ascorbic-acid and Mushroom-Poisoning

Cortinarius poisoning is generally caused by orellanine, a hydroxy bipyridine N, N-dioxide. This intoxication is characterized by acute nephritis which can lead to death without treatment. We reported a highly sensitive and simple fluorimetric technique to analyse orellanine by thin-layer chromatography on the basis of its characteristic photodecomposition into orelline. Using this procedure, we detected and assayed orellanine for the first time in plasma and renal biopsies of a woman who had deliberately ingested two fruit-bodies of Cortinarius orellanus. An early original treatment was carried out based on hemodialysis, combination plasmapheresis-hemoperfusion, and amino acids and diltiazem administration. These results indicate that it is now possible to make a precise diagnosis of orellanine poisoning.

Topics: 2,2'-Dipyridyl; Acute Disease; Acute Kidney Injury; Adult; Agaricales; Amino Acids; Ascorbic Acid; Biopsy; Chromatography, Thin Layer; Combined Modality Therapy; Diltiazem; Dopamine; Female; Fluorometry; Furosemide; Hemoperfusion; Humans; Kidney; Mushroom Poisoning; Mycotoxins; Photochemistry; Plasmapheresis; Renal Dialysis

Topics: Ascorbic Acid; Dihydrostreptomycin Sulfate; Drug Therapy, Combination; Humans; Hydroxybenzoates; Mushroom Poisoning; Nitrofurans

Topics: Adolescent; Amanita; Ascorbic Acid; Dihydrostreptomycin Sulfate; Female; Humans; Hydroxybenzoates; Middle Aged; Mushroom Poisoning; Nitrofurans

Topics: Agaricales; Amanita; Animals; Anti-Infective Agents; Ascorbic Acid; Cytochrome c Group; Dihydrostreptomycin Sulfate; Drug Therapy, Combination; Female; Hydroxybenzoates; Hyperbaric Oxygenation; Mice; Mushroom Poisoning; Nitrofurans; Penicillin G; Silymarin; Spironolactone; Thiophenes; Yeast, Dried

Topics: Acute Disease; Adult; Aminophylline; Ascorbic Acid; Blood Transfusion; Drug Therapy, Combination; Hepatic Encephalopathy; Humans; Male; Mushroom Poisoning; Prednisolone; Thiamine Pyrophosphate

Topics: Ascorbic Acid; Dextrans; Humans; Hydrocortisone; Mushroom Poisoning; Thiamine Pyrophosphate