ascorbic-acid and Lichen-Planus

Recent studies have highlighted the role of oxidative stress in the pathogenesis of lichen planus (LP). In the present study, the interest of the authors is focused on the investigation of ascorbic acid status in patients with LP and identification of parameters that might influence the level of this vitamin.. We analyzed the level of urinary ascorbic acid (reflectometric method) in 77 patients with LP (cutaneous LP (CLP)-49 cases; oral LP (OLP)-28 cases) and 50 control subjects. The evaluation of all participants included clinical examination and laboratory and imaging tests.. Compared to the control group (19.82 mg/dl) the level of ascorbic acid was significantly lower both in patients with CLP (8.47 mg/dl, p = 0.001) and in those with OLP (8.04 mg/dl, p = 0.001). In patients with LP it was found that the deficiency of ascorbic acid increases with age (r = -0.318, p = 0.032). The urinary concentrations of ascorbic acid were significantly lower in patients with LP associated with infections compared to patients with LP without infections.. The urinary ascorbic acid level may be a useful parameter in identifying patients with LP who are at risk of developing viral or bacterial infections.

Topics: Ascorbic Acid; Ascorbic Acid Deficiency; Female; Humans; Lichen Planus; Male; Middle Aged

Lichen planus (LP) is an autoimmune inflammatory disease of the mucocutaneous tissue, whose exact pathological course is not yet understood. Many studies have implicated the role of reactive oxygen species (ROS) and the protective role of antioxidants in several autoimmune skin disorders. In this study, serum levels of antioxidants in patients with LP were determined and compared with those of healthy controls.. In total, 30 patients with LP (mean ± SD age 41.63 ± 13.03), who had never received treatment for their disease, were enrolled; 30 healthy people (aged 41.17 ± 13.24) were recruited as the control group. Serum levels of glutathione peroxidase (GPX), vitamin C, selenium, bilirubin and uric acid were determined.. The mean plasma level of vitamin C was significantly lower (P < 0.001) in patients compared with controls. A significant positive correlation was found between selenium and GPX in both patients (Spearman ρ = 0.99, P < 0.001) and controls (ρ = 0.10, P < 0.001).. Lower serum levels of vitamin C in patients with LP indicates that free radicals and the resulting oxidative damage may be important in the pathogenesis of LP lesions.

Topics: Adult; Antioxidants; Ascorbic Acid; Bilirubin; Biomarkers; Case-Control Studies; Female; Glutathione Peroxidase; Humans; Lichen Planus; Male; Middle Aged; Prospective Studies; Selenium; Uric Acid; Young Adult

Topics: Adolescent; Adrenal Cortex Hormones; Adult; Ascorbic Acid; Child; Female; Histamine H1 Antagonists; Humans; India; Keratolytic Agents; Lichen Planus; Male; Middle Aged; Pigmentation Disorders; Sunscreening Agents; Thiosulfates; Vitamin B Complex

Topics: Adrenal Cortex Hormones; Ascorbic Acid; Barbiturates; Bismuth; Chlordiazepoxide; Histamine H1 Antagonists; Humans; Lichen Planus; Lidocaine; Mouth; Ointments; Psychosomatic Medicine; Radiotherapy; Silver Nitrate; Tongue; Trichloroacetic Acid; Vitamin A