Page last updated: 2024-08-05 11:09:17
psoralens
A furanocoumarin with a 7H-furo[3,2-g]chromen-7-one skeleton and its substituted derivatives thereof.
ChEBI ID: 26369
Members (23)
| Member | Definition | Role |
|---|---|---|
| 3-(3,5-dimethyl-7-oxo-6-furo[3,2-g][1]benzopyranyl)propanoic acid | 3-(3,5-dimethyl-7-oxo-6-furo[3,2-g][1]benzopyranyl)propanoic acid | |
| 3-carbethoxypsoralen | 3-(ethoxycarbonyl)psoralen | |
| 3-methyl-5-propyl-7-furo[3,2-g][1]benzopyranone | 3-methyl-5-propyl-7-furo[3,2-g][1]benzopyranone | |
| 4-(2,3-Dihydroxy-3-methylbutoxy)furo(3,2-g)chromen-7-one | 4-(2,3-Dihydroxy-3-methylbutoxy)furo(3,2-g)chromen-7-one | |
| 5-(4-phenylbutoxy)psoralen | A member of the class of psoralens that is psoralen substituted by a 4-phenylbutoxy group at position 5. It is a potent inhibitor of the voltage-gated potassium channel Kv1.3 (EC50 = 3 nM). | psora 4 |
| 5-methoxypsoralen | A 5-methoxyfurocoumarin that is psoralen substituted by a methoxy group at position 5. | 5-methoxypsoralen |
| 6',7'-dihydroxybergamottin | 6',7'-Dihydroxybergamottin | |
| 9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-7h-furo(3,2-g)(1)benzopyran-7-one | Byakangelicin | |
| acetic acid 2-(7-oxo-2,3-dihydrofuro[3,2-g][1]benzopyran-2-yl)propan-2-yl ester | acetic acid 2-(7-oxo-2,3-dihydrofuro[3,2-g][1]benzopyran-2-yl)propan-2-yl ester | |
| bergaptol | bergaptol | |
| byakangelicol | Byakangelicol | |
| cnidilin | Cnidilin | |
| epoxybergamottin | Epoxybergamottin | |
| ficusin | The simplest member of the class of psoralens that is 7H-furo[3,2-g]chromene having a keto group at position 7. It has been found in plants like Psoralea corylifolia and Ficus salicifolia. | psoralen |
| imperatorin | A member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 8. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor. | imperatorin |
| isoimperatorin | A member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 5. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor. | isoimperatorin |
| isopimpinellin | isopimpinellin | |
| methoxsalen | A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis. | methoxsalen |
| Neobyakangelicol | Neobyakangelicol | |
| oxypeucadanin | (R)-Oxypeucedanin | |
| phellopterin | Phellopterin | |
| rutamarin | Chalepin acetate | |
| trioxsalen | 7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis. | trioxsalen |
Research
Studies (4,097)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1,666 (40.66) | 18.7374 |
| 1990's | 812 (19.82) | 18.2507 |
| 2000's | 670 (16.35) | 29.6817 |
| 2010's | 717 (17.50) | 24.3611 |
| 2020's | 232 (5.66) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 240 (4.62%) | 5.53% |
| Reviews | 202 (3.89%) | 6.00% |
| Case Studies | 203 (3.91%) | 4.05% |
| Observational | 1 (0.02%) | 0.25% |
| Other | 4,549 (87.56%) | 84.16% |