Roles > carbamate insecticide
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carbamate insecticide

Derivatives of carbamic acid with insecticidal properties of general formula ROC(=O)NR(1)R(2), where ROH is an alcohol, oxime, or phenol and R(1) is hydrogen or methyl. Like organophosphate insecticides, they are cholinesterase inhibitors, but carbamate insecticides differ in action from the organophosphates in that the inhibitory effect on cholinesterase is generally brief.

ChEBI ID: 38461

Members (13)

MemberDefinitionClass
aminocarbA carbamate ester that is phenyl methylcarbamate substituted by a dimethylamino group at position 4 and a methyl group at position 3.aminocarb
bendiocarbbendiocarb
benfuracarbbenfuracarb
carbarylA carbamate ester obtained by the formal condensation of 1-naphthol with methylcarbamic acid.carbaryl
carbofurancarbofuran
cronetonethiofencarb
deltanitfurathiocarb
dibutylaminosulfenylcarbofurancarbosulfan
formetanateformetanate
isoprocarbisoprocarb
metolcarbmetolcarb
pirimicarbAn aminopyrimidine that is N,N,4,5-tetramethylpyrimidin-2-amine substituted by a (dimethylcarbamoyl)oxy group at position 4.pirimicarb
propoxurA carbamate ester that is phenyl methylcarbamate substituted at position 2 by a propan-2-yloxy group.propoxur

Research

Studies (2,633)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-1990782 (29.70)18.7374
1990's372 (14.13)18.2507
2000's609 (23.13)29.6817
2010's660 (25.07)24.3611
2020's210 (7.98)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials20 (0.66%)5.53%
Reviews67 (2.21%)6.00%
Case Studies72 (2.38%)4.05%
Observational1 (0.03%)0.25%
Other2,871 (94.72%)84.16%

Protein Targets (56)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
acetylcholinesteraseHomo sapiens (human)Potency8.1224459
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency33.803413
AR proteinHomo sapiens (human)Potency34.5117923
aryl hydrocarbon receptorHomo sapiens (human)Potency30.8055310
Ataxin-2Homo sapiens (human)Potency10.870711
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency10.870711
Cellular tumor antigen p53Homo sapiens (human)Potency18.926224
Chain A, Ferritin light chainEquus caballus (horse)Potency33.552012
Chain A, HADH2 proteinHomo sapiens (human)Potency35.716822
Chain B, HADH2 proteinHomo sapiens (human)Potency35.716822
chromobox protein homolog 1Homo sapiens (human)Potency79.432811
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency7.063222
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency24.336511
DNA dC->dU-editing enzyme APOBEC-3F isoform aHomo sapiens (human)Potency3.162311
DNA polymerase kappa isoform 1Homo sapiens (human)Potency26.679511
estrogen nuclear receptor alphaHomo sapiens (human)Potency35.5785823
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency34.321926
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency37.4748624
farnesoid X nuclear receptorHomo sapiens (human)Potency26.986222
gemininHomo sapiens (human)Potency2.310911
GLI family zinc finger 3Homo sapiens (human)Potency29.0139213
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency39.985233
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency48.557711
Guanine nucleotide-binding protein GHomo sapiens (human)Potency22.387211
heat shock protein beta-1Homo sapiens (human)Potency47.717225
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency35.481311
Histone H2A.xCricetulus griseus (Chinese hamster)Potency111.829928
Interferon betaHomo sapiens (human)Potency33.294011
lamin isoform A-delta10Homo sapiens (human)Potency14.125411
lysosomal alpha-glucosidase preproproteinHomo sapiens (human)Potency35.481311
mitogen-activated protein kinase 1Homo sapiens (human)Potency0.001312
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency26.6783418
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency30.300122
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency32.7228333
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency0.025611
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency41.251613
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency30.511725
pregnane X nuclear receptorHomo sapiens (human)Potency61.0886210
progesterone receptorHomo sapiens (human)Potency28.847112
RAR-related orphan receptor gammaMus musculus (house mouse)Potency33.5768210
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency38.2028212
retinoid X nuclear receptor alphaHomo sapiens (human)Potency28.4488211
serine/threonine-protein kinase PLK1Homo sapiens (human)Potency33.587511
TDP1 proteinHomo sapiens (human)Potency27.185526
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency42.871838
thyroid stimulating hormone receptorHomo sapiens (human)Potency41.432844
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency29.193625
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency30.652335
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency8.643812
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency48.557711

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
AcetylcholinesteraseAnopheles gambiae (African malaria mosquito)IC500.112822
AcetylcholinesteraseElectrophorus electricus (electric eel)IC503.100011
AcetylcholinesteraseHomo sapiens (human)IC501.445022
Fatty-acid amide hydrolase 1Homo sapiens (human)IC5030.000022
Hormone-sensitive lipaseRattus norvegicus (Norway rat)IC500.370011
kallikrein-5 preproproteinHomo sapiens (human)IC5050.000011
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