Roles > interferon inducer
Page last updated: 2024-08-05 15:26:37

interferon inducer

An agent that promotes the production and release of interferons.

ChEBI ID: 36710

Members (2)

MemberDefinitionClass
imiquimodAn imidazoquinoline fused [4,5-c] carrying isobutyl and amino substituents at N-1 and C-4 respectively. A prescription medication, it acts as an immune response modifier and is used to treat genital warts, superficial basal cell carcinoma, and actinic keratosis.imiquimod
tiloroneA member of the class of fluoren-9-ones that is 9H-fluoren-9-one which is substituted by a 2-(diethylamino)ethoxy group at positions 2 and 7. It is an interferon inducer and a selective alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonist. Its hydrochloride salt is used as an antiviral drug.tilorone

Research

Studies (3,353)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-1990200 (5.96)18.7374
1990's95 (2.83)18.2507
2000's929 (27.71)29.6817
2010's1,382 (41.22)24.3611
2020's747 (22.28)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials296 (8.15%)5.53%
Reviews473 (13.02%)6.00%
Case Studies748 (20.59%)4.05%
Observational15 (0.41%)0.25%
Other2,101 (57.83%)84.16%

Protein Targets (60)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
acetylcholinesteraseHomo sapiens (human)Potency2.092444
AR proteinHomo sapiens (human)Potency12.232146
aryl hydrocarbon receptorHomo sapiens (human)Potency9.439222
Cellular tumor antigen p53Homo sapiens (human)Potency12.849923
cytochrome P450 2D6Homo sapiens (human)Potency6.008111
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency5.955711
DNA polymerase betaHomo sapiens (human)Potency100.000011
DNA polymerase kappa isoform 1Homo sapiens (human)Potency25.118911
estrogen nuclear receptor alphaHomo sapiens (human)Potency17.4538811
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency25.156622
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency17.280244
EWS/FLI fusion proteinHomo sapiens (human)Potency15.340644
farnesoid X nuclear receptorHomo sapiens (human)Potency25.016333
Fumarate hydrataseHomo sapiens (human)Potency10.000011
gemininHomo sapiens (human)Potency12.223923
GLI family zinc finger 3Homo sapiens (human)Potency0.966822
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency23.914511
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency26.603211
Histone H2A.xCricetulus griseus (Chinese hamster)Potency55.196511
histone-lysine N-methyltransferase 2A isoform 2 precursorHomo sapiens (human)Potency39.810711
Interferon betaHomo sapiens (human)Potency13.254611
lamin isoform A-delta10Homo sapiens (human)Potency12.589311
LuciferasePhotinus pyralis (common eastern firefly)Potency38.901811
Microtubule-associated protein tauHomo sapiens (human)Potency19.952611
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency10.614622
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency23.914511
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency8.017235
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency12.112012
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency37.575111
plasminogen precursorMus musculus (house mouse)Potency1.412511
polyproteinZika virusPotency10.000011
pregnane X nuclear receptorHomo sapiens (human)Potency22.478022
RAR-related orphan receptor gammaMus musculus (house mouse)Potency22.687422
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency25.305033
TDP1 proteinHomo sapiens (human)Potency10.529123
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency26.603211
thyroid stimulating hormone receptorHomo sapiens (human)Potency21.540544
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency1.412511
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency1.412511
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency21.313811
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency26.603211

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)IC500.646011
Adenosine receptor A2aHomo sapiens (human)IC505.320011
Adenosine receptor A2aHomo sapiens (human)Ki2.987011
Alpha-1D adrenergic receptorHomo sapiens (human)IC502.621011
Alpha-1D adrenergic receptorHomo sapiens (human)Ki1.288011
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000012
Bile salt export pumpHomo sapiens (human)IC50133.666723
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000012
cystic fibrosis transmembrane conductance regulatorHomo sapiens (human)IC5030.250011
DNA primaseMycobacterium tuberculosis CDC1551IC5038.050012
Histamine H2 receptorHomo sapiens (human)IC501.506011
Histamine H2 receptorHomo sapiens (human)Ki1.481011
Multidrug resistance-associated protein 4Homo sapiens (human)IC50133.000012
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2IC504.090011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Neuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)EC5010.000022
Neuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)EC5010.000022
Neuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)EC502.500011
Neuronal acetylcholine receptor subunit alpha-7Rattus norvegicus (Norway rat)EC5010.000011
Neuronal acetylcholine receptor subunit beta-2Homo sapiens (human)EC5010.000022
Neuronal acetylcholine receptor subunit beta-4Homo sapiens (human)EC5010.000022
Toll-like receptor 7Homo sapiens (human)EC508.220066
Toll-like receptor 8Homo sapiens (human)EC50270.000011