A drug used to relieve nasal congestion in the upper respiratory tract.
| Member | Definition | Class |
|---|
| corbadrine | A catecholamine in which the 2-aminoethyl group is substituted with a hydroxy group at C-1 and a methyl group at C-2, with configurations 1R,2S. A metabolite of alpha-methyl-L-dopa, it is an alpha2-adrenergic agonist and acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry. | (-)-alpha-Methylnoradrenaline; alpha-methylnoradrenaline |
| ephedrine | A phenethylamine alkaloid that is 2-phenylethanamine substituted by a methyl group at the amino nitrogen and a methyl and a hydroxy group at position 2 and 1 respectively. | (-)-ephedrine |
| oxymetazoline | A member of the class of phenols that is 2,4-dimethylphenol which is substituted at positions 3 and 6 by 4,5-dihydro-1H-imidazol-2-ylmethyl and tert-butyl groups, respectively. A direct-acting sympathomimetic with marked alpha-adrenergic activity, it is a vasoconstrictor that is used (generally as the hydrochloride salt) to relieve nasal congestion. | oxymetazoline |
| oxymetazoline hydrochloride | A hydrochloride salt resulting from the reaction of equimolar quantities of oxymetazoline and hydrogen chloride. A direct-acting sympathomimetic with marked alpha-adrenergic activity, it is a vasoconstrictor that is used to relieve nasal congestion. | oxymetazoline hydrochloride |
| phenylephrine | A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring. | phenylephrine |
| pseudoephedrine | A member of the class of the class of phenylethanolamines that is (1S)-2-(methylamino)-1-phenylethan-1-ol in which the pro-S hydrogen at position 2 is replaced by a methyl group. | pseudoephedrine |
| tetrahydrozoline | | tetryzoline |
| tetrahydrozoline hydrochloride | The hydrochloride salt of tetryzoline. It is used as a nasal decongestant. | tetrahydrozoline hydrochloride |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 1.7802 | 1 | 2 |
| 67.9K protein | Vaccinia virus | Potency | 0.4467 | 1 | 1 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 9.8446 | 2 | 4 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 32.4648 | 2 | 2 |
| arylsulfatase A | Homo sapiens (human) | Potency | 0.7569 | 1 | 1 |
| Ataxin-2 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.0034 | 2 | 4 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 4.4668 | 1 | 1 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 1.7783 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 4.4668 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 10.0000 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 1.2956 | 2 | 5 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 0.4789 | 1 | 3 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 7.0627 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 40.9140 | 1 | 3 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 1.2956 | 2 | 5 |
| chaperonin GroEL | Methanococcus maripaludis S2 | Potency | 100.0000 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 94.5626 | 1 | 2 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 3.9472 | 1 | 2 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 0.7943 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 2.4656 | 1 | 3 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 7.2999 | 1 | 4 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 20.3068 | 2 | 6 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 0.7762 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 4.1081 | 2 | 2 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 5.6298 | 1 | 3 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 1.8356 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 1.7783 | 1 | 1 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 5.9557 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 9.3427 | 4 | 5 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 1.0969 | 1 | 3 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 27.3536 | 4 | 5 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| geminin | Homo sapiens (human) | Potency | 1.2589 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 9.8891 | 2 | 5 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 9.7436 | 2 | 3 |
| GLS protein | Homo sapiens (human) | Potency | 16.5176 | 1 | 2 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 0.0082 | 1 | 1 |
| guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1 | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 6.2214 | 2 | 7 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 43.8442 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 1.3049 | 2 | 6 |
| IDH1 | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 0.0082 | 1 | 1 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 14.8719 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 2.3196 | 1 | 3 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 6.3010 | 1 | 2 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 39.8107 | 1 | 1 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 9.1063 | 2 | 2 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 15.2858 | 2 | 6 |
| Ornithine decarboxylase | Rattus norvegicus (Norway rat) | Potency | 7.9433 | 1 | 1 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 75.6863 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 42.6148 | 3 | 3 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 10.2918 | 1 | 2 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 13.5346 | 1 | 2 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 6.5812 | 2 | 4 |
| pyruvate kinase PKM isoform b | Homo sapiens (human) | Potency | 7.9433 | 2 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 11.8832 | 1 | 1 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 47.9904 | 1 | 2 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 0.0299 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 0.0211 | 1 | 1 |
| RGS12 | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 0.2391 | 1 | 1 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 0.2391 | 1 | 1 |
| snurportin-1 | Homo sapiens (human) | Potency | 0.0082 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 39.8107 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 20.5291 | 2 | 6 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 7.6237 | 1 | 2 |
| Thrombopoietin | Homo sapiens (human) | Potency | 7.8758 | 2 | 4 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 27.3914 | 2 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 22.0553 | 5 | 9 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 7.0795 | 1 | 1 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |