Page last updated: 2024-08-05 11:13:07

pyridone

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ChEBI ID: 38183

Members (20)

MemberDefinitionRole
1-[1-[(2-chloro-6-fluorophenyl)methyl]-2-oxo-3-pyridinyl]-3-(phenylmethyl)urea1-[1-[(2-chloro-6-fluorophenyl)methyl]-2-oxo-3-pyridinyl]-3-(phenylmethyl)urea
2,4-dihydroxypyridine2,4-Dihydroxypyridine
3-amino-1H-pyrazolo[4,3-c]pyridine-4,6-diol3-amino-1H-pyrazolo[4,3-c]pyridine-4,6-diol
3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)-2-pyridoneA member of the class of pyridones that is 2-pyridone carrying cyano, phenyl and 3-bromo-6-hydroxyphenyl substituents at positions 3, 4 and 6 respectively3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)-2-pyridone
3,5,6-trichloro-2-pyridinolA pyridone that is pyridin-2(1H)-one substituted by chloro groups at positions 3, 5 and 6. It is a metabolite of the agrochemical chlorpyrifos.3,5,6-trichloro-2-pyridinol; 3,5,6-trichloropyridine-2-one
acromelic acid aA pyrrolidinecarboxylic acid that is siolated from the poisonous mushroom Clitocybe amoenolens.acromelic acid A
ciclopiroxA cyclic hydroxamic acid that is 1-hydroxypyridin-2(1H)-one in which the hydrogens at positions 4 and 6 are substituted by methyl and cyclohexyl groups, respectively. A broad spectrum antigfungal agent, it also exhibits antibacterial activity against many Gram-positive and Gram-negative bacteria, and has anti-inflammatory properties. It is used a a topical treatment of fungal skin and nail infections.ciclopirox
gsk343A member of the class of indazoles that is 1-isopropyl-1H-indazole-4-carboxamide in which the nitrogen of the carboxamide group is substituted by a (6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl group and in which the indazole ring is substituted at position 6 by a 2-(4-methylpiperazin-1-yl)pyridin-4-yl group. A highly potent and selective EZH2 inhibitor (IC50 = 4 nM).GSK343
huperzine aA sesquiterpene alkaloid isolated from a club moss Huperzia serrata that has been shown to exhibit neuroprotective activity. It is also an effective inhibitor of acetylcholinesterase and has attracted interest as a therapeutic candidate for Alzheimer's disease.huperzine A
ilicicolin hAn aromatic ketone in which the ketone carbonyl group is attached to a (1R,2R,4aS,7S,8aR)-4,7-dimethyl-1-[(1E)-prop-1-en-1-yl]-1,2,4a,5,6,7,8,8a-octahydronaphthalen-2-yl group and a 4-hydroxy-5-(4-hydroxyphenyl)-2-oxo-1,2-dihydropyridin-3-yl group. Isolated from the from the "imperfect" fungus Cylindrocladium iliciola strain MFC-870.ilicicolin H
milrinoneA member of the class of bipyridines that is 2-pyridone which is substituted at positions 3, 5, and 6 by cyano, pyrid-4-yl, and methyl groups, respectively. It is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure.milrinone
n-(2-pyridone-6-yl)-n',n'-di-n-propylformamidineCGP 28014
n-methyl-2-pyridone1-Methyl-2-pyridone
n'-methyl-2-pyridone-5-carboxamideA pyridone that is 2-pyridone substituted with a carboxamide group at C-5 and a methyl group at N-1.N-methyl-6-pyridone-3-carboxamide
pd 0348292A member of the class of pyrrolidines that is (2R,4R)-N(1)-(p-chlorophenyl)-4-methoxypyrrolidine-1,2-dicarboxamide in which the nitrogen of the 2-carbamoyl group has been substituted by a 2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl group. It is a synthetic organic anticoagulant compound that targets activated factor Xa in the coagulation cascade.eribaxaban
perampanelA member of the class of bipyridines that is 2,3'-bipyridin-6'-one substituted at positions 1' and 5' by phenyl and 2-cyanophenyl groups respectively. Used as an adjunctive therapy for the treatment of partial-onset seizures in patients with epilepsy.perampanel
ph 797804A member of the class of benzamides obtained by formal condensation of the carboxy group of 3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-oxopyridin-1-yl}-4-methylbenzoic acid with the amino group of methylamine.PH 797804
pirfenidoneA pyridone that is 2-pyridone substituted at positions 1 and 5 by phenyl and methyl groups respectively. An anti-inflammatory drug used for the treatment of idiopathic pulmonary fibrosis.pirfenidone
ricininericinine
SYC-435A cyclic hydroxamic acid that is 1-hydroxypyridin-2(1H)-one in which the hydrogens at positions 4 and 6 are substituted by methyl and benzyl groups, respectively. It is a potent inhibitor of mutant isocitrate dehydrogenase 1 (Ki values of 190 nM against R132H mutant and 120 nM against R132C mutant).SYC-435

Research

Studies (3,915)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-1990327 (8.35)18.7374
1990's504 (12.87)18.2507
2000's765 (19.54)29.6817
2010's1,531 (39.11)24.3611
2020's788 (20.13)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials502 (11.99%)5.53%
Reviews505 (12.06%)6.00%
Case Studies295 (7.05%)4.05%
Observational102 (2.44%)0.25%
Other2,783 (66.47%)84.16%