Page last updated: 2024-08-05 15:15:33
antimanic drug
Antimanic drugs are agents used to treat bipolar disorders or mania associated with other affective disorders.
ChEBI ID: 35477
Members (6)
| Member | Definition | Class |
|---|---|---|
| carbamazepine | A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant. | carbamazepine |
| lamotrigine | A member of the class of 1,2,4-triazines in which the triazene skeleton is substituted by amino groups at positions 3 and 5, and by a 2,3-dichlorophenyl group at position 6. | lamotrigine |
| lithium carbonate | lithium carbonate | |
| lithium chloride | A metal chloride salt with a Li(+) counterion. | lithium chloride |
| valproate | A branched-chain saturated fatty acid anion that is the conjugate base of valproic acid. | valproate |
| valproic acid | A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem. | valproic acid |
Research
Studies (30,669)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 6,269 (20.44) | 18.7374 |
| 1990's | 5,491 (17.90) | 18.2507 |
| 2000's | 7,862 (25.64) | 29.6817 |
| 2010's | 8,499 (27.71) | 24.3611 |
| 2020's | 2,548 (8.31) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 3,324 (9.09%) | 5.53% |
| Reviews | 3,741 (10.23%) | 6.00% |
| Case Studies | 6,779 (18.54%) | 4.05% |
| Observational | 167 (0.46%) | 0.25% |
| Other | 22,544 (61.67%) | 84.16% |
Protein Targets (122)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 35.4002 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 5.4728 | 6 | 6 |
| arylsulfatase A | Homo sapiens (human) | Potency | 0.4775 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 0.1299 | 1 | 1 |
| Ataxin-2 | Homo sapiens (human) | Potency | 68.5896 | 1 | 1 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 8.4921 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 68.5896 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 89.1251 | 2 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 24.7883 | 2 | 3 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 6.3096 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 0.3162 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| Cholecystokinin receptor type A | Rattus norvegicus (Norway rat) | Potency | 710.0000 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 38.9018 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 2 | 2 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 23.5174 | 1 | 2 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 0.5255 | 1 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 21.2229 | 3 | 3 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 57.7308 | 3 | 4 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 2.1260 | 1 | 4 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 27.5199 | 4 | 5 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 41.5798 | 2 | 2 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 5.3233 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| GALC protein | Homo sapiens (human) | Potency | 0.7079 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gastrin/cholecystokinin type B receptor | Rattus norvegicus (Norway rat) | Potency | 710.0000 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 1.3366 | 2 | 4 |
| GLS protein | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 187.8544 | 5 | 5 |
| IDH1 | Homo sapiens (human) | Potency | 1.0323 | 1 | 1 |
| inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 708.9730 | 2 | 2 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 0.0040 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 36.1254 | 1 | 1 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 23.8445 | 2 | 3 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 1.2659 | 2 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 1,412.5400 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 30.8678 | 1 | 2 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 66.8242 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 54.2058 | 1 | 1 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 84.9214 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 794.3280 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 24.4712 | 1 | 3 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 44.8436 | 2 | 2 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 501.1870 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 0.2371 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 0.1887 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 39.0931 | 2 | 4 |
| TDP1 protein | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 17.2039 | 3 | 5 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 0.2794 | 2 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 14.7473 | 2 | 3 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Vpr | Human immunodeficiency virus 1 | Potency | 0.8913 | 1 | 1 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Aldo-keto reductase family 1 member A1 | Bos taurus (cattle) | IC50 | 57.4000 | 1 | 1 |
| Aldo-keto reductase family 1 member A1 | Homo sapiens (human) | IC50 | 50.1000 | 1 | 1 |
| Aldo-keto reductase family 1 member A1 | Rattus norvegicus (Norway rat) | IC50 | 53.1000 | 2 | 2 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 56.1000 | 5 | 5 |
| Aldo-keto reductase family 1 member B7 | Rattus norvegicus (Norway rat) | IC50 | 56.1000 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 711.0000 | 3 | 6 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 2 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Cocaine esterase | Homo sapiens (human) | Ki | 7,900.0000 | 1 | 1 |
| Cytochrome P450 2A6 | Homo sapiens (human) | Ki | 9,150.0000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Dihydrofolate reductase | Escherichia coli K-12 | IC50 | 348.9000 | 1 | 1 |
| Dihydrofolate reductase | Escherichia coli K-12 | Ki | 15.2400 | 1 | 1 |
| Glycogen synthase kinase-3 beta | Homo sapiens (human) | IC50 | 6.5300 | 1 | 1 |
| Histone deacetylase 1 | Homo sapiens (human) | IC50 | 1,262.6014 | 7 | 7 |
| Histone deacetylase 1 | Homo sapiens (human) | Ki | 564.0000 | 1 | 1 |
| Histone deacetylase 11 | Homo sapiens (human) | IC50 | 4,117.5000 | 2 | 2 |
| Histone deacetylase 11 | Homo sapiens (human) | Ki | 564.0000 | 1 | 1 |
| Histone deacetylase 2 | Homo sapiens (human) | IC50 | 1,819.9480 | 5 | 5 |
| Histone deacetylase 2 | Homo sapiens (human) | Ki | 564.0000 | 1 | 1 |
| Histone deacetylase 3 | Homo sapiens (human) | IC50 | 1,846.1340 | 5 | 5 |
| Histone deacetylase 3 | Homo sapiens (human) | Ki | 564.0000 | 1 | 1 |
| Histone deacetylase 4 | Homo sapiens (human) | IC50 | 2,808.7500 | 4 | 4 |
| Histone deacetylase 4 | Homo sapiens (human) | Ki | 564.0000 | 1 | 1 |
| Histone deacetylase 5 | Homo sapiens (human) | IC50 | 2,808.7500 | 4 | 4 |
| Histone deacetylase 5 | Homo sapiens (human) | Ki | 564.0000 | 1 | 1 |
| Histone deacetylase 6 | Homo sapiens (human) | IC50 | 2,290.0020 | 5 | 5 |
| Histone deacetylase 6 | Homo sapiens (human) | Ki | 564.0000 | 1 | 1 |
| Histone deacetylase 7 | Homo sapiens (human) | IC50 | 3,411.6667 | 3 | 3 |
| Histone deacetylase 7 | Homo sapiens (human) | Ki | 564.0000 | 1 | 1 |
| Histone deacetylase 8 | Homo sapiens (human) | IC50 | 2,130.5750 | 4 | 4 |
| Histone deacetylase 8 | Homo sapiens (human) | Ki | 564.0000 | 1 | 1 |
| Histone deacetylase 9 | Homo sapiens (human) | IC50 | 3,411.6667 | 3 | 3 |
| Histone deacetylase 9 | Homo sapiens (human) | Ki | 564.0000 | 1 | 1 |
| Liver carboxylesterase 1 | Homo sapiens (human) | Ki | 363.0000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| NAD-dependent protein deacylase sirtuin-5, mitochondrial | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| P2X purinoceptor 4 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Polyamine deacetylase HDAC10 | Homo sapiens (human) | IC50 | 4,117.5000 | 2 | 2 |
| Polyamine deacetylase HDAC10 | Homo sapiens (human) | Ki | 564.0000 | 1 | 1 |
| Potassium voltage-gated channel subfamily E member 1 | Homo sapiens (human) | IC50 | 158.4890 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 246.8570 | 5 | 5 |
| Potassium voltage-gated channel subfamily KQT member 1 | Homo sapiens (human) | IC50 | 158.4890 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | Ki | 10.0000 | 1 | 1 |
| Sodium channel protein type 1 subunit alpha | Rattus norvegicus (Norway rat) | IC50 | 116.3800 | 2 | 5 |
| Sodium channel protein type 10 subunit alpha | Homo sapiens (human) | IC50 | 97.0000 | 2 | 2 |
| Sodium channel protein type 2 subunit alpha | Homo sapiens (human) | IC50 | 42.3333 | 3 | 3 |
| Sodium channel protein type 2 subunit alpha | Rattus norvegicus (Norway rat) | IC50 | 93.1286 | 4 | 7 |
| Sodium channel protein type 3 subunit alpha | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| Sodium channel protein type 3 subunit alpha | Rattus norvegicus (Norway rat) | IC50 | 116.3800 | 2 | 5 |
| Sodium channel protein type 4 subunit alpha | Homo sapiens (human) | Ki | 34.5000 | 1 | 2 |
| Sodium channel protein type 5 subunit alpha | Homo sapiens (human) | IC50 | 67.2702 | 3 | 3 |
| Sodium channel protein type 9 subunit alpha | Homo sapiens (human) | IC50 | 19.5000 | 2 | 2 |
| Sodium channel protein type 9 subunit alpha | Homo sapiens (human) | Ki | 32.7000 | 1 | 1 |
| Tissue factor | Homo sapiens (human) | IC50 | 1,750.0000 | 2 | 2 |
| UDP-glucuronosyltransferase 2B7 | Homo sapiens (human) | Ki | 1,600.0000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens (human) | IC50 | 1,421.9100 | 2 | 2 |
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Albumin | Rattus norvegicus (Norway rat) | Kd | 103.0000 | 1 | 1 |
| Cytochrome P450 2B6 | Homo sapiens (human) | EC50 | 145.0000 | 1 | 1 |
| Frizzled-8 | Mus musculus (house mouse) | Kd | 16.8000 | 1 | 1 |
| Glycogen synthase kinase-3 beta | Homo sapiens (human) | EC50 | 3,000.0000 | 1 | 1 |
| Major prion protein | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
Other Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Sodium channel protein type 4 subunit alpha | Homo sapiens (human) | Kr | 1,080.0000 | 2 | 2 |
| UDP-glucuronosyltransferase 1-6 | Homo sapiens (human) | Km | 3,200.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 1A9 | Homo sapiens (human) | Km | 5,200.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 2B7 | Homo sapiens (human) | Km | 1,157.0000 | 1 | 2 |