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14beta-hydroxy steroid
A 14-hydroxy steroid in which the hydroxy group has a beta-configuration.
ChEBI ID: 36862
Members (12)
| Member | Definition | Role |
|---|---|---|
| bufalin | A 14beta-hydroxy steroid that is bufan-20,22-dienolide having hydroxy substituents at the 5beta- and 14beta-positions. It has been isolated from the skin of the toad Bufo bufo. | bufalin |
| convallatoxin | A cardenolide glycoside that consists of strophanthidin having a 6-deoxy-alpha-L-mannopyranosyl (L-rhamnosyl) group attached at position 3. | convallatoxin |
| deslanoside | A cardenolide glycoside that is lanatoside C with the acetoxy group replaced by a hydroxy group. | deslanoside |
| digitoxigenin | A 5beta-cardenolide that is 5beta-cardanolide with hydroxy substituents at the 3beta- and 14beta-positions and double bond unsaturation at C(20)-C(22). | digitoxigenin |
| digoxigenin | A hydroxy steroid that consists of 5beta-cardanolide having a double bond at the 20(22)-position as well as hydroxy groups at the 3beta-, 12beta- and 14beta-positions. It has been isolated from the plant species of the genus Digitalis. | digoxigenin |
| gitoxigenin | gitoxigenin | |
| helveticoside | A cardenolide glycoside that consists of strophanthidin having a digitoxosyl group attached at position 3. | helveticoside |
| oleandrigenin | A steroid ester that is the 16-acetyl derivative of gitoxigenin. | oleandrigenin |
| oleandrin | A steroid saponin that consists of oleandrigenin having a 2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl residue attached to the oxygen function at position 3. | oleandrin |
| ouabagenin | A hexahydroxy steroidal lactone obtained by hydrolysis of ouabain. | ouabagenin |
| ouabain | A steroid hormone that is a multi-hydroxylated alpha-L-rhamnosyl cardenoloide. It binds to and inhibits the plasma membrane Na(+)/K(+)-ATPase (sodium pump). It has been isolated naturally from Strophanthus gratus. | ouabain |
| strophanthidin | strophanthidin |
Research
Studies (18,209)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 11,062 (60.75) | 18.7374 |
| 1990's | 3,975 (21.83) | 18.2507 |
| 2000's | 1,796 (9.86) | 29.6817 |
| 2010's | 1,160 (6.37) | 24.3611 |
| 2020's | 216 (1.19) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 93 (0.48%) | 5.53% |
| Reviews | 483 (2.50%) | 6.00% |
| Case Studies | 59 (0.31%) | 4.05% |
| Observational | 1 (0.01%) | 0.25% |
| Other | 18,657 (96.70%) | 84.16% |