Page last updated: 2024-08-05 15:24:15
nasal decongestant
A drug used to relieve nasal congestion in the upper respiratory tract.
ChEBI ID: 77715
Members (8)
| Member | Definition | Class |
|---|---|---|
| corbadrine | A catecholamine in which the 2-aminoethyl group is substituted with a hydroxy group at C-1 and a methyl group at C-2, with configurations 1R,2S. A metabolite of alpha-methyl-L-dopa, it is an alpha2-adrenergic agonist and acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry. | (-)-alpha-Methylnoradrenaline; alpha-methylnoradrenaline |
| ephedrine | A phenethylamine alkaloid that is 2-phenylethanamine substituted by a methyl group at the amino nitrogen and a methyl and a hydroxy group at position 2 and 1 respectively. | (-)-ephedrine |
| oxymetazoline | A member of the class of phenols that is 2,4-dimethylphenol which is substituted at positions 3 and 6 by 4,5-dihydro-1H-imidazol-2-ylmethyl and tert-butyl groups, respectively. A direct-acting sympathomimetic with marked alpha-adrenergic activity, it is a vasoconstrictor that is used (generally as the hydrochloride salt) to relieve nasal congestion. | oxymetazoline |
| oxymetazoline hydrochloride | A hydrochloride salt resulting from the reaction of equimolar quantities of oxymetazoline and hydrogen chloride. A direct-acting sympathomimetic with marked alpha-adrenergic activity, it is a vasoconstrictor that is used to relieve nasal congestion. | oxymetazoline hydrochloride |
| phenylephrine | A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring. | phenylephrine |
| pseudoephedrine | A member of the class of the class of phenylethanolamines that is (1S)-2-(methylamino)-1-phenylethan-1-ol in which the pro-S hydrogen at position 2 is replaced by a methyl group. | pseudoephedrine |
| tetrahydrozoline | tetryzoline | |
| tetrahydrozoline hydrochloride | The hydrochloride salt of tetryzoline. It is used as a nasal decongestant. | tetrahydrozoline hydrochloride |
Research
Studies (18,290)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 6,949 (37.99) | 18.7374 |
| 1990's | 4,267 (23.33) | 18.2507 |
| 2000's | 3,877 (21.20) | 29.6817 |
| 2010's | 2,547 (13.93) | 24.3611 |
| 2020's | 650 (3.55) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1,785 (8.88%) | 5.53% |
| Reviews | 508 (2.53%) | 6.00% |
| Case Studies | 932 (4.64%) | 4.05% |
| Observational | 42 (0.21%) | 0.25% |
| Other | 16,832 (83.75%) | 84.16% |
Protein Targets (138)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 1.7802 | 1 | 2 |
| 67.9K protein | Vaccinia virus | Potency | 0.4467 | 1 | 1 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 9.8446 | 2 | 4 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 32.4648 | 2 | 2 |
| arylsulfatase A | Homo sapiens (human) | Potency | 0.7569 | 1 | 1 |
| Ataxin-2 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.0034 | 2 | 4 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 4.4668 | 1 | 1 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 1.7783 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 4.4668 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 10.0000 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 1.2956 | 2 | 5 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 0.4789 | 1 | 3 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 7.0627 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 40.9140 | 1 | 3 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 1.2956 | 2 | 5 |
| chaperonin GroEL | Methanococcus maripaludis S2 | Potency | 100.0000 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 94.5626 | 1 | 2 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 3.9472 | 1 | 2 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 0.7943 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 2.4656 | 1 | 3 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 7.2999 | 1 | 4 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 20.3068 | 2 | 6 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 0.7762 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 4.1081 | 2 | 2 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 5.6298 | 1 | 3 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 1.8356 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 1.7783 | 1 | 1 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 5.9557 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 9.3427 | 4 | 5 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 1.0969 | 1 | 3 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 27.3536 | 4 | 5 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| geminin | Homo sapiens (human) | Potency | 1.2589 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 9.8891 | 2 | 5 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 9.7436 | 2 | 3 |
| GLS protein | Homo sapiens (human) | Potency | 16.5176 | 1 | 2 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 0.0082 | 1 | 1 |
| guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1 | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 6.2214 | 2 | 7 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 43.8442 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 1.3049 | 2 | 6 |
| IDH1 | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 0.0082 | 1 | 1 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 14.8719 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 2.3196 | 1 | 3 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 6.3010 | 1 | 2 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 39.8107 | 1 | 1 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 9.1063 | 2 | 2 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 15.2858 | 2 | 6 |
| Ornithine decarboxylase | Rattus norvegicus (Norway rat) | Potency | 7.9433 | 1 | 1 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 75.6863 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 42.6148 | 3 | 3 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 10.2918 | 1 | 2 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 13.5346 | 1 | 2 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 6.5812 | 2 | 4 |
| pyruvate kinase PKM isoform b | Homo sapiens (human) | Potency | 7.9433 | 2 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 11.8832 | 1 | 1 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 47.9904 | 1 | 2 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 0.0299 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 0.0211 | 1 | 1 |
| RGS12 | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 0.2391 | 1 | 1 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 0.2391 | 1 | 1 |
| snurportin-1 | Homo sapiens (human) | Potency | 0.0082 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 39.8107 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 20.5291 | 2 | 6 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 7.6237 | 1 | 2 |
| Thrombopoietin | Homo sapiens (human) | Potency | 7.8758 | 2 | 4 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 27.3914 | 2 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 22.0553 | 5 | 9 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 7.0795 | 1 | 1 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 0.0056 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | IC50 | 0.0056 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Homo sapiens (human) | Ki | 0.0003 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 1 |
| 5-hydroxytryptamine receptor 1D | Homo sapiens (human) | Ki | 0.0004 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 1.2850 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.3670 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 3.0560 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 1.9450 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 0.5780 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.3030 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 0.5780 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 0.3030 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 1.6700 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 0.7750 | 1 | 1 |
| Alpha-1A adrenergic receptor | Bos taurus (cattle) | Ki | 0.4732 | 1 | 2 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Ki | 0.1378 | 3 | 4 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 2.1978 | 2 | 3 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | Ki | 0.5842 | 3 | 4 |
| Alpha-1B adrenergic receptor | Mesocricetus auratus (golden hamster) | Ki | 0.7316 | 1 | 2 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 6.1000 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | IC50 | 2.8440 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Ki | 0.9297 | 3 | 3 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 2.1978 | 2 | 3 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 0.0230 | 1 | 1 |
| Alpha-2A adrenergic receptor | Bos taurus (cattle) | Ki | 0.0015 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.1027 | 18 | 22 |
| Alpha-2A adrenergic receptor | Mus musculus (house mouse) | Ki | 0.0913 | 3 | 3 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.2093 | 14 | 19 |
| Alpha-2A adrenergic receptor | Sus scrofa (pig) | Ki | 0.0210 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 1.2730 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 0.4091 | 17 | 20 |
| Alpha-2B adrenergic receptor | Mus musculus (house mouse) | Ki | 0.0913 | 3 | 3 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.2043 | 15 | 20 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | IC50 | 2.6330 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.1218 | 18 | 22 |
| Alpha-2C adrenergic receptor | Mus musculus (house mouse) | Ki | 0.0913 | 3 | 3 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.2093 | 14 | 19 |
| Beta-1 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 13.0000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 0.2000 | 1 | 1 |
| guanine nucleotide-binding protein subunit alpha-15 | Homo sapiens (human) | IC50 | 29.8680 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 3.2610 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 0.4550 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 1.3320 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 0.9570 | 1 | 1 |
| Nischarin | Homo sapiens (human) | Ki | 0.0062 | 1 | 2 |
| trace amine-associated receptor 1 | Homo sapiens (human) | IC50 | 0.1571 | 1 | 1 |
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | EC50 | 0.0700 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | EC50 | 12.5694 | 2 | 2 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | EC50 | 0.0200 | 1 | 1 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | EC50 | 0.0200 | 1 | 1 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | EC50 | 0.0200 | 1 | 1 |
| Alpha-1A adrenergic receptor | Bos taurus (cattle) | EC50 | 0.0090 | 1 | 1 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | EC50 | 0.0343 | 5 | 5 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 0.7760 | 1 | 1 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | EC50 | 7.0299 | 5 | 5 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 0.7760 | 1 | 1 |
| Alpha-1B adrenergic receptor | Cricetulus griseus (Chinese hamster) | EC50 | 0.0100 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | EC50 | 11.7142 | 3 | 3 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 0.7760 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | EC50 | 0.1547 | 2 | 2 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 25.1189 | 1 | 1 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 25.1189 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | EC50 | 0.3400 | 1 | 1 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 25.1189 | 1 | 1 |
| alternatively spliced Trp4 | Mus musculus (house mouse) | EC50 | 3.3500 | 1 | 1 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | EC50 | 6.0000 | 1 | 1 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | EC50 | 6.0000 | 1 | 1 |
| Beta-3 adrenergic receptor | Homo sapiens (human) | EC50 | 6.0000 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | EC50 | 0.0700 | 1 | 2 |
| guanine nucleotide-binding protein subunit alpha-15 | Homo sapiens (human) | EC50 | 29.8680 | 1 | 2 |
| trace amine-associated receptor 1 | Homo sapiens (human) | EC50 | 0.1544 | 1 | 1 |
Other Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Alpha-2A adrenergic receptor | Mus musculus (house mouse) | IC40 | 0.0780 | 1 | 1 |
| Alpha-2B adrenergic receptor | Mus musculus (house mouse) | IC40 | 0.0780 | 1 | 1 |
| Alpha-2C adrenergic receptor | Mus musculus (house mouse) | IC40 | 0.0780 | 1 | 1 |
| POU domain, class 2, transcription factor 1 | Homo sapiens (human) | Km | 221.2000 | 1 | 1 |