IC50 | 80.9080 | 1 | 1 |
| exodeoxyribonuclease V subunit RecC | Escherichia coli str. K-12 substr. MG1655 | IC50 | 80.9080 | 1 | 1 |
| exodeoxyribonuclease V subunit RecD | Escherichia coli str. K-12 substr. MG1655 | IC50 | 80.9080 | 1 | 1 |
| Exportin-1 | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| G-protein coupled receptor 35 isoform a | Homo sapiens (human) | IC50 | 1.3707 | 1 | 1 |
| Glandular kallikrein | Sus scrofa (pig) | Ki | 2.7000 | 1 | 1 |
| glucose-6-phosphate 1-dehydrogenase isoform b | Homo sapiens (human) | IC50 | 44.7000 | 1 | 1 |
| glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | Plasmodium berghei | IC50 | 22.0000 | 3 | 3 |
| Glutathione reductase | Plasmodium falciparum 3D7 | IC50 | 6.4000 | 1 | 1 |
| Glutathione reductase, mitochondrial | Homo sapiens (human) | IC50 | 16.2000 | 2 | 2 |
| Glutathione S-transferase P | Homo sapiens (human) | IC50 | 0.0512 | 1 | 1 |
| Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | Homo sapiens (human) | IC50 | 0.2000 | 1 | 1 |
| Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | Homo sapiens (human) | IC50 | 0.2000 | 1 | 1 |
| Inhibitor of nuclear factor kappa-B kinase subunit beta | Homo sapiens (human) | IC50 | 5.4000 | 1 | 1 |
| integrase, partial | Human immunodeficiency virus 1 | IC50 | 19.2405 | 2 | 2 |
| intestinal alkaline phosphatase precursor | Mus musculus (house mouse) | IC50 | 1.5500 | 1 | 1 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | IC50 | 282.9000 | 1 | 1 |
| large T antigen | Betapolyomavirus macacae | IC50 | 1.9300 | 1 | 1 |
| lens epithelium-derived growth factor p75 | Homo sapiens (human) | IC50 | 19.2405 | 2 | 2 |
| Luciferin 4-monooxygenase | Photinus pyralis (common eastern firefly) | IC50 | 11.0400 | 5 | 5 |
| matrix metalloproteinase-14 preproprotein | Homo sapiens (human) | IC50 | 80.0000 | 1 | 1 |
| metallo beta-lactamase | Pseudomonas aeruginosa | IC50 | 40.8525 | 1 | 2 |
| metallo-beta-lactamase IMP-1 | Pseudomonas aeruginosa | IC50 | 68.9255 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | IC50 | 9.4250 | 4 | 4 |
| Monocarboxylate transporter 4 | Homo sapiens (human) | IC50 | 0.7300 | 1 | 1 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | IC50 | 3.3000 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 500.0220 | 2 | 2 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 0.0550 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 0.0300 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 0.1030 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 0.0830 | 1 | 1 |
| Myc proto-oncogene protein | Homo sapiens (human) | IC50 | 14.0600 | 1 | 1 |
| NACHT, LRR and PYD domains-containing protein 1 isoform 1 | Homo sapiens (human) | IC50 | 19.5000 | 1 | 1 |
| neutrophil cytosol factor 1 | Homo sapiens (human) | IC50 | 0.3900 | 1 | 1 |
| nonstructural protein 1 | Influenza A virus (A/California/07/2009(H1N1)) | IC50 | 5.2530 | 1 | 2 |
| nuclear receptor corepressor 2 isoform 2 | Homo sapiens (human) | IC50 | 1.0250 | 1 | 1 |
| peroxisome proliferator-activated receptor gamma isoform 2 | Homo sapiens (human) | IC50 | 1.0250 | 1 | 1 |
| phospholipase A2, group III | Homo sapiens (human) | IC50 | 40.5870 | 1 | 1 |
| photoreceptor-specific nuclear receptor | Homo sapiens (human) | IC50 | 39.8410 | 1 | 2 |
| Prothrombin | Bos taurus (cattle) | Ki | 8.3700 | 1 | 1 |
| Proto-oncogene tyrosine-protein kinase Src | Homo sapiens (human) | IC50 | 30.9000 | 1 | 1 |
| rac GTPase-activating protein 1 isoform a | Homo sapiens (human) | IC50 | 15.5750 | 2 | 2 |
| receptor-interacting serine/threonine-protein kinase 2 isoform 1 | Homo sapiens (human) | IC50 | 10.8950 | 1 | 1 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | IC50 | 141.0000 | 1 | 1 |
| Retinal dehydrogenase 1 | Homo sapiens (human) | IC50 | 0.7600 | 2 | 2 |
| Retinal dehydrogenase 1 | Homo sapiens (human) | Ki | 1.0350 | 2 | 2 |
| Retinal dehydrogenase 2 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | IC50 | 51.5250 | 4 | 4 |
| rho GTPase-activating protein 1 | Homo sapiens (human) | IC50 | 22.0800 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | IC50 | 19.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | Ki | 18.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | IC50 | 18.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | Ki | 16.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 2B1 | Homo sapiens (human) | IC50 | 51.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 2B1 | Homo sapiens (human) | Ki | 20.0000 | 1 | 1 |
| Sorbitol dehydrogenase | Homo sapiens (human) | IC50 | 124.0000 | 1 | 1 |
| Telomerase reverse transcriptase | Homo sapiens (human) | IC50 | 12.2000 | 3 | 3 |
| Thioredoxin reductase 1, cytoplasmic | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| Thiosulfate sulfurtransferase | Homo sapiens (human) | IC50 | 54.3500 | 1 | 2 |
| toll-like receptor 9 | Homo sapiens (human) | IC50 | 8.4210 | 1 | 1 |
| Transthyretin | Homo sapiens (human) | IC50 | 11.0000 | 1 | 1 |
| Tyrosine-protein phosphatase 1 | Saccharomyces cerevisiae S288C | IC50 | 1.2000 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 1.3000 | 1 | 1 |
| Tyrosyl-DNA phosphodiesterase 1 | Homo sapiens (human) | IC50 | 0.0170 | 2 | 2 |
| Vesicular glutamate transporter 3 | Rattus norvegicus (Norway rat) | Ki | 0.0400 | 1 | 1 |
| XBP1 | Homo sapiens (human) | IC50 | 2.4000 | 1 | 1 |
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Albumin | Homo sapiens (human) | Kd | 2.5000 | 1 | 1 |
| Cell division protein FtsZ | Escherichia coli K-12 | Kd | 16.6000 | 1 | 1 |
| Cystathionine gamma-lyase | Homo sapiens (human) | Kd | 3.4000 | 1 | 1 |
| G-protein coupled receptor 55 | Homo sapiens (human) | EC50 | 0.5000 | 1 | 1 |
| Hsf1 protein | Mus musculus (house mouse) | EC50 | 260.0000 | 1 | 1 |
| Immunoglobulin lambda variable 6-57 | Homo sapiens (human) | EC50 | 5.6667 | 2 | 3 |
| karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b | Homo sapiens (human) | EC50 | 119.5000 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | EC50 | 0.3600 | 2 | 2 |
| NPYLR7B | Aedes aegypti (yellow fever mosquito) | EC50 | 4.8300 | 1 | 1 |
| POsterior Segregation | Caenorhabditis elegans | EC50 | 186.6810 | 1 | 1 |
| recombinase A | Mycobacterium tuberculosis H37Rv | EC50 | 78.6500 | 2 | 2 |
| regulator of G-protein signaling 16 | Homo sapiens (human) | EC50 | 6.6700 | 1 | 1 |
| regulator of G-protein signaling 19 | Homo sapiens (human) | EC50 | 30.0000 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | EC50 | 3.4100 | 1 | 1 |
| RGS7, partial | Homo sapiens (human) | EC50 | 30.0000 | 1 | 1 |
| Serine/threonine-protein kinase mTOR | Homo sapiens (human) | Kd | 130.0000 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | EC50 | 113.8860 | 1 | 1 |
| streptokinase A precursor | Streptococcus pyogenes M1 GAS | EC50 | 2.1540 | 1 | 1 |
| Tyrosine-protein kinase Lck | Homo sapiens (human) | Kd | 2.5000 | 1 | 1 |
| Zinc finger protein mex-5 | Caenorhabditis elegans | EC50 | 113.8860 | 1 | 1 |
Other Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Albumin | Bos taurus (cattle) | Kdiss | 2.9000 | 1 | 1 |
| aryl hydrocarbon receptor nuclear translocator | Homo sapiens (human) | AC50 | 0.7340 | 1 | 1 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Ki1 | 0.1100 | 1 | 1 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Ki2 | 3.4000 | 1 | 1 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | Kact | 4.5000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Rattus norvegicus (Norway rat) | Km | 3.7000 | 1 | 1 |
| Caspase 6, apoptosis-related cysteine peptidase | Homo sapiens (human) | AC50 | 1.6000 | 1 | 1 |
| CDK5 | Homo sapiens (human) | AC50 | 12.3230 | 1 | 1 |
| Cell death-related nuclease 4 | Caenorhabditis elegans | INH | 100.0000 | 1 | 1 |
| Cell division protein FtsZ | Escherichia coli K-12 | Km | 29.4000 | 1 | 1 |
| Cyclin-dependent kinase 5, regulatory subunit 1 (p35) | Homo sapiens (human) | AC50 | 12.3230 | 1 | 1 |
| Cystathionine gamma-lyase | Homo sapiens (human) | alphaKi | 4.2000 | 1 | 1 |
| Dihydrolipoyl dehydrogenase | Plasmodium falciparum (malaria parasite P. falciparum) | Km | 49.0000 | 1 | 1 |
| Dihydrolipoyl dehydrogenase, mitochondrial | Sus scrofa (pig) | Km | 28.0000 | 1 | 1 |
| DNA repair protein RAD52 homolog isoform a | Homo sapiens (human) | AC50 | 0.9360 | 1 | 1 |
| DNA topoisomerase 2-beta | Homo sapiens (human) | Ka | 0.2740 | 1 | 2 |
| FAD-linked sulfhydryl oxidase ALR | Homo sapiens (human) | AC50 | 0.5220 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | Kis | 453.0000 | 1 | 1 |
| Glutathione reductase, mitochondrial | Homo sapiens (human) | Km | 6.3000 | 1 | 1 |
| glycogen synthase kinase-3 alpha | Homo sapiens (human) | AC50 | 24.6100 | 1 | 1 |
| heat shock protein 90, putative | Plasmodium falciparum 3D7 | AC50 | 0.7350 | 1 | 1 |
| heat shock protein HSP 90-alpha isoform 2 | Homo sapiens (human) | AC50 | 0.5700 | 1 | 1 |
| histone-lysine N-methyltransferase NSD2 isoform 1 | Homo sapiens (human) | AC50 | 10.5050 | 1 | 2 |
| Hsf1 protein | Mus musculus (house mouse) | AbsAC40_uM | 26.0000 | 1 | 1 |
| kelch-like ECH-associated protein 1 | Homo sapiens (human) | AC50 | 2.8000 | 1 | 1 |
| kelch-like ECH-associated protein 1 | Homo sapiens (human) | Max_Activity_Concentration_uM | 1.6000 | 1 | 1 |
| Multidrug resistance-associated protein 1 | Homo sapiens (human) | Km | 97.3333 | 3 | 3 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | AC50 | 2.8000 | 1 | 1 |
| Nuclear factor NF-kappa-B p105 subunit | Homo sapiens (human) | Concentration | 100.0000 | 1 | 1 |
| protein AF-9 isoform a | Homo sapiens (human) | AC50 | 2.1165 | 1 | 2 |
| replicative DNA helicase | Mycobacterium tuberculosis H37Rv | AC50 | 58.1800 | 2 | 2 |
| Ribonuclease T | Escherichia coli K-12 | INH | 10.0000 | 1 | 1 |
| Thioredoxin reductase 1, cytoplasmic | Homo sapiens (human) | Km | 95.0000 | 1 | 1 |
| transforming acidic coiled-coil-containing protein 3 | Homo sapiens (human) | AC50 | 0.7340 | 1 | 1 |