A compound used to form the matrix for MALDI (matrix-assisted laser desorption/ionization) mass spectrometry. MALDI matrix materials are crystalline compounds with a fairly low molecular weight, so as to allow facile vaporization, have strong absorption at UV or IR wavelengths (to rapidly and efficiently absorb laser irradiation), generally contain polar groups (enabling them to be used in aqueous solutions) and are frequently acidic (so assisting ionisation of the compound being studied, which is contained within the matrix material).
| Member | Definition | Class |
|---|
| 2,4,6-trihydroxyacetophenone | A benzenetriol that is acetophenone in which the hydrogens at positions 2, 4, and 6 on the phenyl group are replaced by hydroxy groups. It is used as a matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of acidic glycans and glycopeptides. | 2',4',6'-trihydroxyacetophenone |
| 2,5-dihydroxybenzoic acid | A dihydroxybenzoic acid having the two hydroxy groups at the 2- and 5-positions. | 2,5-dihydroxybenzoic acid |
| 3-hydroxypicolinic acid | A monohydroxypyridine that is picolinic acid in which the hydrogen at position 3 is replaced by a hydroxy group. It is used as a matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of oligonucleotides. | 3-hydroxypicolinic acid |
| alpha-cyano-4-hydroxycinnamic acid | A monohydroxycinnamic acid that is 4-hydroxycinnamic acid in which the hydrogen alpha- to the carboxy group is replaced by a cyano group. It is used as a matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of peptides and oligonucleotides. | alpha-cyano-4-hydroxycinnamic acid |
| aminacrine | An aminoacridine that is acridine in which the hydrogen at position 9 is replaced by an amino group. A fluorescent dyd and topical antiseptic agent, it is used (usually as the hydrochloride salt) in eye drops for the treatment of superficial eye infections. | 9-aminoacridine |
| ferulic acid | A ferulic acid consisting of trans-cinnamic acid bearing methoxy and hydroxy substituents at positions 3 and 4 respectively on the phenyl ring. | ferulic acid |
| picolinic acid | A pyridinemonocarboxylic acid in which the carboxy group is located at position 2. It is an intermediate in the metabolism of tryptophan. | picolinic acid |
| sinapinic acid | A sinapic acid in which the double bond has trans-configuration. | trans-sinapic acid |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 18.8740 | 1 | 3 |
| 67.9K protein | Vaccinia virus | Potency | 20.4598 | 2 | 3 |
| acid sphingomyelinase | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 24.0682 | 1 | 2 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 40.0748 | 2 | 2 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 2.8184 | 1 | 1 |
| caspase-1 isoform alpha precursor | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Caspase-7 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 31.7626 | 1 | 3 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 50.1187 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 31.6228 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
| ClpP | Bacillus subtilis | Potency | 19.9526 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 17.3926 | 2 | 4 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 7.7619 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 51.6252 | 1 | 2 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 2.4882 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 0.5623 | 1 | 1 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 17.3926 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 17.3926 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 17.3926 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 17.3926 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 17.3926 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 17.3926 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 17.3926 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 17.3926 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 17.3926 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 17.3926 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 17.3926 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 17.3926 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 17.3926 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 17.3926 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 17.3926 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 17.3926 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 7.2288 | 2 | 4 |
| GLS protein | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 11.2202 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 25.1189 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 3.5298 | 2 | 3 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 50.1187 | 1 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 0.0151 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 | Homo sapiens (human) | IC50 | 115.0000 | 1 | 1 |
| 72 kDa type IV collagenase | Homo sapiens (human) | IC50 | 115.0000 | 1 | 1 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 100.0000 | 3 | 3 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Ki | 9.9033 | 3 | 3 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | Ki | 8.4200 | 2 | 2 |
| Alpha-(1,3)-fucosyltransferase 7 | Homo sapiens (human) | IC50 | 115.0000 | 1 | 1 |
| Alpha-glucosidase MAL12 | Saccharomyces cerevisiae S288C | IC50 | 251.4000 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | IC50 | 0.7500 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 26.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 | 112.0000 | 1 | 1 |
| Aminopeptidase N | Sus scrofa (pig) | IC50 | 100.0000 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 163.1150 | 2 | 2 |
| Beta-carbonic anhydrase 1 | Mycobacterium tuberculosis H37Rv | Ki | 3.6633 | 1 | 3 |
| Beta-lactamase | Klebsiella pneumoniae | IC50 | 2,000.0000 | 1 | 1 |
| Beta-lactamase | Aeromonas hydrophila | Ki | 333.5400 | 5 | 5 |
| Cannabinoid receptor 2 | Mus musculus (house mouse) | IC50 | 10.7000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 156.2725 | 3 | 4 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 8.9533 | 3 | 3 |
| Carbonic anhydrase 13 | Mus musculus (house mouse) | Ki | 12.2000 | 2 | 2 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 28.6200 | 3 | 3 |
| Carbonic anhydrase 2 | Homo sapiens (human) | IC50 | 2,503.2200 | 2 | 2 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 156.1250 | 3 | 4 |
| Carbonic anhydrase 2 | Mycobacterium tuberculosis H37Rv | Ki | 3.6633 | 1 | 3 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 11.1000 | 1 | 1 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 10.8000 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | IC50 | 8.8600 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 7.0400 | 1 | 1 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 10.5000 | 1 | 1 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 8.4500 | 1 | 1 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 37.7050 | 2 | 2 |
| Carbonic anhydrase 9 | Homo sapiens (human) | IC50 | 9.3900 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 8.2350 | 2 | 2 |
| Cholinesterase | Equus caballus (horse) | IC50 | 100.0000 | 1 | 1 |
| Cholinesterase | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 | Homo sapiens (human) | IC50 | 115.0000 | 1 | 1 |
| D-amino-acid oxidase | Homo sapiens (human) | IC50 | 2,478.0000 | 1 | 1 |
| D-aspartate oxidase | Homo sapiens (human) | IC50 | 10,000.0000 | 1 | 1 |
| Delta-type opioid receptor | Mus musculus (house mouse) | IC50 | 10.7000 | 1 | 1 |
| Dihydroorotate dehydrogenase | Leishmania major | IC50 | 405.7535 | 1 | 2 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 182.5000 | 2 | 2 |
| Epidermal growth factor receptor | Homo sapiens (human) | Ki | 236.5000 | 2 | 2 |
| G-protein coupled receptor 35 | Homo sapiens (human) | IC50 | 30.4000 | 1 | 1 |
| Hyaluronidase-1 | Homo sapiens (human) | IC50 | 2,000.0000 | 1 | 1 |
| Integrase | Human immunodeficiency virus 1 | IC50 | 100.0000 | 1 | 1 |
| Matrilysin | Homo sapiens (human) | IC50 | 115.0000 | 1 | 1 |
| Monocarboxylate transporter 1 | Rattus norvegicus (Norway rat) | IC50 | 212.6405 | 2 | 2 |
| Monocarboxylate transporter 2 | Rattus norvegicus (Norway rat) | IC50 | 24.0000 | 1 | 1 |
| Monocarboxylate transporter 4 | Homo sapiens (human) | IC50 | 348.4000 | 3 | 3 |
| Mu-type opioid receptor | Mus musculus (house mouse) | IC50 | 10.7000 | 1 | 1 |
| Neuronal proto-oncogene tyrosine-protein kinase Src | Mus musculus (house mouse) | IC50 | 194.7000 | 1 | 1 |
| Nicotinate phosphoribosyltransferase | Homo sapiens (human) | Ki | 0.0012 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 350.5000 | 1 | 2 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | IC50 | 75.0000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 3.9750 | 1 | 1 |
| Prolyl 4-hydroxylase subunit alpha-1 | Gallus gallus (chicken) | Ki | 1,400.0000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 | 39.2000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 28.0000 | 1 | 1 |
| Proton-coupled amino acid transporter 1 | Homo sapiens (human) | Ki | 18,000.0000 | 1 | 1 |
| Pyruvate kinase PKM | Homo sapiens (human) | IC50 | 11.4000 | 1 | 1 |
| Ribosyldihydronicotinamide dehydrogenase [quinone] | Homo sapiens (human) | IC50 | 0.4450 | 2 | 2 |
| Solute carrier family 28 member 3 | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| Transmembrane prolyl 4-hydroxylase | Homo sapiens (human) | IC50 | 105.7500 | 2 | 2 |
| Trypanothione reductase | Trypanosoma cruzi | Ki | 38.0000 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | IC50 | 8.2000 | 1 | 1 |