A form of chronic pain that tends to be non-localized and wide-reaching.
| Excerpt | Reference |
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| "One hundred and sixty-three chronic pain patients treated at a specialty pain clinic completed self-report questionnaires at two time points assessing affective and sensory components of pain, depression, and self-criticism." | ( Lerman, SF; Rudich, Z; Shahar, G, 2012) |
| "A systematic review of chronic pain treatment with strong opioids (step 3 WHO pain ladder) and a comparison to a new drug recently approved for the treatment of severe chronic pain in Europe, tapentadol (Palexia, Nucynta*), were performed." | ( Forbes, C; Harker, J; Kleijnen, J; Misso, K; Riemsma, R; Schäfer, M; Stürzebecher, S; Worthy, G, 2011) |
| "Treatment of chronic pain is complicated by the evidence that abuse of prescription opioids is rising; therefore, in many cases, chronic pain remains undertreated." | ( El-Feky, G; Kamel, R; Mahmoud, A, 2012) |
| "Patients with opioid pharmacotherapy for chronic pain who undergo surgery merit special attention for acute pain management." | ( Chapman, CR; Davis, J; Donaldson, GW; Naylor, J; Winchester, D, 2011) |
| "LP1 is a novel analgesic agent for chronic pain treatment, and its low tolerance-inducing capability may be correlated with its ability to bind both the MOR and DOR." | ( Aricò, G; Fourla, DD; Georgoussi, Z; Marrazzo, A; Parenti, C; Pasquinucci, L; Prezzavento, O; Ronsisvalle, G; Ronsisvalle, S; Scoto, GM; Turnaturi, R, 2012) |
| "Compared to those not reporting chronic pain, those doing so were more likely to have a regular physician but were more likely to report difficulty gaining admission to substance abuse treatment programs." | ( Dasgupta, N; Givens, A; Grau, LE; Harvey, AP; Heimer, R; Irwin, KS; Kinzly, M, 2012) |
| "Inadequately treated chronic pain can seriously affect one's quality of life." | ( Bernhofer, EI; Sorrell, JM, 2012) |
| "There is a broad distinction of chronic pain into chronic non-cancer pain and chronic cancer pain, and important subgroups of these include patients with rheumatic and/or orthopaedic diseases, pain syndromes caused by cancer itself and caused by cancer treatment." | ( Cherubino, P; Labianca, R; Sarzi-Puttini, P; Zuccaro, SM, 2012) |
| "When prescribing opioids to treat chronic pain, physicians face the dilemma of balancing effective pain management while avoiding iatrogenic opioid addiction." | ( Ashrafioun, L; Blondell, RD; Fox, CH; Keller, CE; Neumann, AM; Van Klein, J, 2012) |
| "Patients with chronic pain, including fibromyalgia (FM), may seek treatments outside of mainstream medicine." | ( Fitzcharles, MA; Gamsa, A; Shir, Y; Ste-Marie, PA; Ware, MA, 2012) |
| "In the treatment of chronic pain in the frail elderly, the opioids of first choice are buprenorphine, fentanyl, hydromorphone, morphine and oxycodone." | ( Brouwers, JR; Jansen, PA; van Ojik, AL; van Roon, EN, 2012) |
| "We examined chronic pain management practices and confidence and satisfaction levels in treating chronic pain among primary care providers (PCPs) who cared for high-risk patients in safety net health settings." | ( Guzman, D; Kushel, MB; Miaskowski, C; Penko, J; Vijayaraghavan, M, 2012) |
| "Physicians who treat patients with chronic pain must be cognizant of the federal and state policies that govern the distribution of opioid medications as well as the current standards of medical practice for opioid prescribing." | ( Copenhaver, DJ; Stayner, RS, 2012) |
| "While chronic pain is a main symptom in endometriosis, the underlying mechanisms and effective therapy remain elusive." | ( Alvarez, P; Chen, X; Giudice, LC; Green, PG; Hendrich, J; Irwin, JC; Levine, JD, 2012) |
| "Many persons with chronic pain also have significant medical and psychiatric comorbidities that affect treatment decisions." | ( Edwards, RR; Jamison, RN, 2013) |
| "To improve prevention and treatment of chronic pain, epidemiologic studies are mandatory for assessing chronic pain." | ( Ekholm, O; Højsted, J; Juel, K; Kurita, GP; Sjøgren, P, 2012) |
| "Particularly for severe chronic pain requiring long-term medication, a reduction of common opioid side-effects with tapentadol PR therapy could contribute to better patient compliance." | ( Litzenburger, BC; Schumann, C; Schwenke, K; Schwittay, A, 2012) |
| "Additionally, 77% of people with chronic pains also have a degree of medically treatable depression." | ( Al-Othman, AM; Khan, I; Rauf, K; Shah, MR; Subhan, F; Zarrelli, A, 2013) |
| "However, chronic pain and addiction treatment contexts are vastly different." | ( Friedman, CK; Reisfield, GM, 2012) |
| "The observed treatment effects in chronic pain patients suggest a role for CPM engagement in analgesic efficacy of ketamine, morphine, and placebo treatment." | ( Aarts, L; Dahan, A; Niesters, M; Sarton, E, 2013) |
| "There is a broad distinction of chronic pain into chronic non-cancer pain and chronic cancer pain, and important subgroups of these include patients with rheumatic and/or orthopaedic diseases, pain syndromes caused by cancer itself and caused by cancer treatment." | ( Cherubino, P; Labianca, R; Sarzi-Puttini, P; Zuccaro, SM, 2012) |
| "Treatment of chronic pain remains a clinical challenge and sufficient pharmacological management is difficult to achieve without concurrent adverse drug effects." | ( Hansen, RR; Malcangio, M, 2013) |
| "Treatment of chronic pain conditions is commonly assessed at specific endpoints at preset times during or after treatment by analysis of the total study population." | ( Dahan, A; Krebs-Brown, A; Martini, CH; Olofsen, E; Passier, P; Stoker, M; Yassen, A, 2013) |
| "However, treatment of chronic pain conditions in depressive patients has, so far, received limited attention in research." | ( Beekman, AT; Bet, PM; de Heer, EW; Dekker, J; Hakkaart-Van Roijen, L; Holwerda, TJ; Kat, F; Ringoir, L; Roth, J; van der Feltz-Cornelis, CM; van Eck van der Sluijs, JF; van Marwijk, HW, 2013) |
| "Neuropathic pain is a common chronic pain condition that can be challenging to treat, particularly for non-specialists." | ( Baranowski, AP; Lee, J; Price, C; Smith, BH, 2013) |
| "Thirty-four participants who experienced chronic pain and received methadone for treatment of opiate addiction were willing to tell the story of their experiences." | ( St Marie, B, 2014) |
| "There is much information on chronic pain and its treatment, but it is often published outside of surgery and diffusion of this information across disciplines is slow." | ( Carroll, I; Curtin, CM, 2013) |
| "Most important objective of chronic pain treatment is to improve QOL and ADL of patients." | ( Hamaguchi, S; Ikeda, T, 2013) |
| "The treatment of chronic pain, whether of cancer or noncancer origin, frequently involves the use of opioids." | ( Shimoyama, M; Shimoyama, N, 2013) |
| "Uncertainties about opioid treatment for chronic pain, particularly addiction and misuse, play an important role in communicating about pain treatment." | ( Bair, MJ; Bergman, AA; Coffing, J; Collins, LA; Krebs, EE; Matthias, MS, 2013) |
| "The pharmacological treatment of chronic pains induced by an excess of nociception is mainly based on analgesics which are classified according to their pharmacological nature (not opioid/opioid) and to their power according to the three World Health Organization steps." | ( Lantéri-Minet, M, 2013) |
| "For physicians treating patients with chronic pain, deciding whether to prescribe opioids, especially long-term, can be a challenge." | ( Schultz, D, 2013) |
| "A total of 67 chronic pain patients were randomized to an 8-week Mindfulness-Oriented Recovery Enhancement (MORE) intervention or a social support group intervention and began treatment." | ( Garland, EL; Howard, MO, 2013) |
| "Some patients with chronic pain who are intolerant of or refractory to treatment with systemic analgesics may benefit from intrathecal therapy." | ( Hanley, KL; Lokey, KJ; McDowell, GC; Mitchell, AA; Sapienza-Crawford, AJ; Stanton-Hicks, M; Wells, L, 2013) |
| "Patients diagnosed with chronic pain who received long-term opioid analgesic therapy (N = 50)." | ( Froude, CK; Meleger, AL; Walker, J, 2014) |
| "A proportion of patients with chronic pain have dysphagia and cannot swallow solid, oral dosage forms, which creates a serious treatment challenge for pain specialists and other healthcare providers." | ( Carlson, DR; Kopecky, EA; Nalamachu, S; Pergolizzi, JV; Raffa, RB; Taylor, R; Varanasi, RK, 2014) |
| "Preoperative evaluation of patients with chronic pain is important because it may lead to multidisciplinary preoperative treatment of patients' pain and a multimodal analgesia plan for effective pain control." | ( Chen, G; Salama-Hanna, J, 2013) |
| "Clinicians are challenged when managing chronic pain while facing substance abuse issues during the course of chronic opioid therapy (COT)." | ( Chang, YP; Compton, P, 2013) |
| "With the increased use of opioids in chronic pain treatment, the research focuses mainly on their effects on the endocrine system in patients with chronic non-malignant pain." | ( Buss, T; Leppert, W, 2014) |
| "Oral agents are the cornerstone of chronic pain treatment, but their use may be limited in certain patients, particularly the elderly." | ( Galluzzi, KE; Stanos, SP, 2013) |
| "To improve treatment outcomes for chronic pain as recommended by current guidelines, the Biobehavioral Pain Profile (BPP), which includes six pain response subscales, was developed to guide cognitive behavioral therapy (CBT)." | ( Chang, YP; Matteliano, D; Scherer, YK, 2014) |
| "Opioid-tolerant patients with chronic pain who completed the previous randomized, double-blind, crossover portion of a study comparing fentanyl buccal tablet and immediate-release oxycodone for treatment of breakthrough pain." | ( Narayana, A; Passik, SD; Yang, R, 2014) |
| "Millions of Americans have chronic pain for which chronic opioid therapy may be warranted." | ( Broglio, K; Cole, BE, 2014) |
| "The treatment of patients with chronic pain due to osteoarthritis with oral osmotic hydromorphone resulted in a significant reduction of all documented pain related assessments." | ( Blimke, B; Giesecke, T; Hesselbarth, S; Müller-Schwefe, GH, 2014) |
| "Although patients with severe chronic pain may respond to treatment with an opioid analgesic, opioids are often associated with adverse effects that may lead patients to disrupt or discontinue therapy." | ( Drost, T; Kern, KU; Sánchez Del Águila, MJ; Schenk, M; Steigerwald, I, 2015) |
| "Women with chronic pain should be screened for depression as well as a history of prior sexual abuse, and treatment or referral initiated when indicated." | ( Steele, A, 2014) |
| "Thirty-five chronic pain patients (age 24-66) were previously treated with high-dose opioid-agonist drugs and converted to SL buprenorphine." | ( Daitch, D; Daitch, J; Frey, M; Mitnick, C; Novinson, D; Pergolizzi, J, 2014) |
| "Veterans have high rates of chronic pain and long-term opioid therapy (LTOT)." | ( Austen, M; Edlund, MJ; Fortney, J; Hudson, T; Martin, BC; Sullivan, MD; Vanderlip, ER; Williams, JS, 2014) |
| "Individuals seeking treatment for chronic pain in multidisciplinary pain management services are typically already on high doses of pain medications." | ( Allen, AR; Arnold, CA; Gibson, SJ; Giummarra, MJ; Pichler, AS, 2015) |
| "Even in known or suspected drug abusers, chronic pain warrants the use of adequate pharmacotherapy, although treatment in such cases may exclude drugs with high abuse potential." | ( Axford-Gatley, RA; Cone, EJ; DePriest, AZ; Gordon, A; Passik, SD, 2014) |
| "The treatment of chronic pain arising from deep tissues is currently inadequate and there is need for new pharmacological agents to provide analgesia." | ( Goodin, BR; Ness, TJ; Robbins, MT, 2015) |
| "Opioid therapy (OT) for chronic pain has increased dramatically over the past decade, as have related negative outcomes." | ( Becker, W; Dorflinger, L; Goulet, J; Heapy, AA; Kerns, RD; Moore, B; Sellinger, JJ, 2014) |
| "Specifically, in chronic pain subjects receiving opioid therapy, 1) sensitivity to heat pain was increased; threshold to heat pain was significantly lower; 2) tolerance to supra-threshold heat pain was significantly decreased; and 3) temporal pain summation was exacerbated, as compared with chronic pain subjects receiving non-opioid therapy." | ( Ahmed, S; Chen, L; Cohen, AS; Houghton, M; Mao, J; St Hilaire, K; Vo, T; Zhang, Y, 2015) |
| "Some patients with severe and chronic pain fail to obtain adequate pain relief with standard pharmacologic treatment agents, including low to moderate dosages of opioids." | ( Tennant, F, 2015) |
| "Veterans with chronic pain on long-term opioids hold pervasive attitudes that prevent them from using multimodality pain management options, lack social support and social norms for non-opioid-based pain treatment options, and have poor perceived control due to poor access to multimodality care." | ( Finley, EP; Pugh, MJ; Simmonds, MJ; Turner, BJ; Vale, S, 2015) |
| "Current literature indicates many chronic pain patients could be treated with cannabis alone or with lower doses of opioids." | ( Carlini, BH; Carter, GT; Garret, S; Javaher, SP; Nguyen, MH, 2015) |
| "This study reports on the outcome of chronic pain patients treated with buprenorphine in an outpatient psychiatric consultation clinic." | ( Davidson, R; Goebert, D; Streltzer, J, 2015) |
| "Historically, chronic pain generally went under-treated for a variety of objective and subjective reasons, including difficulty to objectively diagnose and manage over a long period of time, potential serious adverse effects of commonly available medications, and patient, healthcare and societal concerns over opioid medications." | ( Pergolizzi, JV; Raffa, RB; Taylor, R; Zampogna, G, 2015) |
| "The patients were veterans with chronic painful conditions who began therapy with opioid analgesics between January 1, 2000, and December 31, 2009." | ( Barber, CW; Cho, K; Fonda, J; Gagnon, DR; Hermos, JA; Leatherman, S; Miller, M, 2015) |
| "Little is known about the experience of chronic pain and the occurrence of illicit drug use behaviors in the population enrolled in methadone maintenance treatment (MMT) programs." | ( Cheatle, MD; Chen, J; Dhingra, L; Jordan, AE; Masson, C; McKnight, C; Perlman, DC; Portenoy, RK; Wasser, T, 2015) |
| "Opioid use in chronic pain treatment is complex, as patients may derive both benefit and harm." | ( Frohe, T; Julnes, PS; McEntee, ML; Ney, JP; van der Goes, DN; Vowles, KE, 2015) |
| "Opioid treatment of non-malignant chronic pain can result in hypoxemia, hypercarbia, and central sleep apnea." | ( Chung, SA; Doekel, RC; Holle, RH; Hossain, NK; Jasko, JG; Muehlbach, MJ; Pegram, GV; Rosenberg, RP; Shapiro, CM; Wylie, PE, 2015) |
| "In conclusion, chronic pain induction during early life induced short memory impairment, and pretreatment with sucrose prevented this impairment via mechanisms that seem to involve BDNF." | ( Alabwaini, J; Alzoubi, KH; Kassab, MI; Khabour, OF; Nuseir, KQ, 2015) |
| "Opioid treatment for chronic pain is a known risk factor for falls and/or fractures in elderly patients." | ( Akehurst, R; Dunlop, W; Hirst, A; Hirst, M; Knight, C, 2016) |
| "This article describes chronic pain as a disease process that has ineffective treatment modalities, explores the mechanisms of glial cell activation and inflammatory responses that lead to chronic pain and decreased opioid treatment efficacy, and hypothesizes novel chronic pain treatment modalities based on the glial cell inactivation and anti-inflammatory pathways." | ( Burkard, JF; Giron, SE; Griffis, CA, 2015) |
| "Opioids are frequently used to treat chronic pain, although adverse effects often restrict their long-term benefits." | ( Alarcão, J; Costa, J; Fareleira, F; Santos, J; Vaz-Carneiro, A, 2015) |
| "Opioids remain a routine treatment for chronic pain, but extended exposure to opioid therapy can produce opioid tolerance and hyperalgesia." | ( Bekker, A; Lutz, BM; Nia, S; Tao, YX; Xiong, M, 2015) |
| "Opioids are useful in treating chronic pain but have accompanying complications." | ( Jamison, RN; Mao, J, 2015) |
| "Seventy-seven chronic pain patients referred to dental treatment with conscious sedation with nitrous oxide/oxygen had their records included in this research." | ( Mattos Júnior, FM; Mattos, RV; Siqueira, JT; Siqueira, SR; Teixeira, MJ, 2015) |
| "Current treatments for chronic pain have limited effectiveness and commonly known side effects." | ( Amirdelfan, K; Benyamin, R; Brown, LL; Bundschu, R; Burgher, AH; Burton, AW; Doust, MW; Gliner, BE; Kapural, L; Morgan, DM; Sitzman, BT; Vallejo, R; Yang, T; Yearwood, TL; Yu, C, 2015) |
| "Further, many treatments for chronic pain also carry significant side effects." | ( Sowa, NA; Street, SE, 2015) |
| "Adequate management of chronic pain can represent a unique challenge, but remains an integral component of clinical treatment in relevant contexts." | ( Enamandram, M; Kimball, AB; Rathmell, JP, 2015) |
| "Pharmacotherapy is a mainstay in chronic pain treatment." | ( Arendt-Nielsen, L; Curatolo, M; Juni, P; Schliessbach, J; Siegenthaler, A; Vuilleumier, PH; Zeilhofer, HU, 2015) |
| "Opioids are commonly used to treat chronic pain, but their metabolic interactions with concurrently prescribed medications for concomitant disease burdens can affect potency and efficacy of pain therapy." | ( Berner, T; Ernst, FR; Herndon, C; House, J; Mills, JR, 2015) |
| "Cognitive-behavioral treatments for chronic pain typically target pain-related fear; exposure in vivo is a common treatment focusing on disconfirming harm expectancy of feared movements." | ( Claes, N; Karsdorp, PA; Meulders, A; Vlaeyen, JWS, 2015) |
| "The use of opioids to treat chronic pain has come under increased scrutiny, as such use has been associated with significant risk of death, with limited data regarding the long-term effectiveness, especially when used to treat noncancer pain." | ( Ashburn, MA; Chen, A, 2015) |
| "Many pain-killing drugs prescribed for chronic pain disorders are highly addictive, have limited clinical efficacy, and do not treat the cognitive symptoms reported by many patients." | ( Albrecht, DS; Christian, BT; Chumin, EJ; Hutchins, GD; Kareken, DA; MacKie, PJ; Yoder, KK, 2016) |
| "Guidelines for the management of chronic pain support the use of controlled-release (CR) opioids to treat chronic pain." | ( Goeree, J; Goeree, R, 2016) |
| "For other indications (acute and chronic pain treatment), toxicity and the absence of significant benefit call for guidelines from scientific societies." | ( Beloeil, H; Derivaux, B; Martinez, V, 2015) |
| "Chronic opioid therapy for chronic pain treatment has increased." | ( Binswanger, IA; Calcaterra, SL; Frank, JW; Keniston, A; Min, SJ; Yamashita, TE, 2016) |
| "TrkA is a target for chronic pain treatment due to the central position of the nerve growth factor (NGF)/TrkA pathway in nociception." | ( Bernard-Gauthier, V; Schirrmacher, R, 2016) |
| "The 17 patients treated for acute or chronic pain during the opioid-free shift were managed mainly with i." | ( Bosoy, D; Cohen, V; Fromm, C; Hossain, R; Jellinek-Cohen, SP; Likourezos, A; Marshall, J; Motov, S; Rockoff, B; Smith, A, 2015) |
| "Patients with chronic pain can be challenging to manage and historically providers have relied on opiates to treat pain." | ( Beal, BR; Wallace, MS, 2016) |
| "The pharmacological treatment of chronic pain in children and adolescents can be challenging, ineffective, and is mostly based on expert opinions and consensus." | ( Finkel, JC; Lippold, C; Muller, EA; Nouraie, M; Quezado, ZM; Sheehy, KA, 2015) |
| "Despite the heavy impact of chronic pain on patients' quality of life, epidemiological data suggest that chronic pain is often untreated or undertreated." | ( Fanelli, G; Leonardi, C; Mammucari, M; Vellucci, R, 2015) |
| "Long-term management of chronic pain is often associated with the development of tolerance, addiction, and other side effects, reducing the therapeutic value of treatment." | ( Gajavelli, S; Jergova, S; Sagen, J; Shekane, P; Varghese, MS, 2016) |
| "This review will define chronic pain and its categories and then will summarize the effectiveness and side effects associated with the use of various antidepressants, including the tricyclics, the selective serotonin reuptake inhibitors, the serotonin norepinephrine reuptake inhibitors, other miscellaneous antidepressants and the atypical antipsychotics in the treatment of chronic pain." | ( Khouzam, HR, 2016) |
| "Physical activity may improve chronic pain, anxiety, and depression, which are prevalent among patients in methadone maintenance treatment (MMT), but relatively little is known about the physical activity levels or interest in exercise of patients in MMT." | ( Barry, DT; Beitel, M; Cutter, CJ; Eggert, K; Ginn, J; Kerns, RD; Liong, C; Madden, LM; Schottenfeld, RS; Stults-Kolehmainen, M, 2016) |
| "Skeletal conditions are common causes of chronic pain and there is an unmet medical need for improved treatment options." | ( Frost, CØ; Hansen, RR; Heegaard, AM, 2016) |
| "While chronic pain has been said to impact patient's response to methadone maintenance treatment for opioid dependence, the reported findings are inconsistent." | ( Bawor, M; Daiter, J; Dennis, BB; Desai, D; Marsh, DC; Pare, G; Paul, J; Plater, C; Samaan, Z; Thabane, L; Varenbut, M; Worster, A, 2016) |
| "Posttraumatic stress disorder (PTSD), chronic pain, and substance use disorders are prevalent co-occurring conditions that are challenging to treat individually, and there is no evidence-based treatment for all 3." | ( Batki, SL; Bertenthal, D; Madden, E; Maguen, S; Neylan, TC; Seal, KH; Stein, MB; Striebel, J, 2016) |
| "The landscape of chronic pain management has been changing rapidly with an array of treatment innovations, better understanding of established therapies, and care coordination across specialties." | ( Grandhe, R; Gritsenko, K; Souzdalnitski, D, 2016) |
| "Clinicians treating patients with chronic pain need to understand the many contributors to the reported experience of pain." | ( Stannard, C, 2016) |
| "Two-thirds of older people suffer from chronic pain and finding valid treatment options is essential." | ( Corli, O; Greco, MT; Guerriero, F; Roberto, A; Rollone, M; Sgarlata, C, 2016) |
| "This study of the long-term treatment of chronic pain in a geriatric population with OXN-PR shows satisfying analgesic effects achieved with a stable low daily dose, coupled with a good safety profile and, in particular, with a reduction of constipation, often present during opioid therapy." | ( Corli, O; Greco, MT; Guerriero, F; Roberto, A; Rollone, M; Sgarlata, C, 2016) |
| "Confidence in treating chronic pain patients also correlated with the likelihood of covering several specific pain subtopics, including pain assessment, documentation skills, non-pharmacologic treatment, treatment with opioids, and treatment with non-opioids." | ( Antoun, J; Everard, KM; Schiel Zoberi, K, 2016) |
| "Clinicians who manage patients with chronic pain often focus on interventions that relieve pain, and assessing and treating sleep disturbance are secondary or not addressed." | ( Cheatle, MD; Dhingra, L; Foster, S; Lesneski, M; Pinkett, A; Qu, D, 2016) |
| "Obstructive sleep apnea syndrome, chronic pain, chronic spinal pain, chronic opioid therapy, obesity, smoking, cardiovascular risk factors, pulmonary risk factors." | ( Manchikanti, L; Pampati, S, 2016) |
| "Patients attending tertiary chronic pain clinics at the Western General Hospital, Edinburgh, treated with long-term opioid analgesia (n = 48) with no recent exposure to exogenous glucocorticoids." | ( Gibb, FW; Stewart, A; Strachan, MW; Walker, BR, 2016) |
| "With the understanding of how chronic pain is related to mental illnesses such as depression and posttraumatic stress disorder, mindfulness techniques and behavioral therapy can be used to help decrease the dependence on dangerous opioid medications and help patients understand, accept, and cope with their chronic pain." | ( Baker, N, 2016) |
| "The treatment of chronic pain consumes a significant share of primary care." | ( Chang, F; Jurcic, J; Khan, A; Mohammed, HT; Patel, T; Raman-Wilms, L; Sproule, B, 2016) |
| "The molecular mechanisms of chronic pain are poorly understood and effective mechanism-based treatments are lacking." | ( Adebiyi, MG; Blackburn, MR; Eltzschig, HK; Hu, H; Hu, X; Huang, A; Huang, D; Karmouty-Quintana, H; Kellems, RE; Le, TT; Liu, H; Luo, J; Mamenko, M; Pochynyuk, OM; Sun, K; Walters, ET; Wen, YE; Wu, H; Xia, Y; Zaika, OL; Zhang, Y; Zhao, S, 2016) |
| "Among respondents with potentially chronic pain conditions, adults with mood disorders initiated opioid therapy more frequently for their chronic pain condition (11." | ( Davis, RB; Halbert, BT; Wee, CC, 2016) |
| "This study utilized 151 chronic pain patients being considered for chronic opioid therapy to determine if a psychological opioid-risk evaluation influenced physicians' opioid prescribing." | ( Foley, KP; McNeil, DW; Sperry, J; Vargovich, AM, 2016) |
| "Long-term opioid treatment of chronic pain may interfere with treatment of depression." | ( Ahmedani, B; Bucholz, KK; Burroughs, T; Copeland, L; Lustman, PJ; Salas, J; Scherrer, JF; Schneider, FD; Sullivan, MD, 2016) |
| "Treatment of chronic pain has created a "silent epidemic," a term that describes the serious public health problem of the abuse of opioid painkillers and other prescription drugs." | ( Kibaly, C; Law, PY; Loh, HH, 2016) |
| "No common nonopioid treatment for chronic pain has been studied in aggregate over longer intervals of active treatment than opioids." | ( Barreiro, AE; Bradshaw, YS; Carr, DB; Chui, KK; Tayeb, BO, 2016) |
| "More commonly the responsibility for chronic pain management and initiating opioid therapy rests with the primary care physician and other non-specialist opioid prescribers." | ( Christrup, LL; Drewes, AM; Fallon, MT; Kress, HG; McQuay, HJ; Mikus, G; Morlion, BJ; O'Brien, T; Perez-Cajaraville, J; Pogatzki-Zahn, E; Varrassi, G; Wells, JC, 2017) |
| "This study aimed to assess chronic pain therapy with regard to the interaction potential in a sample of inpatients with multiple chronic conditions." | ( Battegay, E; Blaser, J; Eschmann, E; Holzer, BM; Kienast, A; Minder, CE; Saller, R; Schneider, D; Siebenhuener, K; Zimmerli, L, 2017) |
| "Data were obtained from a sample of 115 chronic pain patients on long-term opioid therapy (68% females, M age=48." | ( Garland, EL; Thomas, EA, 2017) |
| "Additionaly, chronic pain is more or less an economic burden for the patients because it requires immediate medical treatments and seriously hinders pepople in their work." | ( Bai, B; Liu, W; Xin, Q, 2017) |
| "Treatments for chronic pain are inadequate, and new options are needed." | ( Chew, LA; Gilbraith, KB; Ibrahim, MM; Khanna, R; Largent-Milnes, T; Malan, TP; Moutal, A; Patwardhan, A; Porreca, F; Vanderah, TW; Yang, X, 2017) |
| "Adults with chronic pain receiving out-patient treatment with buprenorphine-naloxone (BUP-NLX) for prescription opioid addiction have an elevated risk for opioid use when tapering off maintenance treatment." | ( Heinzerling, KG; Ling, W; Shoptaw, S; Worley, MJ, 2017) |
| "Using a depression comorbidity of chronic pain rat model induced by spinal nerve ligation (SNL), we investigated the potency of T10 for the treatment of comorbid depression in comparison with a widely used antidepressant, fluoxetine (FLX)." | ( Dong, Y; Hu, X; Jin, X; Li, J; Shi, J; Zhang, C; Zhang, T; Zhao, J, 2017) |
| "Opioid therapy for patients with chronic pain is increasing in frequency along with rates of opioid abuse." | ( Muir, H; Seymour, F, 2017) |
| "The assessment and treatment of chronic pain will continue to be one of the most common functions of a health care provider." | ( Compton, P; Hobelmann, JG; Tompkins, DA, 2017) |
| "In patients with chronic pain who received HYD over a 52-week period, treatment was generally well tolerated and provided effective analgesia among those who rotated from a pain regimen primarily consisting of IR oxycodone." | ( He, E; Kowalski, M; Pergolizzi, J, 2018) |
| "A common treatment for chronic pain is prescription of analgesics, but their long-term use entails risk of morbidity, addiction and misuse." | ( Bell, P; Glinn, MA; Harvey, A; Lickteig, AJ; Rappold, B; Recer, S; Salske, M; Stensland, J; Weber, L, 2017) |
| "Moxibustion has been employed to relieve chronic pain as an alternative therapy for knee osteoarthritis." | ( Luo, L; Lv, P; Peng, JX; Tang, Y; Wu, Q; Yin, HY; Yu, SG; Zhang, CS; Zhou, JY; Zhu, LL, 2017) |
| "For people with chronic pain, treatment with OXN PR decreases the incidence of OIC and provides intermediate-term bowel function improvement with clinical importance; in addition, pain relief is not weakened." | ( Bai, YJ; Huang, L; Jin, SH; Li, XJ; Liu, DH; Lv, SP; Ma, H; Wang, F; Wang, Y; Zhang, Y; Zhou, JG, 2017) |
| "Individuals with chronic pain are commonly prescribed opioids to treat pain, and by this mere exposure are at increased risk for the development of problematic opioid use." | ( Dunn, KE; Finan, PH; Remeniuk, B, 2018) |
| "Patients in addiction treatment with chronic pain (N = 501) were classified based on use of non-pharmacological pain treatments." | ( Bohnert, ASB; Goesling, J; Ilgen, MA; Jannausch, M; Lin, LA, 2017) |
| "Patients with chronic pain experiencing insufficient pain relief and/or unacceptable side effects were switched to PR OXN and monitored in this observational study with respect to efficacy regarding bowel function and efficacy regarding pain relief in comparison with previous analgesic therapy." | ( Huygen, F; Koopmans-Klein, G; Mancini, I; Prenen, H; van Megen, Y; Van Op den Bosch, J, 2017) |
| "Evaluation and treatment of chronic pain worldwide are limited by the lack of standardized assessment tools incorporating consistent definitions of pain chronicity and specific queries of known social and psychological risk factors for chronic pain." | ( Baxter, K; Chapman, H; Couldridge, M; Jackson, T; Jense, RJ; Joshi, HR; Kassebaum, NJ; Kundra, P; Liu, X; McQueen, KAK; Nair, D; Sethuramachandran, A; Shotwell, MS; Sullivan, B; Walters, JL, 2017) |
| "In the past two decades, chronic pain has been increasingly treated with prescription opioids, particularly in developed countries." | ( Brill, S; Delayahu, Y; Feingold, D; Goor-Aryeh, I; Lev-Ran, S, 2017) |
| "So far chronic pain has been treated according to the pain ladder of the World Health Organization (WHO), which prioritizes the intensity of pain." | ( Bialas, P; Hubner, W; Müller, CSL; Vogt, T; Volk, T, 2018) |
| "The treatment of chronic pain remains a challenge for clinicians worldwide, independent of its pathogenesis." | ( Cechinel Filho, V; Corrêa, R; da Silva, GF; Dos Anjos, MF; Ferreira, LFGR; Hernandes, MZ; Quintão, NLM; Rocha, LW; Santin, JR; Stiz, DS, 2017) |
| "After the implementation of a chronic pain management pathway in an ED, there is a decrease noted in opioids administered to patients with chronic pain both in the ED and prescriptions on discharge." | ( Pace, C; Shah, S; Zhang, AX; Zosel, AE, 2018) |
| "However, chronic pain management often extends beyond this 12-week boundary, resulting in health-care professionals questioning the safety and efficacy of continued treatment with OIC agents." | ( Bowers, BL; Crannage, AJ, 2019) |
| "Opioid-treated chronic pain patients at a specialty pain practice who screened positive for aberrant drug-related behavior (N = 110) were randomized to receive treatment as usual plus the web-based program or treatment as usual alone." | ( Acosta, MC; Cruciani, RA; Fong, C; Guarino, H; Marsch, LA; Moore, SK; Portenoy, RK; Rosenblum, A; Syckes, C; Turk, DC, 2018) |
| "Opioids remain part of chronic pain treatment in primary care." | ( Berg, S; Case, H; Porter, J; Whittington, J; Whittington, K; Whittington, R; Zimmermann, K, 2018) |
| "The implementation of a chronic pain protocol (CPP) and its effects on the management of long-term opioid therapy are described." | ( Downes, JM; Foster, J; Klepser, DG; Nelson, M, 2018) |
| "Over 12 months, 97 fewer patients with chronic pain were treated with a long-term opioid at the clinic." | ( Downes, JM; Foster, J; Klepser, DG; Nelson, M, 2018) |
| "Treatment of chronic pain and comorbid mental health issues requires a multidisciplinary approach." | ( Clauw, DJ; Goesling, J; Lin, LA, 2018) |
| "In adults treated with opioids for chronic pain, point-of-care urine drug screens (immunoassays) for detecting opioids show a false-negative rate of 1." | ( Daly, S; Hall, B, 2018) |
| "Despite high rates of chronic pain among their patients, opioid agonist treatment (OAT) counselors report an absence of training to manage chronic pain." | ( Barry, DT; Beitel, M; Bone, C; Bono, MH; Butner, JL; Eller, A; Kwon, G; Madden, LM; Ponce Martinez, CC, 2018) |
| "Perceived ability to assess chronic pain and suggest appropriate treatment interventions were higher at follow-up than at pre-test (p's <." | ( Barry, DT; Beitel, M; Bone, C; Bono, MH; Butner, JL; Eller, A; Kwon, G; Madden, LM; Ponce Martinez, CC, 2018) |
| "Benefits in chronic pain treatment with cannabidiol (CBD) have been reported." | ( Arnaiz, J; Cuñetti, L; Curi, L; Manzo, L; Orihuela, S; Peyraube, R, 2018) |
| "Findings suggest that opioid-treated chronic pain patients exhibit Pavlovian conditioned responses to opioid cues strengthened by an associative learning process of second-order conditioning when primed by pain-related images." | ( Bryan, CJ; Froeliger, B; Garland, EL; Howard, MO; Kreighbaum, L; Nakamura, Y, 2018) |
| "Among 1,094,569 veterans with incident chronic pain from 2010 to 2015, there was wide facility-level variation in utilization of 10 pain-related treatment modalities, including initiation of LTOT (median, 16%; range, 5-32%)." | ( Carey, EP; Frank, JW; Ho, PM; Kerns, RD; Nolan, C, 2018) |
| "Many patients with chronic pain take opioids either because opioids were previously prescribed as a first-line treatment for chronic pain, on the basis of old standards of care, or because opioids were initially prescribed for acute pain." | ( Bradt, J; Drott, J; Fillipo, R; Findlay, A; Genung, A; Heiden, J; Wenger, S, 2018) |
| "Study results suggest that chronic pain treatments that address symptoms of depression and enhance pain self-efficacy may be prioritized, particularly among patients who are prescribed long-term opioid therapy." | ( Adams, MH; Deyo, RA; Dobscha, SK; Morasco, BJ; Smith, NX; Yarborough, BJ, 2018) |
| "Opioid-treated chronic pain patients may be at risk for prescription opioid misuse due to heightened opioid craving coupled with deficits in attention to naturally rewarding, positive stimuli." | ( Baker, AK; Garland, EL; Hanley, AW; Platt, KA; Priddy, SE; Riquino, MR, 2018) |
| "Non-addictive treatments for chronic pain are, therefore, highly needed." | ( Haleem, DJ, 2018) |
| "Among patients with chronic pain prescribed long-term opioid therapy, one-quarter of patients had co-occurring prescriptions for benzodiazepines, and dual use was associated with increased odds of falls and emergency department visits." | ( Deyo, RA; Dobscha, SK; Morasco, BJ; Smith, N; Stoneburner, A; Stumbo, SP; Yarborough, BJH, 2019) |
| "Long-term opioid therapy for chronic pain management requires regularly assessing and documenting benefits and side effects." | ( Brill, S; Hochberg, U; Ojeda, A; Perez, J, 2019) |
| "Evidence on long-term opioid therapy for chronic pain is very limited but suggests an increased risk of serious harms that appears to be dose-dependent." | ( Blazina, I; Bougatsos, C; Chou, R; Dana, T; Devine, B; Deyo, R; Hansen, R; Jarvik, JG; Sullivan, S; Turner, J, 2014) |
| "The respondents on average treated 30 chronic pain patients per month predominately in a community setting." | ( Giannetti, V; Kamal, KM; Provenzano, DA, 2018) |
| "Opioid use disorder, chronic pain relief, methadone maintenance treatment, prescriptions, male, female." | ( Bhatt, M; de Souza, R; Luo, C; Samaan, MC; Samaan, Z; Sanger, N; Shahid, H; Shams, I; Tam, SL; Thabane, L, 2018) |
| "Providers who treat patients with chronic pain face a dual challenge: providing adequate access to opioid therapies for appropriate pain management while adopting strategies to minimize the risk for abuse." | ( Rauck, RL, 2019) |
| "The population will be patients who have chronic pain, the intervention will be the administration of PEA alone or in combination with other drugs for the pain management; the comparison will be the standard therapy in accordance with the current guidelines for the treatment of pain." | ( Alfieri, A; Aurilio, C; Barbarisi, M; Fiore, M; Pace, MC; Passavanti, MB; Piccinno, G; Pota, V; Sansone, P, 2019) |
| "Among opioid-treated chronic pain patients, deficient response inhibition in the context of emotional distress may contribute to maladaptive pain coping and prescription opioid misuse." | ( Bryan, MA; Froeliger, B; Garland, EL; Howard, MO; Priddy, SE; Riquino, MR, 2019) |
| "The treatment of chronic pain is particularly important to anesthesiologists given our unique role as perioperative physicians and pain medicine specialists." | ( Cordonnier, SA; Forman, TE; Haight, ES; James, ML; Tawfik, VL, 2019) |
| "The rate of chronic pain after amputation surgery is not significantly improved with the perioperative administration of valproic acid." | ( Buchheit, T; Buckenmaier, CT; Cooter, M; Hsia, HJ; Kent, M; McDuffie, M; Shaw, A; Shortell, C; Van de Ven, T, 2019) |
| "Patients with chronic pain treated with opioids are at an increased risk for opioid misuse or opioid use disorder (OUD)." | ( Adekoya, P; Hirji, S; Jatinder, G; Olusunmade, M; Orhurhu, MS; Orhurhu, V; Peck, J; Sampson, J; Simopoulos, T; Urits, I; Viswanath, O, 2019) |
| "Patients treated in interdisciplinary chronic pain rehabilitation programs show long-term improvements in symptoms; however, outcomes may vary across heterogenous patient subpopulations." | ( Huffman, KL; Jimenez, XF; Lapin, BR; Lehmann, JK; Mandell, D, 2019) |
| "Approaches used to treat chronic pain outside the eye can be applied to ocular pain that is not responsive to traditional therapies." | ( Felix, ER; Galor, A; Horn, DB; Levitt, RC; Sarantopoulos, CD; Small, LR, 2020) |
| "Treating patients with chronic pain and progressive disease should include assessment of "total pain" (physical, psychological, and spiritual suffering) and the care givers as part of treatment team." | ( Eti, S; Lewis Ramos, V, 2019) |
| "Participants with OUD and chronic pain (N = 30) were randomized to 8 weeks of MORE or treatment as usual (TAU)." | ( Cooperman, NA; Garland, EL; Hanley, AW; Kline, A, 2019) |
| "We sought to provide a resource for chronic pain physicians treating an iodine-allergic patient and considering the use of IT gadolinium." | ( Bendel, MA; Deer, TR; Hagedorn, JM; Lamer, TJ; Moeschler, SM; Pope, JE, 2019) |
| "Individuals with chronic pain (study 1, n = 364; study 2, n = 437) were administered measures of pain, alcohol use, and opioid misuse." | ( Bakhshaie, J; Paulus, DJ; Rogers, AH; Vowles, KE; Zvolensky, MJ, 2019) |
| "Ketamine has been used to treat chronic pain; however, it is still unknown as to what types of chronic pain is ketamine effective against." | ( Izuta, S; Kan, S; Mizobuchi, S; Motoyama, Y; Obata, N; Oshiro, Y; Sato, H; Takao, Y, 2019) |
| "Opioid treatment for chronic pain has garnered heightened public attention and political pressure to control a devastating public health crisis in the United States (U." | ( DeBar, LL; Firemark, A; Gruß, I; Mayhew, M; McMullen, CK, 2019) |
| "For adults with chronic pain receiving treatment for prescription opioid addiction, interventions that address cravings through behavioral pain coping skills may be crucial for achieving optimal treatment outcomes." | ( Messina, BG; Worley, MJ, 2019) |
| "Patients with opioid-treated chronic pain (N = 95; age = 56." | ( Atchley, R; Baker, AK; Bedford, CE; Bryan, MA; Froeliger, B; Garland, EL; Hanley, AW; Howard, MO; Nakamura, Y; Reese, SE; Riquino, MR; Salas, K; Yack, BP, 2019) |
| "Among those with chronic pain, drug use to treat pain was commonly reported (76%; 95% CI, 66%-83%)." | ( Allen, ST; Bicket, MC; Park, JN; Sherman, SG; Torrie, A; Weir, BW, 2020) |
| "The treatment of chronic pain frequently combines pharmacologic and non-pharmacological options, and analgesia after surgery is of major importance." | ( Bagaphou, TC; Caserio, M; Milia, P; Orfei, M, 2019) |
| "GP attitudes towards opioid use for chronic pain varied by age of patient and goals for therapy." | ( Barton, C; Mazza, D; Prathivadi, P, 2020) |
| "Effectively treating chronic pain remains a therapeutic challenge in the clinic." | ( Atone, J; Hammock, BD; Wagner, KM, 2020) |
| "Current treatments for chronic pain have limited effectiveness and tolerability." | ( Campbell, F; Gilron, I; Haroutounian, S; Mizubuti, GB; Mohiuddin, MM; Park, R; Rice, ASC; Smith, SM, 2020) |
| "Given the growing challenges in chronic pain management coupled with the ongoing consequences of the opioid epidemic, pain management practitioners are looking into more effective, innovative, and safer alternatives to treat pain." | ( Boyaji, S; Elman, RNM; Kaye, AD; Merkow, J; Urman, RD; Yong, RJ, 2020) |
| "The use of long-term opioid therapy for chronic pain remains common, yet data on long-term outcomes, especially after dose escalation, are sparse." | ( Deyo, RA; Dobscha, SK; Hyde, S; Morasco, BJ; Smith, N; Yarborough, BJH, 2020) |
| "The use of opioids to relieve chronic pain has increased during the last decades, but experiences of chronic opioid therapy (COT) (> 90 days) point at risks and loss of beneficial effects." | ( Åsenlöf, P; Ljungvall, H; Rhodin, A; Wagner, S; Zetterberg, H, 2020) |
| "Ten individuals with chronic pain and opioid therapy were purposively sampled in Swedish tertiary care." | ( Åsenlöf, P; Ljungvall, H; Rhodin, A; Wagner, S; Zetterberg, H, 2020) |
| "Co-existing chronic pain and depression pose a serious socio-economic burden and result in disability affecting millions of individuals, which urges the development of treatment strategies targeting this comorbidity." | ( Ayazgök, B; Becker, LJ; Humo, M; Rantamäki, T; Waltisperger, E; Yalcin, I, 2020) |
| "The long-term treatment of chronic pain by opioids is limited by tolerance and risk of addiction/dependence." | ( Brewer, KL; Clemens, S; Dinkins, ML; Lim, SA; Patton, R; Rodgers, HM; Yow, J, 2020) |
| "This cross-sectional study included 209 chronic pain patients prescribed smoked MM, in flower or other plant form, with no concurrent opioid treatment." | ( Brill, S; Delayahu, Y; Feingold, D; Goor-Aryeh, I; Lev-Ran, S, 2020) |
| "To assess CYP2D6 genotype prevalence in chronic pain patients treated with tramadol or codeine." | ( Batistaki, C; Chrona, E; Gazouli, M; Kostopanagiotou, G; Kostroglou, A, 2020) |
| "Patients with chronic pain, treated with codeine or tramadol." | ( Batistaki, C; Chrona, E; Gazouli, M; Kostopanagiotou, G; Kostroglou, A, 2020) |
| "In clinical trials of treatments for chronic pain, the percentage of participants who withdraw early can be as high as 50%." | ( Cai, X; Dworkin, RH; Gewandter, JS; He, H; McDermott, MP; Turk, DC, 2020) |
| "In the US, first-line treatment for chronic pain is often opioids." | ( Block-Lerner, J; Lomauro, T; Marks, D; Rhodes, A, 2021) |
| "A total of 751 chronic pain patients initiating medical cannabis treatment." | ( Hendin, B; Ko, G; Loheswaran, G; Safakish, R; Salimpour, V; Sohanpal, I; Yoon, SYR, 2020) |
| "Patients living with chronic pain require appropriate access to opioid therapy along with improved access to pain care and additional therapeutic options." | ( Christo, PJ, 2020) |
| "For geriatric patients with chronic pain, a comprehensive well-coordinated pain management is pivotal to ensure the best possible pain relief and to minimize as far as possible preventable negative side effects of treatment." | ( Donnerer, J; Geyrhofer, S; Leeb, B; Likar, R; Mitrovic, N; Pils, K; Pinter, G; Stromer, W, 2021) |
| "Treatment of chronic pain encompasses analgesic medications; adjuvant pharmacotherapy, including antidepressants and anticonvulsants; interventional techniques; as well as integrative medicine." | ( Blasco, MA; Cordero, J; Dundar, Y, 2020) |
| "Managing patients with chronic pain on chronic opioid therapy (COT) can be challenging if done mainly by an individual clinician." | ( Colasanti, JA; Samet, JH; Vettese, T, 2020) |
| "Long-term opioid therapy for chronic pain arose amid limited availability and awareness of other pain therapies." | ( Clothier, B; Donaldson, MT; Goldsmith, ES; Jensen, AC; Krebs, EE; MacLehose, RF; Martinson, BC; Noorbaloochi, S, 2020) |
| "Choosing an appropriate treatment for chronic pain remains problematic, and despite the available medication for its treatment, still, many patients complain about pain and appeal to the use of cannabis derivatives for pain control." | ( Guevara, N; Guido, PC; Maldonado, C; Schaiquevich, P; Vázquez, M, 2020) |
| "High-quality chronic pain care emphasizes multimodal treatments that include medication and nonpharmacological treatments." | ( Bartman, AE; Bernstein, C; Gillman, AG; Jeong, JH; Wasan, AD; Zhang, D, 2020) |
| "In discussion of chronic pain management, PCCs often explained their beliefs about opioid therapy." | ( Anders, S; Cook, RL; Danielson, EC; Diiulio, J; Downs, SM; Harle, CA; Hurley, RW; Militello, LG, 2020) |
| "Patients with chronic pain (n = 194) prescribed long-term opioid therapy enrolled in this longitudinal observational cohort study." | ( Edwards, RR; Jamison, RN; Martel, MO, 2020) |
| "Future or reality? Treating acute and chronic pain is a part of the daily routine of clinical anesthesiologists." | ( Latoschik, ME; Lindner, S; Rittner, H, 2020) |
| "Veterans experience chronic pain at greater rates than the rest of society and are more likely to receive long-term opioid therapy (LTOT), which, at high doses, is theorized to induce maladaptive neuroplastic changes that attenuate self-regulatory capacity and exacerbate opioid dose escalation." | ( Garland, EL; Hanley, AW; Hudak, J; Marchand, WR; Nakamura, Y; Yabko, B, 2021) |
| "Gabapentin is effective in treating some chronic pain conditions." | ( Daniels, JP; Doust, AM; Hewitt, CA; Horne, AW; Koscielniak, M; Middleton, LJ; Szubert, W; Vincent, K, 2020) |
| "Reclassification of chronic pain as a disease may be helpful because patients with chronic pain require significant treatment and rehabilitation with a clear diagnosis." | ( Amgalan, A; Bandi, P; Berardino, K; Jung, JW; Kaye, AD; Kaye, AM; Kaye, RJ; Manchikanti, L; Paladini, A; Pham, C; Swanson, D; Urits, I; Varrassi, G; Viswanath, O, 2020) |
| "Opioids can be used to treat chronic pain but at the cost of adverse effects and risk of dependence." | ( Charipova, K; Gress, K; Jung, JW; Kaye, AD; Paladini, A; Urits, I; Varrassi, G; Viswanath, O, 2020) |
| "Related to the complex nature of chronic pain, treatments have a pharmacological and non-pharmacological approach." | ( Charipova, K; Cornett, E; Gress, K; Habib, K; Jung, JW; Kassem, H; Kaye, AD; Lee, C; Lee, D; Paladini, A; Urits, I; Varrassi, G; Viswanath, O, 2020) |
| "Current therapies for the treatment of chronic pain provide inadequate relief for millions of suffering patients, demonstrating the need for better therapies that will treat pain effectively and improve the quality of patient's lives." | ( Krajewski, JL, 2020) |
| "Patients with chronic pain, licensed to use MC in Israel, reported weekly average pain intensity (primary outcome) and related symptoms before and at 1, 3, 6, 9 and 12 months following MC treatment initiation." | ( Adahan, HM; Amital, H; Aviram, J; Brill, S; Eisenberg, E; Fogelman, Y; Gershoni, T; Goor, R; Goor-Aryeh, I; Green, L; Meiri, D; Morag, O; Ogintz, M; Pud, D; Robinson, D; Schiff-Keren, B; Segal, R; Sheinfeld, R; Tashlykov, V; Tsvieli, O; Vulfsons, S; Vysotski, Y; Yashar, T; Yellin, B, 2021) |
| "Up to 17%-20% of pediatric patients with chronic pain are prescribed opioid pharmacotherapy and face an increased risk of opioid misuse in adulthood." | ( Bhandari, RP; Birnie, KA; Goya Arce, AB; Richardson, PA, 2021) |
| "In patients with chronic pain taking opioids not reaching treatment goals, there was consensus that cannabinoids may be considered for patients experiencing or displaying opioid-related complications, despite psychological or physical interventions." | ( Ahmed, SA; Bell, A; Blain, A; Clarke, H; Cooper, ZD; Cyr, C; Daeninck, P; Deshpande, A; Ethans, K; Flusk, D; Le Foll, B; Milloy, MJ; Moulin, DE; Naidoo, V; O'Connell, C; Ong, M; Perez, J; Rod, K; Sealey, R; Sihota, A; Smith, BK; Sulak, D; Walsh, Z, 2021) |
| "The questionnaires administered included Chronic pain screening questionnaire, self-reported Chronic physical health condition checklist, Patient Health Questionnaire-SADS, The Alcohol Use Disorders Identification Test, Fagerström Test for Nicotine Dependence, WHO Disability Assessment Schedule and WHOQOL- BREF for Quality/Satisfaction with Life." | ( Bajaj, A; Chaturvedi, SK; Desai, G; G R, G; G, SK; K, T; L, M; T S, J, 2020) |
| "Over 50% of participants on opioids for chronic pain with newly diagnosed sleep apnea declined attendance for sleep clinic review or treatment." | ( Bellingham, G; Chung, F; Kashgari, A; Mir, S; Ryan, C; Waseem, R; Wasef, S; Wong, J, 2021) |
| "Among opioid-treated chronic pain patients, response inhibition deficits in emotional contexts may contribute to opioid misuse." | ( Garland, EL; Howard, MO, 2021) |
| "This has been shown in treatment of chronic pain but postoperative studies are sparse." | ( Comelon, M; Drægni, T; Lenz, H; Lieng, M; Raeder, J, 2021) |
| "Treatment of chronic pain remains an unmet medical need." | ( Guo, X; Hou, X; Hu, F; Ju, C; Liu, Y; Wang, J; Wang, K; Yang, J, 2021) |
| "Treating chronic pain with escalating doses of strong systemic opioids often leads to inconsistent pain control, impaired function, untenable side effects, and reduced quality of life and this practice has contributed to the current opioid crisis in the United States." | ( Abd-Elsayed, A; Calodney, A; Schultz, DM; Spencer, RJ; Stromberg, K; Weaver, T, 2021) |
| "Among soldiers with chronic pain, comorbid PTSD and lack of nonpharmacologic treatment was associated with increased odds of receiving an opioid days' supply of >30 days (odds ratio [OR]=1." | ( Adams, RS; Bauer, MR; Highland, KB; Larson, MJ; Saadoun, M, 2021) |
| "Persons with HIV (PWH) experience chronic pain and Post-Traumatic Stress Disorder (PTSD) at higher rates than the general population, and more often receive opioid medications to treat chronic pain." | ( Bhatraju, E; Colasanti, J; Del Rio, C; Forman, LS; Kim, TW; Liebschutz, JM; Lira, MC; Lodi, S; Samet, JH; Tsui, JI, 2023) |
| "Individuals with chronic pain are uniquely challenged by the COVID-19 pandemic, as increased stress may exacerbate chronic pain, and there are new barriers to receiving chronic pain treatment." | ( Aaron, RV; Campbell, CM; McGill, LS; Mun, CJ, 2021) |
| "However, most appointments for chronic pain treatment were either postponed or canceled, with no future session scheduled." | ( Aaron, RV; Campbell, CM; McGill, LS; Mun, CJ, 2021) |
| "Despite research suggesting that chronic pain may influence OUD treatment outcomes, participants with and without CNCP achieved similar rates of treatment retention and significant reductions in illicit opioid use and psychiatric symptomatology during low-barrier buprenorphine treatment." | ( Badger, GJ; Ochalek, TA; Peck, KR; Sigmon, SC; Streck, JM, 2021) |
| "We report the prevalence of chronic pain and pain characteristics in an opioid-dependent population by treatment type and gender." | ( Latif, ZH; Skjaervø, I; Solli, KK; Tanum, L, 2021) |
| "Cognitive behavioral therapy (CBT) for chronic pain is an evidence-based non-pharmacological treatment for pain with demonstrated efficacy when delivered using collaborative care models." | ( Baecher, B; Bair, MJ; Bushey, MA; Damush, TM; French, DD; Froman, A; Kempf, C; Kroenke, K; Outcalt, SD; Saha, C; Sargent, C; Slaven, J; Zillich, A, 2021) |
| "It is indicated in a variety of chronic pain conditions and has an excellent safety profile, with no association between the frequency in side-effects and duration of therapy or total daily dosages." | ( Aggarwal, A; Gibson, SB; Maudlin, B, 2022) |
| "The epidemics of chronic pain and opioid misuse have given rise to the widespread use of non-opioid drugs such as the gabapentinoids for treatment." | ( Alles, SRA; Goins, A; Patel, K, 2021) |
| "Treatment for chronic pain remains insufficient and therapeutical advances have not made comparable progress with that for many chronic disorders, thus amplifying the concern on the future burden of the disease." | ( Apkarian, AV; Barroso, J; Branco, P, 2021) |
| "Opioids are used worldwide to treat chronic pain conditions, but there is still an ambiguous and inadequate understanding about their therapeutic use, mostly because of their dual effect in acutely reducing pain and inducing, at the same time, tolerance, dependence, and a risk for opioid use disorder." | ( Balzani, E; Bonci, A; Ilari, S; Malafoglia, V; Muscoli, C; Raffaeli, W; Tenti, M; Vitiello, L, 2022) |
| ""Tapering of Long-term Opioid Therapy in Chronic Pain Population." | ( Anders, H; Åsa, R; Henrik, G; Marcelo, RF; Patrik, M; Ulf, J, 2021) |
| "Opioid use disorder and chronic pain are increasingly commonly encountered in medicine and many patients now are prescribed medications (such as buprenorphine) to help treat these conditions." | ( Burgan, C; Downer, K; Galgano, SJ; Kezar, CE, 2022) |
| "Thirty-one clinics used ketamine for chronic pain treatment." | ( Bharwani, KD; Dirckx, M; Huygen, FJPM; Mangnus, TJP; Stronks, DL, 2022) |
| "Current treatments for chronic pain (eg, opioids) can have adverse side effects and rarely result in resolution of pain." | ( Campbell, TS; Cooper, L; Flusk, D; MacInnes, A; Mekhael, AA; Nasr-Esfahani, M; Poulin, PA; Rash, JA; Robert, M; Yi, Y, 2021) |
| "From those with chronic pain and concurrent opioid use, we matched 478 SATP-MOUD patients to 647 untreated patients." | ( Axon, RN; Casarella, J; Rauch, SAM; Tang, YL; Ward, R; Whitfield, N, 2022) |
| "Adults (aged ≥18 years) with mixed chronic pain conditions receiving long-term opioid therapy." | ( Benes, L; Bonifay, A; DeBar, L; Deyo, RA; Elder, CR; Keefe, FJ; Leo, MC; Mayhew, M; McMullen, C; Owen-Smith, A; Smith, DH; Trinacty, CM; Vollmer, WM, 2022) |
| "As traditional treatments for chronic pain in general and nociplastic pain in particular are imperfect, there is a need to identify other treatment options." | ( Fitzcharles, MA; Häuser, W; Petzke, F; Tölle, TR, 2021) |
| "Patients on long-term opioid therapy for chronic pain who had undergone a reduction of opioid daily prescribed dosage of ≥50% in the past 2 years in two distinct medical systems and regions." | ( Bazzi, AR; Benintendi, A; Bohnert, ASB; Kosakowski, S; Lagisetty, P; Larochelle, MR, 2022) |
| "This Delphi survey in chronic pain reached agreement on four main aspects: (1) Priority to treat neuropathic pain with evaluation of effectiveness at 1 month; (2) No deleterious effects in the majority of listed diseases/situations with the absence or <3% of suggested adverse events; (3) 0." | ( Amodéo, JM; André, G; Barmaki, M; Collard, O; Colomb, C; Créac'h, C; de Chazeron, I; de Montgazon, G; Deleens, R; Delorme, C; Dixneuf, V; Dy, L; Gaillard, J; Gov, C; Kieffer, X; Lanteri-Minet, M; Le Borgne, JM; Le Caër, F; Maamar, F; Maindet, C; Marcaillou, F; Morel, V; Pickering, G; Plantevin, F; Pluchon, YM; Riant, T; Rioult, B; Rostaing, S; Salvat, E; Sep Hieng, V; Sorel, M; Vergne-Salle, P; Voute, M, 2022) |
| "Few studies have treated chronic pain or concurrent depression and pain with ketamine." | ( Haroutounian, S; Lenze, EJ; Palanca, BJA; Subramanian, S, 2022) |
| "The Graded Chronic Pain Scale evaluates pain-related disability and its dichotomous grading (high/low impact pain) can determine patient care pathways and in general high-impact pain patients have worse treatment outcomes." | ( Bereiter, DA; Eberly, LE; Exposto, FG; Herrero Babiloni, A; Lenglet, C; Lindgren, BR; Martel, MO; Moana-Filho, EJ; Peck, CM, 2022) |
| "A cohort of Veterans with chronic pain in 2018 was built utilizing VA administrative data." | ( Au, V; Driscoll, MA; Hadlandsmyth, K; Lund, BC; Mares, JG; Miell, KR, 2023) |
| "Opioid therapy is a common treatment for chronic pain, despite accumulating evidence regarding harm and a lack of data to support the efficacy of long-term treatment." | ( Fischer, MR; Grelz, H; Midlöv, P; Priouzifard, M; Ringqvist, Å, 2022) |
| "After describing the common chronic pain syndromes caused by cancer treatment, and the pathophysiologic mechanisms involved, the pharmacologic management of entities such as post-surgical pain, chemotherapy-induced neuropathy, aromatase inhibitor musculoskeletal syndrome and checkpoint inhibitor-related pain are described." | ( Aubrey, K; Glare, P; Gulati, A; Lee, YC; Moryl, N; Overton, S, 2022) |
| "However, optimal treatments for chronic pain-related sleep disorders are not well established." | ( Ito, H; Matsuo, M; Sasaoka, T; Toyooka, N; Tsuneki, H; Yamazaki, M, 2022) |
| "The study included 250 adults with chronic pain receiving long-term opioid therapy who were misusing opioid medications." | ( Baker, AK; Barrett, JW; Donaldson, GW; Froeliger, B; Garland, EL; Hanley, AW; Nakamura, Y; Reese, SE; Riquino, MR, 2022) |
| "Patients at risk of developing chronic pain must be identified and treated as early as possible." | ( Andereggen, L; Beilstein, CM; Bello, C; Luedi, MM, 2022) |
| "Adults with chronic pain on long-term opioid treatment (N=814)." | ( Benes, L; Bonifay, A; DeBar, L; Deyo, RA; Elder, CR; Keefe, FJ; Leo, MC; Mayhew, M; McMullen, C; O'Keeffe-Rosetti, M; Owen-Smith, A; Smith, DH; Trinacty, CM; Vollmer, WM, 2022) |
| "In all, 178 patients with chronic pain were treated for a period of 366 days (median; range 31-2590 days)." | ( Böhm, R; Gastmeier, A; Gastmeier, K; Herdegen, T; Rottmann, F, 2023) |
| "To choose the appropriate treatment for chronic pains, such as PHN, not only efficacy but also tolerability, manageability, practicality, and compliance are important factors, especially in the long term." | ( Fornasari, D; Magni, A; Pais, P; Palao, T; Polati, E; Sansone, P, 2022) |
| "In the 182 patients with chronic pain, those receiving combination therapy were more likely to respond than those taking AC alone (35." | ( Alfahmy, A; Dao, A; Mitchell, D; Roberts, K; Sheyn, D, 2022) |
| "Factors predictive of chronic pain in older adults could help focus prevention and treatment efforts for those most at risk of chronic pain." | ( McDonald, DD; Walsh, SJ, 2022) |
| "Cognitive behavioral therapy (CBT) for chronic pain is an empirically supported approach to managing chronic pain, functional impairment, and related distress." | ( Adamowicz, JL; Burgess, DJ; Campbell, EJ; Cho, H; Hadlandsmyth, K; Johnson, NL; Leparski, RF; Lund, BC; Mosher, HJ; Obrecht, AA; Odom, AS; Richards, CC; Steffensmeier, KS; Vander Weg, MW; Yoon, P, 2022) |
| "Non-pharmacological chronic pain treatments increasingly incorporate values-based approaches as an alternative to opioid therapy." | ( Hager, BN; Lehinger, E; McGeary, DD; Reed, DE; Roache, JD, 2022) |
| "Low-dose CBD that appears effective for chronic pain and mental health has good tolerability and safety, with few adverse effects and is appropriate as an initial treatment." | ( Hall, S; Henson, JD; Vitetta, L, 2022) |
| "Most systematic reviews of opioids for chronic pain have pooled treatment effects across individual opioids under the assumption they provide similar benefits and harms." | ( Bhandari, M; Busse, JW; Couban, RJ; Guyatt, GH; Hong, PJ; Jeddi, M; Juurlink, DN; Kum, E; Montoya, L; Noori, A; Sadeghirad, B; Shokoohi, M; Siemieniuk, RAC; Thabane, L; Wang, L; Zhou, E, 2022) |
| "Most patients with chronic pain turn to primary care clinicians who must choose from myriad treatment options based on relative risks and benefits, patient history, available resources, symptoms, and goals." | ( Bian, J; Bilello, L; Diiulio, J; Gurka, MJ; Gutierrez, M; Harle, CA; Hurley, RW; Jones, RE; Marcial, L; Martinez-Wittinghan, F; Masri, G; McDonnell, C; Militello, LG; Modave, F; Nguyen, K; Paz, LG; Rhodes, B; Salloum, RG; Siler, K; Willis, D, 2022) |
| "The public health crisis of chronic pain has only increased in recognition since the Institute of Medicine's (IOM) Relieving Pain in America (2011) called for a cultural transformation in the way pain is viewed, treated, and put forward specific recommendations for action." | ( Benes, LL; DeBar, LL; Keefe, FJ, 2022) |
| "Fibromyalgia syndrome (FMS) is a chronic pain condition that requires multidisciplinary treatment." | ( Armağan, O; Berkan, F; Çıracıoğlu, AM; Çolak, E; Dal Erdoğan, S; Özgen, M; Uslu, S, 2023) |
| "From those with chronic pain and prescription opioids, we matched 237 EVP patients to 375 untreated patients." | ( Axon, RN; Rauch, SAM; Saenger, MS; Ward, R, 2023) |
| "Multidisciplinary approaches to treating chronic pain have been proven effective." | ( Carvès, S; Colin, F; Collet, MP; Coste, J; Deleens, R; Laroche, F; Medkour, T; Meyer, S; Perrot, S; Rouquette, A; Trouvin, AP, 2022) |
| "Demographic, drug use behaviors, and chronic pain status were collected at treatment intake, and self-reported opioid withdrawal and craving were measured at intake and 1-3 days, 4-6 days, and 7-9 days after intake." | ( Dunn, KE; Ellis, JD; Finan, P; Hobelmann, JG; Huhn, AS; Ware, OD, 2022) |
| "Women and persons with chronic pain would benefit from earlier engagement in treatment and may require a more intensive strategy to mitigate opioid withdrawal in early treatment." | ( Dunn, KE; Ellis, JD; Finan, P; Hobelmann, JG; Huhn, AS; Ware, OD, 2022) |
| "Treatment of chronic pain is challenged by concurrent anxiety symptoms." | ( Chai, XQ; Chen, DY; Gao, W; Hu, R; Jin, Y; Long, DD; Mao, Y; Pan, TT; Wang, D; Zhang, Z, 2022) |
| "Currently, the first-line therapy for chronic pain is opioids, which are often accompanied by unwanted psychoactive side effects." | ( Jiang, X; Li, Q; Zhang, W; Zhang, Y; Zhou, R; Zhu, T, 2022) |
| "Surrogate measures for primary chronic pain treatment modalities, including pharmacologic and nonpharmacologic pain interventions (epidural and facet corticosteroid injections, radiofrequency ablation, and spine surgery), as well as total costs." | ( Ameli, O; Cohen, K; Dhruva, SS; Morin, PE; Murillo, J; Redberg, RF; Spencer, DL, 2023) |
| "Surrogate measures for primary chronic pain treatment modalities, including pharmacologic and nonpharmacologic pain interventions (epidural and facet corticosteroid injections, radiofrequency ablation, and spine surgery), as well as total costs." | ( Ameli, O; Cohen, K; Dhruva, SS; Morin, PE; Murillo, J; Redberg, RF; Spencer, DL, 2023) |
| "Providers in specialties treating chronic pain - primary care, pain management, and neurology-will be coming across medical cannabis as a treatment for chronic pain, regardless of whether they are prescribers." | ( Fermo, O; Shah, J, 2022) |
| "Evidence suggests that patients with chronic pain and mental illness are more likely to receive long-term opioid therapy (LTOT) and at higher doses but are also at increased risk of experiencing opioid-related harm." | ( Brinkers, M; Hachenberg, T; Haghikia, A; Pfau, G; Vielhaber, S; Vogt, S, 2023) |
| "Adults with chronic pain requiring long-term treatment with opioids completed the POMAQ and other study questionnaires." | ( Barsdorf, AI; Butler, SF; Coyne, KS; Farrar, JT; Gelfand, CHJ; Lanza, ST; Mazière, JY; Pierson, RF; Porter, LN; Schnoll, SH, 2023) |
| "Patients with chronic pain often receive long-term opioid therapy (LOT), which places them at risk of opioid use disorder and overdose." | ( Greene, D; Li, Y; Nguyen, T; Quackenbush, N; Stancliff, S, 2023) |
| "In patients with chronic pain, oral analgesics are essential treatment options to manage pain appropriately, improve activities of daily living abilities and achieve a higher quality of life (QOL)." | ( Aono, H; Endo, M; Hara, T; Kawahara, S; Kawano, T; Mawatari, T; Miyaji, T; Miyake, M; Nakashima, Y; Sakamoto, S; Sato, T; Shimokawa, M; Takano, T; Tokunaga, M; Zenda, S, 2023) |
| "Further studies should stratify chronic pain patients into groups who is in higher risk in developing opioid dependence or abuse and develop alternative strategies for pain management and treatments beyond opioids." | ( Ma, S; Pruinelli, L; Simon, G; Stalter, N, 2023) |
| "To determine predictors of chronic pain and disability among patients with distal radius fractures (DRF) treated conservatively with closed reduction and cast immobilization." | ( Chan, ACM; Cho, JSY; Lam, ICY; Luk, MLM; Miller, T; Ng, DMT; Pang, MYC; Yau, ELK, 2023) |
| "Despite high co-occurrence, chronic pain is often unaddressed in treatment for opioid use disorder (OUD) and little is known about mechanisms that may underlie associations between pain and opioid use." | ( Heapy, AA; MacLean, RR; Meyerovich, J; Sofuoglu, M; Szollosy, SK; Waters, AJ; Wolkowicz, N, 2023) |
| "By reducing the use of nonpharmacologic chronic pain treatments and marginally increasing out-of-pocket costs among those using these services, high-deductible health plans may discourage more holistic, integrated approaches to caring for patients with chronic pain conditions." | ( Barry, CL; Bicket, MC; Busch, AB; Eddelbuettel, JCP; Eisenberg, MD; Hollander, MAG; Huskamp, HA; Kennedy-Hendricks, A; Meiselbach, MK; Stuart, EA, 2023) |
| "The Graded Chronic Pain Scale (GCPS) is frequently used in pain research and treatment to classify mild, bothersome, and high impact chronic pain." | ( DeBar, L; Gordon, KS; Goulet, J; Kerns, RD; Lee, A; Mayhew, M; Taub, C; Von Korff, M, 2023) |
| "To investigate if chronic pain in children with cerebral palsy is undertreated with the current pharmacological/non-pharmacological interventions using a pain management index." | ( Sultan, T; Wong, C, 2023) |
| "Caring for chronic pain patients under opioid therapy is challenging." | ( Berna, C; Gutzmann, MD; Jean-Scherb, S; Suter, MR, 2023) |
| "veterans on long-term opioid therapy for chronic pain at ≥ 50 mg morphine equivalent daily dose (MEDD)." | ( Abelleira, A; Becker, WC; Edmond, SN; Falker, C; Frank, JW; Moore, BA; Nolan, C; Rogers, DG; Schroeder, A; Wesolowicz, DM, 2023) |
| "The patient with chronic pain syndrome, who was treated by carboxytherapy during rehabilitation, was also observed, with a subsequent evaluation of the carboxytherapy application in comprehensive treatment." | ( Beloklokova, IG; Bofanova, NS; Sagitova, DR, 2023) |
| "Carboxytherapy reduces the intensity of chronic pain syndrome and can be applied as an additional method in medical rehabilitation." | ( Beloklokova, IG; Bofanova, NS; Sagitova, DR, 2023) |
| "Existing treatment for chronic pain in sickle cell disease (SCD) is opioid-dependent, which is ineffective and carries risks." | ( Aboul-Hassan, D; Bergmans, R; Clauw, DJ; Cofield, C; Sidhom, D, 2023) |
| "In the management of chronic pain, ketamine has shown potential to manage neuropathic pain and complex regional pain syndrome and has been used as a treatment for chronic pain management by clinics across the USA." | ( Bloomfield, A; Chan, N; Fryml, L; Horace, R; Pyati, S, 2023) |
| "What questions did we seek to answer? Chronic pain is a common problem with limited effective treatments." | ( Marzoughi, S; Ong, M; Ripsman, D, 2023) |
| "In addition, the causes of chronic pain and its cures are unknown, and treatment is limited by these unknowns and the dangers of opioids." | ( Gromala, D; Wang, L; Zhou, S, 2023) |