Page last updated: 2024-08-05 15:31:24
antifolate
An antimetabolite that impairs the action of folic acids
ChEBI ID: 73913
Members (2)
| Member | Definition | Class |
|---|
| cycloguanil | A triazine in which a 1,6-dihydro-1,3,5-triazine ring is substituted at N-1 by a 4-chlorophenyl group, at C-2 and -4 by amino groups and at C-6 by gem-dimethyl groups. A dihydrofolate reductase inhibitor, it is a metabolite of the antimalarial drug proguanil. | cycloguanil |
| o 129 | A member of the class of pteridines that is pteridine in which the hydrogens at positions 2 and 4 are replaced by amino groups, whilst those at positions 6 and 7 are replaced by isopropyl groups. | 2,4-diamino-6,7-diisopropylpteridine |
Research
Studies (245)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|
| pre-1990 | 45 (18.37) | 18.7374 |
| 1990's | 81 (33.06) | 18.2507 |
| 2000's | 74 (30.20) | 29.6817 |
| 2010's | 40 (16.33) | 24.3611 |
| 2020's | 5 (2.04) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|
| Trials | 16 (6.13%) | 5.53% |
| Reviews | 4 (1.53%) | 6.00% |
| Case Studies | 3 (1.15%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 238 (91.19%) | 84.16% |
Protein Targets (10)
Inhibition Measurements
Activation Measurements