An EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor that interferes with the action of gamma-butyrobetaine dioxygenase (EC 1.14.11.1).
ChEBI ID: 131844
| Member | Definition | Class |
|---|---|---|
| 3-(2,2,2-trimethylhydrazine)propionate | An ammonium betaine that is beta-alaninate in which one of the amino hydrogens is replaced by a trimethylamino group. A clinically used cardioprotective drug that is used for treatment of heart failure, myocardial infarction, arrhythmia, atherosclerosis and diabetes. | meldonium |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 9 (4.62) | 18.7374 |
| 1990's | 21 (10.77) | 18.2507 |
| 2000's | 53 (27.18) | 29.6817 |
| 2010's | 84 (43.08) | 24.3611 |
| 2020's | 28 (14.36) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 35 (13.94%) | 5.53% |
| Reviews | 11 (4.38%) | 6.00% |
| Case Studies | 3 (1.20%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 202 (80.48%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Gamma-butyrobetaine dioxygenase | Homo sapiens (human) | IC50 | 62.0000 | 1 | 1 |
| Gamma-butyrobetaine dioxygenase | Homo sapiens (human) | Ki | 16.0000 | 1 | 1 |