Hematoma, Subdural, Chronic

Accumulation of blood in the SUBDURAL SPACE with delayed onset of neurological symptoms. Symptoms may include loss of consciousness, severe HEADACHE, and deteriorating mental status.

Synonym
Hematoma, Subdural, Chronic
Hemorrhage, Subdural, Chronic
Subdural Hematoma, Chronic

Excerpt	Reference
"Antiplatelet therapy in patients with chronic subdural hematoma (cSDH) presents significant neurosurgical challenges."	( Fandino, J; Kamenova, M; Lutz, K; Mariani, L; Schaedelin, S; Soleman, J, 2016)
"The high recurrent rate of chronic subdural hematoma (CSDH) has consistently confused the neurosurgeons, and the role of atorvastatin in the management of CSDH has remained unclear over past decade, and atorvastatin seems to be a safe and cost-effective treatment to CSDH."	( Qiu, S; Shen, L; Su, Z; Sun, C; Yan, A; Zhuo, W, 2017)
"BACKGROUND Chronic subdural hematoma (CSDH) is a common neurosurgical condition that is treated using a cranial burr hole evacuation procedure, but recurrence is common."	( Anker-Møller, T; Hvas, AM; Mikkelsen, R; Sunde, N, 2017)
"Atorvastatin therapy in chronic subdural hematoma patients has attracted more and more clinical attention."	( Chen, L; He, C; Xia, P; Xu, J; Zhang, Q, 2021)
"Among adults with symptomatic chronic subdural hematoma, most of whom had undergone surgery to remove their hematomas during the index admission, treatment with dexamethasone resulted in fewer favorable outcomes and more adverse events than placebo at 6 months, but fewer repeat operations were performed in the dexamethasone group."	( Agyemang, K; Al-Tamimi, YZ; Allison, A; Anderson, IA; Barton, G; Belli, A; Bond, S; Brennan, PM; Bulters, D; Caldwell, K; Chari, A; Davis-Wilkie, C; Edlmann, E; Gherle, M; Henderson, D; Holton, P; Hutchinson, PJ; King, AT; Kolias, AG; Marcus, HJ; Mee, H; Myint, PK; Pantaleo, B; Santarius, T; Suttner, N; Tarantino, S; Thelin, EP; Thomson, S; Turner, C; Warburton, EA; Whitfield, PC; Wilkinson, I; Zolnourian, A, 2020)
"The second ATorvastatin On Chronic subdural Hematoma (ATOCH-II) study is a multi-centre, randomized, placebo-controlled, double-blind trial which aims to enrol 240 adult patients with a conservative therapeutic indication for CSDH, randomly allocated to standard treatment with atorvastatin 20 mg combined with low-dose dexamethasone (or matching placebos) daily for 28 days, and with 152 days of follow-up."	( Anderson, CS; De Zhu, X; Gao, C; Huang, Y; Ji, HM; Jiang, RC; Jiang, XC; Kang, Z; Lei, P; Li, X; Liu, JF; Qu, Y; Quan, W; Song, LL; Sun, XC; Tian, Y; Wang, D; Wang, JJ; Wang, RZ; Wei, HJ; Wei, JJ; Yue, SY; Zhang, JN; Zhang, S; Zhao, SG; Zhao, ZM; Zhu, XG, 2021)
"The main treatment strategy for chronic subdural hematoma is surgical intervention."	( Blanter, A; Dammers, R; den Hertog, HM; der Gaag, NAV; Holl, DC; Jellema, K; Lingsma, HF; Miah, IP; Peul, WC; Rosendaal, FR; Tank, Y; van der Naalt, J; Zwet, EWV, 2023)
"Patients with unilateral or bilateral chronic subdural hematoma undergoing surgical treatment by burr-hole were randomized as to whether or not to use TXA in the postoperative period."	( de Freitas, PVV; de Oliveira, MF; de Paula, MVCT; Melo, MM; Pahl, FH; Ribeiro, BDC; Rotta, JM, 2023)
"In a trial that involved patients with chronic subdural hematoma and that was stopped early, dexamethasone treatment was not found to be noninferior to burr-hole drainage with respect to functional outcomes and was associated with more complications and a greater likelihood of later surgery."	( Blaauw, J; Dammers, R; den Hertog, HM; Dirven, CMF; Groen, RJM; Holl, DC; Jacobs, B; Jellema, K; Kho, KH; Kruyt, ND; Lingsma, HF; Miah, IP; Peul, WC; Polinder, S; van der Gaag, NA; van der Naalt, J; van Kooten, F, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	4 (2.30)	23.3326
1990's	0 (0.00)	12.5806
2000's	31 (17.82)	18.1394
2010's	82 (47.13)	28.8240
2020's	57 (32.76)	9.53

Drug	Relationship Strength	Studies	Trials
beta-alanine	low	1	0
salicylic acid	low	1	0
glutaric acid	low	1	0
phenytoin	low	1	0
acetazolamide	low	1	0
albendazole	low	1	0
amantadine	low	1	0
aspirin	medium	15	1
cefuroxime	low	1	0
diazepam	medium	3	2
valproic acid	low	2	0
etizolam	medium	3	2
fentanyl	low	1	0
ibudilast	low	2	0
iofetamine	low	1	0
lorazepam	low	1	0
midazolam	low	1	0
phenindione	low	1	0
phenobarbital	low	1	0
ticlopidine	low	2	0
tranexamic acid	medium	16	6
prednisolone	low	1	0
prednisone	medium	4	1
levodopa	low	3	0
edetic acid	low	1	0
mannitol	low	3	0
phencyclidine	low	3	0
methylprednisolone	medium	1	1
pyrroles	low	1	0
malondialdehyde	low	1	0
durapatite	low	2	0
methylprednisolone hemisuccinate	low	1	0
enbucrilate	low	5	0
tantalum	low	2	0
gadolinium	low	1	0
chlormerodrin	low	1	0
ribavirin	low	1	0
clopidogrel	low	4	0
remifentanil	medium	1	1
atorvastatin	medium	22	4
artemether	low	1	0
fibrinogen	low	2	0
perindopril	medium	1	1
3-hydroxyglutaric acid	low	1	0
dabigatran	low	3	0
meropenem	low	1	0
dinoprostone	low	1	0
vitamin k semiquinone radical	low	1	0
dexmedetomidine	medium	3	1
dizocilpine maleate	low	1	0
apixaban	low	2	0
losartan potassium	low	1	0
ro13-9904	low	1	0
interleukin-8	low	6	0
natriuretic peptide, brain	low	1	0
ascorbic acid	low	1	0
warfarin	low	8	0
ethyl biscoumacetate	low	1	0
transforming growth factor beta	low	1	0
exudates	medium	1	1

Protein Targets (692)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Solute carrier family 22 member 6	0	3	0	5
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	7	0	0	7
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	6	0	0	6
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
thioredoxin reductase	8	0	0	8
GALC protein	1	0	0	1
GLI family zinc finger 3	17	0	0	17
nuclear receptor subfamily 1, group I, member 3	15	0	0	15
cytochrome P450 family 3 subfamily A polypeptide 4	12	0	0	12
glucocorticoid receptor [Homo sapiens]	18	0	0	18
retinoic acid nuclear receptor alpha variant 1	19	0	0	19
retinoid X nuclear receptor alpha	10	0	0	10
estrogen-related nuclear receptor alpha	23	0	0	23
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
arylsulfatase A	5	0	0	5
Carbonic anhydrase	0	1	0	1
euchromatic histone-lysine N-methyltransferase 2	16	0	0	16
Bloom syndrome protein isoform 1	5	0	0	5
thyroid hormone receptor beta isoform a	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 1	13	0	0	13
geminin	19	0	0	19
peripheral myelin protein 22	8	0	0	8
survival motor neuron protein isoform d	4	0	0	4
muscleblind-like protein 1 isoform 1	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	5	5	1	11
ATP-binding cassette sub-family C member 3	0	12	0	12
Multidrug resistance-associated protein 4	0	12	0	14
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	3	0	3
Carbonic anhydrase 12	0	3	1	7
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	21	0	21
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Carbonic anhydrase 1	0	6	1	12
Carbonic anhydrase 2	0	6	1	11
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	1	0	1
Carbonic anhydrase 3	0	3	1	7
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	3	1	4
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cytochrome P450 2C8	0	3	0	3
Cytochrome P450 2D6	0	3	0	3
Cytochrome P450 2A6	0	2	0	2
Cytochrome P450 2C9	0	6	0	6
5-hydroxytryptamine receptor 2A	0	1	0	1
Androgen receptor	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-1	5	5	1	11
Translocator protein	0	3	1	5
Gamma-aminobutyric acid receptor subunit delta	5	5	1	11
Gamma-aminobutyric acid receptor subunit gamma-2	5	5	1	11
Gamma-aminobutyric acid receptor subunit alpha-5	5	5	1	11
Gamma-aminobutyric acid receptor subunit alpha-3	5	5	1	11
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	5	1	6
Carbonic anhydrase 4	0	3	1	6
Carbonic anhydrase 6	0	3	1	6
Gamma-aminobutyric acid receptor subunit gamma-1	5	5	1	11
Gamma-aminobutyric acid receptor subunit alpha-2	5	5	1	11
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	2	0	3
Serum paraoxonase/arylesterase 1	0	1	0	1
Dipeptidyl peptidase 4	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	5	5	1	11
Gamma-aminobutyric acid receptor subunit gamma-3	5	5	1	11
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	5	5	1	11
Adenosine receptor A2a	0	2	0	3
5-hydroxytryptamine receptor 2B	0	1	0	1
Sodium-dependent serotonin transporter	0	2	0	2
Delta-type opioid receptor	0	3	0	4
Cytochrome P450 2C19	0	4	0	4
Delta-type opioid receptor	0	3	0	3
Mu-type opioid receptor	0	4	1	5
Carbonic anhydrase 5A, mitochondrial	0	3	1	7
Carbonic anhydrase	0	1	0	2
Kappa-type opioid receptor	0	3	0	3
Carbonic anhydrase 7	0	3	1	6
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	1	0	2
D(2) dopamine receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	5	6	1	12
Gamma-aminobutyric acid receptor subunit beta-3	5	5	1	11
Gamma-aminobutyric acid receptor subunit beta-2	5	5	1	11
Cholinesterase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	3	0	3
Fatty-acid amide hydrolase 1	0	2	0	2
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	6	0	7
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Carbonic anhydrase 9	0	3	1	7
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	5	0	5
Renin	0	1	0	1
Carbonic anhydrase	0	1	0	2
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	2	1	4
GABA theta subunit	5	5	1	11
Canalicular multispecific organic anion transporter 1	0	10	0	10
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase 15	0	2	0	4
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	3	0	5
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	5	5	1	11
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	3	1	7
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	3	1	7
Luciferase	9	0	0	9
glp-1 receptor, partial	5	0	0	5
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
RAR-related orphan receptor gamma	14	0	0	14
ATAD5 protein, partial	2	0	0	2
Fumarate hydratase	1	0	0	1
TDP1 protein	16	0	0	16
AR protein	23	0	0	23
caspase 7, apoptosis-related cysteine protease	2	0	0	2
progesterone receptor	9	0	0	9
farnesoid X nuclear receptor	5	0	0	5
pregnane X nuclear receptor	17	0	0	17
estrogen nuclear receptor alpha	28	0	0	28
polyprotein	1	0	0	1
67.9K protein	1	0	0	1
peroxisome proliferator activated receptor gamma	8	0	0	8
vitamin D (1,25- dihydroxyvitamin D3) receptor	11	0	0	11
caspase-3	2	0	0	2
IDH1	6	0	0	6
aryl hydrocarbon receptor	4	0	0	4
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	12	0	0	12
v-jun sarcoma virus 17 oncogene homolog (avian)	6	0	0	6
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
Histone H2A.x	3	0	0	3
cellular tumor antigen p53 isoform a	3	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
chromobox protein homolog 1	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 2	9	0	0	9
transcriptional regulator ERG isoform 3	2	0	0	2
thyroid hormone receptor beta isoform 2	15	0	0	15
histone deacetylase 9 isoform 3	2	0	0	2
heat shock protein beta-1	3	0	0	3
mitogen-activated protein kinase 1	4	0	0	4
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
Vif	0	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
lamin isoform A-delta10	11	0	0	11
neuropeptide S receptor isoform A	2	0	0	2
Voltage-dependent calcium channel gamma-2 subunit	8	0	0	8
Interferon beta	11	0	0	11
Cellular tumor antigen p53	14	0	0	14
Integrin beta-3	2	1	0	3
Integrin alpha-IIb	2	1	0	3
Methionine aminopeptidase	0	1	0	1
Glutamate receptor 2	8	0	0	8
Inositol monophosphatase 1	2	0	0	2
ATPase family AAA domain-containing protein 5	6	0	0	6
Ataxin-2	8	0	0	8
acetylcholinesterase	7	0	0	7
NFKB1 protein, partial	1	0	0	1
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
thyroid stimulating hormone receptor	8	0	0	8
regulator of G-protein signaling 4	4	0	0	4
EWS/FLI fusion protein	9	0	0	9
putative alpha-glucosidase	1	0	0	1
histone acetyltransferase KAT2A isoform 1	3	0	0	3
Solute carrier family 22 member 2	0	2	0	4
Solute carrier family 22 member 1	0	2	0	4
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Matrix protein 2	0	1	1	2
Matrix protein 2	0	1	2	3
Glutamate receptor ionotropic, NMDA 1	0	5	0	6
Spike glycoprotein	5	0	1	6
Glutamate receptor ionotropic, NMDA 2A	0	5	0	6
Glutamate receptor ionotropic, NMDA 2C	0	5	0	7
Glutamate receptor ionotropic, NMDA 1	0	3	0	3
Glutamate receptor ionotropic, NMDA 2A	0	3	0	3
Glutamate receptor ionotropic, NMDA 2B	0	3	0	3
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	5	0	6
Solute carrier family 22 member 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	5	0	6
Multidrug and toxin extrusion protein 1	0	2	0	2
Solute carrier family 22 member 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	5	0	6
ATP-dependent phosphofructokinase	4	0	0	4
Chain A, Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor)	0	1	0	1
Coagulation factor X	0	1	0	1
Prothrombin	0	3	0	3
Coagulation factor X	0	3	0	3
Trypsin-1	0	2	0	2
Trypsin-2	0	2	0	2
Trypsin-3	0	2	0	2
G	8	0	0	8
HLA class I histocompatibility antigen, B alpha chain	8	0	0	8
Inositol hexakisphosphate kinase 1	8	0	0	8
cytochrome P450 2C9, partial	8	0	0	8
Chain A, Hyaluronidase, phage associated	0	1	0	1
thioredoxin glutathione reductase	4	0	0	4
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
lethal factor (plasmid)	4	0	0	4
Polyphenol oxidase 2	0	2	0	4
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	2	0	2
Alpha-2B adrenergic receptor	0	2	1	3
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	6	0	0	6
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
Chain A, 2-oxoglutarate Oxygenase	5	0	0	5
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	2	0	0	2
GLS protein	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	9	0	0	9
hypothetical protein, conserved	1	0	0	1
cytochrome P450 2D6	3	0	0	3
glucocerebrosidase	2	0	0	2
peroxisome proliferator-activated receptor delta	4	0	0	4
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
DNA polymerase iota isoform a (long)	5	0	0	5
DNA polymerase kappa isoform 1	3	0	0	3
muscarinic acetylcholine receptor M1	4	0	0	4
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Epidermal growth factor receptor	0	2	0	2
Fatty acid-binding protein, liver	0	4	0	4
Myeloperoxidase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	5	0	5
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	4	0	0	4
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	4	0	4
Solute carrier family 22 member 6	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	5	1	6
Sigma non-opioid intracellular receptor 1	0	3	1	4
Chain A, Cruzipain	2	0	0	2
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
estrogen receptor 2 (ER beta)	5	0	0	5
Caspase-7	1	0	0	1
vitamin D3 receptor isoform VDRA	4	0	0	4
caspase-3	1	0	0	1
Solute carrier organic anion transporter family member 2B1	0	0	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
ATP-dependent translocase ABCB1	0	3	0	4
Insulin receptor	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Histone deacetylase 1	0	3	0	3
Histone deacetylase 2	0	3	0	3
Solute carrier organic anion transporter family member 1B3	0	0	0	1
Histone deacetylase 6	0	3	0	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	1	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Proton-coupled amino acid transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
USP1 protein, partial	4	0	0	4
Vpr	1	0	0	1
Bile salt export pump	0	4	0	4
Albumin	0	0	3	3
Major prion protein	0	0	1	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	2	0	4
Sodium channel protein type 4 subunit alpha	0	2	0	4
Cytochrome P450 2J2	0	3	0	3
Potassium voltage-gated channel subfamily H member 2	0	4	0	4
Sodium channel protein type 9 subunit alpha	0	3	0	3
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
nonstructural protein 1	3	0	0	3
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
Liver carboxylesterase 1	0	1	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Rap guanine nucleotide exchange factor 4	1	0	0	1
P2Y purinoceptor 12	0	1	0	1
Plasminogen	0	3	1	4
Coagulation factor XII	0	1	0	1
Tissue-type plasminogen activator	0	1	0	1
Vitamin K-dependent protein C	0	1	0	1
Serine protease hepsin	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	1	2
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Multidrug and toxin extrusion protein 2	0	1	0	1
Alpha-1B adrenergic receptor	0	0	1	1
cytochrome P450 2D6 isoform 1	3	0	0	3
cytochrome P450 2C19 precursor	3	0	0	3
cytochrome P450 2C9 precursor	3	0	0	3
cytochrome P450 3A4 isoform 1	5	0	0	5
Alpha-2A adrenergic receptor	0	3	1	4
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	0	1	1
Alpha-2C adrenergic receptor	0	3	1	4
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Histamine H2 receptor	4	0	0	4
Gamma-aminobutyric acid	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
Alpha-1-acid glycoprotein 1	0	0	0	1
Albumin	0	1	2	4
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	2	5
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	1	4
5-hydroxytryptamine receptor 1A	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	3	1	4
Translocator protein	0	1	0	1
Translocator protein	0	2	0	2
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	2	5
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-2	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
thyroid stimulating hormone receptor	3	0	0	3
activating transcription factor 6	4	0	0	4
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostacyclin receptor	0	2	1	3
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 7	0	0	0	2
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 8	0	1	0	2
Solute carrier family 22 member 7	0	0	0	2
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	6	0	0	6
Eyes absent homolog 2	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Amyloid-beta precursor protein	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Metallo-beta-lactamase VIM-13	0	1	0	2
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	2
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
NAD	0	1	0	1
Protease	0	4	0	4
Integrase	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
D(2) dopamine receptor	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
D(4) dopamine receptor	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Histamine H1 receptor	0	1	0	1
Mu-type opioid receptor	0	2	1	3
D(3) dopamine receptor	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	1	0	2
Chain A, Dihydrofolate reductase	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
Chain A, Ferritin light chain	4	0	0	4
acid sphingomyelinase	1	0	0	1
alpha-galactosidase	2	0	0	2
lysosomal alpha-glucosidase preproprotein	1	0	0	1
DNA polymerase beta	1	0	0	1
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	0	1	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Alpha-synuclein	1	0	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
Chain A, Protein (aspartate Aminotransferase)	0	0	1	1
Chain A, Aspartate Aminotransferase	0	0	1	1
nuclear receptor ROR-gamma isoform 1	3	0	0	3
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Macrophage migration inhibitory factor	0	1	1	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	1	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
TAR DNA-binding protein 43	2	0	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	2	0	2
atrial natriuretic peptide receptor 1 precursor	3	0	0	3
flap endonuclease 1	3	0	0	3
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
dopamine D1 receptor	1	0	0	1
15-lipoxygenase, partial	1	0	0	1
WRN	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
phosphopantetheinyl transferase	1	0	0	1
apical membrane antigen 1, AMA1	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
pyruvate kinase	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
snurportin-1	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
Plasma kallikrein	0	0	0	1
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
SLC16A10 protein	0	0	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
phosphoglycerate kinase	1	0	0	1
Smad3	1	0	0	1
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	1	2
Metallo-beta-lactamase VIM-11	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
streptokinase A precursor	0	0	1	1
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase TEM	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	1	2
Metallo-b-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Histamine H3 receptor	0	0	0	1
Beta-lactamase class B VIM-2	0	0	1	2
Beta-lactamase	0	0	0	1
PPM1D protein	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
Glucocorticoid receptor	0	6	2	13
Glycine receptor subunit alpha-1	0	6	0	6
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
ATP-dependent translocase ABCB1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	2
ATP-dependent translocase ABCB1	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Atrial natriuretic peptide receptor 1	0	1	0	1
Chain A, Immunoglobulin	0	0	1	1
Chain B, Immunoglobulin	0	0	1	1
Muscarinic acetylcholine receptor M3	0	0	1	1
Muscarinic acetylcholine receptor M4	0	0	1	1
Muscarinic acetylcholine receptor M5	0	0	1	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Muscarinic acetylcholine receptor M1	0	0	1	2
Muscarinic acetylcholine receptor M4	0	0	1	2
Kappa-type opioid receptor	0	0	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Cholinesterase	0	1	0	1
Muscarinic acetylcholine receptor M5	0	0	1	2
Muscarinic acetylcholine receptor M3	0	0	1	2
Muscarinic acetylcholine receptor M2	0	0	1	2
Microtubule-associated protein tau	2	0	0	2
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
endonuclease IV	1	0	0	1
peripheral myelin protein 22 isoform 1	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
pregnane X receptor	2	0	0	2
NS5	0	0	1	1
Thrombopoietin	1	0	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Polymerase basic protein 2	0	0	1	1
RNA-directed RNA polymerase catalytic subunit	0	0	1	1
Polymerase acidic protein	0	0	2	2
Procathepsin L	0	0	1	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Adenosine receptor A3	0	1	0	1
Replicase polyprotein 1ab	0	0	1	1
Adenosylhomocysteinase	0	0	0	2
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Adenosine receptor A1	0	1	0	1
Genome polyprotein	0	0	1	1
Angiotensin-converting enzyme 2	0	0	1	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Acetylcholinesterase	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Chain A, PLASMINOGEN	0	0	1	1
Chain A, PLASMINOGEN	0	0	1	1
Urokinase-type plasminogen activator	0	1	0	1
Cocaine esterase	0	1	0	1
Histone deacetylase 3	0	2	0	2
UDP-glucuronosyltransferase 1A9	0	0	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Histone deacetylase 4	0	2	0	2
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Histone deacetylase 7	0	2	0	2
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	2	0	2
Histone deacetylase 8	0	2	0	2
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	2	0	2
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Hematoma, Subdural, Chronic

Synonyms(3)

Research Excerpts

Treatment

Research

Studies (174)

Protein Targets (692)

Hematoma, Subdural, Chronic

Synonyms(3)

Research Excerpts

Treatment

Research

Studies (174)

Drugs Studied (73)

Protein Targets (692)