An EC 2.4.1.* (hexosyltransferase) inhibitor that interferes with the activity of ceramide glucosyltransferase (EC 2.4.1.80).
ChEBI ID: 50382
| Member | Definition | Class |
|---|---|---|
| eliglustat | A carboxamide obtained by formal condensation of the carboxy group of octanoic acid with the primary amino group of (1R,2R)-2-amino-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-(pyrrolidin-1-yl)propan-1-ol. A ceramide glucosyltransferase inhibitor used (as its tartrate salt) for treatment of Gaucher's disease. | eliglustat |
| eliglustat tartrate | A tartrate that is the hemitartrate salt of eliglustat. A ceramide glucosyltransferase inhibitor used (as its tartrate salt) for treatment of Gaucher's disease. | eliglustat tartrate |
| miglustat | A hydroxypiperidine that is deoxynojirimycin in which the amino hydrogen is replaced by a butyl group. | miglustat |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (0.31) | 18.7374 |
| 1990's | 35 (5.34) | 18.2507 |
| 2000's | 224 (34.20) | 29.6817 |
| 2010's | 311 (47.48) | 24.3611 |
| 2020's | 83 (12.67) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 69 (9.93%) | 5.53% |
| Reviews | 128 (18.42%) | 6.00% |
| Case Studies | 89 (12.81%) | 4.05% |
| Observational | 18 (2.59%) | 0.25% |
| Other | 391 (56.26%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 21.8761 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 13.0032 | 2 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 33.4915 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 39.8107 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Alpha-mannosidase 2 | Rattus norvegicus (Norway rat) | Ki | 50.0000 | 1 | 1 |
| Beta-galactosidase | Mus musculus (house mouse) | IC50 | 750.0000 | 1 | 1 |
| Ceramide glucosyltransferase | Homo sapiens (human) | IC50 | 29.7500 | 4 | 4 |
| Ceramide glucosyltransferase | Mus musculus (house mouse) | IC50 | 40.9667 | 3 | 3 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 22.0000 | 1 | 1 |
| Glycogen debranching enzyme | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Lactase-phlorizin hydrolase | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Lactase-phlorizin hydrolase | Rattus norvegicus (Norway rat) | IC50 | 637.0000 | 2 | 2 |
| Lysosomal acid glucosylceramidase | Homo sapiens (human) | IC50 | 259.0000 | 9 | 9 |
| Lysosomal acid glucosylceramidase | Homo sapiens (human) | Ki | 116.0000 | 1 | 1 |
| Lysosomal alpha-glucosidase | Homo sapiens (human) | IC50 | 52.7333 | 3 | 3 |
| Lysosomal alpha-glucosidase | Mus musculus (house mouse) | IC50 | 9.0000 | 1 | 1 |
| Lysosomal alpha-glucosidase | Rattus norvegicus (Norway rat) | IC50 | 3.7000 | 2 | 2 |
| Lysosomal alpha-glucosidase | Homo sapiens (human) | Ki | 0.2000 | 1 | 1 |
| Maltase-glucoamylase, intestinal | Homo sapiens (human) | IC50 | 5.5500 | 2 | 2 |
| Non-lysosomal glucosylceramidase | Homo sapiens (human) | IC50 | 25.8906 | 7 | 7 |
| Non-lysosomal glucosylceramidase | Mus musculus (house mouse) | IC50 | 11.5200 | 2 | 2 |
| Protein-lysine 6-oxidase | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Protein-lysine 6-oxidase | Homo sapiens (human) | Ki | 116.0000 | 1 | 1 |
| Putative alpha-glucosidase | Oryza sativa Japonica Group (Japanese rice) | IC50 | 0.4200 | 1 | 1 |
| Sucrase-isomaltase | Mus musculus (house mouse) | IC50 | 1.0500 | 2 | 2 |
| Sucrase-isomaltase, intestinal | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| Sucrase-isomaltase, intestinal | Rattus norvegicus (Norway rat) | IC50 | 18.1114 | 7 | 7 |
| Trehalase | Rattus norvegicus (Norway rat) | IC50 | 25.5000 | 2 | 2 |
| Trehalase | Sus scrofa (pig) | IC50 | 36.0000 | 1 | 1 |