Page last updated: 2024-08-05 11:13:07
pyridone
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ChEBI ID: 38183
Members (20)
| Member | Definition | Role |
|---|---|---|
| 1-[1-[(2-chloro-6-fluorophenyl)methyl]-2-oxo-3-pyridinyl]-3-(phenylmethyl)urea | 1-[1-[(2-chloro-6-fluorophenyl)methyl]-2-oxo-3-pyridinyl]-3-(phenylmethyl)urea | |
| 2,4-dihydroxypyridine | 2,4-Dihydroxypyridine | |
| 3-amino-1H-pyrazolo[4,3-c]pyridine-4,6-diol | 3-amino-1H-pyrazolo[4,3-c]pyridine-4,6-diol | |
| 3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)-2-pyridone | A member of the class of pyridones that is 2-pyridone carrying cyano, phenyl and 3-bromo-6-hydroxyphenyl substituents at positions 3, 4 and 6 respectively | 3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)-2-pyridone |
| 3,5,6-trichloro-2-pyridinol | A pyridone that is pyridin-2(1H)-one substituted by chloro groups at positions 3, 5 and 6. It is a metabolite of the agrochemical chlorpyrifos. | 3,5,6-trichloro-2-pyridinol; 3,5,6-trichloropyridine-2-one |
| acromelic acid a | A pyrrolidinecarboxylic acid that is siolated from the poisonous mushroom Clitocybe amoenolens. | acromelic acid A |
| ciclopirox | A cyclic hydroxamic acid that is 1-hydroxypyridin-2(1H)-one in which the hydrogens at positions 4 and 6 are substituted by methyl and cyclohexyl groups, respectively. A broad spectrum antigfungal agent, it also exhibits antibacterial activity against many Gram-positive and Gram-negative bacteria, and has anti-inflammatory properties. It is used a a topical treatment of fungal skin and nail infections. | ciclopirox |
| gsk343 | A member of the class of indazoles that is 1-isopropyl-1H-indazole-4-carboxamide in which the nitrogen of the carboxamide group is substituted by a (6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl group and in which the indazole ring is substituted at position 6 by a 2-(4-methylpiperazin-1-yl)pyridin-4-yl group. A highly potent and selective EZH2 inhibitor (IC50 = 4 nM). | GSK343 |
| huperzine a | A sesquiterpene alkaloid isolated from a club moss Huperzia serrata that has been shown to exhibit neuroprotective activity. It is also an effective inhibitor of acetylcholinesterase and has attracted interest as a therapeutic candidate for Alzheimer's disease. | huperzine A |
| ilicicolin h | An aromatic ketone in which the ketone carbonyl group is attached to a (1R,2R,4aS,7S,8aR)-4,7-dimethyl-1-[(1E)-prop-1-en-1-yl]-1,2,4a,5,6,7,8,8a-octahydronaphthalen-2-yl group and a 4-hydroxy-5-(4-hydroxyphenyl)-2-oxo-1,2-dihydropyridin-3-yl group. Isolated from the from the "imperfect" fungus Cylindrocladium iliciola strain MFC-870. | ilicicolin H |
| milrinone | A member of the class of bipyridines that is 2-pyridone which is substituted at positions 3, 5, and 6 by cyano, pyrid-4-yl, and methyl groups, respectively. It is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure. | milrinone |
| n-(2-pyridone-6-yl)-n',n'-di-n-propylformamidine | CGP 28014 | |
| n-methyl-2-pyridone | 1-Methyl-2-pyridone | |
| n'-methyl-2-pyridone-5-carboxamide | A pyridone that is 2-pyridone substituted with a carboxamide group at C-5 and a methyl group at N-1. | N-methyl-6-pyridone-3-carboxamide |
| pd 0348292 | A member of the class of pyrrolidines that is (2R,4R)-N(1)-(p-chlorophenyl)-4-methoxypyrrolidine-1,2-dicarboxamide in which the nitrogen of the 2-carbamoyl group has been substituted by a 2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl group. It is a synthetic organic anticoagulant compound that targets activated factor Xa in the coagulation cascade. | eribaxaban |
| perampanel | A member of the class of bipyridines that is 2,3'-bipyridin-6'-one substituted at positions 1' and 5' by phenyl and 2-cyanophenyl groups respectively. Used as an adjunctive therapy for the treatment of partial-onset seizures in patients with epilepsy. | perampanel |
| ph 797804 | A member of the class of benzamides obtained by formal condensation of the carboxy group of 3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-oxopyridin-1-yl}-4-methylbenzoic acid with the amino group of methylamine. | PH 797804 |
| pirfenidone | A pyridone that is 2-pyridone substituted at positions 1 and 5 by phenyl and methyl groups respectively. An anti-inflammatory drug used for the treatment of idiopathic pulmonary fibrosis. | pirfenidone |
| ricinine | ricinine | |
| SYC-435 | A cyclic hydroxamic acid that is 1-hydroxypyridin-2(1H)-one in which the hydrogens at positions 4 and 6 are substituted by methyl and benzyl groups, respectively. It is a potent inhibitor of mutant isocitrate dehydrogenase 1 (Ki values of 190 nM against R132H mutant and 120 nM against R132C mutant). | SYC-435 |
Research
Studies (3,915)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 327 (8.35) | 18.7374 |
| 1990's | 504 (12.87) | 18.2507 |
| 2000's | 765 (19.54) | 29.6817 |
| 2010's | 1,531 (39.11) | 24.3611 |
| 2020's | 788 (20.13) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 502 (11.99%) | 5.53% |
| Reviews | 505 (12.06%) | 6.00% |
| Case Studies | 295 (7.05%) | 4.05% |
| Observational | 102 (2.44%) | 0.25% |
| Other | 2,783 (66.47%) | 84.16% |