Excessive URIC ACID or urate in blood as defined by its solubility in plasma at 37 degrees C; greater than 0.42mmol per liter (7.0mg/dL) in men or 0.36mmol per liter (6.0mg/dL) in women. This condition is caused by overproduction of uric acid or impaired renal clearance. Hyperuricemia can be acquired, drug-induced or genetically determined (LESCH-NYHAN SYNDROME). It is associated with HYPERTENSION and GOUT.
| Excerpt | Reference |
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| "Hypertension and hyperuricemia are common, especially in males, the former encountered more frequently in advanced chronic renal failure (CRF)." | ( Christofides, T; Deltas, CC; Hildebrandt, F; Koptides, M; Kyriacou, K; Patsias, C; Pierides, A; Psara, E; Stavrou, C; Tombazos, C; Zouvani, I, 2002) |
| "Hyperuricemia is associated with renal disease, but it is usually considered a marker of renal dysfunction rather than a risk factor for progression." | ( Feng, L; Han, L; Harris, R; Johnson, RJ; Kang, DH; Mazzali, M; Nakagawa, T; Truong, L; Watanabe, S, 2002) |
| "Hyperuricemia is associated with hypertension, vascular disease, renal disease, and cardiovascular events." | ( Feig, D; Herrera-Acosta, J; Johnson, RJ; Kanellis, J; Kang, DH; Kivlighn, S; Mazzali, M; Rodriguez-Iturbe, B; Tuttle, KR; Watanabe, S, 2003) |
| "Since hyperuricemia is associated with obesity, renal disease, hyperlipidemia, and atherosclerosis, whether or not serum urate is a cardiovascular risk factor per se has remained elusive." | ( Alvur, M; Arik, N; Bedir, A; Tanyeri, F; Topbas, M, 2003) |
| "Hyperuricemia is part of the "metabolic syndrome"." | ( Debatin, KM; Denzer, C; Heinze, E; Mayer, H; Muche, R; Wabitsch, M, 2003) |
| "Underexcretory hyperuricemia is strongly related to hypertensive organ damage and this relationship does not seem to be mediated by a decreased renal function." | ( Campo, C; Garcia-Puig, J; García-Robles, R; Rodicio, JL; Ruilope, LM; Segura, J, 2003) |
| "The hyperuricemia is believed to result primarily from the decreased renal excretion that occurs as a consequence of the pre-eclampsia, and as such is widely viewed as a marker for pre-eclampsia as opposed to having a role in the pathogenesis." | ( Finch, J; Granger, J; Johnson, RJ; Kanellis, J; Kang, DH; Karumanchi, SA; Nakagawa, T, 2004) |
| "Hyperuricemia is associated with multiple risk factor syndrome." | ( Fujimori, S, 2004) |
| "Experimental hyperuricemia is marked by an activated intrarenal renin-angiotensin system (RAS)." | ( Brown, NJ; Fisher, ND; Gumieniak, O; Hollenberg, NK; Hopkins, PN; Murphey, LJ; Perlstein, TS; Williams, GH, 2004) |
| "Hyperuricemia is the hallmark of severe gout with tophi formation." | ( Frey, FJ; Gugger, M; Vogt, B, 2004) |
| "One likely cause of hyperuricemia is the destruction of nucleated RBC precursors by autoantibodies." | ( Jastaniah, WA; Pritchard, SL; Wadsworth, LD; Wu, JK, 2004) |
| "Although hyperuricemia is a major risk factor for the development of gout, acute gouty arthritis can occur in the presence of normal serum UA levels." | ( Peronato, G, 2005) |
| "Hyperuricemia is also a well-known side effect of cyclosporine A, the reference drug for the prevention of post-BMT GVHD, which may affect uric acid turnover by reducing glomerular filtration and/or affecting tubular handling; the available evidence favors the former explanation." | ( Annaloro, C; Deliliers, GL, 2005) |
| "Hyperuricemia is a common problem among renal transplant recipients." | ( Caruso, M; Codreanu, I; Perico, N; Remuzzi, G, 2005) |
| "Hyperuricemia is a common complication in organ transplant recipients, and frequently is associated with chronic cyclosporine immunosuppressive therapy." | ( Mazzali, M, 2005) |
| "Hyperuricemia is associated with cardiovascular risk." | ( Fu, Y; Katsuya, T; Masuo, K; Ogihara, T; Rakugi, H; Tuck, ML, 2005) |
| "Hyperuricemia is associated with a number of pathological conditions such as gout." | ( Cheng, CH; Fong, WP; Yu, Z, 2006) |
| "Hyperuricemia is a common disease in elderly people and more attention should be paid to the closer relations among hyperuricemia with hyperlipaemia, high blood sugar and hypertension among the elderly." | ( Liu, BL; Lu, JB; Yang, YB; Yu, JW; Yu, SY; Zhang, XJ, 2005) |
| "Although hyperuricemia is a well-known adverse effect of cyclosporine (CsA) treatment, there are contradictory data regarding the effect of tacrolimus on uric acid levels." | ( Akcay, A; Arat, Z; Haberal, M; Huddam, B; Kanbay, M; Ozdemir, FN; Usluogullari, CA, 2005) |
| "Hyperuricemia is a lifestyle-related disease." | ( Inaba, T; Kobayashi, E; Nogawa, K; Oishi, M; Suwazono, Y; Uetani, M, 2006) |
| "Hyperuricemia is associated strongly with the development of hypertension, renal disease, and progression." | ( Kwan, TH; Leung, KT; Siu, YP; Tong, MK, 2006) |
| "Hyperuricemia is described as an increased concentration of uric acid in blood." | ( Chizyński, K; Rózycka, M, 2005) |
| "Asymptomatic hyperuricemia is clearly associated with hypertension, chronic kidney disease, cardiovascular disease, and the insulin resistance syndrome, and the pathogenetic significance of these associations is under intensive study." | ( Becker, MA; Ellman, MH, 2006) |
| "Hyperuricemia is commonly associated with obesity, glucose intolerance, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease." | ( Chan, WL; Ho, LT; Hsiao, LC; Hwu, CM; Lin, MW; Liou, TL; Tsai, TT, 2006) |
| "Hyperuricemia is considered a feature of the metabolic syndrome (MS) despite serum uric acid (SUA) is not considered a diagnostic criterion." | ( Bascuñana-Quirell, A; Benítez-Rodríguez, E; Elvira-González, J; Escribano-Serrano, J; López-Suárez, A; Michán-Doña, A; Rosal-Obrador, J, 2006) |
| "Hyperuricemia is a frequent finding in diseases in which the clinical manifestations are thought to be secondary to a state of generalized vascular endothelial dysfunction and related to the cardiovascular disease present in conditions associated with the metabolic syndrome, such as hypertension or diabetes." | ( Corry, DB; Tuck, ML, 2006) |
| "Hyperuricemia is postulated to be a risk factor for atherosclerotic diseases, although whether it is independent of classical atherogenic risk factors is controversial." | ( Hashimoto, H; Ishizaka, N; Ishizaka, Y; Nagai, R; Toda, E; Yamakado, M, 2007) |
| "Hyperuricemia is commonly associated with traditional risk factors such as abnormalities in glucose metabolism, dyslipidemia, and hypertension." | ( Leoncini, G; Pontremoli, R; Ratto, E; Viazzi, F, 2006) |
| "Hyperuricemia is one of the risk factors for cardiovascular disease." | ( Honmyo, R; Ishikawa, M; Kokaze, A; Masuda, Y; Matsunaga, N; Satoh, M; Takashima, Y; Teruya, K; Uchida, Y; Yorimitsu, M; Yoshida, M, 2006) |
| "Hyperuricemia is common after renal and cardiac transplantations, but it is rarely reported after liver transplantations." | ( Arikan, C; Aydogdu, S; Kilic, M; Tumgor, G, 2006) |
| "We conclude that hyperuricemia is common among pediatric renal transplant recipients and rather a consequence of chronic renal transplant dysfunction than the use of calcineurin inhibitors." | ( Kemper, MJ; Neuhaus, TJ; Spartà, G, 2006) |
| "Hyperuricemia is prevalent among Thai men and women receiving routine health exams." | ( Dhanamun, B; Lohsoonthorn, V; Williams, MA, 2006) |
| "Hyperuricemia is a common feature in patients with chronic kidney disease (CKD)." | ( Axelsson, J; Bárány, P; Carrero, JJ; García-López, E; Heimbürger, O; Johnson, RJ; Lindholm, B; Molinaei, H; Qureshi, AR; Stenvinkel, P; Suliman, ME, 2006) |
| "Marked hyperuricemia is known to cause acute renal failure via intrarenal crystal deposition." | ( Croker, B; Ejaz, AA; Johnson, RJ; Mu, W; Ouyang, X; Reungjui, S; Roncal, CA; Tabah-Fisch, I, 2007) |
| "Hyperuricemia is a feature of several pathologies and requires an appropriate and often early treatment, owing to the severe consequences that it may cause." | ( Cammalleri, L; Malaguarnera, M, 2007) |
| "Hyperuricemia is a common complication in renal transplant recipients, and uric acid (UA) may play a role in renal dysfunction." | ( Akgul, A; Arat, Z; Bilgic, A; Haberal, M; Ibis, A; Ozdemir, FN, 2007) |
| "Although mild hyperuricemia is common in patients with renal disease, it has usually been considered a marker of reduced nephron mass rather than a risk factor for progression of kidney disease." | ( el-Sheikh, AR; Talaat, KM, 2007) |
| "Hyperuricemia is defined as >or=7 mg/dl (in men) or >or=6." | ( Chen, JH; Chen, LQ; Chen, LY; Chen, ZW; Dai, HL; Fang, LZ; Ren, JJ; Zhu, WH, 2007) |
| "Hyperuricemia is prevalent among Chinese population." | ( Chen, JH; Chen, LQ; Chen, LY; Chen, ZW; Dai, HL; Fang, LZ; Ren, JJ; Zhu, WH, 2007) |
| "Hyperuricemia is often found in patients with chronic heart failure (CHF)." | ( Duan, X; Ling, F, 2008) |
| "Hyperuricemia is associated with hypertension, vascular disease and cardiovascular (CV) disease." | ( Caliskan, M; Erdogan, D; Gullu, H; Muderrisoglu, H; Ozer, I; Yildirim, I; Yildirir, A, 2007) |
| "Hyperuricemia is known to be associated with various metabolic abnormalities of the metabolic syndrome, but its precise contribution is not well defined." | ( Choi, SJ; Ji, JD; Lee, YH; Rho, YH; Song, GG; Woo, JH, 2008) |
| "Hyperuricemia is a common finding in preeclamptic pregnancies evident from early pregnancy." | ( Bainbridge, SA; Roberts, JM, 2008) |
| "Hyperuricemia is present in approximately 5% of the population." | ( Markel, A; Rimbroth, S; Rozenman, D; Shalom, R, 2008) |
| "Idiopathic hyperuricemia is generally defined as hyperuricemia caused by unknown origin." | ( Hisatome, I; Igawa, O; Mizuta, E, 2008) |
| "Hyperuricemia is also thought as a one of the complications of metabolic syndrome." | ( Tomita, K; Yamasaki, T, 2008) |
| "Hyperuricemia is a risk factor associated with cardiovascular and renal disease." | ( Boni, P; Guardigli, M; Mandreoli, M; Ramazzotti, E; Roda, A; Santoro, A; Sestigiani, E, 2008) |
| "Moreover, hyperuricemia is significantly correlated with hypertriglyceridemia, hypertension, and visceral obesity." | ( Bandarian, F; Ebrahimpour, P; Fakhrzadeh, H; Heshmat, R; Larijani, B, 2008) |
| "Hyperuricemia is a common feature in adult liver transplant recipients but there is limited information in children." | ( Boillot, O; Cochat, P; Dubourg, L; Fargue, S; Hadj-Aïssa, A; Harambat, J; Lachaux, A; Ranchin, B; Rivet, C, 2008) |
| "Hyperuricemia is associated with primary hypertension (HTN) in adults and children." | ( Alpert, BS; Jones, DP; Li, R; Richey, PA, 2008) |
| "Hyperuricemia is associated with renal insufficiency and may predispose to Na retention and hypertension." | ( Eräranta, A; Kööbi, P; Kurra, V; Lakkisto, P; Mustonen, JT; Niemelä, OJ; Pörsti, IH; Tahvanainen, AM; Tikkanen, I; Vehmas, TI, 2008) |
| "Moreover, hyperuricemia is likely a risk factor for the development of diabetes mellitus." | ( Chen, X; Chen, Y; Hu, J; Li, C; Miao, Z; Song, W; Sun, R; Wang, CY; Wang, F; Wang, Y; Wang, Z; Xu, F; Yan, S; Zhao, S, 2008) |
| "Hyperuricemia is a significant factor in a variety of diseases, including gout and cardiovascular diseases." | ( Anzai, N; Babu, E; Endou, H; Hisatome, I; Ichida, K; Jin, CJ; Jutabha, P; Kimura, T; Kitamura, K; Sakurai, H; Srivastava, S, 2008) |
| "Hyperuricemia is a predictor for the development of hypertension and is commonly present in new-onset essential hypertension." | ( Feig, DI; Johnson, RJ; Soletsky, B, 2008) |
| "Hyperuricemia is a rare finding in children." | ( Dusek, J; Groene, HJ; Janda, J; John, U; Misselwitz, J; Pohl, M; Seeman, T; Stejskal, J; Vondrák, K, 2008) |
| "Hyperuricemia is significantly predicted by anthropometric measure of SFT which is a simple clinical screening method along with creatinine levels." | ( Akar, S; Akkoc, N; Birlik, M; Gurler, O; Onen, F; Pakoz, B; Sari, I; Sisman, AR, 2009) |
| "Hyperuricemia is present in about 5% of the population, and allopurinol is frequently used to treat it." | ( Brugnano, R; Fagugli, RM; Ferrara, G; Gentile, G, 2008) |
| "Hyperuricemia is associated with incident HF in community-dwelling older adults." | ( Aban, I; Ahmed, A; Anker, SD; Arnett, D; Bakris, G; Dell'Italia, LJ; Ekundayo, OJ; Filippatos, G; Lloyd-Jones, DM; Love, TE; Mujib, M; Sanders, PW, 2010) |
| "Hyperuricemia is associated with hypertension, metabolic syndrome, preeclampsia, cardio-vascular disease and renal disease, all conditions associated with oxidative stress." | ( Angerhofer, A; Gersch, C; Henderson, GN; Imaram, W; Johnson, RJ; Karumanchi, SA; Kim, KM; Palii, SP, 2009) |
| "Hyperuricemia is a prevalent condition in chronic heart failure (CHF), describing increased oxidative stress and inflammation." | ( Alimonda, AL; Bodí, V; Darmofal, H; Husser, O; Llácer, A; Mainar, L; Merlos, P; Miñana, G; Núñez, E; Núñez, J; Robles, R; Sanchis, J, 2009) |
| "Hyperuricemia is common after kidney transplantation." | ( Bandukwala, F; Huang, M; Nash, MM; Prasad, GV; Zaltzman, JS, 2009) |
| "Hyperuricemia is prevalent in patients with chronic kidney disease (CKD); however, data are limited about the relationship of uric acid levels with long-term outcomes in this patient population." | ( Beck, GJ; Collins, AJ; Greene, T; Kusek, JW; Levey, AS; Madero, M; Menon, V; Sarnak, MJ; Wang, X, 2009) |
| "Hyperuricemia is defined by cut-off values of > 420 mumol/L for men and > 360 mumol/L for women." | ( Cai, Z; Li, D; Wu, X; Xu, X; Zhou, C, 2009) |
| "Hyperuricemia is prevalent in the Taiwan population." | ( Chen, HW; Chen, YM; Chuang, FH; Kuo, CF; Li, HY; See, LC; Yu, KH, 2009) |
| "Hyperuricemia is a common finding in hypertensive patients, especially among those who are on diuretic therapy." | ( Batista, MC; Borges, RL; Hirota, AH; Quinto, BM; Ribeiro, AB; Zanella, MT, 2009) |
| "In summary, hyperuricemia is common in RTR, but was not related to BP." | ( Bandukwala, F; Huang, M; Prasad, GV, 2009) |
| "Hyperuricemia is associated with the metabolic syndrome, gout, renal and cardiovascular disease (CVD)." | ( Almasy, L; Best, LG; Cole, SA; Comuzzie, AG; Devereux, RB; Fabsitz, RR; Franceschini, N; Göring, HH; Haack, K; Howard, BV; Laston, S; Lee, ET; MacCluer, JW; Mottl, A; Umans, JG; Voruganti, VS, 2009) |
| "First-trimester hyperuricemia is associated with an increased risk of developing GDM, independent of body mass index." | ( Catov, J; Gandley, RE; Laughon, SK; Provins, T; Roberts, JM, 2009) |
| "Hyperuricemia is common in renal transplant recipients treated with calcineurin inhibitors." | ( Boratynska, M; Karbowska, A; Klinger, M; Kusztal, M, 2009) |
| "In conclusion, hyperuricemia is associated with hypertension in a Chinese population at a high risk of hypertension." | ( Li, L; Lu, H; Lu, ZH; Lu, ZS; Wang, JA; Yan, SG; You, W, 2009) |
| "Hyperuricemia is a novel, independent risk factor for heart failure in a group of young general community dwellers." | ( Krishnan, E, 2009) |
| "Hyperuricemia is common in chronic heart failure (CHF), and it is a strong independent marker of prognosis." | ( Anker, SD; Doehner, W; Furuse, Y; Hisatome, I; Igawa, O; Ishida, K; Kato, M; Kinugasa, Y; Kinugawa, T; Ogino, K; Osaki, S; Shigemasa, C, 2010) |
| "The prevalence of hyperuricemia is low in Uygurs, who have a high prevalence of cardiovascular risk factors such as hypertension, overweight-obesity, dyslipidemia, hyperglycemia, and insulin resistance (IR)." | ( Hong, J; Li, NF; Wang, HM; Yang, J; Yao, XG; Zhou, L, 2009) |
| "Hyperuricemia is considered to be a risk factor of not only gout but also renal and cardiovascular diseases, thus, it is important to use CCBs without adverse effect on uric acid metabolisms." | ( Hamada, T; Hisatome, I; Igawa, O; Mizuta, E; Shigemasa, C, 2010) |
| "Hyperuricemia is associated with metabolic syndrome and has emerged as a marker for both type 2 diabetes and cardiovascular disease." | ( Cai, Q; Elasy, T; Fazio, S; Li, H; Linton, M; Shu, XO; Villegas, R; Xiang, YB; Zheng, W, 2010) |
| "Asymptomatic hyperuricemia is not associated with suppressed neutrophil function." | ( Grainger, R; Harper, JL; Harrison, A; Martin, WJ, 2010) |
| "Hyperuricemia is an independent risk factor for CKD in middle-aged and elderly Taiwanese adults." | ( Chang, HH; Chang, HY; Chao, YS; Chen, CY; Fang, KY; Hsu, YC; Jong, MC; Lee, PH; Lei, CC; Lin, CL; Lu, LC; Shih, YH; Tung, CW; Yang, HF, 2010) |
| "Hyperuricemia is a prevalent finding in patients presenting metabolic syndrome, although its clinical meaning is still controversial and often underestimated." | ( Batista, MC; Borges, RL; Ribeiro, AB; Zanella, MT, 2010) |
| "Hyperuricemia is associated with renal disease, and recent studies have reported that mild hyperuricemia results in hypertension, intrarenal vascular disease, and renal injury." | ( Junwei, Y; Lei, J; Li, F; Mingxia, X; Ping, W; Ruoyun, T; Weichun, H; Xiaohua, W; Yang, Z, 2010) |
| "Hyperuricemia is associated with cardiovascular and renal diseases, as glomerulosclerosis." | ( Borges, FT; Convento, MS; Dalboni, MA; Pessoa, E; Schor, N, 2011) |
| "Hyperuricemia is associated with hypertension, inflammation, renal disease progression, and cardiovascular disease." | ( Ampuero, J; Arroyo, D; de Vinuesa, SG; Goicoechea, M; Luño, J; Rincón, A; Ruiz-Caro, C; Verdalles, U, 2010) |
| "Hyperuricemia is associated with worse outcomes of patients with chronic heart failure (HF)." | ( Furumoto, T; Goto, D; Goto, K; Hamaguchi, S; Kinugawa, S; Takeshita, A; Tsuchihashi-Makaya, M; Tsutsui, H; Yokoshiki, H; Yokota, T, 2011) |
| "Early-onset hyperuricemia is a significant predictor of cardiovascular complications and graft survival independently of graft function." | ( Choi, BS; Chung, BH; Hwang, HS; Kang, SH; Kim, JI; Kim, YS; Moon, IS; Park, CW; Yang, CW, 2011) |
| "Hyperuricemia is thought to be associated with an increased risk of hypertension, impaired renal function and cardiovascular disease." | ( Chang, SC; Chen, KF; Chi, WC; Hung, YJ; Lee, DY; Lee, WL; Lin, CS, 2012) |
| "In conclusion, hyperuricemia is associated with increased risk of myocardial infarction and sudden cardiac death in patients with MS." | ( Behar, S; Boyko, V; Brodov, Y; Chouraqui, P, 2010) |
| "INTRODUCTION." | ( Bonakdaran, S; Hami, M; Shakeri, MT, 2011) |
| "Hyperuricemia is an elevated uric acid level in blood." | ( Aronow, WS; Ash, JY; Chilappa, CS; Patel, U; Shapiro, D; Sperber, K, 2010) |
| "Hyperuricemia is strongly associated with obesity and metabolic syndrome and can predict visceral obesity and insulin resistance." | ( Baldwin, W; Baylis, C; Johnson, RJ; Marek, G; McRae, S; Pannu, V; Sautin, YY; Wymer, D, 2011) |
| "Hyperuricemia is a common complication after kidney transplantation, and may adversely affect graft survival." | ( Einollahi, B; Hossieni, MS; Kalantar, E; Khalili, N; Rostami, Z, 2011) |
| "Hyperuricemia is a common complication after kidney transplantation, and renal allograft insufficiency predisposes to higher uric acid concentration." | ( Einollahi, B; Hossieni, MS; Kalantar, E; Khalili, N; Rostami, Z, 2011) |
| "The definition of hyperuricemia is currently arbitrary." | ( Covic, A; Goldsmith, D; Riegersperger, M, 2011) |
| "Hyperuricemia is associated with cardiovascular disease, but it is usually considered a marker rather than a risk factor." | ( Chen, CC; Hsu, YJ; Lee, TM, 2011) |
| "Development of hyperuricemia is associated with excessive body mass, insulin resistance, metabolic syndrome, overuse of diuretics, elderly age, and abnormal renal function." | ( Bart, BIa; Brodskiĭ, MS; Larina, VN, 2011) |
| "Hyperuricemia is a recognized risk factor for cardiovascular disease." | ( Chuang, SY; Hsieh, YT; Lee, SC; Pan, WH, 2011) |
| "Hyperuricemia is a specific risk factor for cardiovascular morbidity and mortality." | ( Hurtes, X; Meria, P, 2011) |
| "Hyperuricemia is common in patients with chronic kidney disease (CKD)." | ( Dukes, J; Hinyard, LJ; Lentine, KL; Neri, L; Pinsky, B; Rocca Rey, LA; Schnitzler, MA; Xiao, H, 2011) |
| "In NAFLD patients, hyperuricemia is independently associated with the severity of liver damage, representing, in this setting of patients, together with insulin resistance, a potential new therapeutic target in future intervention trials." | ( Cabibi, D; Cammà, C; Craxì, A; Di Marco, V; Petta, S, 2011) |
| "Hyperuricemia is a risk factor for CKD in Taiwan, future studies are still necessary to determine whether hypouricemia increases the risk of CKD." | ( Li, L; Shu, Z; Tao, Q; Wang, S; Yu, C; Zhan, S, 2011) |
| "Hyperuricemia is associated with hypertension, coronary artery disease, and chronic kidney disease." | ( Arrington, CJ; Karaboyas, A; Kleophas, W; Latif, W; Levin, NW; Marshall, MR; Pisoni, RL; Robinson, BM; Saran, R; Sen, A; Tong, L; Winchester, JF, 2011) |
| "Hyperuricemia is considered as a risk factor for the development of renal dysfunction." | ( Hu, QH; Jiao, RQ; Kong, LD; Wang, X; Zhang, X, 2012) |
| "Hyperuricemia is a common complication in organ transplant recipients, with a higher incidence in kidney and heart recipients." | ( Mazali, FC; Mazzali, M, 2011) |
| "Hyperuricemia is an independent risk factor for renal progression in IgA nephropathy (IgAN)." | ( Chen, W; Jalal, D; Johnson, RJ; Li, Z; Mao, H; Shi, Y; Yang, Q; Yu, X, 2012) |
| "Hyperuricemia is associated with increased risk for coronary heart disease (CHD) and/or mortality; however, it is unknown if serum urate (sUA) levels predict outcomes in patients with previous MI." | ( Dabbous, O; Hariri, A; Krishnan, E; Lingala, B; Pandya, BJ, 2012) |
| "Hyperuricemia is particularly common in patients with arterial hypertension, metabolic syndrome, or kidney disease." | ( Filiopoulos, V; Hadjiyannakos, D; Vlassopoulos, D, 2012) |
| "Hyperuricemia is an independent risk factor for mortality, cardiovascular disease, and renal disease in general population." | ( Chang, JM; Chen, HC; Chen, SC; Chiu, YW; Hung, CC; Hwang, SJ; Kuo, MC; Lin, MY; Liu, WC; Yeh, SM, 2012) |
| "In stages 3-5 CKD, hyperuricemia is a risk factor for all-cause mortality and cardiovascular events but not renal replacement therapy and rapid renal progression." | ( Chang, JM; Chen, HC; Chen, SC; Chiu, YW; Hung, CC; Hwang, SJ; Kuo, MC; Lin, MY; Liu, WC; Yeh, SM, 2012) |
| "While asymptomatic hyperuricemia is currently not considered to be an indication for urate lowering therapy, there is growing evidence indicating a linear relationship between pharmacological reduction in serum uric acid and incidence of cardiovascular and renal events." | ( Leoncini, G; Pontremoli, R; Viazzi, F, 2012) |
| "Hyperuricemia is an independent predictor for early atherosclerosis in hypertensive subjects with normal renal function." | ( Bahadir, E; Citil, R; Deger, SM; Durmaz, AO; Mutluay, R; Sindel, S, 2012) |
| "Although hyperuricemia is suggested to increase allantoin production in both pro- and antioxidant manners, it remains undetermined whether it increases the serum concentration of allantoin." | ( Koga, M; Koyama, H; Kurajoh, M; Moriwaki, Y; Shoji, T; Sumida, C; Tsutsumi, Z; Yamamoto, A; Yamamoto, T, 2012) |
| "Hyperuricemia is linked to gout and features of metabolic syndrome." | ( Beyene, J; Carleton, AJ; Chiavaroli, L; Cozma, AI; de Souza, RJ; Di Buono, M; Ha, V; Jenkins, AL; Jenkins, DJ; Kendall, CW; Leiter, LA; Mirrahimi, A; Sievenpiper, JL; Wang, DD; Wolever, TM; Yu, ME, 2012) |
| "Hyperuricemia is known to be associated with obesity and metabolic syndrome." | ( Bhasker, AG; Lakdawala, M; Remedios, C; Shah, M, 2012) |
| "Hyperuricemia is the greatest risk factor for gout and is caused by an overproduction and/or inefficient renal clearance of urate." | ( Day, RO; Graham, GG; Indraratna, PL; Jones, G; Kannangara, DR; Portek, I; Ramasamy, SN; Stocker, SL; Williams, KM, 2012) |
| "Hyperuricemia is a common complication after kidney transplantation that may adversely affect graft survival." | ( Almeida, M; Cabrita, A; Dias, L; Fonseca, I; Henriques, AC; Malheiro, J; Martins, LS; Pedroso, S, 2012) |
| "In addition, hyperuricemia is largely prevalent in patients with CKD." | ( Chen, W; Chonchol, M; Jalal, DI; Targher, G, 2013) |
| "Hyperuricemia is seen when kidney function declines." | ( Fried, LF; Nashar, K, 2012) |
| "Hyperuricemia is commonly associated with traditional risk factors such as dysglicemia, dyslipidemia, central obesity and abnormal blood pressure, i." | ( Cheli, P; Del Pinto, R; Desideri, G; Di Giosia, P; Ferri, C; Ferri, L; Grassi, D; Properzi, G, 2013) |
| "Hyperuricemia is a risk factor for end-stage renal disease." | ( Ichikawa, K; Ikeda, A; Kato, T; Kayama, T; Konta, T; Kubota, I; Kudo, K; Sato, H; Suzuki, K; Ueno, Y, 2013) |
| "Hyperuricemia is closely associated with obesity and metabolic abnormalities, which is also an independent risk factor for cardiovascular diseases." | ( Chen, HH; Hsu, CT; Lee, MF; Lee, WJ; Liou, TH; Pan, WH; Wang, W; Wu, SF, 2013) |
| "Hyperuricemia is common in those subjects and might be considered a potential clinical parameter in the definition of MetS." | ( Cohen, E; Fraser, A; Garty, M; Goldberg, E; Krause, I, 2012) |
| "Hyperuricemia is a risk factor for contrast-induced acute kidney injury in patients with chronic kidney disease." | ( Chen, J; Chen, L; Chen, S; Chen, Z; Li, L; Liu, Y; Tan, N; Zhou, Y, 2013) |
| "Hyperuricemia is defined as a serum uric acid level>7 mg/ dL in males and >6 mg/dL in females." | ( Chen, J; Chen, L; Chen, S; Chen, Z; Li, L; Liu, Y; Tan, N; Zhou, Y, 2013) |
| "Hyperuricemia is known to be a risk factor for incident type 2 diabetes mellitus, but the absolute magnitude of the association is not known." | ( Akhras, KS; Krishnan, E; Liu, J; Marynchenko, M; Sharma, H; Shi, L; Tawk, R; Wu, EQ, 2013) |
| "Hyperuricemia is now regarded as a risk factor for cardiovascular disease." | ( Chang, HY; Hsu, YC; Huang, TJ; Lee, PH; Lei, CC; Lin, CL; Lu, LC; Tung, CW, 2013) |
| "Hyperuricemia is significantly associated with micro-albuminuria in middle-aged and elderly males and females from a general population in Taiwan." | ( Chang, HY; Hsu, YC; Huang, TJ; Lee, PH; Lei, CC; Lin, CL; Lu, LC; Tung, CW, 2013) |
| "Hyperuricemia is considered to be a component of cardiovascular continuum, risk factor of chronic heart failure and marker of its unfavourable outcome." | ( Bart, BIa; Donskov, AS; Larin, VG; Larina, VN, 2013) |
| "Hyperuricemia is related to a variety of pathologies, including chronic kidney disease (CKD)." | ( Dankers, AC; Dijkman, HB; Hoenderop, JG; Masereeuw, R; Mutsaers, HA; Russel, FG; Sweep, FC; van den Heuvel, LP, 2013) |
| "Hyperuricemia is common in chronic kidney disease (CKD), but data regarding the relationship between serum uric acid levels and the long-term outcomes of CKD patients have been limited." | ( Miyaoka, T; Mochizuki, T; Nitta, K; Takei, T; Tsuchiya, K, 2014) |
| "Hyperuricemia is associated with the presence and severity of obstructive sleep apnea (OSA)." | ( Prudon, B; Roddy, E; Stradling, JR; West, SD, 2013) |
| "Hyperuricemia is increasing in prevalence and this is paralleled by an increased incidence of acute gout." | ( Hasegawa, K; Hiramitsu, S; Ishiguro, Y; Ishii, J; Kani, A; Kato, H; Kato, K; Kato, Y; Kimura, H; Matsubara, S; Matsubara, Y; Matsuyama, H; Mori, K; Noba, M; Shino, K; Tokuda, M; Uchiyama, T; Uemura, A; Yamada, K; Yoshida, S, 2014) |
| "Hyperuricemia is a common finding in psoriatic patients." | ( Cagalli, A; Girolomoni, G; Gisondi, P; Targher, G, 2014) |
| "Hyperuricemia is common among chronic kidney disease (CKD) patients." | ( de Vinuesa, MS; Goicoechea, M; Luño, J; Macías, N; Verdalles, U, 2013) |
| "While hyperuricemia is a clear risk factor for gout, local factors have been hypothesized to play a role in crystal formation, such as temperature, pH, mechanical stress, cartilage components, and other synovial and serum factors." | ( Crittenden, DB; Martillo, MA; Nazzal, L, 2014) |
| "Hyperuricemia is a risk factor for the onset of chronic kidney disease (CKD) and is significantly associated with the progression of CKD." | ( Hayakawa, H; Hosoya, T; Iimuro, S; Imai, N; Inaba, M; Itoh, S; Kimura, K; Kuwabara, M; Makino, H; Matsuo, S; Ohno, I; Shibagaki, Y; Tomino, Y; Uchida, S; Yamamoto, T, 2014) |
| "We found that hyperuricemia is an independent risk factor for the development of CKD." | ( Ishizaka, Y; Tani, M; Toda, A; Yamakado, M, 2014) |
| "Hyperuricemia is a common finding in patients with NAFLD and is independently associated with early histological findings in this clinically relevant condition." | ( Celebi, G; Dogru, T; Ercin, CN; Genc, H; Gurel, H; Kara, M; Kayadibi, H; Sertoglu, E, 2014) |
| "Hyperuricemia is a recognized risk factor for cardiovascular diseases." | ( Chen, YM; Ho, CS; Liu, ZM; Woo, J, 2015) |
| "Mild hyperuricemia is a strong, independent marker of MS and high cardio-renal risk profile in hypertensive patients under specialist care." | ( Agabiti Rosei, E; Ambrosioni, E; Costa, FV; Deferrari, G; Garneri, D; Gonnella, A; Leoncini, G; Leonetti, G; Muiesan, ML; Pessina, AC; Pontremoli, R; Trimarco, B; Viazzi, F; Volpe, M, 2014) |
| "Hyperuricemia is a non-communicable disease that threatens human health, and its prevalence has been increasing in recent decades." | ( Liu, BC; Liu, H; Wang, YL; Zhang, XM, 2014) |
| "Hyperuricemia is prevalent in the economically developed areas of China." | ( Liu, BC; Liu, H; Wang, YL; Zhang, XM, 2014) |
| "Hyperuricemia is an independent risk factor for renal function decline." | ( Cheetham, TC; Levy, GD; Niu, F; Rashid, N, 2014) |
| "Hyperuricemia is strongly associated with cardiovascular disease in OSA patients." | ( Erden, A; Inonu, H; Johnson, RJ; Kanbay, A; Kanbay, M; McFann, K; Ozturk, MA; Solak, Y; Uslu, E; Yuksel, SA, 2014) |
| "Hyperuricemia is predisposing factor for gout, chronic heart failure, atherosclerosis, tissue injury, and ischemia." | ( Kapoor, N; Saxena, S, 2014) |
| "Although hyperuricemia is a risk factor for cardiovascular diseases, the relationship between serum uric acid (UA) levels and thromboembolic risk has not been fully elucidated in patients with AF." | ( Fukuda, N; Hirai, T; Inoue, H; Nakagawa, K; Nozawa, T; Numa, S; Ohara, K, 2014) |
| "Hyperuricemia is a biochemical hallmark of gout, renal urate lithiasis, and inherited purine disorders, and may be a result of enormous ATP breakdown or purine release as a result of cardiovascular disease, hypertension, kidney disease, eclampsia, obesity, metabolic syndrome, psoriasis, tumor lysis syndrome, or intense physical training." | ( Andjelkovic, T; Chiesa, LM; Cvetkovic, T; Jevtovic-Stoimenov, T; Kocic, G; Kocic, H; Nikolic, G; Nikolic, R; Panseri, S; Pavlovic, R; Sokolovic, D; Stojanovic, S; Veljkovic, A, 2014) |
| "Gout/hyperuricemia is a common multifactorial disease having typical environmental risks." | ( Abe, J; Akashi, A; Chiba, T; Hosoya, T; Ichida, K; Kawai, S; Kawamura, Y; Matsuo, H; Nakamura, T; Nakaoka, H; Nakashima, H; Nakayama, A; Oikawa, Y; Okada, R; Sakiyama, M; Sakurai, Y; Shichijo, Y; Shimizu, S; Shinomiya, N; Suzuki, H; Takada, T; Takada, Y; Tamura, T; Wakai, K, 2014) |
| "Hyperuricemia is associated with the development of AF in elderly people with normal blood pressure." | ( Chia-Yu Chen, R; Chuang, SY; Hsu, PF; Hsu, YY; Liu, WL; Pan, WH; Wu, CC, 2014) |
| "Hyperuricemia is a frequent complication of chronic kidney disease (CKD)." | ( Itabashi, M; Mochizuki, T; Moriyama, T; Nitta, K; Takei, T; Tsuchiya, K; Tsuruta, Y, 2014) |
| "Hyperuricemia is a risk factor for adverse renal outcomes in patients with chronic kidney disease." | ( Asahi, K; Fujimoto, S; Hirayama, A; Ichikawa, K; Iseki, K; Kamei, K; Kimura, K; Kondo, M; Konta, T; Moriyama, T; Narita, I; Suzuki, K; Tsuruya, K; Watanabe, T; Yamagata, K, 2014) |
| "Hyperuricemia is a new probable cause of hemospermia." | ( Aboul-Ella, HA; Abulsorour, S; Altaher, A; Awad, SM; Elderwy, AA; Kurkar, A, 2014) |
| "Hyperuricemia is well known as the cause of gout." | ( Li, M; Mei, L; Xie, A; Yang, D; Yuan, J; Yuan, L, 2014) |
| "Hyperuricemia is an important foundation of gouty arthritis." | ( Liu, SM; Lu, F; Yu, DH; Zhang, C; Zhou, Q, 2014) |
| "Hyperuricemia is characterized by inhibited nitric oxide system and enhanced synthesis of reactive oxygen species." | ( Barbieri, L; Cassetti, E; De Luca, G; Marino, P; Schaffer, A; Suryapranata, H; Verdoia, M, 2015) |
| "Hyperuricemia is an important risk factor for atherosclerosis, yet the potential mechanisms are not well understood." | ( Feng, XR; Liang, WY; Liu, ML; Wang, YC; Zhang, JW; Zhu, XY, 2015) |
| "Hyperuricemia is a common finding in psoriatic patients." | ( Gisondi, P, 2014) |
| "Hyperuricemia is a common feature of patients with non-alcoholic fatty liver disease (NAFLD)." | ( Dooley, S; Li, Y; Miao, M; Sun, Y; Wan, X; Weng, H; Xu, C; Xu, G; Xu, L; Yan, M; Yu, C, 2015) |
| "Hyperuricemia is very common in industrialized countries and known to promote vascular smooth muscle cell proliferation." | ( Adamczak, M; Blondin, D; Dekomien, G; Epplen, JT; Helmchen, U; Januszewicz, A; Januszewicz, M; Litwin, M; Matuszkiewicz-Rowińska, J; Michałowska, I; Prejbisz, A; Rump, LC; Sajnaga, D; Sellin, L; Szwench-Pietrasz, E; Więcek, A; Woznowski, M, 2015) |
| "Hyperuricemia is associated with the onset of chronic kidney disease (CKD) and renal disease progression." | ( Asahi, K; Hayashi, Y; Kanno, M; Kimura, H; Nakayama, M; Tanaka, K; Tani, Y; Terawaki, H; Watanabe, K; Watanabe, T, 2015) |
| "Hyperuricemia is an independent risk factor for CKD and contributes to kidney fibrosis." | ( Bao, W; Cheng, SB; Chin, YE; Liu, N; Qiu, A; Shi, Y; Wang, L; Xiong, C; Xu, L; Yan, H; Yang, T; Zhuang, S, 2015) |
| "Hyperuricemia is common in pediatric renal transplant recipients, and it is associated with poor allograft outcomes." | ( Akdur, A; Baskın, E; Fidan, C; Gülleroğlu, K; Haberal, M; Kantar, A; Moray, G, 2015) |
| "In conclusion, hyperuricemia is a common complication in renal transplant recipients." | ( Akdur, A; Ayvazoglu Soy, EH; Haberal, M; Karakaya, E; Karatas Togral, A; Moray, G, 2015) |
| "Hyperuricemia is an independent risk factor for hypertension." | ( Gao, Y; Huang, J; Li, Y; Niu, K; Sun, Y; Wan, Z; Wu, X; Yao, W; Zhang, W; Zhao, H, 2015) |
| "Hyperuricemia is one of the many metabolic changes that occur during the course of chronic kidney disease (CKD)." | ( Mandreoli, M; Santoro, A, 2015) |
| "Hyperuricemia is a key biochemical feature in preeclampsia with elevated levels of uric acid being diagnosed as early as the 10(th) week of gestation." | ( Athanasiadis, A; Kourtis, A; Makedou, K; Masoura, S; Theodoridis, T; Zepiridis, L, 2015) |
| "Hyperuricemia is frequently reported in adults, but there are few data for the pediatric population." | ( Aslan, AT; Budakoğlu, I; Şişmanlar, T, 2015) |
| "In summary, hyperuricemia is highly prevalent among the adult participants in this Chinese community, especially for men." | ( Li, G; Li, J; Li, X; Song, P; Wang, P, 2015) |
| "Hyperuricemia is associated with essential hypertension in children." | ( Furth, SL; Mitsnefes, MM; Moxey-Mims, MM; Rodenbach, KE; Schneider, MF; Schwartz, GJ; Warady, BA; Weaver, DJ, 2015) |
| "Hyperuricemia is a previously undescribed independent risk factor for faster progression of CKD in children and adolescents." | ( Furth, SL; Mitsnefes, MM; Moxey-Mims, MM; Rodenbach, KE; Schneider, MF; Schwartz, GJ; Warady, BA; Weaver, DJ, 2015) |
| "Hyperuricemia is a risk factor for various diseases, but knowledge on acute hyperuricemia is still not sufficient." | ( Li, K; Li, L; Liu, Y; Tong, X; Wang, X; Xie, L; Xu, S; Yao, W, 2015) |
| "Hyperuricemia is a putative risk factor for the progression of chronic kidney disease (CKD)." | ( Chatterjee, S; Golay, V; Pandey, R; Raychaudhury, A; Sircar, D; Waikhom, R, 2015) |
| "Hyperuricemia is associated with hypertension, kidney disease, vascular and cardiovascular (CV) events." | ( Borghi, C; Grassi, G; Mancia, G, 2015) |
| "Hyperuricemia is an independent risk factor for chronic kidney disease and cardiovascular disease." | ( Gui, D; Guo, Y; Jiang, Q; Wang, N, 2015) |
| "Hyperuricemia is associated with an increased risk of NAFLD in Asian populations." | ( Gong, S; Song, J; Wang, L; Wang, Y; Zhang, S, 2016) |
| "Hyperuricemia is an independent predictor of impaired fasting glucose and type 2 diabetes, but whether it has a causal role in insulin resistance remains controversial." | ( Afsar, B; ALanaspa, M; Bakan, A; Elcioglu, OC; Erek, A; Johnson, RJ; Kanbay, M; Kostek, O; Mutlu, HH; Odabas, AR; Ozkok, A; Semerci, A; Sharma, S; Smits, G; Takir, M; Telci, O, 2015) |
| "Hyperuricemia is a prognostic factor in patients with chronic heart failure, but whether uric acid level can predict clinical outcome of acute heart failure (AHF) remains to be elucidated." | ( Chen, CH; Cheng, HM; Cheng, YL; Guo, CY; Hsu, PF; Huang, WM; Lu, DY; Sung, SH; Yu, WC, 2016) |
| "In conclusion, hyperuricemia is a promising biomarker of early mortality in patients with COPD." | ( Jin, S; Liang, R; Liu, L; Zhang, X, 2015) |
| "Hyperuricemia is highly heritable and is associated with sex and body weight." | ( Cheng, ST; Hsu, LA; Ko, YL; Su, CW; Teng, MS; Wu, S, 2017) |
| "Hyperuricemia is closely related to renal diseases." | ( Chen, H; Huang, F; Lin, C; Lin, F; Zhang, H; Zhu, P, 2016) |
| "Hyperuricemia is a risk factor for not only gout, but also to a variety of disorders that affect the vital organ systems of the human body." | ( Gopal, S; Rangappa, KS; Sathisha, KR, 2016) |
| "Prevalence of hyperuricemia is high in patients with hypertension." | ( Acevedo, A; Benavides, J; Chowdhury, M; Lievano, M; Lombo, B; Lopez, M; Montenegro, A; Pena, L, 2016) |
| "BACKGROUND Hyperuricemia is very common after renal transplantation." | ( Babel, N; Bauer, F; Giese, A; Kor, S; Pagonas, N; Reinke, P; Seibert, FS; Westhoff, TH; Westoff, TH; Zidek, W, 2016) |
| "BACKGROUND Hyperuricemia is very common after renal transplantation." | ( Babel, N; Bauer, F; Giese, A; Kor, S; Pagonas, N; Reinke, P; Seibert, FS; Westhoff, TH; Westoff, TH; Zidek, W, 2016) |
| "Hyperuricemia is associated with cardiovascular disease and its prevalence is unknown in black Africans." | ( Baldo, MP; Capingana, DP; Luchi, WM; Magalhães, P; Mill, JG; Moulin, SR; Souza, JB, 2017) |
| "Hyperuricemia is an established risk factor for cardiovascular events and mortality." | ( Asahi, K; Fujimoto, S; Hirayama, A; Ichikawa, K; Iseki, K; Kamei, K; Kasahara, M; Kondo, M; Konta, T; Kubota, I; Moriyama, T; Narita, I; Shibagaki, Y; Tsuruya, K; Watanabe, T; Yamagata, K, 2017) |
| "In addition, hyperuricemia is associated with metabolic syndrome, diabetes, hypertension, and kidney and cardiovascular diseases." | ( Jalal, DI, 2016) |
| "Chronic hyperuricemia is responsible for a relevant burden of articular diseases and cardio-nephrometabolic disorders." | ( Borghi, C; Buda, S; Degli Esposti, L; Desideri, G; Pontremoli, R; Saragoni, S, 2016) |
| "Asymptomatic hyperuricemia is not a current indication for therapy as the definite role of serum uric acid elevation as a cardiovascular risk factor is extremely likely but still controversial." | ( Ferri, C; Grassi, D; Izzo, R; Rozza, F; Trimarco, V, 2016) |
| "Hyperuricemia is becoming increasingly frequent in the population, and is known to be sometimes the cause of gout." | ( Bardou-Jacquet, E; Chalès, G; Coiffier, G; Deugnier, Y; Flais, J; Guggenbuhl, P; Loréal, O; Perdriger, A; Ropert, M, 2017) |
| "Hyperuricemia is a common symptom in adult population." | ( Adamczyk, P; Beck, B; Dyga, K; Kaminska-Pajak, KA; Szczepańska, M; Tkaczyk, M; Zaniew, M, 2016) |
| "Hyperuricemia is an important predictor for poor prognosis in patients with LN." | ( Chen, M; Li, G; Li, J; Tang, X; Wang, X; Xie, T; Yin, H; Zhang, W; Zuo, X, 2016) |
| "Hyperuricemia is an independent competing risk factor for AF." | ( Hisatome, I; Kario, K; Kuwabara, M; Nishi, Y; Nishihara, S; Niwa, K; Takahashi, O; Yamamoto, K; Yamashita, T, 2017) |
| "Hyperuricemia is strongly linked to cardiovascular complications including atherosclerosis and thrombosis." | ( Bengtsson, AA; Biermann, MH; Bilyy, R; Czegley, C; Dumych, T; Herrmann, M; Hoffmann, M; Jeremic, I; Maueröder, C; Munoz, LE; Pieterse, E; Schauer, C; Schett, G; van der Vlag, J; Veissi, S; Weidner, D, 2016) |
| "Hyperuricemia is significantly associated with hypertension, renal dysfunction, MACE, and independently confers a higher risk of mortality in patients with AMI." | ( Mayise, C; Myeni, NN; Ranjith, N; Sartorius, B, 2017) |
| "Hyperuricemia is a kind of metabolic disease resulted from imbalance between urate production and excretion." | ( Hao, K; Hu, Q; Li, H; Lu, G; Zheng, D; Zhou, M; Zhu, H, 2017) |
| "Hyperuricemia is associated with development of gout, hypertension, and renal disease." | ( Blumenthal, D; Gerber, D; Krishnamurthy, A; Lazaro, D; Patel, S; Stefanov, DG, 2017) |
| "Hyperuricemia is not only the main feature of gout but also a cause of gout-related organ injuries including glomerular hypertrophy and sclerosis." | ( Chen, Q; Ding, G; Gong, W; He, JC; Huang, S; Jia, Z; Li, S; Ruan, Y; Sun, Z; Xia, W; Yu, J; Zhang, A; Zhang, Y, 2017) |
| "Hyperuricemia is associated with the progression of chronic kidney disease (CKD) and cardiovascular diseases." | ( Nakamura, T; Node, K; Sato, E; Tanaka, A, 2017) |
| "Hyperuricemia is associated with a number of effects on the vascular endothelium and vascular smooth muscle cells, including an increase in oxidative stress, production of vasoconstrictors, and changes on the structural properties of the large artery wall." | ( Madero, M; Ramirez-Sandoval, JC; Sanchez-Lozada, LG, 2017) |
| "Whether hyperuricemia is an independent risk factor for hypertension in adults is still under debate." | ( Cui, LF; Han, YX; Liu, N; Mu, R; Shi, HJ; Shu, R; Song, HC; Sun, K; Wang, GY; Wang, J; Wang, JR; Wu, SL; Yang, WH; Yu, P; Zhou, B, 2017) |
| "Hyperuricemia is associated with metabolic syndrome (MetS), but the association is often confounded by the shared background of obesity." | ( Du, T; Li, M; Lin, X; Lu, H; Yu, X; Zhang, S, 2017) |
| "Although hyperuricemia is shown to accelerate chronic kidney disease, the mechanisms remain unclear." | ( Asakawa, S; Hosoyamada, M; Kumagai, T; Morimoto, C; Nakamura, T; Shibata, S; Shiraishi, T; Tamura, Y; Uchida, S, 2017) |
| "Hyperuricemia is a common complication in renal transplant recipients." | ( Akturk, S; Eyupoglu, D; Eyupoglu, S; Kendi-Celebi, Z; Keven, K; Sengul, S; Tuzuner, A, 2017) |
| "Although hyperuricemia is common after orthotopic liver transplantation (OLT), its relationship to mortality, progressive kidney disease, or the development of end stage renal disease (ESRD) is not well-described." | ( Atta, MG; Bandak, G; Gelber, AC; Longenecker, JC; McMahon, BA; Murakami, CA; Waheed, S, 2017) |
| "Hyperuricemia is an important risk factor for cardiovascular and renal diseases." | ( Chen, Y; Cheng, J; Liu, J; Liu, S; Lu, Y; Yuan, Y; Zhao, M; Zhou, Y, 2017) |
| "Hyperuricemia is associated with the development of chronic kidney disease." | ( Beibei, T; Huijuan, W; Jianchun, M; Rui, S; Xiaoxu, C; Xinghui, L, 2017) |
| "Hyperuricemia is a clinical condition characterized by an elevated level of serum uric acid and is a key risk factor for the development of gout and metabolic disorders." | ( Choi, CW; Choi, Y; Hong, SS; Hyun, JM; Kim, JK; Kim, P; Kim, WJ; Kwon, JG; Lee, JK; Lee, JS; Park, K; Seo, C; Song, MJ; Sung, H, 2017) |
| "Hyperuricemia is associated with incident cardiovascular events in different settings of patients." | ( Addesi, D; Baggetta, R; Cimellaro, A; Maio, R; Perticone, F; Perticone, M; Sciacqua, A; Sesti, G; Tripepi, G, 2017) |
| "Hyperuricemia is a significant risk factor for nonalcoholic fatty liver disease (NAFLD)." | ( Ahuja, W; Jaruvongvanich, V; Ungprasert, P; Wijarnpreecha, K; Wirunsawanya, K, 2017) |
| "BACKGROUND Hyperuricemia is associated with an increased risk of cardiovascular disease and chronic allograft nephropathy after renal transplantation." | ( Babel, N; Bauer, F; Pagonas, N; Seibert, FS; Viebahn, R; Westhoff, TH; Zidek, W, 2017) |
| "Hyperuricemia is common in China and the relevance of hyperuricemia and cardiovascular disease (CVD) risk has been highlighted, but to date there has been rarely nation-wide study in China." | ( Cheng, Q; Cheng, XQ; Guo, XZ; Liu, L; Liu, Q; Qiu, L; Wu, J; Wu, W; Xu, CL; Xu, T; Ye, YC; Zeng, XJ; Zhu, GJ, 2017) |
| "Hyperuricemia is associated with chronic kidney disease (CKD)." | ( Hatakeyama, Y; Horino, T; Ichii, O; Inoue, K; Matsumoto, T; Okuhara, Y; Shimamura, Y; Terada, Y, 2018) |
| "Hyperuricemia is common in approximately 50% of patients with kidney failure due to decreased uric acid excretion, and it has been recently known as an independent factor in the progression of renal insufficiency." | ( Almasi, A; Golmohammadi, S; Manouchehri, M; Omrani, HR; Zandkarimi, MR, 2017) |
| "Hyperuricemia is characterized by the accumulation of serum UA and is an important risk factor for gout and many chronic disorders." | ( Chen, HM; Chen, MH; Chen, RJ; Chen, SJ; Chen, YL; Hsiao, CM; Wang, YJ; Wu, MD; Yech, YJ; Yuan, GF, 2017) |
| "If hyperuricemia is an independent risk factor in blood-pressure control, urate-lowering therapy should be used to reduce cardiovascular risk." | ( Grassi, G, 2017) |
| "Hyperuricemia is an independent risk factor for causing chronic kidney disease and contributes to kidney fibrosis." | ( He, T; Huang, Y; Li, Y; Liu, H; Xiao, T; Xiong, J; Xu, X; Yu, Y; Zhang, B; Zhang, J; Zhao, J, 2017) |
| "Hyperuricemia is associated with the progression of chronic kidney disease (CKD), but it is not known whether the relationship is causal." | ( Arrigain, S; Jolly, SE; Konig, V; Nakhoul, G; Nally, JV; Navaneethan, SD; Rincon-Choles, H; Rothberg, MB; Schold, JD, 2017) |
| "Hyperuricemia is associated with increased risk of progression to ESRD in patients with CKD stages 3 and 4, but UALT does not ameliorate the risk, suggesting that the relationship is not causal." | ( Arrigain, S; Jolly, SE; Konig, V; Nakhoul, G; Nally, JV; Navaneethan, SD; Rincon-Choles, H; Rothberg, MB; Schold, JD, 2017) |
| "Hyperuricemia is associated with hypertension, with elevated serum uric acid levels postulated to have a causal role in the development of hypertension." | ( Feig, DI; Gunawardhana, L; Hunt, B; McLean, L; Palmer, RN; Punzi, HA; Whelton, A, 2017) |
| "Hyperuricemia is the term for an abnormally high serum uric acid level." | ( Li, ZL; Yuan, S; Zhang, ZW, 2018) |
| "Moreover, gout or hyperuricemia is clearly associated with a variety of comorbidities, including cardiovascular diseases, chronic kidney disease, urolithiasis, metabolic syndrome, diabetes mellitus, thyroid dysfunction, and psoriasis." | ( Chen, DY; Chen, JH; Chen, SM; Chen, SY; Cheng, TT; Hsieh, SC; Hsieh, TY; Hsu, PF; Kuo, CF; Kuo, MC; Lam, HC; Lee, IT; Liang, TH; Lin, HY; Lin, SC; Tsai, WC; Tsai, WP; Tsay, GJ; Wei, JC; Yang, CH; Yu, KH, 2018) |
| "Hyperuricemia is supposed to be an independent risk factor for kidney dysfunction in diabetic patients." | ( Honda, D; Hosoya, T; Kimura, K; Narita, K; Okui, D; Sakamoto, R; Sasaki, T; Wada, T, 2018) |
| "Hyperuricemia is defined as serum uric acid values greater than 6 mg/dl and could occur either due to hyperproduction or as a result of reduced renal excretion, which exceeds gut compensation." | ( Balia, F; Borrelli, S; De Nicola, L; De Stefano, T; Garofalo, C; Minutolo, R; Nettuno, F; Pacilio, M; Sagliocchi, A; Scarpati, L; Sguazzo, A; Vinci, G; Vita, C, 2018) |
| "Hyperuricemia is a risk factor for causing end-stage kidney disease and cardiovascular disease in the general population; however, several aspects, such as the site of kidney damaged by hyperuricemia and the threshold levels of serum uric acid for the development of renal damage, have not been fully clarified." | ( Ichikawa, K; Kamei, K; Kayama, T; Konta, T; Kubota, I, 2018) |
| "Hyperuricemia is associated with metabolic syndrome, diabetes, hypertension, and kidney and cardiovascular diseases." | ( Méndez Landa, CE, 2018) |
| "Key Message: Hyperuricemia is closely associated with the incidence and progression of CKD." | ( Iseki, K, 2018) |
| "Hyperuricemia is common in subjects with obesity, metabolic syndrome, and type 2 diabetes." | ( Jensen, T; Johnson, RJ; King, C; Lanaspa, MA; Sánchez-Lozada, LG; Tolan, DR, 2018) |
| "Hyperuricemia is associated with higher medium/long-term mortality and major cardiovascular event rates in patients following acute coronary syndrome." | ( Bertomeu-Gonzalez, V; Bertomeu-Martinez, V; Carratala-Munuera, C; Cordero, A; Gil-Guillen, VF; Lopez-Pineda, A; Orozco-Beltran, D; Quesada, JA, 2018) |
| "Hyperuricemia is associated with an increased risk for multiple cardiovascular diseases, but the underlying mechanisms remain largely elusive." | ( Chen, K; He, L; Huang, D; Li, J; Li, S; Yan, M, 2018) |
| "Hyperuricemia is a leading risk factor for the development of chronic kidney disease (CKD)." | ( Assadi, F; Ghane Sharbaf, F, 2018) |
| "Hyperuricemia is strongly linked to hypertension, insulin resistance, obesity and hypertriglyceridemia." | ( Battelli, MG; Bolognesi, A; Bortolotti, M; Polito, L, 2018) |
| "Hyperuricemia is defined as a serum uric acid level of 7 mg/dL or more in men or 6 mg/dL or more in women." | ( Chang, WC; Chen, KH; Hwang, JJ; Lee, CC; Liu, CW; Wu, YW, 2018) |
| "Hyperuricemia is not only a risk factor for gout but also an independent determinant of hypertension, diabetes, and chronic kidney diseases." | ( Kang, J; Kim, GT; Kim, Y, 2018) |
| "Hyperuricemia is not associated with poor clinical outcomes after repeat PCI for ISR lesions." | ( Hong, SJ; Jeong, HS; Joo, HJ; Kook, H; Lee, SH; Lim, DS; Park, JH; Yu, CW, 2018) |
| "We conclude that hyperuricemia is associated with PP HTN, especially among obese women." | ( Dixon, L; Marrs, CC; Olson, G; Rahman, M, 2018) |
| "Hypertension and hyperuricemia are closely associated with an intermingled cause and effect relationship." | ( Chen, W; Fu, C; Guo, H; Li, F; Lu, Y; Xiao, J; Ye, Z; Zhang, X; Zou, J, 2018) |
| "Hyperuricemia is an independent predictor of mortality in patients with chronic heart failure." | ( Fukushima, A; Kinugawa, S; Murohara, T; Okumura, T; Tsutsui, H; Yokota, T, 2018) |
| "Hyperuricemia is a risk factor for cardiovascular diseases." | ( Huang, G; Liu, Y; Liu, ZH; Xie, X; Xu, JB; Xu, RH; Zhang, TJ, 2018) |
| "Hyperuricemia is associated with cardiovascular disease, but the relationship between uric acid (UA) and pulse pressure (PP) is unclear." | ( Jung, EY; Kim, HS; Moon, AE; Park, CE; Sung, HH; Yoon, H, 2019) |
| "Hyperuricemia is highly prevalent and especially common in subjects with metabolic, cardiovascular and renal diseases." | ( Blas-Marron, MG; Frank, DN; García-Arroyo, FE; Gonzaga, G; Ir, D; Irvin, A; Johnson, RJ; Muñoz-Jiménez, I; Ranganathan, N; Ranganathan, P; Robertson, CE; Sánchez-Lozada, LG; Silverio, O; Soto, V; Tapia, E; Vyas, U, 2018) |
| "Hyperuricemia is the main risk factor for gout." | ( Chen, X; Cui, W; Ding, X; Duan, N; Jin, T; Wang, Z, 2018) |
| "Hyperuricemia is an independent risk factor for progression of kidney disease." | ( Cheetham, TC; Levy, G; Rashid, N; Shi, JM, 2018) |
| "Hyperuricemia is a common and serious public health problem." | ( Chen, X; Diao, Y; Feng, J; Langtai, Z; Liao, H; Meng, Q; Renqian, L; Shi, D; Shi, R; Zhang, X, 2018) |
| "Whether hyperuricemia is the cause or the effect is debatable." | ( Agarwal, VK; Kapoor, D; Raina, S; Sharma, KN; Yadav, RS, 2018) |
| "Hyperuricemia is a common condition, and in a subset of patients leads to gout, the most common inflammatory arthritis." | ( Krasnokutsky, S; Neogi, T; Pillinger, MH, 2019) |
| "WIT and post-LT hyperuricemia are associated with the prevalence of PTMS." | ( Chai, YC; Hu, LS; Jia, A; Lv, Y; Shi, JH; Tian, M; Wang, B; Zhang, C; Zheng, J, 2018) |
| "Hypoalbuminemia and hyperuricemia are independently associated with the occurrence of CIN among the patients undergoing CAG and/or intervention." | ( Chen, G; Huang, L; Lu, Y; Qin, Q; Wang, C; Zhang, E; Zhang, J, 2019) |
| "In conclusion, hyperuricemia is relatively common among patients with severe CAD and is independently associated with mortality." | ( Feng, X; Gao, R; Hui, R; Jiang, L; Liu, J; Song, L; Sun, K; Tian, J; Wang, D; Xu, B; Xu, L; Yuan, J; Zhang, C; Zhang, Y; Zhao, W; Zhao, X, 2019) |
| "Hyperuricemia is an important risk factor for vascular inflammation, yet the potential mechanisms of uric acid (UA) in endothelial cells are not well understood." | ( Cheng, Y; Gu, J; Jiang, Y; Li, H; Liu, Y; Lv, H; Yang, X, 2019) |
| "Background Hyperuricemia is a recognised risk factor for the development of nonalcoholic fatty liver disease (NAFLD)." | ( Bao, J; Fu, X; Li, Y; Li, Z; Liu, S; Miao, L; Qiao, L; Xu, K; Zhang, X; Zhao, X; Zhou, Y, 2019) |
| "Hyperuricemia is becoming a serious public health issue, which is highly influenced by environmental factors, although there is still controversial information on the potential influence of the exposure to Persistent Toxic Substances (PTSs) in the general population." | ( Arrebola, JP; Bartolomé, M; Calvo, E; Cañas, AI; Castaño, A; Esteban, M; Huetos, O; López-Herranz, A; Pérez-Gómez, B; Ramos, JJ, 2019) |
| "Hyperuricemia is a risk factor for high morbidity and mortality in several diseases." | ( Chin, HJ; Han, SS; Joo, KW; Kang, MW; Kim, S; Na, KY, 2019) |
| "Hyperuricemia is known to be a risk factor for diabetes." | ( Guo, X; Liu, J; Mu, Y; Tao, L; Zhang, J; Zhao, Z; Zou, D, 2018) |
| "Hyperuricemia is reportedly associated with poor outcome in acute heart failure (AHF)." | ( Bai, YJ; Huang, XF; Liu, SR; Xu, DL; Xu, TY; Zeng, QC; Zhan, Q; Zhou, HB, 2019) |
| "Hyperuricemia is the only biochemical index in the classification of acute gouty arthritis in American Rheumatism Association 1977 and the main basis of clinical diagnosis for most doctors." | ( Deng, B; Deng, M; Fei, X; Huang, Z; Wang, Y; Ye, L, 2019) |
| "Hyperuricemia is a metabolic condition characterized by an elevated serum uric acid, and associated with renal damage, diabetes, autoimmune disorders, and cardiovascular diseases." | ( An, K; Cao, W; Dong, H; Ge, S; Hou, H; Hu, S; Li, D; Li, Y; Song, M; Sun, F; Sun, Q; Wang, L; Wang, W; Wang, Y; Xing, W; Xu, X; Zhang, X, 2019) |
| "Hyperuricemia is an emerging risk factor for the development of heart failure (HF) and is associated with a worsen prognosis of the disease." | ( Borghi, C; Cicero, AFG; Cosentino, ER; Degli Esposti, D; Kuwabara, M, 2019) |
| "Hyperuricemia is prevalent in CKD." | ( Fan, S; Hong, D; Li, G; Wang, AY; Wang, L; Wang, X; Zhang, P, 2019) |
| "Hyperuricemia is closely correlated with cardiovascular disease, metabolic syndrome, and chronic kidney disease, as attested by the epidemiological and empirical research." | ( Cheng, J; Huangfu, N; Wang, Y; Xu, Z; Zhang, D; Zhang, F; Zhang, S; Zhao, R; Zheng, W, 2019) |
| "Hyperuricemia is a metabolic disease caused by disorders of purine metabolism, the prevalence of which has increased worldwide." | ( Gong, C; Hou, C; Li, Y; Liu, D; Ren, J; Wang, M; Yang, L; Yao, M; Yuan, E, 2019) |
| "Hyperuricemia is considered a potential predictive factor for ischemic type of stroke and may indicate the need for preventive management in patients with hypertriglyceridemia (Tab." | ( Hsu, CY; Lai, YJ, 2019) |
| "Hyperuricemia is associated with a poorer prognosis in heart failure (HF) patients." | ( Al-Hiti, H; Bambuch, M; Belohlavek, J; Benesova, K; Bohacova, S; Cihalik, C; Dostalova, G; Dusek, L; Fedorco, M; Felsoci, M; Fojt, R; Havranek, S; Jarkovsky, J; Kettner, J; Kruger, A; Linhart, A; Malek, F; Malek, J; Miklik, R; Mikusova, T; Monhart, Z; Ostadal, P; Parenica, J; Pavlusova, M; Pohludkova, L; Rohac, F; Spac, J; Spinar, J; Spinarova, L; Svobodová, I; Vaclavik, J; Vitovec, J; Vondrakova, D; Vyskocilova, K; Widimsky, P; Zeman, K, 2019) |
| "The onset of hyperuricemia is often observed within the first several months after surgery." | ( Chen, XG; Liu, H; Shen, ZY; Shi, Y, 2019) |
| "Intervention for hyperuricemia is considered to improve patient outcomes." | ( Kidoguchi, S; Maruyama, Y; Masakane, I; Ohno, I; Shigematsu, T; Sugano, N; Wada, A; Yokoo, T, 2019) |
| "Although hyperuricemia is a risk factor for CKD progression, the causal role of uric acid remains controversial in patients with CKD and asymptomatic hyperuricemia." | ( Jeon, HJ; Oh, J; Shin, DH, 2019) |
| "Risk of hyperuricemia is modified by genetic and environmental factors." | ( Canizales-Quinteros, S; de la Cruz-Montoya, A; Denova-Gutiérrez, E; Fernandez-Lopez, JC; Flores, YN; Macías-Kauffer, L; Martinez-Aguilar, MM; Quiterio, M; Ramírez-Palacios, P; Ramírez-Salazar, EG; Rivera-Paredez, B; Romero-Hidalgo, S; Salmerón, J; Velázquez-Cruz, R; Villalobos-Comparán, M; Villamil-Ramírez, H; Villarreal-Molina, MT, 2019) |
| "Hyperuricemia is a risk factor for nonalcoholic fatty liver disease (NAFLD), however, the effect of gender on the hyperuricemia-related NAFLD development remains unclear." | ( Bao, J; Cai, Z; Fu, X; Li, Y; Li, Z; Miao, L; Qiao, L; Xu, K; Zhao, X, 2019) |
| "Hyperuricemia is a compounding factor for NAFLD, particularly in males." | ( Bao, J; Cai, Z; Fu, X; Li, Y; Li, Z; Miao, L; Qiao, L; Xu, K; Zhao, X, 2019) |
| "Hyperuricemia is a metabolic disease of the kidney that results in decreased uric acid excretion." | ( Kong, J; Su, H; Zhang, J; Zhang, Y, 2019) |
| "Hyperuricemia is a risk factor for acute kidney injury and may prompt treatment in critically ill patients." | ( Axelrod, DM; Kwiatkowski, DM; Moss, JD; Wu, M, 2019) |
| "Hyperuricemia is an independent risk factor for renal dysfunction, cardiovascular events, and gouty arthritis." | ( Tohyo, S, 2019) |
| "Hyperuricemia is closely associated with increased risk of CAC development and CAC progression in asymptomatic patients." | ( Bainey, KR; Banh, HL; Hou, X; Li, W; Liang, L; Qi, Z; Tymchak, W; Zhang, Y, 2019) |
| "Hyperuricemia is highly prevalent, affecting approximately 38 million individuals in the United States." | ( Cohen, RE; Pillinger, MH; Yip, K, 2020) |
| "Hyperuricemia is caused by hepatic overproduction of uric acid and/or underexcretion of urate from the kidneys and small intestine." | ( Harada-Shiba, M; Hirata, H; Ogura, M; Ota-Kontani, A; Tsuchiya, Y, 2020) |
| "Hyperuricemia is an old emerging metabolic disorder, and interaction among uric acid and cardiovascular diseases has been clearly described." | ( Borghi, C; Cosentino, E; Landolfo, M; Palazzuoli, A, 2020) |
| "The prevalence of hyperuricemia is increasing in adults, while the prevalence among adolescents is seldom reported." | ( Cui, L; Han, L; He, Y; Ji, A; Ji, X; Li, C; Li, H; Li, X; Liu, Z; Lu, J; Ren, W; Sun, W; Wang, C; Wang, X; Zhang, H, 2020) |
| "Hyperuricemia is an important risk factor for many diseases including hypertension and type 2 diabetes." | ( Bao, W; Han, J; Li, Y; Lu, C; Ming, T; Su, X; Tang, S; Wan, H; Zhou, J, 2020) |
| "Hyperuricemia is the main risk factor for gout and is linked to the development of comorbidities." | ( Cabău, G; Crișan, TO; Joosten, LAB; Klück, V; Popp, RA, 2020) |
| "Introduction: Hyperuricemia is an independent risk factor for high-normal blood pressure (BP) both in men and women." | ( Kovalenko, YL; Melekhovets, OK; Melekhovets, YV; Orlovskiy, VF, 2019) |
| "Hyperuricemia is associated with the development, progression and outcome of several diseases." | ( Abu Sneineh, M; Breuer, GS; Freier Dror, Y; Nesher, G; Schwartz, Y, 2020) |
| "Hyperuricemia is an important potential pathogenic factor for hypertension, cardiovascular disease and stroke." | ( Cai, GY; Chen, XM; Han, QX; Li, J; Liu, DW; Liu, L; Liu, ZS; Luan, FX; Zhang, D; Zhang, F; Zhao, YL; Zhu, HY, 2019) |
| "Gout and hyperuricemia are common public health problem." | ( Baima, Y; Gong, H; Lin, C; Lin, J; Liu, Q; Wang, Y; Zhang, Q, 2020) |
| "Hyperuricemia is a strong precursor of gout, which deteriorates patients' health and quality of life." | ( Chang, SS; Lin, CH; Lin, SY; Lin, YJ; Wang, ST, 2020) |
| "Hyperuricemia is an abnormal increase in uric acid levels in the blood." | ( Alghamdi, YS; Nassan, MA; Soliman, MM, 2020) |
| "Hyperuricemia is independently associated with cardiovascular disease (CVD) and is considered to be one of the major risk factors for CVD." | ( Chan, WL; Charng, MJ; Chen, JW; Chen, SC; Chen, YH; Cheng, HM; Chou, CY; Hsu, PF; Huang, CC; Huang, PH; Huang, SS; Leu, HB; Lim, SS; Lin, SJ; Lin, YJ; Lu, TM; Pan, JP; Sung, SH; Wu, CH; Wu, TC; Yang, YL, 2020) |
| "Hyperuricemia is a major risk for non-alcoholic fatty liver disease." | ( Chen, D; Chen, S; Wang, J; Wang, X; Xu, C; Yang, H, 2020) |
| "Hyperuricemia is closely associated with cardiovascular disease (CVD)." | ( Angerås, O; Bergström, G; Dehlin, M; Drivelegka, P; Forsblad-d'Elia, H; Jacobsson, LTH; Schmidt, C, 2020) |
| "Hyperuricemia is the hallmark of developing gout and mostly caused by uric acid underexcretion." | ( Prom-Wormley, E; Roman, Y; Tiirikainen, M, 2020) |
| "Although hyperuricemia is associated with congestive heart failure (CHF), hyperuricemic patients frequently have other comorbidities." | ( Cheng, H; Jian, G; Tang, Y; Wang, N; Wu, J; Wu, X, 2020) |
| "Asymptomatic hyperuricemia is frequently observed in patients with kidney disease." | ( Jung, SW; Kim, SM; Kim, YG; Lee, SH; Moon, JY, 2020) |
| "Hyperuricemia is a central risk factor for gout and increases the risk for other chronic diseases, including cardiometabolic disease, kidney disease, and hypertension." | ( Dai, S; Guo, Y; Hong, F; Li, L; Liu, G; Pan, S; Qiao, X; Wang, J; Xie, X; Xu, P; Xue, T; Zhai, Y; Zheng, A, 2020) |
| "Prolonged hyperuricemia is a cause of gout and an independent risk factor for chronic health conditions including diabetes and chronic kidney diseases." | ( Chae, J; Cho, B; Im, SW; Kim, JI; Park, JH; Son, HY, 2020) |
| "Hyperuricemia is associated with renal damage and ESRD occurrence in MPA and GPA patients." | ( Ahn, SS; Jung, SM; Kwon, HC; Lee, SW; Park, YB; Song, JJ; Yoo, BW; Yoo, J, 2020) |
| "Hyperuricemia is diagnosed when the serum urate level is continuously above 7 mg/dl as the solubility limit, and urate accumulates in the kidneys and joints." | ( Anzai, N; Hisatome, I; Kudo, H; Otani, N; Ouchi, M; Tsuruoka, S, 2020) |
| "Hyperuricemia is known to be associated with adverse outcomes in cardiovascular intensive care patients, but its mechanisms are unknown." | ( Asai, K; Asano, K; Goda, H; Hata, N; Kiuchi, K; Kobayashi, N; Matsushita, M; Murase, T; Nakamura, T; Okazaki, H; Shibata, Y; Shigihara, S; Shimizu, W; Shirakabe, A; Tani, K, 2020) |
| "Hyperuricemia is present in 20-35% of patients with chronic kidney disease." | ( Braga, TT; Camara, NOS; Foresto-Neto, O, 2020) |
| "Hyperuricemia is a risk factor for cardiovascular metabolic diseases." | ( Cai, L; Huang, G; Liu, H; Wu, J; Xu, J; Yu, X; Zhang, T, 2020) |
| "Hyperuricemia is an abnormal metabolic condition characterized by an increase in uric acid levels in the blood." | ( Aldhahrani, A; Althobaiti, F; Mohamed, WA; Nassan, MA; Soliman, MM, 2020) |
| "Hyperuricemia is considered a risk factor for increased postoperative complications and adverse functional outcomes in a variety of orthopedic surgeries." | ( Chen, S; Fan, C; Liu, W; Peng, S; Sun, Z; Wang, W; Xiong, H, 2020) |
| "Hyperuricemia is an independent risk factor for renal damage and can promote the progression of chronic kidney disease (CKD)." | ( Chen, H; Deng, J; Shao, X; Wang, X; Xia, Y; Xiong, C; Zhou, Q; Zou, H, 2020) |
| "Hyperuricemia is one of the important risk factors for gout, arteriosclerosis, cardiovascular and cerebrovascular disease." | ( Xiao, Y; Yuan, Z; Zeng, X; Zhang, C, 2020) |
| "Hyperuricemia is an important risk factor of chronic kidney disease, metabolic syndrome and cardiovascular disease." | ( Bao, R; Chen, Q; Liu, L; Liu, M; Wang, D; Wang, T; Wen, S; Yu, H; Zhang, Y, 2020) |
| "Hyperuricemia is related to health issues among children and adolescents, once the uric acid concentration is associated with metabolic syndrome, hypertension, insulin resistance, obesity, and dyslipidemia." | ( Borfe, L; Brand, C; Brazo-Sayavera, J; Franke, SIR; Gaya, AR; Reis, LN; Renner, JDP; Reuter, CP, 2020) |
| "Gout and hyperuricemia are essentially specific to humans and other higher primates, with varied prevalence across ancestral groups." | ( Bixley, M; Cadzow, M; Choi, HK; Dalbeth, N; Guo, H; He, M; Hu, H; Li, C; Li, Z; Major, TJ; Markie, D; Merriman, TR; Phipps-Green, A; Shi, Y; Stamp, LK; Takei, R; Wei, WH, 2021) |
| "While hyperuricemia is recognized as a risk factor for chronic kidney disease (CKD), the risk of CKD in subjects with a low level of serum uric acid (UA) remains controversial." | ( Furuhashi, M; Hanawa, N; Higashiura, Y; Hisasue, T; Inyaku, M; Koyama, M; Matsumoto, M; Miura, T; Moniwa, N; Mori, K; Numata, K; Ohnishi, H; Osanami, A; Tanaka, M, 2021) |
| "Hyperuricemia is an independent risk factor for the development of many diseases." | ( Lagumdzija, D; Muratovic, S; Omerovic, N; Pehlivanovic, B; Skrbo, S; Ziga-Smajic, N, 2020) |
| "Hyperuricemia is associated with decreased platelet inhibition by thienopyridines but a normal response to ticagrelor." | ( Gremmel, T; Hoberstorfer, T; Kopp, CW; Lee, S; Panzer, S; Pultar, J; Wadowski, PP; Weikert, C, 2021) |
| "Hyperuricemia is defined by a blood urate level > 405 µmol/L, the cut-off value at which urate forms crystals in vivo." | ( Bengtsson Boström, K; Dehlin, M; Forsblad d'Elia, H; Jacobsson, L; Kapetanovic, M; Sigurdardottir, V; Svärd, A; Wändell, P, 2020) |
| "Hyperuricemia is mainly the result of relative underexcretion of urate." | ( Gao, L; Li, H; Li, L; Li, Q; Lin, H; Niu, Y; Yang, P, 2020) |
| "Hyperuricemia is a common metabolic disease that is intimately correlated with inflammation." | ( Chen, MQ; Shi, WR; Sun, YX; Wang, HY, 2021) |
| "Hyperuricemia is an independent risk factor in chronic kidney disease (CKD)." | ( Koilagundla, N; Nutalapati, C; Pingali, U; Taduri, G, 2020) |
| "Hyperuricemia is an independent risk factor for chronic kidney disease (CKD)." | ( Feng, Y; Fu, P; Guo, F; Huang, R; Liao, D; Ma, L; Shi, M; Zeng, X, 2020) |
| "Hyperuricemia is a common laboratory finding in different types of patients." | ( Bandúr, Š, 2020) |
| "Hyperuricemia is a state in which the serum levels of uric acid are elevated." | ( Bevc, S; Ekart, R; Hojs, R; Petreski, T, 2020) |
| "Hyperuricemia is usually associated with gout flares and tophi development but can also present as asymptomatic hyperuricemia." | ( Bevc, S; Ekart, R; Hojs, R; Petreski, T, 2020) |
| "Hyperuricemia is prevalent throughout the world." | ( Huang, C; Huang, XB; Liu, JX; Liu, Y; Ning, Y; Tang, WW; Wang, TD; Xu, RH; Yi, YJ; Zhang, WQ, 2020) |
| "Hyperuricemia is an important problem also in healthy subjects and its prevalence could further increase if lower cut-off will be used." | ( Bombelli, M; Brambilla, P; Cartella, I; Casati, M; Giannattasio, C; Grassi, G; Grasso, E; Maloberti, A; Milani, M; Occhi, L; Qualliu, E; Signorini, S; Sun, J; Tavecchia, G; Tognola, C; Vallerio, P, 2021) |
| "Hyperuricemia is defined as an abnormally high level of uric acid (UA; i." | ( Sun, D; Waheed, Y; Yang, F, 2021) |
| "Hyperuricemia is a well-known key risk factor for gout and can cause a variety of metabolic diseases." | ( Gao, J; Han, L; Ma, J; Tan, Y; Wang, L; Wang, T; Yu, H; Zhang, Y, 2021) |
| "Hyperuricemia is characterized by excessive production and deposition of urate crystals." | ( Li, L; Zeng, C; Zhang, C; Zhang, Y, 2020) |
| "Hyperuricemia is defined as a disease with high uric acid (UA) levels in the blood and a strong risk factor for gout." | ( Adachi, SI; Isoda, H; Komatsu, W; Kondo, S; Sasaki, K; Yagasaki, K; Yoshizawa, F, 2020) |
| "Hyperuricemia is more likely to occur in women (risk ratio (RR) = 1." | ( Bachórzewska-Gajewska, H; Dobrzycki, S; Kulikowska, A; Kurasz, A; Kuźma, Ł; Niwińska, MM; Zalewska-Adamiec, M, 2020) |
| "Thus, hyperuricemia is associated with impaired endothelial function." | ( Bahrudin, U; Hisatome, I; Kuwabara, M; Li, P; Maharani, N; Mahati, E; Miake, J; Ninomiya, H; Taufiq, F; Utami, SB, 2021) |
| "Hyperuricemia is defined by the European Rheumatology Society as a uric acid level greater than 6 mg/dl (60 mg/l or 360 μmol/l)." | ( Affes, H; Charfi, S; Dhouibi, R; Hammami, S; Jamoussi, K; Ksouda, K; Marekchi, R; Moalla, D; Sahnoun, Z; Salem, MB; Zeghal, KM, 2021) |
| "Asymptomatic hyperuricemia is a condition where the serum uric acid levels are elevated but the individual does not have any sign or symptoms of gout or renal stones." | ( Fatima, J; Joshi, P; Kugashiya, R; Shukla, V; Varshney, AR, 2021) |
| "Studies show that hyperuricemia is an element of the pathophysiology of many conditions." | ( Bozic, J; Rada, M; Rumboldt, M; Rumboldt, Z; Rusic, D; Tomicic, M; Zuzic Furlan, S, 2021) |
| "Hyperuricemia is associated with insulin resistance, pancreatic β-cell dysfunction and consequently with development of type 2 diabetes." | ( Ghasemi, A, 2021) |
| "Hyperuricemia is the key risk factor for gout and is considered a prerequisite for monosodium urate (MSU) crystal formation." | ( Dalbeth, N; Narang, RK, 2020) |
| "Hyperuricemia is commonly observed in patients with chronic kidney disease (CKD)." | ( Barbagallo, CM; Bombelli, M; Borghi, C; Casiglia, E; Cicero, AFG; Cirillo, M; Cirillo, P; D'Elia, L; Desideri, G; Ferri, C; Galletti, F; Gesualdo, L; Giannattasio, C; Grassi, G; Iaccarino, G; Leoncini, G; Mallamaci, F; Maloberti, A; Masi, S; Mazza, A; Mengozzi, A; Muiesan, ML; Nazzaro, P; Palatini, P; Parati, G; Pontremoli, R; Rattazzi, M; Rivasi, G; Russo, E; Salvetti, M; Tikhonoff, V; Tocci, G; Ungar, A; Verdecchia, P; Viazzi, F; Virdis, A; Volpe, M, 2022) |
| "Hyperuricemia is highly prevalent in chronic kidney disease (CKD) patients, but the evidence for a relationship between uric acid (UA) and clinical outcomes in CKD patients is limited and inconsistent." | ( Ito, S; Miyazaki, M; Nakayama, M; Sato, H; Watanabe, K; Yamada, G; Yamamoto, T, 2021) |
| "Hyperuricemia is an independent risk factor for non-renal outcomes in primary renal disease and hypertensive renal disease patients." | ( Ito, S; Miyazaki, M; Nakayama, M; Sato, H; Watanabe, K; Yamada, G; Yamamoto, T, 2021) |
| "Hyperuricemia is associated with cardiovascular mortality, but the association of the age at hyperuricemia onset with cardiovascular disease (CVD) and mortality is still unclear." | ( Chen, S; Cui, L; Li, L; Wang, C; Wu, S; Xue, H; Yun, C; Zhang, S; Zhao, M, 2021) |
| "Early onset of hyperuricemia is associated with increased cardiovascular disease and mortality risk." | ( Chen, S; Cui, L; Li, L; Wang, C; Wu, S; Xue, H; Yun, C; Zhang, S; Zhao, M, 2021) |
| "Hyperuricemia is closely associated with insulin resistance syndrome (and its many cardiometabolic sequelae); however, whether they are causally related has long been debated." | ( Choi, HK; Leong, A; McCormick, N; Merriman, TR; Mount, DB; O'Connor, MJ; Yokose, C, 2021) |
| "Hyperuricemia is a growing public health problem with its increasing prevalence." | ( Chen, J; Ding, X; Gong, S; Gu, Y; Lv, S; Shen, Z; Wang, Y; Yu, X; Zhang, D; Zhang, H; Zhang, X, 2021) |
| "Hyperuricemia is a common disease that may lead to gout, renal damage, and cardiovascular events." | ( Chen, J; Deng, Q; Guo, J; Xie, Q; Xie, S; Yu, Y; Zhang, S; Zhong, L, 2021) |
| "Patients with hyperuricemia are among the high-risk group of postoperative gout attacks." | ( Fu, L; Liu, Y; Wen, J; Xu, C; Yan, T; Yang, H; You, Y; Yu, J; Zhan, D; Zhang, T, 2021) |
| "Hyperuricemia is often associated with pre-eclampsia and when this occurs, fetal outcome may become worse." | ( Adebara, IO; Adeniyi, AA; Adewara, OE; Adeyemo, OT; Awoyinka, SB; Ayankunle, OM; Bakare, A; Jimoh, AK; Olumodeji, AM, 2022) |
| "Hyperuricemia is found to be associated with the development and progression of gout, chronic kidney disease, cardiovascular diseases and several others." | ( Sholapuri, D; Tiwaskar, M, 2021) |
| "Hyperuricemia is a frequent finding in patients with arterial hypertension, and there is increasing evidence that this entity is also a risk factor for cardiovascular disease." | ( Albulescu, N; Ardelean, M; Buzas, R; Dorobantu, M; Gheorghe-Fronea, OF; Ivan, VS; Lighezan, DF; Morgovan, AF, 2021) |
| "And gout and hyperuricemia are also possible connection with cardiovascular disease and metabolic syndrome." | ( Dai, LJ; He, FX; Luo, LS; Wang, Y; Zhang, JL; Zhou, Q, 2022) |
| "Hyperuricemia is related to an increased risk of cardiovascular events from a meta-analysis and antihyperuricemia agents may influence to cardiac function." | ( Akasaki, Y; Eguchi, K; Fukumoto, Y; Kamiya, H; Kario, K; Kusunose, K; Node, K; Sata, M; Tanaka, A; Teragawa, H; Yamada, H; Yoshida, H, 2022) |
| "Hyperuricemia is the primary cause of gouty arthritis and other metabolic disorders." | ( Kim, DS; Sung, YY, 2021) |
| "Hyperuricemia is a precursor to gout and is often present in other metabolic diseases that are promoted by microbiome dysbiosis." | ( Dalbeth, N; Lei, G; Li, J; Terkeltaub, R; Wang, Y; Wei, J; Wu, Z; Yang, T; Yang, Z; Zeng, C; Zhang, Y, 2022) |
| "Hyperuricemia is a metabolic condition closely linked to xanthine oxidase (XOD) function, which is involved in the production of uric acid (UA)." | ( Fang, L; Song, D; Su, X; Wang, F; Zhao, X; Zou, F, 2021) |
| "Hyperuricemia is a common metabolic syndrome." | ( Kimura, Y; Kono, H; Tsukui, D, 2021) |
| "Whether hyperuricemia is a true risk factor for elevated blood pressure (BP) is controversial, and the sex-specific effects of serum uric acid (SUA) on BP during a follow-up period remain unclear." | ( Furuhashi, M; Hanawa, N; Higashiura, Y; Koyama, M; Mori, K; Ohnishi, H; Tanaka, M, 2022) |
| "Asymptomatic hyperuricemia is prevalent among young adults and associated with markers of prediabetes, dyslipidemia, and subclinical inflammation." | ( Al Shanableh, Y; Al-Mansoori, A; Al-Mohannadi, M; Aljalham, B; Hussein, YY; Nurulhoque, H; Robelah, F; Saidwali, AH; Zughaier, SM, 2022) |
| "Hyperuricemia is caused by reduced renal/extrarenal excretion and overproduction of uric acid." | ( Maeda, N; Nishizawa, H; Shimomura, I, 2022) |
| "Hyperuricemia is common among patients with chronic kidney disease (CKD)." | ( Coelho, VA; Costa, TEM; Elias, RM; Innecchi, MLR; Lauar, JC; Moysés, RMA, 2022) |
| "Hyperuricemia is widely thought as a risk factor for myocardial infarction (MI) and all-cause mortality; however, the relation of serum uric acid (sUA) and subclinical myocardial injury (SCeMI) remains unclear." | ( Chen, S; Huang, Y; Li, Z; Lin, W; Lin, Z; Wang, F; Yan, L; Yang, X; Zhang, L, 2022) |
| "PCOS patients with hyperuricemia are more obese and have a higher waist-to-hip ratio (WHR) and worse lipid metabolism than those without hyperuricemia." | ( Cai, M; Cui, R; Dilimulati, D; Fei, H; Gao, X; Lin, Z; Qu, S; Shao, X; Sun, H; Zeng, Q; Zhang, M; Zhang, Y, 2021) |
| "Hyperuricemia is a common laboratory finding in pregnant women compromised by preeclampsia." | ( Albrecht, C; Baumann, MU; Lüscher, BP; Stieger, B; Surbek, DV, 2022) |
| "Hyperuricemia is often encountered as glomerular filtration rate decreased." | ( Auberson, M; Bonny, O; Livio, F; Schwotzer, N; So, A, 2022) |
| "Asymptomatic hyperuricemia is frequently observed in pediatric kidney transplant recipients; symptomatic hyperuricemia, however, is a rare complication." | ( Babenko, N; Bald, M; Dello Strologo, L; Ehren, R; Ernst, A; Habbig, S; König, S; Krupka, K; Murer, L; Özçakar, ZB; Pohl, M; Spartà, G; Staude, H; Szabó, AJ; Tönshoff, B; Weber, LT, 2022) |
| "Hyperuricemia is the fundamental factor of gout." | ( Chen, J; Liu, N; Yin, H, 2022) |
| "Hyperuricemia is an independent risk factor for the progression of chronic kidney disease." | ( Lin, X; Wang, M; Yang, X; Yang, Y, 2022) |
| "The prevalence of Hyperuricemia is increasing even in developing countries." | ( Kulkarni, A; N, R; Subhash, N; T, AK, 2022) |
| "Background Hyperuricemia is associated with poor cardiovascular outcomes, although it is uncertain whether this relationship is causal in nature." | ( Bacq-Daian, D; Boivin, JM; Dandine-Roulland, C; Deleuze, JF; Ferreira, JP; Girerd, N; Kanbay, M; Le Floch, E; Rossignol, P; Wagner, S; Xhaard, C; Zannad, F, 2022) |
| "Hyperuricemia is closely related to a variety of diseases and has been listed as one of the twenty most persistent diseases in the 21st century by the United Nations." | ( Cao, H; Cui, X; Feng, Y; He, W; Li, J; Li, Y; Qiu, Y; Wang, D; Yang, X; Yang, Z, 2022) |
| "Hyperuricemia is one of the independent risk factors for atherosclerotic cardiovascular disease." | ( Bao, R; Chen, B; Chen, Q; Han, L; Liu, M; Pan, J; Wang, D; Wang, T; Wang, W; Wu, Y; Yu, H; Zhang, Y, 2022) |
| "Hyperuricemia is defined as serum uric acid of 6." | ( Ingawale, S; Raghorte, N; Rajadhyaksha, A; Sarate, N, 2022) |
| "Hyperuricemia is more prevalent in patients with a sedentary lifestyle." | ( Ingawale, S; Raghorte, N; Rajadhyaksha, A; Sarate, N, 2022) |
| "Hyperuricemia is associated with the activation of the Nod-like receptor protein 3 inflammasome." | ( Hayashi, T; Hiramitsu, S; Hisatome, I; Jinnouchi, H; Kakuda, H; Kawai, N; Kimura, K; Kojima, S; Matsui, K; Mori, H; Ogawa, H; Ohya, Y; Saito, Y; Sugawara, M; Tokutake, E; Tsujita, K; Uchiyama, K; Wakasa, Y; Waki, M; Yokota, N, 2023) |
| "In conclusion, Hyperuricemia is prevalent among Chinese adults." | ( Chen, F; Han, S; Liu, J; Xu, T; Yuan, L, 2022) |
| "Hyperuricemia is a common metabolic disease with a series of complications." | ( Chen, JS; Liu, C; Liu, YF; Sun, B; Sun, JY; Wang, CZ; Wang, MM; Wang, MX; Wang, Z; Yang, QL; Zhang, YK, 2022) |
| "Hyperuricemia is characterized with high serum uric acids (SUAs) and directly causes suffering gout." | ( Cai, M; Chen, S; Gao, X; Hu, H; Huang, L; Li, X; Liang, D; Liu, Y; Wu, Q; Xiao, C; Xie, Y; Yong, T, 2022) |
| "Hyperuricemia is associated with several disease conditions, such as atherosclerosis, arthritis, kidney stones, and many others." | ( Choudhary, MI; Gul, A; Khan, KM; Saad, SM; Zafar, H, 2023) |
| "Hyperuricemia is associated with the risk of developing atrial fibrillation (AF) and heart failure." | ( Bakuła-Ostalska, E; Bednarski, J; Bil, J; Błaszczyk, R; Gawałko, M; Gorczyca-Głowacka, I; Jelonek, O; Kapłon-Cieślicka, A; Krzciuk, M; Lubas, A; Maciorowska, M; Mamcarz, A; Rajtar-Salwa, R; Szpotowicz, A; Szyszkowska, A; Tokarek, T; Tomaszuk-Kazberuk, A; Uziębło-Życzkowska, B; Wełnicki, M; Wójcik, M; Wójcik, W; Wojewódzki, M; Wożakowska-Kapłon, B, 2022) |
| "Hyperuricemia is a chronic disease prevalent worldwide and is associated with high recurrence rates." | ( Chen, C; Chen, FA; Chen, HC; Chiu, PY; Li, YL; Wang, CC, 2022) |
| "Hyperuricemia is a critical threat to human health, and conventional medical treatment only aims to treat acute gouty arthritis." | ( Chen, X; Lu, Y; Lu, Z; Meng, F; Pang, X; Zhang, L; Zhao, H; Zhou, L, 2022) |
| "Hyperuricemia is an independent risk factor for high AIP level." | ( An, Y; Chang, X; Ding, X; Duan, Y; Liu, J; Wang, G, 2022) |
| "Although hyperuricemia is undoubtedly related to CKD, controversial findings have been hitherto reported in patients treated with urate-lowering therapies." | ( Battelli, MG; Bolognesi, A; Bortolotti, M; Polito, L, 2022) |
| "Hyperuricemia is a state in which the serum levels of uric acid (UA) are elevated." | ( Aili, A; Nuermaimaiti, B; Rehemu, N; Sun, H; Tuerxun, Z; Xilifu, D; Zhang, X, 2022) |
| "Hyperuricemia is associated with aortic dissection and cardiovascular diseases." | ( Chen, X; Hu, Q; Huang, L; Lin, G; Luo, W; Ma, S; Wu, D; Xu, Q, 2022) |
| "Whether hyperuricemia is an independent risk factor for renal progression and whether there are sex differences in the relationships between serum uric acid (UA) and a decline in renal function are unclear." | ( Chen, JH; Chen, SC; Chung, TL; Huang, JC; Liu, YH; Su, HM; Tsai, CC; Wu, PY, 2022) |
| "Hyperuricemia is a purine metabolism disorder, with increasing prevalence worldwide." | ( Hou, C; Li, Y; Ren, J; Sha, W; Yao, M, 2022) |
| "The prevalence of hyperuricemia is very high in Guangxi." | ( Lin, F; Lujie, Z; Min, G; Peng, W; Qingyun, C; Yuanyuan, Q; Yunhua, H, 2022) |
| "Asymptomatic hyperuricemia is a common comorbidity among older outpatients with knee osteoarthritis." | ( Cao, TN; Huynh, KN; Nguyen, MD; Tran, HT, 2022) |
| "Hyperuricemia is a well-known cause of gout and also a risk factor for various comorbidities." | ( Chen, S; Chen, Z; Gao, K; Ge, H; Li, L; Li, Y; Lin, G; Zhu, J, 2022) |
| "hyperuricemia is positively associated with insulin resistance and beta-cell function in nondiabetic Korean men and postmenopausal women but not in premenopausal women." | ( Cha, JA; Gi, MY; Park, CH; Park, SY; Seong, JM; Sung, HH; Yoon, H, 2023) |
| "In our study, hyperuricemia is significantly associated with the prevalence of metabolic syndrome and part of its components, and these relationships are not affected by sex or age." | ( Bao, S; Feng, H; Ge, W; Xu, L; Yao, S; Zhang, Q; Zhou, Y, 2022) |
| "Hyperuricemia is the chief cause of gout and has been linked with hypertension, cardiovascular and renal disease, diabetes and metabolic syndrome." | ( Chen, SC; Lee, WH; Liu, YH; Lu, CC; Su, HM, 2022) |
| "Hyperuricemia is prevalent and associated with individual cardiometabolic diseases, highlighting the potential role of serum uric acid (SUA) in the development and progression of cardiometabolic multimorbidity (CMM, the coexistence of diabetes, heart disease, or stroke)." | ( Dai, X; Li, D; Ni, Y; Wang, D; Xu, X, 2022) |
| "Hyperuricemia is prevalent and associated with individual cardiometabolic diseases, highlighting the potential role of serum uric acid (SUA) in the development and progression of cardiometabolic multimorbidity (CMM, the coexistence of diabetes, heart disease, or stroke)." | ( Dai, X; Li, D; Ni, Y; Wang, D; Xu, X, 2022) |
| "Hyperuricemia is prevalent and associated with individual cardiometabolic diseases, highlighting the potential role of serum uric acid (SUA) in the development and progression of cardiometabolic multimorbidity (CMM, the coexistence of diabetes, heart disease, or stroke)." | ( Dai, X; Li, D; Ni, Y; Wang, D; Xu, X, 2022) |
| "Hyperuricemia is prevalent among middle-aged and elderly individuals, which affects the development of various chronic diseases." | ( Chen, J; Chen, X; Han, J; Li, N; Liu, Q; Shen, L; Wang, H; Xie, H; Yu, P; Zhou, G, 2022) |
| "Hyperuricemia is defined as serum uric acid levels higher than or equal to 420 mmol/l in men and 360 mmol/l in women." | ( Chen, J; Chen, X; Han, J; Li, N; Liu, Q; Shen, L; Wang, H; Xie, H; Yu, P; Zhou, G, 2022) |
| "Hyperuricemia is prevalent among middle-aged and elderly individuals, which affects the development of various chronic diseases." | ( Chen, J; Chen, X; Han, J; Li, N; Liu, Q; Shen, L; Wang, H; Xie, H; Yu, P; Zhou, G, 2022) |
| "Hyperuricemia is defined as serum uric acid levels higher than or equal to 420 mmol/l in men and 360 mmol/l in women." | ( Chen, J; Chen, X; Han, J; Li, N; Liu, Q; Shen, L; Wang, H; Xie, H; Yu, P; Zhou, G, 2022) |
| "Hyperuricemia is prevalent among middle-aged and elderly individuals, which affects the development of various chronic diseases." | ( Chen, J; Chen, X; Han, J; Li, N; Liu, Q; Shen, L; Wang, H; Xie, H; Yu, P; Zhou, G, 2022) |
| "Hyperuricemia is defined as serum uric acid levels higher than or equal to 420 mmol/l in men and 360 mmol/l in women." | ( Chen, J; Chen, X; Han, J; Li, N; Liu, Q; Shen, L; Wang, H; Xie, H; Yu, P; Zhou, G, 2022) |
| "Hyperuricemia is a common feature in pregnancies compromised by pre-eclampsia, a pregnancy disease characterized by hypertension and proteinuria." | ( Baumann, MU; Lüscher, BP; Schoeberlein, A; Surbek, DV, 2022) |
| "Hyperuricemia is a common feature in pregnancies compromised by pre-eclampsia, a pregnancy disease characterized by hypertension and proteinuria." | ( Baumann, MU; Lüscher, BP; Schoeberlein, A; Surbek, DV, 2022) |
| "Hyperuricemia is a common feature in pregnancies compromised by pre-eclampsia, a pregnancy disease characterized by hypertension and proteinuria." | ( Baumann, MU; Lüscher, BP; Schoeberlein, A; Surbek, DV, 2022) |
| "Hyperuricemia is a metabolic disease caused by the accumulation of uric acid in the body." | ( Cui, J; Hou, J; Wang, W; Zhang, X, 2022) |
| "Hyperuricemia is a metabolic disease caused by the accumulation of uric acid in the body." | ( Cui, J; Hou, J; Wang, W; Zhang, X, 2022) |
| "It is known that hyperuricemia is recognized as an independent cardiovascular risk factor." | ( Ariev, AL; Kunitskaya, NA, 2022) |
| "Hyperuricemia is the result of overproduction and/or underexcretion of uric acid, and it is a well-known risk factor for gout, hypertension, and diabetes." | ( Gao, L; Li, L; Li, N; Li, Q; Lin, H; Niu, Y; Tu, C; Wang, Z; Zhou, Z, 2023) |
| "Hyperuricemia is a metabolic disease caused by purine nucleotide metabolism disorder." | ( Cheng, J; Koyama, H; Yamamoto, T; Yu, W, 2023) |
| "Hyperuricemia is closely related to the occurrence of gout, hypertension, diabetes, hyperlipidemia, cardiovascular disease, kidney disease, metabolic syndrome, etc." | ( Lin, Z; Liu, Y; Shu, M; Sun, J; Wang, R; Yi, B; Zhang, Z, 2023) |
| "Hyperuricemia is well-known as an independent risk factor for the development of hypertension, metabolic syndrome, and cardiovascular disease." | ( Badarienė, J; Čypienė, A; Gimžauskaitė, S; Jasiūnas, E; Kazėnaitė, E; Rinkūnienė, E; Rugienė, R; Ryliškytė, L, 2023) |
| "Hyperuricemia is an overlooked cardiovascular and renal risk factor." | ( Agnoletti, D; Borghi, C; Piani, F, 2023) |
| "In Japan, hyperuricemia is on the rise." | ( Akiyama, M; Arai, H; Asai, T; Kawakami, Y; Koike, R; Kondo, R; Onishi, M, 2023) |
| "Hyperuricemia is an independent risk factor for chronic kidney disease." | ( Cao, H; Chen, Q; Li, K; Liu, L; Liu, M; Wang, D; Wang, T; Wu, Y; Zhang, Y, 2023) |
| "Hyperuricemia is an important pathological basis of gout and a distinct hazard factor for metabolic syndromes and cardiovascular and chronic renal disease, but lacks safe and effective treatments currently." | ( An, J; Li, C; Li, Y; Lin, F; Ma, S; Wang, S; Xie, Y; Xu, L; Zhang, Y; Zhao, Y, 2023) |
| "Hyperuricemia is an independent predictor of incident CKD." | ( Guo, Y; Ke, S; Liu, Q; Yan, Y; Zhou, Q, 2023) |
| "Asymptomatic hyperuricemia is associated with an increased risk of developing nephrolithiasis." | ( Cheng, N; Deng, H; Hou, Z; Li, Y; Meng, Q; Song, C; Sun, Y; Wang, Q; Yin, J; Zhang, J; Zhang, X, 2023) |
| "Hyperuricemia is perceived as one of the risk factors for developing and progressing cardiovascular disease and metabolic syndrome through various pathological mechanisms." | ( Badarienė, J; Čypienė, A; Gimžauskaitė, S; Jasiūnas, E; Laucevičius, A; Rinkūnienė, E; Ryliškytė, L, 2023) |
| "Hyperuricemia is characterized by elevated uric acid (UA) level in the body." | ( Fan, M; Gao, Q; Li, Y; Lou, Y; Qian, H; Waleed, AA; Wang, L, 2023) |
| "Drug-induced hyperuricemia is increasingly prevalent in clinical practice." | ( Bohra, GK; Kumar, D; Meena, DS, 2023) |
| "Hyperuricemia is common during tuberculosis (TB) treatment, especially in association with pyrazinamide (PZA)." | ( Jeong, SH; Kho, BG; Kim, TO; Kim, YI; Kwon, YS; Lee, JK; Lim, SC; Na, YO; Shin, HJ; Yoon, JY, 2023) |
| "Hyperuricemia is a clinical disease characterized by a continuous increase in uric acid (UA) due to purine metabolism disorder." | ( Bian, W; Fu, Z; Li, C; Liu, N; Liu, Y; Peng, Y; Ru, Z; Wang, Y; Wu, Y; Yang, X; Zhang, Y, 2023) |
| "Asymptomatic hyperuricemia is considered an independent cardiovascular risk factor." | ( Calderón-García, JF; Juárez-Vela, R; López-Espuela, F; Rey-Sánchez, P; Rico-Martín, S; Sánchez Muñoz-Torrero, JF; Sánchez-Bacaicoa, C; Santano-Mogena, E, 2023) |
| "Hyperuricemia is a known risk factor of lipid metabolism disorder." | ( Bao, R; Chen, B; Chen, Q; Pan, J; Wang, A; Wang, T; Yu, H; Zhang, Y, 2023) |
| Excerpt | Reference |
|---|
| "Hyperuricemia has been shown to be associated with an increased risk of cardiovascular disease in hypertensive patients in some but not in all epidemiological studies in which this relationship has been investigated." | ( Campo, C; Garcia-Puig, J; García-Robles, R; Rodicio, JL; Ruilope, LM; Segura, J, 2003) |
| "The prevalence of hyperuricemia has rarely been investigated in developing countries." | ( Bovet, P; Burnier, M; Conen, D; Paccaud, F; Riesen, W; Shamlaye, C; Wietlisbach, V, 2004) |
| "Hyperuricemia has been proposed as a risk marker in chronic heart failure, but its value as an independent prognostic is not well established." | ( Castro, P; Cerda, C; Corbalán, R; González, A; Isa, R; Martínez, A; Pérez, O; Pérez, P, 2004) |
| "Although hyperuricemia has long been associated with renal disease, uric acid has not been considered as a true mediator of progression of renal disease." | ( Kang, DH; Nakagawa, T, 2005) |
| "Hyperuricemia has been linked to cardiovascular and renal diseases, possibly through the generation of reactive oxygen species (ROS) and subsequent endothelial dysfunction." | ( Block, ER; Finch, JL; Johnson, RJ; Khosla, UM; Krotova, K; Mu, W; Nakagawa, T; Prabhakar, S; Roncal, C; Zharikov, S, 2005) |
| "Hyperuricemia has been shown to be related to cardiovascular morbidity and mortality." | ( Chang, YY; Chen, SS; Chen, WH; Huang, CC; Liu, JS; Peng, MC; Tsai, WC, 2005) |
| "Hyperuricemia has been identified in patients who have congestive heart failure and is a marker of poor prognosis in such patients." | ( Hiraoka, H; Honda, T; Ishihara, M; Kimura, K; Kojima, S; Matsui, K; Miyazaki, S; Ogata, Y; Ogawa, H; Sakamoto, T; Shimoyama, N; Sonoda, M; Tei, C; Tsuchihashi, K; Yamagishi, M, 2005) |
| "Hyperuricemia has been associated with an increased risk for cardiovascular disease and increased mortality." | ( Hisatome, I; Igawa, O; Ishida, K; Kato, M; Kinugawa, T; Kotani, K; Ogino, K; Shigemasa, C; Somers, VK; Tomikura, Y, 2005) |
| "Hyperuricemia has been observed in patients with non-treated hypertension." | ( Chizyński, K; Rózycka, M, 2006) |
| "Hyperuricemia has been associated with increased cardiovascular mortality in the general population, but less is known about this association in patients with CKD." | ( Axelsson, J; Bárány, P; Carrero, JJ; García-López, E; Heimbürger, O; Johnson, RJ; Lindholm, B; Molinaei, H; Qureshi, AR; Stenvinkel, P; Suliman, ME, 2006) |
| "Hyperuricemia has long been known to be associated with cardiovascular disease, and it is particularly common in people with hypertension, metabolic syndrome, or kidney disease." | ( Heinig, M; Johnson, RJ, 2006) |
| "Hyperuricemia has been associated with the development of hypertension, cardiovascular, and renal disease." | ( Akcay, A; Bavbek, N; Covic, A; Isik, B; Kanbay, M; Ozkara, A; Selcoki, Y; Turgut, F; Uz, E; Yigitoglu, R, 2007) |
| "Hyperuricemia has been reported as being an adverse effect of pegylated-interferon-alpha2b (Peg-IFNalpha2b) and ribavirin combination therapy for chronic hepatitis C and hyperuricemic changes occur in some patients during the therapy." | ( Enjoji, M; Higuchi, N; Horikawa, Y; Kato, M; Kinukawa, N; Kotoh, K; Nakamuta, M; Tajiri, H; Takayanagi, R; Ueda, A; Yamashita, N, 2008) |
| "Hyperuricemia has also been found to be an independent risk factor for cardiovascular disease and hypertension." | ( Edwards, NL, 2008) |
| "Hyperuricemia has recently been recognized to be a risk factor for nephropathy in the diabetic subject." | ( Heinig, M; Johnson, RJ; Kosugi, T; Nakagawa, T; Nakayama, T; Roncal, C; Sanchez-Lozada, LG; Yuzawa, Y; Zhang, L, 2009) |
| "Hyperuricemia has been shown to be associated with metabolic syndrome and to be an independent risk factor for cardiovascular disease." | ( Keenan, RT; Pillinger, MH, 2009) |
| "Gout and hyperuricemia have long been suspected to be risk factors for cardiovascular disease." | ( Keenan, RT; Shah, A, 2010) |
| "Although gout and hyperuricemia have received considerable attention recently, there is limited information on the two conditions in young people." | ( Yamanaka, H, 2011) |
| "Hyperuricemia has been found in 60% of patients hospitalized because of decompensation of CHF." | ( Bart, BIa; Brodskiĭ, MS; Larina, VN, 2011) |
| "Hyperuricemia has been associated with metabolic disorders." | ( Cabibi, D; Cammà, C; Craxì, A; Di Marco, V; Petta, S, 2011) |
| "Hyperuricemia has been reported to be a common feature of sickle cell disease occurring between 32 to 41% of the patients, in studies conducted during the 1970's." | ( Arlet, JB; Chatellier, G; Courbebaisse, M; de Montalembert, M; Pouchot, J; Prié, D; Ribeil, JA, 2012) |
| "Hyperuricemia has also demonstrated its usefulness as a predictor of maternal and fetal complications and maternal sequelae of late postpartum." | ( Rico-Trejo, EI; Vázquez-Rodríguez, JG, 2011) |
| "Hyperuricemia has been associated with an increased risk of endothelial dysfunction (ED), cardiovascular and renal disease." | ( Espinola-Zavaleta, N; Kuri-Alfaro, J; López-Osorio, C; Meléndez-Ramírez, G; Pérez-Méndez, O, 2012) |
| "Generally, hyperuricemia has been classified into urate 'overproduction type' and/or 'underexcretion type' based solely on renal urate excretion, without considering an extra-renal pathway." | ( Hosoya, T; Hosoyamada, M; Ichida, K; Ikebuchi, Y; Inoue, H; Ito, K; Kasuga, H; Kawamura, Y; Matsuo, H; Murakami, K; Nakamura, M; Nakamura, T; Nakashima, H; Nakayama, A; Okada, C; Sakurai, Y; Shimizu, T; Shinohara, Y; Shinomiya, N; Suzuki, H; Takada, T; Takada, Y; Utsumi, Y; Yamanashi, Y, 2012) |
| "Hyperuricemia has been implicated in the development and progression of chronic kidney disease, both in animal experiments and in clinical studies." | ( Fick-Brosnahan, GM; Helal, I; McFann, K; Reed, B; Schrier, RW; Yan, XD, 2013) |
| "Gout and hyperuricemia have likewise been associated with the development of cardiovascular disease and metabolic syndrome." | ( De Jesus, E; Rachabattula, S; Torralba, KD, 2012) |
| "Hyperuricemia has been shown to be a strong correlate of hypertension in children." | ( Antolini, L; Brambilla, P; Galbiati, S; Genovesi, S; Giussani, M; Mastriani, S; Pontremoli, R; Stella, A; Valsecchi, MG; Viazzi, F, 2013) |
| "Whether hyperuricemia has any impact on the association between C-reactive protein (CRP) and hypertension is not known." | ( Krishnan, E, 2014) |
| "Gouty arthritis and hyperuricemia have ailed humans for centuries." | ( Espinoza, LR; Grewal, HK; Martinez, JR, 2014) |
| "The prevalence of hyperuricemia has doubled worldwide during the last few decades." | ( Castañón-Robles, S; Cervantes-Rodríguez, M; Denova-Gutiérrez, E; Granados-García, V; Huitrón-Bravo, GG; Meneses-Leon, J; Quiterio-Trenado, M; Rivera-Paredez, B; Rudolph, SE; Salmerón, J; Talavera, JO, 2014) |
| "Generally, hyperuricemia has been classified into urate "overproduction type," "underexcretion type," and "combined type" based on only renal urate excretion, without considering an extra-renal pathway such as gut excretion." | ( Chiba, T; Hosoya, T; Ichida, K; Matsuo, H; Nakamura, T; Nakashima, H; Nakayama, A; Sakiyama, M; Sakurai, Y; Shimizu, S; Shimizu, T; Shinomiya, N; Takada, T; Takada, Y, 2014) |
| "Hyperuricemia has been associated with hypertension, diabetes mellitus, and metabolic syndrome." | ( Andrade, JA; Garcia Rosa, ML; Greffin, S; Kang, HC; Lugon, JR, 2014) |
| "Hyperuricemia has been considered to be a key risk factor for kidney disease." | ( Ding, G; Guo, C; Huang, W; Li, N; Meng, Z; Tang, Z; Wang, Z; Xiao, W; Yan, Y; Yang, Z, 2015) |
| "Hyperuricemia has been reported to affect renal hemodynamics in rat models." | ( Ichii, M; Inaba, M; Ishimura, E; Mori, K; Nakatani, S; Nakatani, T; Ochi, A; Ohno, Y; Tsuda, A; Uchida, J; Uedono, H; Yasumoto, M, 2015) |
| "Hyperuricemia has long been established as the major etiologic factor in gout." | ( Gliozzi, M; Malara, N; Mollace, V; Muscoli, S, 2016) |
| "Hyperuricemia has been shown as an independent risk factor for acute myocardial infarction and an independent and conjoint association of either gout and SUA with total and cardiovascular mortality has been reported, with mortality impact in gout patients increasing with rising SUA concentrations, even for SUA levels in the normal to high range." | ( Iellamo, F; Romeo, F; Sposato, B; Volterrani, M, 2016) |
| "Secondary hyperuricemia has to be differentiated from primary forms." | ( Gröbner, W, 2015) |
| "Recently hyperuricemia has been identified as a risk factor for progression of chronic kidney disease (CKD)." | ( Almaani, S; Ayoub, I; Brodsky, S; Hebert, L; Nadasdy, T; Prosek, J; Rovin, B, 2016) |
| "Hyperuricemia has been shown to be associated with increased risks of gout and cardiovascular diseases." | ( Chen, S; Cong, H; Cui, L; Gao, J; Gao, X; Huang, Z; Li, W; Li, Z; Meng, L; Wang, Z; Wu, S; Zhang, G; Zhang, R; Zheng, X; Zhou, J, 2016) |
| "Hyperuricemia has been associated with increased risk of endothelial dysfunction, cardiovascular, and renal disease." | ( Burata, A; Ruangkanchanasetr, P; Satirapoj, B; Supasyndh, O; Wirajit, O, 2015) |
| "Hyperuricemia has been widely accepted to be associated with the incidence of paroxysmal or persistent AF, as well as to the risk of AF in post cardiovascular surgery patients." | ( Hisatome, I; Kuwabara, M; Maharani, N, 2016) |
| "Hyperuricemia has been linked to metabolic syndrome, cardiovascular disease, and chronic kidney disease." | ( Ahmadieh, H; Azar, S, 2017) |
| "Hyperuricemia has recently emerged as an independent risk factor in the development of type 2 diabetes mellitus and hypertension through several proposed mechanisms." | ( Mortada, I, 2017) |
| "Hyperuricemia has long been known to cause gout, and has recently been correlated with cardiovascular disease, hypertension, and renal disease." | ( Pontremoli, R, 2017) |
| "The prevalence of hyperuricemia has increased rapidly over the past decades." | ( Gao, R; He, JC; Hu, J; Li, J; Li, Q; Luo, T; Ma, L; Peng, C; Qing, H; Wang, Y; Wang, Z; Wu, C; Xiang, X; Xiao, X; Yang, S; Yang, Y; Zhang, L; Zou, L, 2018) |
| "Hyperuricemia has been associated with an increased risk of comorbidities such as metabolic syndrome or cardiovascular diseases." | ( Ahn, JK; Chung, PW; Hwang, J; Hwang, JH; Ryu, S; Yoon, WT, 2018) |
| "Hyperuricemia has been associated in epidemiological studies with the development of obesity, hypertension, insulin resistance and type 2 diabetes." | ( Maalouf, NM; Marin, M, 2018) |
| "As uncontrolled hyperuricemia has been associated with an increased risk of cardiovascular disease and the progression of chronic kidney disease (CKD), management of serum uric acid levels is important." | ( Cho, YS; Han, N; Kim, YS; Kwak, CH; Oh, JM; Sohn, M, 2018) |
| "Hyperuricemia has a close relationship with cardiovascular diseases including heart failure." | ( Adachi, T; Anraku, K; Arikawa, T; Inoue, T; Ishimura, K; Kato, T; Koyabu, Y; Narita, JI; Sakuma, M; Sato, Y; Suwa, H; Toyoda, S; Yamauchi, F, 2018) |
| "Hyperuricemia has been epidemiologically associated with multiple comorbidities including chronic renal failure and cardiovascular disease." | ( Block, C; Field, C; Li, Z; Taylor, T; Xie, J; Yamamoto, T, 2019) |
| "Hyperuricemia has been recognized as an independent cardiovascular risk factor in epidemiological studies." | ( Meschi, T; Nouvenne, A; Prati, B; Tana, C; Ticinesi, A, 2018) |
| "Hyperuricemia has been associated with cardiovascular risk factors but it remains controversial if uric acid is an independent predictor of cardiac mortality." | ( Martínez-Quintana, E; Riaño-Ruiz, M; Rodríguez-González, F; Rodríguez-Hernández, JL, 2018) |
| "Hyperuricemia has been associated with high blood pressure (BP) values, diabetes mellitus, metabolic syndrome and chronic kidney disease (CKD)." | ( Bombelli, M; Facchetti, R; Grassi, G; Lurbe, E; Maloberti, A; Mancia, G; Redon, J; Redon, P, 2019) |
| "Hyperuricemia has been associated with mortality in patients with coronary artery disease (CAD)." | ( Feng, X; Gao, R; Hui, R; Jiang, L; Liu, J; Song, L; Sun, K; Tian, J; Wang, D; Xu, B; Xu, L; Yuan, J; Zhang, C; Zhang, Y; Zhao, W; Zhao, X, 2019) |
| "Hyperuricemia has been identified as an independent risk factor for chronic kidney disease (CKD) and is associated with the progression of kidney diseases." | ( Bao, W; Fang, L; Gu, H; Lin, T; Liu, N; Lu, J; Ma, S; Qiu, A; Shi, Y; Tao, M; Wang, Y; Xu, L; Zhuang, S, 2019) |
| "Hyperuricemia has been associated with decreased amount of HDL cholesterol and increased amounts of triglycerides and LDL cholesterol." | ( Arora, T; Bidri, RC; Mantur, PG; Mulimani, MS, 2018) |
| "Hyperuricemia has been recognized as a risk factor for insulin resistance as well as one of the factors leading to diabetic kidney disease (DKD)." | ( Asano, T; Fujishiro, M; Inoue, MK; Kikuchi, T; Kushiyama, A; Masaki, T; Matsunaga, Y; Mizuno, Y; Morii, K; Nakatsu, Y; Ono, H; Sakoda, H; Sasaki, K; Takahashi, M; Ueda, K; Yamamotoya, T, 2019) |
| "Hyperuricemia has received increasing attention as a major public health problem." | ( Chen, C; Du, H; Lu, X; Ni, Q; Zhang, R, 2019) |
| "Hyperuricemia has been associated with chronic kidney disease (CKD) progression." | ( Anderson, GF; Chang, SH; Chen, YC; Hsiao, CY; Hsu, YO; Huang, YT; Hung, CC; Kuo, CF; Kuo, G; Lee, CC; Lin, CY; Lin, HL; Lin, WT; Tian, YC; Tsai, CY; Wu, CY; Wu, IW; Yang, CC; Yang, CW; Yang, HY; Yen, TH, 2020) |
| "BACKGROUND Hyperuricemia has a pathogenic role in the development of hypertension and other cardiovascular diseases (CVD)." | ( Li, H; Liu, H; Qian, F; Zhang, Z, 2019) |
| "Hyperuricemia has been reported to be associated with the development of postoperative acute kidney injury (pAKI)." | ( Hatakeyama, Y; Horino, T; Kawano, T; Locatelli, FM; Matsumoto, T; Nagata, K; Okuhara, Y; Terada, Y; Watanabe, S; Yokoyama, M, 2019) |
| "Hyperuricemia has been found to cluster with multiple components of metabolic syndrome (MetS)." | ( Biradar, MI; Chiang, KM; Huang, YT; Pan, WH; Yang, HC, 2020) |
| "Hyperuricemia has been reported to be a risk factor for hypertension, but this association may be affected by alcohol consumption." | ( Asayama, K; Izawa, S; Miyamatsu, N; Miyamoto, Y; Morimoto, A; Ohkubo, T; Ohno, Y; Satoh, M; Sonoda, N; Tatsumi, Y, 2020) |
| "The prevalence of hyperuricemia has increased substantially in recent decades." | ( Abete, I; Alonso-Gómez, ÁM; Altozano Rodado, MC; Álvarez-Pérez, J; Arellano, AG; Babio, N; Barragán, R; Becerra-Tomás, N; Bernal, R; Cano-Ibáñez, N; Carmona-González, FJ; Caro, JLL; Casas, R; Corbella, E; Corella, D; Daimiel, L; de la Hera, MG; Díaz-López, A; Estruch, R; Fernández-Carrión, R; Fernández-García, JC; Fitó, M; Gaforio, JJ; Goday, A; Lapetra, J; Lopez-Miranda, J; Martín, M; Martínez, JA; Martínez-González, MÁ; Matía-Martín, P; Mena-Sánchez, G; Morey, M; Palau, A; Pérez-Vega, KA; Pintó, X; Romaguera, D; Ros, E; Ruiz-Canela, M; Salas-Salvadó, J; Santos-Lozano, JM; Serra-Majem, L; Sureda, A; Toledo, E; Tur, JA; Vaquero-Luna, J; Vázquez, C; Vidal, J; Vioque, J; Wärnberg, J; Zomeño, MD, 2020) |
| "Hyperuricemia has been associated with metabolic syndrome, and the association with various cardiometabolic risk factors may be affected by sex." | ( Hoshide, S; Kwon, Y; Lee, JT; Lin, CS; Lin, GM; Lin, YK; Lin, YP; Su, FY; Tsai, KZ; Wu, TJ, 2020) |
| "Hyperuricemia has been well studied in the past two decades, revealing mechanistic insights into UA homeostasis." | ( Dissanayake, LV; Palygin, O; Spires, DR; Staruschenko, A, 2020) |
| "Hyperuricemia has been recognized as a worldwide public health concern." | ( He, H; Jiang, T; Wang, H; Wang, N; Wang, Y; Wu, J; Xie, D; Yang, T; Zhu, Z, 2020) |
| "Although hyperuricemia has been shown to be associated with the progression of cardiovascular disorder and chronic kidney disease (CKD), there is conflicting evidence as to whether xanthine oxidase (XO) inhibitors confer organ protection besides lowering serum urate levels." | ( Hayama, Y; Kuribayashi-Okuma, E; Morimoto, C; Omizo, H; Shibata, S; Tamura, Y; Uchida, S; Ueno, M, 2020) |
| "Although hyperuricemia has been associated with CKD in many studies, it remains controversial whether this is the cause or the result of decreased renal function." | ( Jo, YI; Lee, JH; Park, JH, 2020) |
| "Hyperuricemia has shown to have a J-shaped relationship with mortality, is frequently associated with development and progression of heart and kidney disease, and is correlated with malnutrition-inflammation-atherosclerosis syndrome, although several Mendelian studies have failed to show an association with morbidity and mortality." | ( Bevc, S; Ekart, R; Hojs, R; Petreski, T, 2020) |
| "Hyperuricemia has become a major health problem among urban adults aged 35-79 years in southwestern China, and special attention should be paid to men." | ( Huang, C; Huang, XB; Liu, JX; Liu, Y; Ning, Y; Tang, WW; Wang, TD; Xu, RH; Yi, YJ; Zhang, WQ, 2020) |
| "Hyperuricemia has been considered a complication of chronic kidney disease (CKD)." | ( Sun, D; Waheed, Y; Yang, F, 2021) |
| "Hyperuricemia has been associated with hypertension, however, whether this association exists across all decades of adult life is unknown." | ( Charchar, FJ; Drummond, GR; Golledge, J; Hou, X; Hu, W; Qian, T; Sobey, CG; Sun, H; Wang, Y; Xu, Q; Yang, G; Zhang, G, 2021) |
| "Hyperuricemia has an important influence on the progression of ANCA-associated renal vasculitis." | ( An, D; Guo, Y; Ma, P; Tang, L; Wang, R; Wu, Y, 2021) |
| "Hyperuricemia has not been found to increase the risk of cognitive impairment in people 55 years and older." | ( Chen, P; Fu, Z; Hu, D; Su, C; Wang, H; Wang, X; Wang, Z; Zhang, B; Zhang, Z, 2021) |
| "Hyperuricemia has been associated with a number of chronic diseases, such as type 2 diabetes mellitus, hypertension, and cardiovascular diseases." | ( Lee, KW; Shin, D, 2021) |
| "Hyperuricemia has been reported to be correlated with IgA nephropathy (IgAN)." | ( Cai, Z; Cui, FQ; Jiang, SS; Meng, Y; Tang, L; Wang, MD; Wang, YF; Zhang, K; Zhao, WJ, 2022) |
| "Hyperuricemia has become a common metabolic disease, and is a risk factor for multiple diseases, including chronic kidney disease." | ( Chen, H; Hu, Y; Li, J; Liu, N; Ma, X; Shi, Y; Tao, M; Wang, Y; Zhou, X, 2022) |
| "hyperuricemia has attracted greater attention." | ( Balaraj, K; G, S; Mukherjee, T; Prabhu, R; Sc, R, 2022) |
| "Hyperuricemia has a suspected relationship with hypertension, metabolic syndrome, kidney disease, and cardiovascular disease." | ( Cho, YM; Hong, YC; Kim, BN; Kim, JI; Lee, YA; Lee, YJ; Lim, YH; Shin, CH, 2022) |
| "Hyperuricemia has an increasing incidence in various regions year by year, in this study, we evaluated the prevalence of hyperuricemia in a routine physical examination in Nanning, Guangxi Province, and analyzed the influencing factors of hyperuricemia, aiming to provide evidence for the prevention and treatment of hyperuricemia and related diseases." | ( Lin, F; Lujie, Z; Min, G; Peng, W; Qingyun, C; Yuanyuan, Q; Yunhua, H, 2022) |
| "Although hyperuricemia has been associated with multiple CV complications, it is not officially recognized as a target parameter for CVD risk reduction." | ( Bletsa, E; Kassi, GN; Oikonomou, E; Paschou, SA; Siasos, G; Stampouloglou, PK; Tsigkou, V; Vasileiou, V, 2022) |
| "aristatus treats hyperuricemia has not been clarified." | ( Bian, M; Niu, H; Zhang, X; Zhou, Z; Zhu, C, 2023) |
| "Hyperuricemia has been linked with the development of diabetes, gout, kidney, and cardiovascular diseases." | ( Chen, SC; Huang, JC; Lin, TH; Liu, YH; Su, HM; Su, SY; Wu, PY, 2023) |
| "Hyperuricemia has become a vital public health problem affecting the health of residents." | ( Hang, Y; Huang, X; Jiang, L; Liu, Y; Ma, H; Pan, H; Rong, S; Zhang, X; Zhou, Z; Zou, L, 2023) |