An antimetabolite that impairs the action of folic acids
ChEBI ID: 73913
| Member | Definition | Class |
|---|---|---|
| cycloguanil | A triazine in which a 1,6-dihydro-1,3,5-triazine ring is substituted at N-1 by a 4-chlorophenyl group, at C-2 and -4 by amino groups and at C-6 by gem-dimethyl groups. A dihydrofolate reductase inhibitor, it is a metabolite of the antimalarial drug proguanil. | cycloguanil |
| o 129 | A member of the class of pteridines that is pteridine in which the hydrogens at positions 2 and 4 are replaced by amino groups, whilst those at positions 6 and 7 are replaced by isopropyl groups. | 2,4-diamino-6,7-diisopropylpteridine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 45 (18.37) | 18.7374 |
| 1990's | 81 (33.06) | 18.2507 |
| 2000's | 74 (30.20) | 29.6817 |
| 2010's | 40 (16.33) | 24.3611 |
| 2020's | 5 (2.04) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 16 (6.13%) | 5.53% |
| Reviews | 4 (1.53%) | 6.00% |
| Case Studies | 3 (1.15%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 238 (91.19%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium falciparum K1 | IC50 | 24.9733 | 6 | 6 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium falciparum K1 | Ki | 0.4362 | 17 | 19 |
| cGMP-dependent 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | IC50 | 5.8000 | 1 | 1 |
| Dihydrofolate reductase | Escherichia coli K-12 | IC50 | 20.9100 | 1 | 1 |
| Dihydrofolate reductase | Pneumocystis carinii | IC50 | 0.4500 | 1 | 1 |
| Dihydrofolate reductase | Rattus norvegicus (Norway rat) | IC50 | 0.1100 | 1 | 1 |
| Dihydrofolate reductase | Escherichia coli K-12 | Ki | 1.0200 | 1 | 1 |
| Dihydrofolate reductase | Gallus gallus (chicken) | Ki | 0.1122 | 1 | 1 |
| Dihydrofolate reductase | Homo sapiens (human) | Ki | 14.4885 | 3 | 3 |
| Dihydrofolate reductase | Lacticaseibacillus casei | Ki | 17.3780 | 1 | 1 |
| Dihydrofolate reductase | Pneumocystis carinii | Ki | 36.3776 | 3 | 3 |
| Pteridine reductase 1 | Leishmania major | Ki | 0.2400 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Dihydrofolate reductase | Escherichia coli K-12 | Kd | 11.7700 | 1 | 1 |
| Trace amine-associated receptor 5 | Mus musculus (house mouse) | EC50 | 10.0000 | 1 | 1 |