A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)
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| "Pheochromocytoma is a tumor of chromaffin tissue derived from the neural crest and closely related to other APUD (amine precursor uptake and decarboxylation) cell tumors, including those of the pancreatic islets." | ( Cheikh, IE; Hamilton, BP; Rivera, LE, 1977) |
| "A case of ruptured pheochromocytoma is presented, the pathophysiology discussed, and the literature reviewed." | ( Cleveland, HC; Faraci, RP; Foster, JF; Scott, HW; Van Way, CW, 1976) |
| "A case of adrenal pheochromocytoma is reported characterized by polygonal basophilic granular cells of benign type, plump eosinophilic granular cells of transitional type, and spindle-shaped cells of malignant type." | ( Hosoda, S; Ikuta, K; Nagatsu, T; Oguri, T; Suzuki, H, 1976) |
| "An unusual case of pheochromocytoma is described in this communication." | ( Ishibashi, M; Takeuchi, A; Tsuchimochi, T; Yamaji, T; Yokoyama, S, 1975) |
| "Pheochromocytomas are potentially curable causes of hypertension." | ( Francis, IR; Haka, MS; Kuhl, DE; Rosenspire, KC; Schwaiger, M; Shapiro, B; Shulkin, BL; Sisson, JC; Thompson, NW; Wieland, DM, 1992) |
| "Pheochromocytoma is a rare tumor of childhood." | ( Caty, MG; Coran, AG; Geagen, M; Thompson, NW, 1990) |
| "Malignant pheochromocytoma is a rare cause of hypertension and still has a high mortality rate." | ( Borgonovo, G; Garibotto, G; Pontremoli, R; Ranise, A, 1989) |
| "Pheochromocytoma is usually benign and can be excised totally after medical preparation with an alpha-adrenergic antagonist as we have done; adrenomedullary hyperplasia can only be treated with subtotal adrenalectomy." | ( Chen, NH; Li, XY; Tian, CG, 1989) |
| "Although pheochromocytomas are rare, ophthalmologists should be aware of the signs and symptoms of this tumor as well as of the possible role that postoperative administration of timolol may have in pheochromocytoma-triggered hypertension." | ( Hemmady, P; Klink, M; Snyder, RW, 1989) |
| "Pheochromocytomas are rare tumors, typically found in the adrenal medulla, which may secrete large quantities of catecholamines such as dopamine, norepinephrine, and epinephrine." | ( Hoffman, BB, 1987) |
| "Since pheochromocytoma is considered to be of neural crest origin, these results provide biochemical and immunological evidence for the presence of the renin-angiotensin cycle within human neuronal cells." | ( Fukuchi, S; Hashimoto, S; Itoh, T; Mizuno, K; Niimura, S; Ojima, M; Tani, M; Watari, H, 1985) |
| "Hypertension due to pheochromocytoma is generally considered to be a straightforward, direct consequence of the elevated concentrations of circulating catecholamines." | ( Hoffman, BB; Maze, M; Prokocimer, PG, 1987) |
| "Pheochromocytoma is curable in 90% of cases, yet its diagnosis and localization are among the most challenging problems in clinical medicine." | ( Atuk, NO, 1983) |
| "Ten percent of pheochromocytomas are found in extra-adrenal locations and are called paragangliomas." | ( Ashley, PF; Frelick, RW; Herrera, LO; Hossain, ZM; Lopez, GE; Rafal, HS, 1980) |
| "Where pheochromocytoma is the cause of hypertension, its resection generally results in a better control of hypertension than that obtained in patients whose BPs were elevated from other unknown causes." | ( Beierwaltes, WH; Holland, K; Kalff, V; Lloyd, R; Nakajo, M; Shapiro, B; Sisson, JC, 1982) |
| "Treatment of this pheochromocytoma is surgical and resolves the hypertensive symptoms in 80% of the benign forms." | ( Buzzatti, A; Cagol, PP; De Marchi, F; Zavagno, G, 1982) |
| "Extra-adrenal pheochromocytomas are more common in children (30%) than in adults (10%)." | ( Crowe, JK; Gilchrist, GS; Hodgkinson, DJ; Sheps, SG; Telander, RL, 1980) |
| "Since not all pheochromocytomas are accurately localized preoperatively and significant numbers can be bilateral or extra-adrenal, this predictive index of tumor size has useful surgical implications." | ( Davidson, HA; Farndon, JR; Johnston, ID; Wells, SA, 1980) |
| "ACTH-secreting pheochromocytomas are the exception to the rule; unilateral adrenalectomy is curative and the contralateral hyperplastic adrenal can be preserved." | ( Chen, H; Chrousos, GP; Doppman, JL; Nieman, LK; Norton, JA; Udelsman, R, 1995) |
| "8-10% of pheochromocytomas are malignant, but with the exception of invasion of the capsule or of the veins or the demonstration of metastases, no other reliable criteria for malignancy exist." | ( Saeger, W, 1995) |
| "Pheochromocytoma is mainly characterized by a great deal of variability in its biological activity and in its clinical manifestations." | ( Bellini, F; Ianni, L; Lanzillotti, R; Mannelli, M; Pupilli, C, 1995) |
| "Pheochromocytoma is a rare cause of ectopic Cushing's syndrome." | ( Alì, A; Angeli, A; Bollito, E; Paccotti, P; Pia, A; Reimondo, G; Scardapane, R; Terzolo, M, 1994) |
| "Pheochromocytoma is often associated with paroxysmal hypertension." | ( Eto, T; Ishiyama, Y; Kawasaki, T; Kida, O; Kita, T; Kitamura, K; Ohgi, T; Sasaki, A, 1993) |
| "Pheochromocytomas are rare in mice." | ( Alroy, J; Cahill, AL; Carroll, J; Freund, R; Perlman, RL; Riseberg, JC; Tischler, AS, 1993) |
| "The treatment for pheochromocytoma is adrenalectomy, and successful pregnancy has been achieved after bilateral adrenalectomy." | ( Katz, VL; Sweeney, WJ, 1994) |
| "Bilateral classic pheochromocytomas are rare in type 1 neurofibromatosis, and we believe that bilateral composite pheochromocytomas are an extension of this association." | ( Chetty, R; Duhig, JD, 1993) |
| "Pheochromocytoma is a unique type of hypertension caused by excessive production of catecholamines by the chromaffin tumor." | ( Januszewicz, W; Wocial, B, 1995) |
| "Pheochromocytomas are uncommon tumors that represent a potentially curable cause of hypertension." | ( Dietemann, JL; Gangi, A; Hartheiser, M; Jaeck, D; Jeung, MY; Rimmelin, A; Tongio, J; Welsch, M, 1996) |
| "Pheochromocytoma is usually diagnosed by finding elevated levels of metanephrines, catecholamines, or vanillylmandelic acid in 24-hour urine collections." | ( Shawar, L; Svec, F, 1996) |
| "Urinary bladder pheochromocytoma is an uncommon tumor that produces hypertensive crises coinciding with micturition." | ( López, E; López, R; Piédrola, G; Rueda, MD; Sancho, M; Serrano, J, 1997) |
| "Pheochromocytomas are tumors secreting large amount of catecholamines." | ( Mornex, R; Peyrin, L, 1996) |
| "Pheochromocytoma is an unusual cause of hypertension during pregnancy." | ( Hamada, S; Higuchi, K; Hinokio, K; Naka, O; Sumitani, H; Takahashi, H, 1996) |
| "Pheochromocytomas are catecholamine-producing tumors, representing one of the most important causes of secondary hypertension." | ( Kopf, D; Lehnert, H; Mundschenk, J; Schulz, C, 1997) |
| "Pheochromocytomas are active, catecholamine-producing tumours derived from chromaffine tissue, causing arterial hypertension." | ( Förster, G; Kahaly, G; Schulz, G, 1997) |
| "Malignant pheochromocytomas are rare." | ( Raber, W; Vierhapper, H, 1997) |
| "Pheochromocytomas are functionally active, catecholamine-secreting tumours of chromaffin tissue." | ( Egelhof, J; Engelhardt, D; Fürst, H; Welte, M, 1997) |
| "Pheochromocytoma is a rare tumor that secretes excess catecholamines." | ( Bartoli, P; Bonechi, F; Brandinelli, A; Del Rosso, A; Fradella, G; Ieri, A; Maioli, M; Mannelli, M; Mazza, F; Russo, L; Sansoni, M; Zipoli, A, 1997) |
| "Pheochromocytoma is a rare disease that may occur during pregnancy." | ( Kinoshita, K; Seki, H; Takai, Y, 1997) |
| "Resection of pheochromocytoma is associated with potential risks of hypertensive crises and serious arrhythmias due to massive release of catecholamines from the tumor." | ( Iwasaki, T; Ku, Y; Kuroda, Y; Muramatsu, S; Obara, H; Shima, Y; Takao, Y; Tominaga, M, 1998) |
| "Cardiac pheochromocytoma is an exceedingly rare and unusual clinical entity." | ( Cohen, AJ; Gazzaniga, AB; Jackson, HA; Lin, JC; Palafox, BA, 1999) |
| "Malignant pheochromocytoma is a rare tumor with a poor prognosis because excess production of catecholamines leads to potentially lethal complications." | ( Iwabuchi, M; Nakamura, H; Oki, Y, 1999) |
| "Pheochromocytoma is known to increase morbidity and mortality." | ( Hermayer, KL; Szpiech, M, 1999) |
| "In addition, pheochromocytoma is well known to cause unsuspected operating room deaths." | ( Tsuji, Y; Yokoyama, H, 1999) |
| "Malignant pheochromocytomas are rare in childhood and the prognosis of children with this tumor is not well known." | ( Adamsbaum, C; Bougnères, PF; Coutant, R; Dubousset, J; Guinebretière, JM; Oberlin, O; Pein, F; Teinturier, C, 1999) |
| "Pheochromocytomas are tumors originating from chromaffin cells, the large majority of which are sporadic neoplasms." | ( Bertagna, X; Charlet-Berguerand, N; Colucci-D'Amato, LG; de Franciscis, V; Le Hir, H; Plouin, PF; Thermes, C, 2000) |
| "Adrenal pheochromocytoma is potentially lethal if undetected and is associated with long-term morbidity." | ( Lam, KS; Lam, KY; Lo, CY; Wat, MS, 2000) |
| "Pheochromocytoma is a chromaffin tumor in which 10% are extra-adrenal and 10% are malignant." | ( Fujita, A; Furuse, M; Hyodoh, H; Kanazawa, K; Kanegae, K; Kawamura, Y, 2000) |
| "Pheochromocytomas are rare chromaffin cell tumors that nevertheless must be excluded in large numbers of patients who develop sustained or episodic hypertension as well as in many others with suggestive symptoms or with a familial history of pheochromocytoma." | ( Eisenhofer, G; Friberg, P; Keiser, HR; Lenders, JW; Pacak, K; Walther, M, 2000) |
| "A malignant pheochromocytoma is described in a 71-year-old man." | ( Dezawa, A; Honda, M; Ishibashi, M; Mizuguchi, K; Uesugi, K; Yamaji, T; Yamazaki, H, 2000) |
| "Mouse pheochromocytomas are a new tool for studying genes and signaling pathways that regulate cell growth and differentiation in adrenal medullary neoplasms and are a unique model for studying the regulation of PNMT expression." | ( Alroy, J; Bedri, S; Evinger, MJ; Powers, JF; Shahsavari, M; Tischler, AS; Tsokas, P, 2000) |
| "Pheochromocytoma is a catecholamine-secreting neoplasm of chromaffin tissue." | ( Duclos, JM; Gimenez-Roqueplo, AP; La Batide Alanore, A; Plouin, PF; Salenave, S, 2000) |
| "Malignancy of pheochromocytomas is difficult to estimate on the basis of histopathological features." | ( Arola, J; Haglund, C; Heikkilä, P; Ilvesmäki, V; Kahri, AI; Liu, J; Salmenkivi, K; Voutilainen, R, 2001) |
| "Pheochromocytoma is a rare cause of hypertension resulting from increased catecholamine secretion." | ( Bernroider, E; Gasic, S; Niederle, B; Raber, W; Raffesberg, W; Roden, M; Waldhäusl, W, 2001) |
| "Pheochromocytoma is a tumor secreting catecholamines and is most often a sporadic and benign adrenal tumor." | ( Arnault-Ouary, G; Charbonnel, B; Chatal, JF, 1998) |
| "Pheochromocytomas are chromaffin cell tumors, mostly originating from the adrenal medulla, and represent a rare cause of hypertensiondue to excessive production of catecholamines (norepinephrine and/or epinephrine)." | ( Roden, M, 2002) |
| "Pheochromocytomas are dangerous tumors that, although a rare cause of hypertension, require consideration among large numbers of patients." | ( Eisenhofer, G; Lenders, JW; Pacak, K, 2002) |
| "Pheochromocytoma is a rare but clinically important tumor of catecholamine-secreting chromaffin cells." | ( Carrasquillo, JA; Chen, CC; Eisenhofer, G; Goldstein, DS; Pacak, K; Whatley, M, 2002) |
| "Extra-adrenal Pheochromocytomas are rare entities." | ( Ghosh, AK; Mukherjee, S; Mullick, RN, 2002) |
| "Pheochromocytomas are tumors able to produce catecholamines and a variety of biologically active neuropeptides." | ( Angeli, A; Cappia, S; Daffara, F; Dovio, A; Minetto, M; Terzolo, M; Ventura, M, 2003) |
| "Pheochromocytomas are rare tumors that typically present with catecholamine-stimulated symptoms." | ( Awada, SH; Grisham, A; Woods, SE, 2003) |
| "Pheochromocytomas are rare, but because they are a curable cause of hypertension and potentially fatal if not found, important to diagnose." | ( Capell, PT; Failor, RA, 2003) |
| "Pheochromocytoma is a lethal tumor of chromaffin cells of the adrenal medulla that produces episodes of hypertension with the symptoms of palpitations, severe headaches, and sweating." | ( Singh, RJ, 2004) |
| "Pheochromocytoma is a rare, life-threatening condition." | ( Gafni, A; Sawka, AM; Thabane, L; Young, WF, 2004) |
| "Adrenalectomy for pheochromocytoma is a life-threatening procedure." | ( Devaux, B; Dousset, B; Jude, N; Lentschener, C; Ozier, Y; Pili-Floury, S; Valensi, L, 2004) |
| "Pheochromocytoma is a rare, but clinically important tumor of chromaffin cells." | ( Roman, S; Yeo, H, 2005) |
| "Pheochromocytoma is a neuroendocrine tumor associated with a variety of genetic disorders, which include von Hippel-Lindau disease (VHL), multiple endocrine neoplasia type 2 (MEN 2), neurofibromatosis type 1, hereditary paraganglioma, and succinate dehydrogenase gene-related tumors." | ( Brouwers, FM; Linehan, WM; Lubensky, IA; Oldfield, EH; Pacak, K; Vogel, TW; Vortmeyer, AO; Walther, MM; Weil, RJ; Zhuang, Z, 2005) |
| "Pheochromocytoma is associated with intense physiologic effects of alpha- and beta-adrenergic stimulation from catecholamine secretion." | ( McGowan, FX; Seefelder, C; Shamberger, RC; Sparks, JW, 2005) |
| "Extra-adrenal pheochromocytomas are catecholamine-secreting tumors that arise from chromaffin cells of the paraganglion sympathetic system." | ( Bernet, V; Dainty, L; Elkas, JC; Gherman, RB; Miller, C, 2005) |
| "Pheochromocytomas are known to be rare causes of sudden death." | ( Madea, B; Preuss, J; Schwesinger, G; Woenckhaus, C, 2006) |
| "Composite pheochromocytoma is a neuroendocrine tumor that is composed of pheochromocytoma and ganglioneuroma, both derived from the neural crest." | ( Fukuhara, T; Kanagawa, K; Kanda, M; Maekawa, I; Minoguchi, M; Miyake, T; Onozawa, M; Takahata, M; Yamamoto, Y, 2005) |
| "Pheochromocytoma is a rare neuroendocrine tumor that secretes high levels of catecholamines and usually causes paroxysmal or sustained hypertension." | ( Farroni, JA, 2005) |
| "Normotensive pheochromocytomas are a distinct entity, and all adrenal incidentalomas should be investigated for catecholamine hypersecretion." | ( Agarwal, A; Gupta, S; Mishra, AK; Mishra, SK; Singh, N, 2005) |
| "Pheochromocytoma is a rare, catecholamine-producing tumor with preferential localization in the adrenal gland." | ( Delong, ER; Eubanks, S; Feldman, JM; Guller, U; Oertli, D; Turek, J, 2006) |
| "Pheochromocytomas are rare tumors of chromaffin cells for which the optimal management is surgical resection." | ( Byrd, DR; Kinahan, PE; Krohn, KA; Link, JM; Mankoff, DA; Mann, GN; Pham, P; Pickett, CA, 2006) |
| "Pheochromocytomas are neoplasms generally characterized by the autonomous production of catecholamines." | ( Mann, K; Petersenn, S; Philipp, T; Pitt, C; Schmid, KW; Schmidt, IL; Unger, N; Walz, MK, 2006) |
| "Pheochromocytomas are catecholamine-producing neuroendocrine tumours arising from chromaffin cells of the adrenal medulla or extra-adrenal paraganglionic system that show 2 distinctive features, rarity and clinical variability." | ( Calvieri, S; Ciardi, A; Corsi, A; Cotesta, D; De Toma, G; Divona, L; Giustini, S; Letizia, C; Massa, R; Petramala, L; Reale, MG; Serra, V, 2006) |
| "Sporadic pheochromocytoma is a rare tumor of childhood and accounts for less than 1% of cases of hypertension." | ( Behra, A; Bhansali, A; Khandelwal, N; Radotra, BD; Rajput, R; Rao, KL, 2006) |
| "Malignant pheochromocytoma is a rare disease with a high mortality." | ( Clark, OH; Duh, QY; Kebebew, E; Zarnegar, R, 2006) |
| "Two patients with pheochromocytoma are described in whom treatment with a high dose of an angiotensin receptor blocker was associated with cessation of tumor growth as assessed by serial CT scanning and plasma norepinephrine estimation." | ( Appleton, DS; Ashby, MJ; Balan, KK; Brown, MJ; Mackenzie, IS, 2006) |
| "Pheochromocytomas are rare neuroendocrine tumors that produce, metabolize, and usually secrete catecholamines." | ( Kamaruddin, NA; Saidin, R; Sukor, N, 2007) |
| "Pheochromocytomas are rare tumors of predominantly adrenal origin that often produce and secrete catecholamines." | ( Dralle, H; Eisenhofer, G; Lehnert, H; Pacak, K; Scholz, T, 2007) |
| "Pheochromocytomas are catecholamine-producing tumors presenting with various clinical symptoms, but mostly with headache, sweating, palpitations and hypertension." | ( Eisenhofer, G; Pacak, K; Zelinka, T, 2007) |
| "Pheochromocytoma is a rare tumor of chromaffin tissues most commonly arising from the adrenal medulla." | ( Kondo, K; Kubota, Y; Nakaigawa, N; Noguchi, K; Onuki, T; Saito, K; Suzuki, K; Teranishi, J; Yamagishi, T, 2007) |
| "Extra-adrenal pheochromocytoma is a very rare entity, especially in the pediatric age group; the utility of the laparoscopic approach is not established in this population." | ( Al-Assiri, A; Kravarusic, D; Pinto-Rojas, A; Sigalet, D, 2007) |
| "Pheochromocytoma is an infrequent secondary cause of arterial hypertension, often associated with paroxysmal headache, sweating, weight loss, and palpitations." | ( Beckmann, BM; Hinterseer, M; Kääb, S; Methe, H; Steinbeck, G; Wilbert-Lampen, U, 2007) |
| "Paragangliomas and pheochromocytomas are rare tumors arising from chromaffin cells." | ( Forrer, F; Maecke, HR; Mueller-Brand, J; Riedweg, I, 2008) |
| "Pheochromocytomas are rare tumors in children arising from chromaffin cells of adrenal medullary or extra-adrenal paraganglionic tissue." | ( Adams, K; Eisenhofer, G; Havekes, B; Pacak, K; Romijn, JA, 2009) |
| "Pheochromocytoma is a rare tumor responsible for paroxysmal hypertension which is difficult to control." | ( Abdallah, NB; Abdallah, TB; Abderrahim, E; Bacha, MM; Gorsane, I; Goucha, R; Hedri, H; Kheder, A; Khiari, K; Maiz, HB; Moussa, FB; Zouaghi, K, 2008) |
| "Pheochromocytomas are catecholamine-secreting tumors that also synthesize and secrete several neuropeptides, including opioids." | ( Barontini, M; Cigorraga, SB; Figuerola, Mde L; Levin, G; Pellizzari, EH, 2008) |
| "Pheochromocytomas are rare tumors arising from chromaffin cells of adrenal medullary or extra-adrenal paraganglionic tissue." | ( Corssmit, EP; Havekes, B; Lai, EW; Pacak, K; Romijn, JA; Timmers, HJ, 2008) |
| "A pheochromocytoma is an endocrine tumor that can uniquely mimic numerous stress-associated disorders, with variations in clinical manifestations resulting from different patterns of catecholamine secretion and actions of released catecholamines on physiological systems." | ( Eisenhofer, G; Kantorovich, V; Pacak, K, 2008) |
| "However, pseudopheochromocytoma is characterized by an absence of panic or emotional distress preceding the onset of hypertension and symptoms of catecholamine excess." | ( Eisenhofer, G; Pacak, K; Sharabi, Y, 2008) |
| "Pheochromocytomas are widely believed to induce cardiomyopathy via hypersecretion of catecholamines, including norepinephrine (NE)." | ( Anwar, TR; Edelman, ER; Engelmayr, GC; Freed, LE; Mobine, HR; Moussazadeh, N, 2009) |
| "About 10% of pheochromocytomas are malignant." | ( Kimura, H; Kodama, H; Nomura, K; Obara, T; Okamoto, T; Shimizu, S; Takano, K, 2009) |
| "The diagnosis of pheochromocytoma is based on the overproduction of catecholamines." | ( Deutschbein, T; Mann, K; Petersenn, S; Unger, N; Walz, MK, 2009) |
| "Patients with pheochromocytoma are frequently diabetic." | ( Fu, L; Hara, H; Isobe, K; Kawakami, Y; Nissato, S; Shimano, H; Suzukawa, K; Takahashi, H; Takekoshi, K; Tatsuno, I; Yashiro, T, 2009) |
| "Pheochromocytomas are rare tumors derived from the chromaffin cells of the adrenal medulla." | ( Baker, AB; Edelman, ER; Jacobsen, KC; Mobine, HR; Seidman, CE; Seidman, JG; Wakimoto, H; Wang, L, 2009) |
| "Pheochromocytomas are catecholamine-producing tumors which are generally benign, but which can also present as or develop into malignancy." | ( Anouar, Y; Bertherat, J; Guérin, M; Guillemot, J; Klein, M; Lefebvre, H; Manecka, DL; Muresan, M; Ouafik, L; Pierre, A; Plouin, PF; Tanguy, Y; Thouënnon, E; Yon, L, 2010) |
| "Pheochromocytoma is a rare endocrine tumor of the adrenal gland that mostly occurs sporadic with unknown epigenetic/genetic cause." | ( Akerstrom, G; Andersson, R; Dumanski, JP; Enroth, S; Komorowski, J; Rada-Iglesias, A; Sandgren, J; Wadelius, C; Westin, G, 2010) |
| "Pheochromocytoma is a catecholamine-secreting tumor, for which the treatment of choice is complete surgical resection, when possible." | ( Carvalho, MR; Dias, T; do Carmo, I; Esteves, R; Machado, AP; Rodrigues, A, 2010) |
| "Cortisol secreting pheochromocytoma is rarely reported in literature." | ( Khurana, N; Kumar, M; Kumar, V; Mohta, A; Talukdar, B, 2010) |
| "Pheochromocytomas are rare catecholamine-producing tumors derived in more than 30% of cases from mutations in 9 tumor-susceptibility genes identified to date, including von Hippel-Lindau tumor suppressor (VHL); succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (SDHB); and succinate dehydrogenase complex, subunit D, integral membrane protein (SDHD)." | ( Adams, K; Bornstein, SR; Bratslavsky, G; Eisenhofer, G; Grebe, SK; Hofbauer, LC; Lenders, JW; Linehan, WM; Mannelli, M; Pacak, K; Tiebel, O; Timmers, H, 2011) |
| "Pheochromocytoma is a tumor of the chromaffin cells in the adrenal medulla and sympathetic paraganglia, which synthesizes and secretes catecholamines." | ( Kantorovich, V; Pacak, K; Zuber, SM, 2011) |
| "Pheochromocytomas are tumours arising from chromaffin tissue located in the adrenal medulla associated with typical symptoms and signs which may occasionally develop metastases, which are defined as the presence of tumour cells at sites where these cells are not found." | ( Burton, D; Dušková, J; Merino, MJ; Milosevic, D; Musil, Z; Pacak, K; Widimský, J; Zelinka, T, 2011) |
| "Pheochromocytoma is a catecholamine-producing tumor but rarely delayingly diagnosed until during pregnancy." | ( Huang, CS; Ko, YP; Kuok, CH; Tsai, PS; Yen, CR, 2011) |
| "Pheochromocytoma is a neuroendocrine tumour of the adrenal gland that secretes an excessive amount of catecholamines, leading to a rapid rise and fall in blood pressure, headache, sweating and palpitations." | ( D'Agostino, M; Ferrucci, A; Gregori, M; Paneni, F; Savoia, C; Tocci, G, 2011) |
| "An ACTH-producing pheochromocytoma is a very rare cause of deterioration of glucose control." | ( Adam, P; Dudziak, K; Horger, M; Müssig, K; Neumann, H; Rettig, I, 2011) |
| "Pheochromocytomas are characterized by a high attenuation value on unenhanced computed tomography (CT)." | ( Raade, M; Sane, T; Schalin-Jäntti, C, 2012) |
| "Adrenal pheochromocytomas are neoplasms characterized by catecholamine excess." | ( Deutschbein, T; Hinrichs, J; Mann, K; Petersenn, S; Schmidt, H; Unger, N; Walz, MK, 2012) |
| "Paragangliomas and pheochromocytomas are genetically heterogeneous diseases." | ( Benz, MR; Campbell, D; Dumont, RA; Mix, M; Neumann, HP; Rischke, HC; Rössler, J; Seufert, J; Weber, WA; Wiech, T; Wild, D, 2012) |
| "The prevalence of pheochromocytoma is 2% among adrenal incidentaloma smaller than 3 cm (2/3 of tumors)." | ( Kerlan, V; Thuillier, P, 2012) |
| "Pheochromocytoma is a rare but potentially lethal chromaffin cell tumor with currently no effective treatment." | ( Bergmann, R; Bornstein, SR; Ehrhart-Bornstein, M; Eisenhofer, G; Gebauer, L; Gondek, K; Pacak, K; Pietzsch, J; Qin, N; Schally, AV; Ullrich, M; Ziegler, CG, 2013) |
| "Pheochromocytoma is a rare neoplasm in children." | ( Amini, Z; Babovic-Vuksanovic, D; Lteif, A, 2013) |
| "Pheochromocytomas are rare tumors which can be malignant in 10% of cases." | ( Bal, C; Dhull, VS; Kumar, R; Parida, GK; Sharma, P, 2014) |
| "Pheochromocytoma is a rare tumour, but one of great clinical importance as a risk factor of malignancy, cardiovascular diseases and sudden death." | ( Dadan, J; Górska, M; Kościuszk, M; Myśliwiec, J; Myśliwiec, P; Popławska, A; Siewko, K; Szelachowska, M; Zukowski, L, 2013) |
| "Pheochromocytomas are benign or malignant neuroendocrine tumours." | ( Kowalewicz-Kulbat, M; Lawnicka, H; Melen-Mucha, G; Motylewska, E; Niedziela, A; Sicinska, P; Stepien, H, 2013) |
| "Pheochromocytomas are derived from the adrenal medulla and present with symptoms caused by high secretion of catecholamines." | ( Mihai, R, 2014) |
| "Resection of pheochromocytoma is often associated with hemodynamic instability (HDI)." | ( Broome, JT; Chen, X; Du, L; Kiernan, CM; Peters, MF; Shi, C; Solorzano, CC, 2014) |
| "Pheochromocytoma is a very rare tumor that stems from chromaffin cells and usually develops in the adrenal glands." | ( Bobrzyk, M; Chronowska, J; Kukla, U; Madej, P; Okopień, B; Łabuzek, K, 2015) |
| "Pheochromocytoma is a tumour of the chromaffin tissue." | ( Martín, N; Muxí, À; Ortiz, JT; Taurà, P; Tejedor, A; Vendrell, M, 2016) |
| "Pheochromocytomas are catecholamine-producing tumors with typical clinical presentation." | ( Brabcová Vránková, A; Dušková, J; Hamplová, B; Holaj, R; Indra, T; Kršek, M; Kubinyi, J; Michalský, D; Musil, Z; Novák, K; Petrák, O; Rosa, J; Šomlóová, Z; Štrauch, B; Turková, H; Vránková, AB; Waldauf, P; Widimský, J; Zelinka, T, 2015) |
| "Pheochromocytomas are rare tumours originating in chromaffin cells, representing 0." | ( Alface, MM; Fonseca, C; Jesus, S; Moniz, P, 2015) |
| "Marker-negative pheochromocytoma is uncommon, representing 9% of cases in our series." | ( Heavner, MG; Krane, LS; Mirzazadeh, M; Winters, SM, 2015) |
| "Pheochromocytoma is suggested by the presence of severe and paroxysmal hypertension associated with hyperadrenergy clinical signs." | ( Dollfus, S; Fedrizzi, S; Lecardeur, L; Loggia, G; Nathou, C; Tréhout, M, 2016) |
| "BACKGROUND Pheochromocytoma is a rare catecholamine-producing tumor with an estimated incidence of less than 0." | ( Heimann, DM; Junejo, SZ; Reich, D; Sachmechi, I; Tuli, S, 2017) |
| "Pheochromocytoma is a catecholamine-producing tumour and laparoscopic adrenalectomy is its treatment of choice." | ( Arbonés-Aran, E; Lorente-Poch, L; Luis-García, C; Teixell-Aleu, C; Trillo-Urrutia, L, 2018) |
| "Pheochromocytomas are rare neuroendocrine tumors, with a malignancy frequency of approximately 10%." | ( Ando, R; Hamamoto, S; Hayashi, Y; Iida, K; Inaki, A; Kawai, N; Kayano, D; Kinuya, S; Mizuno, K; Naiki, T; Okada, A; Sugino, T; Tozawa, K; Umemoto, Y; Unno, R; Yasui, T, 2017) |
| "Malignant pheochromocytoma is a rare disease and surgical resection is the only curative treatment." | ( Lu, B; Ma, C; Sun, E, 2018) |
| "Giant malignant pheochromocytomas are rare entities requiring clinical suspicion coupled with strategic diagnostic evaluation to confirm the diagnosis, personalized therapeutic treatment is required, particularly among elderly population." | ( Lu, B; Ma, C; Sun, E, 2018) |
| "Pheochromocytomas are rare catecholamine-secreting tumors arising from adrenomedullary chromaffin cells, usually causing hypertension, palpitation and headache." | ( Chen, X; Tang, L; Tong, N; Wu, R; Xu, S; Zhang, F; Zhang, Y, 2018) |
| "Pheochromocytoma are rare tumors, usually symptomatic due to their hormonal activity with excessive catecholamine secretion." | ( Erlic, Z; Fischli, S, 2018) |
| "Pheochromocytomas are present in approximately 4-7% of patients with adrenal incidentalomas." | ( Almeida, MQ; Bezerra-Neto, JE; Fragoso, MCBV; Latronico, AC; Mendonça, BB, 2018) |
| "Pheochromocytoma is a rare catecholamine-secreting tumour that is typically located in the adrenal medulla or along the sympathetic ganglia." | ( Naqvi, SY; Tafreshi, S; Thomas, S, 2018) |
| "Pheochromocytoma is a rare neuroendocrine tumor, clinically characterized by high blood pressure, palpitations, and headache." | ( De Luca, G; Di Stolfo, G; Maggio, A; Mastroianno, S; Potenza, DR; Russo, A; Salvatori, MP, 2019) |
| "Pheochromocytomas are rare neuroendocrine chromaffin-derived tumors that arise within the adrenal medulla." | ( Grossman, AB; Sbardella, E, 2020) |
| "Paraganglioma and pheochromocytoma are examples, whose etiology and therapy are complicated by the absence of representative cell lines or animal models." | ( Braun, MM; Chen, C; Damjanac, T; Hu, J; Maher, LJ; Zhang, Y, 2019) |
| "Pheochromocytoma is a tumour arising from the adrenal medulla, which secretes catecholamines." | ( Clements, HA; Smith, DM; Wilson, MS, 2020) |
| "Both RA and LA for pheochromocytoma are safe and effective." | ( Dai, J; Fang, C; He, W; Ma, W; Mao, Y; Sun, F; Wang, C; Xu, D; Zhao, J; Zhu, Y; Zhuo, R, 2020) |
| "Dopamine-secreting pheochromocytomas are exceedingly rare." | ( Jiang, B; Jing, J; Yu, M, 2021) |
| "Pheochromocytomas are uncommon tumours that originate in chromaffin cells." | ( Bashir, K; Elmesery, A; Elmoheen, A; Yousry, M, 2020) |
| "Pheochromocytoma is clinically identified in 0." | ( Hashimoto, H; Murakami, H; Nakamura, K; Sonoo, T, 2021) |
| "Pheochromocytoma is a rare cause of acute cardiovascular disease; however, any severe illness may have high catecholamines, simulating pheochromocytoma." | ( Boyd, J; Kline, GA; Leung, AA; Sadrzadeh, HSM, 2021) |
| "Pseudopheochromocytoma is an uncommon form of hypertension." | ( Leshem, YS; Sharabi, Y, 2021) |
| "Pheochromocytoma is a NET that develops from chromaffin cells of the adrenal medulla, and is responsible for an excessive secretion of catecholamines." | ( Andry, V; Bihain, F; Brunaud, L; Gasman, S; Goumon, Y; Hugel, S; Lacomme, S; Lomazzi, S; Moog, S; Mutter, D; Nominé-Criqui, C; Ory, S; Rame, M; Schmid, HA; Streit, L; Tanguy, E; Vitale, N; Vix, M, 2022) |
| "Pheochromocytomas are rare in children." | ( Ng, BW; Toh, TH; Wong, JS, 2021) |
| "Pheochromocytoma is a hormonally active tumour originating from neuroendocrine cells of the adrenal medulla." | ( Glinicki, P; Ostrowska, M; Papierska, L; Zgliczyński, W, 2022) |
| "Pheochromocytomas are rare neuroendocrine tumors that arise from chromaffin cells of the adrenal medulla." | ( López Herrero, R; Rodríguez Jiménez, RP; Sánchez Quirós, B, 2022) |
| "Pheochromocytomas are rare tumors which can present with heterogeneous secretion profiles, clinical manifestations, and radiologic appearance." | ( Alberici, L; Ambrosi, F; Balacchi, C; De Leo, A; Di Dalmazi, G; Golfieri, R; Minni, F; Mosconi, C; Nanni, C; Paccapelo, A; Pagotto, U; Ricci, C; Santini, D; Selva, S; Tucci, L; Vara, G; Vicennati, V, 2022) |
| "Pheochromocytomas are rare tumors and biochemically silent ones with normal catecholamine levels are even rarer." | ( Aggeli, C; Christou, MA; Dimakopoulou, A; Fountas, A; Giagourta, I; Glycofridi, S; Kalantzi, A; Kanti, G; Kounadi, T; Markou, A; Ntali, G; Papanastasiou, L; Saoulidou, E; Tigas, S; Zografos, GN, 2022) |
| "Pheochromocytomas are an uncommon but challenging tumour to manage." | ( Hsieh, YH; Jacovino, J; Linder, T; Mueller, M; Wakamatsu, C, 2023) |
| "Pheochromocytoma is a rare tumor frequently overlooked mainly due to the wide range of its clinical presentation, which may vary from entirely untypical signs and symptoms to life-threatening complications." | ( Anyfanti, P; Aroutsidis, F; Douma, S; Gkaliagkousi, Ε; Kotsis, V; Kyriazidou, Α; Lazaridis, Α; Mastrogiannis, Κ; Papoutsopoulou, Ε; Pavlidou, O; Tasios, Κ; Tiritidou, A; Triantafyllou, Α; Vasilakou, D; Zarifis, Ι, 2023) |
| "Early diagnosis of pheochromocytoma is of great significance not only because it represents a curable form of secondary hypertension, but also because it is often related to familial syndromes, malignancy or metastatic disease." | ( Anyfanti, P; Aroutsidis, F; Douma, S; Gkaliagkousi, Ε; Kotsis, V; Kyriazidou, Α; Lazaridis, Α; Mastrogiannis, Κ; Papoutsopoulou, Ε; Pavlidou, O; Tasios, Κ; Tiritidou, A; Triantafyllou, Α; Vasilakou, D; Zarifis, Ι, 2023) |
| "Giant pheochromocytomas are rare tumors, with the majority being clinically silent." | ( Baniya, S; Bogati, K; Karki, N; Pokhrel, M; Regmi, UK; Thapa, S, 2023) |