A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
| Excerpt | Reference |
|---|
| "Warm ischemia is a potential problem during the harvesting of cadaveric kidneys for transplantation purposes." | ( Emma, J; Khairallah, P; Loening, S; Magnusson, M; Ocon, J; Stowe, N; Straffon, R; Yarimizu, S, 1978) |
| "Acute mesenteric ischemia is extremely difficult to diagnose because peritoneal signs are absent until the bowel becomes necrotic and irretrievably damaged." | ( Durand, D; Jamieson, WG; Taylor, BM, 1979) |
| "As this transient ischemia is only demonstrable with a hemodynamic effective stenosis, in such cases a good effect of coronary surgery can be expected." | ( Aldor, E; Heeger, H; Kahn, P, 1976) |
| "Lower limb ischemia is a frequent complication of intraaortic balloon pump (IABP) use." | ( Bonini, S; Cabin, HS; Foell, DW; Ford, CF; Funk, M; Ostfeld, AM; Sexton, DL, 1992) |
| "When the ischemia is severe or there is a femoropopliteal aneurysm, arterial reconstruction should precede the TKA." | ( Booth, RE; Calligaro, KD; DeLaurentis, DA; Levitsky, KA; Raviola, CA; Rothman, RH; Savarese, RP, 1992) |
| "Noncardiac visceral ischemia is a major complication with acute aortic dissection and is caused by obstruction of the major visceral arteries by dissecting intima." | ( Aoki, N; Arai, H; Kim, K; Saito, S; Tsurugida, M, 1992) |
| "Donor airway ischemia is the main cause for defective tracheal or bronchial healing after double-lung transplantation." | ( Baudet, E; Clerc, F; Couraud, L; Dromer, C; Dubrez, J; Laborde, N; Martigne, C; Roques, X; Vallieres, E; Velly, JF, 1992) |
| "When ischemia is present, patient education regarding foot care and avoidance of trauma are beneficial." | ( Darvin, HI; King, TA, 1992) |
| "Total ischemia is produced in the left limb for 8 h, while the right limb serves as a surgical control." | ( Corbisiero, RM; Graham, AM; Mohamed, F; Ricci, MA; Symes, JF, 1990) |
| "When advanced ischemia is complicated by large areas of tissue loss, combined bypass and microvascular free-issue transfer, performed in stages or simultaneously, is safe and can often result in limb salvage." | ( Fitz, DG; Newton, ED; Shestak, KC; Swartz, WM, 1990) |
| "Six hours of ischemia is associated with irreversible damage and no recovery fo the adenine nucleotides on reperfusion." | ( Bylund-Fellenius, AC; Elander, A; Idström, JP; Soussi, B, 1990) |
| "Temporary renal ischemia is followed by increased DNA synthesis and cell division as the kidney restores the continuity of the renal epithelium." | ( Harris, RC; Price, PM; Safirstein, R; Saggi, SJ, 1990) |
| "Acute mesenteric ischemia is highly lethal and therefore a serious problem for surgery and intensive care medicine; accordingly its pathophysiology warrants further study." | ( Boros, M; Kaszaki, J; Nagy, S, 1989) |
| "Hypoxia and ischemia are potent stimuli to vascular growth." | ( Ellis, MN; Morris, PB; Swain, JL, 1989) |
| "Prolonged ischemia is known to cause severe damage in skeletal muscle and skin as a result of reperfusion failure." | ( Hammersen, F; Menger, MD; Messmer, K; Sack, FU, 1989) |
| "Placental ischemia is one of the etiological factors of pregnancy induced hypertension (PIH), however, the pathogenesis of placental and renal ischemia has not been clarified." | ( Hidaka, A, 1988) |
| "Renal ischemia is a multifactorial insult consisting of both hypoxia and stagnation of blood flow." | ( Galat, JA; Rhodes, RS; Robinson, AV, 1988) |
| "Recovery from ischemia is also rapid but with recovery ATP levels lower than initial values after prolonged ischemic periods." | ( Barlow, C; Blum, H; Buzby, GP; Chance, B; Leigh, JS; Schnall, MD; Summers, JJ, 1986) |
| "If the period of ischemia is long enough, restoration of the circulation may exacerbate cellular damage, due in part to washout of adenine nucleotide precursor, free-radical-mediated injury and finally calcium-dependent necrosis." | ( Walker, PM, 1986) |
| "Severe ischemia is accompanied by suppressed activity of succinate dehydrogenase, myofibril damage, and formation of centres of ischemic dystrophy." | ( Berkutskaia, TS; Bunov, VS; Zusmanovich, FN, 1983) |
| "Focal ischemia is postulated to contribute to gastric mucosal stress ulceration." | ( Gaskill, HV; Levine, BA; Sirinek, KR, 1984) |
| "Hand ischemia is an uncommon, but potentially catastrophic, clinical entity." | ( Satiani, B; Sowden, DT, 1982) |
| "Peripheral ischemia is mostly due to narrowing of the vessels, although blood supply is also influenced by the hemorheologic properties of the blood." | ( Berent, GA; Dormandy, JA; Yates, CJ, 1981) |
| "Lower limb critical ischemia is a clinical condition typical of patients with severe chronic obstructive arterial disease (Fontaine's IIIb and IV degree)." | ( Carcoforo, P; Donini, I; Mascoli, F; Navarra, G; Occhionorelli, S; Santini, M; Vasquez, G, 1995) |
| "Since ischemia is known to uncouple mitochondria, the protection of ATP content and the delay in glycolysis activation observed during hypoxia in the presence of EGb 761 or bilobalide is best explained by a protection of mitochondrial respiratory activity, at least during the first 60 min of hypoxia incubation." | ( Delaive, E; Drieu, K; Eliaers, F; Janssens, D; Michiels, C; Remacle, J, 1995) |
| "Intestinal ischemia is characterized by rapid early inhibition of absorptive function and the appearance of net secretion, although why active secretion persists in the setting of a mucosal energy deficit is unknown." | ( Hrnjez, BJ; Matthews, JB; Smith, JA; Tally, KJ; Zeind, AJ, 1995) |
| "Nerve ischemia is one possible mechanism in the development of thermal hyperesthesia in the nerve constriction injury model." | ( Asano, H; Mizuguchi, T; Shimoyama, N; Yamamoto, T, 1995) |
| "Correction of ischemia is indicated but usually does not improve the neuropathy." | ( Hye, RJ; Wolf, YG, 1994) |
| "Intestinal mucosal ischemia is one of the earliest manifestations of impaired core tissue perfusion in critically ill patients." | ( Ohtsu, S; Okuda, C; Sakio, H, 1994) |
| "Intestinal ischemia is associated with derangement of gastrointestinal motility." | ( Eimerl, D; Haskel, Y; Schiffman, J; Udassin, R, 1994) |
| "Ischemia is a common situation, not always desirable, in liver surgery." | ( Barceló, P; Bilbao, J; García-Alonso, I; Méndez, J; Portugal, V, 1993) |
| "Liver ischemia is a common surgical situation." | ( Barceló, P; Bilbao, J; García-Alonso, I; Méndez, J; Múgica, P; Portugal, V, 1993) |
| "Ischemia is often implicated as a cause of acute renal failure." | ( Dowd, TL; Gupta, RK, 1995) |
| "Acute mesenteric ischemia is a rare and often fatal event after cardiopulmonary bypass." | ( Brühlmann, W; Genoni, M; Niederhäuser, U; Turina, MI; von Segesser, LK, 1996) |
| "Critical ischemia is a pathology which requires the collaboration of a number of specialists and is often burdened by high morbidity and mortality rates." | ( Costantini, E; Lanza, G; Locati, P; Novali, C; Socrate, AM, 1996) |
| "Ischemia is an interruption of oxygen and nutrient supply to a determined area of tissue for a period of time." | ( Scannell, G, 1996) |
| "If the ischemia is unrelenting, there is a high risk that amputation will be required." | ( Iwai, T, 1996) |
| "Limb threatening ischemia is an acute step in the chronic course of peripheral arterial obstructive disease that requires some form of intervention." | ( Falaschi, M; Fazzini, F; Gia, L; Pasquali, L; Rossi, C; Spinetti, C; Sturlese, M; Valentini, D, 1996) |
| "Ischemia is a common clinical event with potentially serious consequences." | ( Aras, N; Bayraktaroğlu, G; Bengisun, J; Bengisun, JS; Camur, A; Köksoy, C, 1997) |
| "However, recurrent ischemia is frequent, and the subsequent need for surgical revascularization is common for any native artery occlusion or chronic (> 14 days) bypass graft occlusion." | ( Toms, C; Weaver, FA, 1997) |
| "Acute hand ischemia is a medical emergency requiring immediate treatment." | ( Swift, R; Wheatley, MJ, 1997) |
| "Liver ischemia is the main mechanism leading to hypoxic hepatitis." | ( Colin, L; Heller, FR; Henrion, J; Schapira, M, 1997) |
| "Acute mesenteric ischemia is a life-threatening vascular emergency." | ( Claeys, L; Czerny, M; Huk, I; Polterauer, P; Prager, M; Scheuba, C; Trubel, W, 1997) |
| "Ischemia is believed to induce neuronal damage by causing a sustained increase in the level of extracellular excitatory amino acids." | ( Katayama, K; Kimura, M; Kuwada, M; Miyagawa, T; Nishizawa, Y; Sawada, K, 1998) |
| "Ischemia is much more common when the brachial artery is used as the flow vessel." | ( Bachleda, P; Grosmanová, T; Utíkal, P; Zadrazil, J, 1998) |
| "Renal ischemia is produced during orthotopic liver transplantation when the inferior vena cava is clamped above the renal veins (inferior vena cava occlusion [IVCO]), and it often leads to postoperative renal failure." | ( Carbonell, LF; Cartagena, J; Fenoy, FJ; López Conesa, E; Parrilla, P; Quesada, T; Ramírez, P; Salom, MG, 1998) |
| "The degree of ischemia is related to the extent of impairment in microcirculation, adding further deleterious effects to stenoses and/or obstructions of the large vessels." | ( Diot, E; Guilmot, JL, 1999) |
| "Ischemia is often a contributing factor in the diabetic foot ulcer that must be recognized and treated to avoid prolonged hospitalization, spreading infection, and unnecessary amputation." | ( Buse, R; Hill, SL; Holtzman, GI, 1999) |
| "Acute mesenteric ischemia is a lethal disease that lacks a noninvasive diagnostic test." | ( Chan, FP; Heiss, SG; Li, KC; Razavi, MK, 1999) |
| "Critical limb ischemia is treated by intra-arterial or intravenous prostaglandins (Alprostadil, Iloprost)." | ( Schellong, SM, 1999) |
| "Severe hand ischemia is an uncommon complication of angioaccess surgery." | ( Farah, I; Guidicelli, H; Magne, JL; Maurizi-Balzan, J; Pecher, M; Pichot, O; Sessa, C; Tonti, F, 2000) |
| "Acute bowel ischemia is a rare but often catastrophic event after coronary bypass surgery." | ( Caleb, MG, 2001) |
| "Placental ischemia is thought to lead to widespread activation/dysfunction of the maternal vascular endothelium that results in enhanced formation of endothelin and thromboxane, increased vascular sensitivity to angiotensin II, and decreased formation of vasodilators such as NO and prostacyclin." | ( Alexander, BT; Bennett, WA; Granger, JP; Khalil, RA; Llinas, MT, 2001) |
| "Lower extremity ischemia is one aspect of atherosclerosis, a disease associated with both inflammation and hypercoagulability." | ( Swedenborg, J; Thor, M; Yu, A, 2002) |
| "Ischemia is an inciting factor in 50% of incidences of acute renal failure, and it increases the risk of organ rejection after renal transplantation." | ( Bertelli, AA; Das, DK; Filippi, C; Giovannini, L; Migliori, M; Origlia, N; Panichi, V, 2002) |
| "Renal ischemia is the result of a complex series of events, including decreases in oxygen supply (hypoxia) and the availability of cellular energy (ATP depletion)." | ( Eickelberg, O; Kashgarian, M; Mann, A; Reidy, KH; Riordan, M; Seebach, F; Siegel, N; Thulin, G; Van Why, SK, 2002) |
| "Severe limb ischemia is a common problem encountered in medical practice." | ( Heymans, O; Lemaire, V; Limet, R; Nélissen, X; Van Damme, H; Verhelle, N, 2002) |
| "Acute limb ischemia is a vascular-surgical emergency requiring immediate referral to a hospital provided with all the necessary therapeutic facilities." | ( Grothe, A; Kettmann, R; Welter, HF, 2002) |
| "Critical limb ischemia is an important clinical problem that often leads to disability and limb loss." | ( Brevetti, LS; Chang, DS; Kan, YW; Messina, LM; Sarkar, R; Su, H; Tang, GL; Wang, R, 2003) |
| "Retinal ischemia is the main chain in the pathogenesis of vascular diseases of the eye." | ( Arkhipova, MM; Neroev, VV, 2003) |
| "Ischemia is known to promote angiogenesis, and the molecular mechanisms and growth factors involved have been thoroughly investigated." | ( Podzuweit, T; Sass, S; Scholz, D; Thomas, S, 2003) |
| "Ischemia is known to inhibit the function of sarcolemmal enzymes, including the (Na+ + K+)-ATPase, but it is unknown whether concomitant injury to sarcolemma (SL)-associated NOS isoforms may contribute to this process by reducing the availability of locally generated NO." | ( Becker, LC; Burnett, AL; Cui, H; Dawson, TM; Huang, PL; Kuppusamy, P; Kuppusamy, SP; Li, H; Wang, JQ; Xu, KY, 2003) |
| "Limb threatening ischemia is a challenge for the vascular surgeon." | ( Baguet, E; Creemers, E; Limet, R; Van Damme, H; Zhang, L, 2003) |
| "Hypoxia and ischemia are thought to be important pathogenetic factors in bringing about hearing loss." | ( Fuchs, J; Gross, J; Haupt, H; Mazurek, B; Winter, E, 2003) |
| "Ischemia is a serious problem in clinical medicine, and effective methods are needed to detect ischemia before the injury becomes irreversible." | ( Kvarstein, G; Mirtaheri, P; Tønnessen, TI, 2004) |
| "Although myocardial ischemia is associated with regional cardiac sympathetic nerve deterioration, it remains unknown whether acute hindlimb ischemia impairs muscle sympathetic nerve function." | ( Akiyama, T; Mori, H; Sano, S; Tokunaga, N; Yamazaki, T, 2003) |
| "Renal ischemia is probably a primary event leading to increased SNA." | ( Joles, JA; Koomans, HA, 2004) |
| "Hand ischemia is a rare complication of angioaccess surgery for hemodialysis." | ( Maghlaoua, M; Magne, JL; Palacin, P; Pichot, O; Porcu, P; Riehl, G; Sessa, C, 2004) |
| "Hand ischemia is a rare but potentially devastating complication of radial artery cannulation for arterial monitoring." | ( Clagett, GP; Modrall, JG; Valentine, RJ, 2005) |
| "Cold ischemia is the best known method to preserve kidneys for transplant." | ( Berenguer García, I; Del Cañizo López, JF; Hernández Fernández, C; Lledó García, E; Pedemonte, G; Rodríguez Martínez, D, 2005) |
| "Visceral ischemia is an early event in the development of shock and organ failure." | ( Andersson, M; Jansson, K; Jansson, M; Magnuson, A; Norgren, L; Ungerstedt, U, 2005) |
| "Although ischemia is the leading cause of acute renal failure in human, there is little information on the remodeling the kidney endothelium matrix during ischemic injury." | ( Béliveau, R; Caron, A; Desrosiers, RR, 2005) |
| "Lower-limb ischemia is a major health problem." | ( Botti, C; Byrns, RE; de Nigris, F; de Rosa, G; Farzati, B; Fiore, A; Ignarro, LJ; Lerman, LO; Matarazzo, A; Napoli, C; Sica, G; Sica, V; Sumi, D; Williams-Ignarro, S, 2005) |
| "Whereas ischemia is often considered to be synonymous with an oxygen deficit, it is also associated with a concomitant local elevation of carbon dioxide (CO2)." | ( Balazy, M; Brault, S; Checchin, D; Chemtob, S; Hardy, P; Kermorvant-Duchemin, E; Sennlaub, F; Sirinyan, M; Zhu, T, 2006) |
| "Ischemia is an important cause of ARF, and ARF caused by ischemic injury is referred to as ischemic acute tubular necrosis (ATN)." | ( Burne-Taney, MJ; Ikeda, M; Prachasilchai, W; Rabb, H; Yokota-Ikeda, N, 2006) |
| "Lower-limb ischemia is a major health problem especially when associated to hypercholesterolemia." | ( Byrns, RE; D'Armiento, FP; de Nigris, F; Fiorito, C; Ignarro, LJ; Lerman, LO; Napoli, C; Sica, G; Sica, V; Williams-Ignarro, S, 2007) |
| "Stress-induced ischemia is associated with poststress reduction in LV EF and increased poststress EDV and ESV." | ( Gibbons, RJ; Hodge, DO; Miller, TD; O'Connor, MK; Ramakrishna, G, 2006) |
| "Critical limb ischemia is a growing public health problem with major human and medical costs." | ( Novelli, L; Pellerin, O; Sapoval, M, 2006) |
| "Retinal ischemia is a common cause of visual impairment for humans and animals." | ( Chang, PH; Huang, YP; Jeng, YY; Lin, CT; Lin, NT; Liu, CH; Pang, VF, 2007) |
| "Transient global ischemia is a neuronal insult that induces delayed, selective death of hippocampal CA1 pyramidal neurons." | ( Bennett, MV; Formisano, L; Mashiko, T; Miyawaki, T; Noh, KM; Zukin, RS, 2007) |
| "Ischemia is a primary cause of neuronal death in retinal diseases." | ( Bagnoli, P; Casini, G; Catalani, E; Cervia, D; Martini, D; Simonetti, E; Timperio, AM, 2007) |
| "Acute lower limb ischemia is not infrequently associated with limb loss 10-30%) or death of the affected patient (15-30%)." | ( Ludwig, M; Rieger, J; Schumann, R, 2007) |
| "Unless the ischemia is addressed concomitantly with local problems in the foot, resulting problems can lead to extensive tissue loss and major amputation." | ( Hagino, RT, 2007) |
| "Although ischemia is associated with disruption of cadherin-mediated adhesion in renal cell lines, the impact of decreased cadherin function on the transcriptional activity of beta-catenin remains poorly defined." | ( Akintola, AD; Burghardt, RC; Catania, JM; Chen, G; Covington, MD; Dean, DD; Parrish, AR; Trzeciakowski, JP, 2007) |
| "Critical lower limb ischemia is a term used to define those patients with chronic ischemic pain at rest, ulcerations or limb necrosis caused by confirmed atherosclerotic lesions of the arteries." | ( Janczak, D; Pawłowski, S; Pupka, A; Skóra, J; Szyber, PP, 2007) |
| "Retinal ischemia is a common cause of visual impairment and blindness." | ( Hanneken, A; Maher, P, 2008) |
| "Critical limb ischemia is associated with a high risk of amputation and death." | ( Emmerich, J; Fiessinger, JN; Messas, E; Pasqualoni, E, 2008) |
| "Critical leg ischemia is associated with a high risk of amputation when revascularization is not possible." | ( Aiach, M; Bruneval, P; Cavazzana-Calvo, M; Dal-Cortivo, L; Duong Van Huyen, JP; Emmerich, J; Fiessinger, JN; Gaussem, P; Julia, P; Smadja, DM, 2008) |
| "Intestinal ischemia is a major cause of anastomotic leak and death and remains a clinical challenge as the physician relies on several nonspecific signs, biologic markers, and radiologic studies to make the diagnosis." | ( Aziz, O; Boutelle, MG; Corcoles, EP; Darzi, A; Deeba, S; Hanna, BG; Hanna, GB; Pareskevas, P, 2008) |
| "Renal ischemia is a common complication in the perioperative period that leads to a high rate of morbidity and mortality." | ( Dunlap, J; Hurn, PD; Hutchens, MP; Jarnberg, PO, 2008) |
| "Acute limb ischemia is a surgical emergency as a delay in reperfusion is associated with a high risk of irreversible tissue infarction potentially leading to limb loss and death." | ( Keramati, S; Mahmud, E; Salami, A, 2008) |
| "Mesenteric ischemia is a quite uncommon disorder, observed in the emergency department." | ( Arampatzi, H; Chatziconstantinou, C; Mastrokalos, D; Safioleas, M; Safioleas, P; Stamatakos, M; Stefanaki, C; Xiromeritis, C, 2008) |
| "Ischemia is the defined pathway leading to steroid-associated osteonecrosis (ON)." | ( Griffith, JF; Leung, KS; Qin, L; Sheng, H; Wang, YX; Yeung, DK; Zhang, G, 2009) |
| "Critical limb ischemia is the end stage of peripheral arterial occlusive disease, with a deep impact in patient's quality of life." | ( Cordobés-Gual, J; Lara-Hernández, R; Lozano-Vilardell, P, 2008) |
| "Brain ischemia is a leading cause of mortality and morbidity in premature infants." | ( Sha, B; Sun, J; Yang, Y; Zhou, W, 2010) |
| "A minimum of 45 min ischemia is needed to study the effects of renal injury on the liver as a remote organ." | ( Arab, HA; Ghaznavi, R; Golab, F; Hedayati, M; Kadkhodaee, M; Ostad, SN; Soleimani, M; Zahmatkesh, M, 2009) |
| "Acute mesenteric ischemia is a potentially fatal vascular emergency with mortality rates ranging between 60% and 80%." | ( Cruz, RJ; Garrido, AG; Harada, T; Ribeiro, CM; Rocha-e-Silva, M, 2010) |
| "Intestinal ischemia is a recognized risk of SPS in sorbitol." | ( Chu, G; McGowan, CE; Moss, SF; Resnick, MB; Saha, S, 2009) |
| "Intestinal ischemia is a potentially catastrophic abdominal emergency that presents a significant diagnostic challenge in the critical care setting." | ( Evennett, NJ; Mittal, A; Petrov, MS; Windsor, JA, 2009) |
| "Acral ischemia is a rare but probably underreported adverse effect of gemcitabine therapy and a potential source of misdiagnosis." | ( Bätge, R; Egberts, EH; Holstein, A, 2010) |
| "Ischemia is an important cause of acute kidney injury (AKI)." | ( Martinelli, R; Okumura, AS; Rodrigues, LE, 2009) |
| "Critical limb ischemia is an increasingly common condition that has high surgical morbidity and limited non-surgical options." | ( Atar, E; Avrahami, R; Belenky, A; Knizhnik, M; Koganovich, Y; Litvin, S, 2009) |
| "Mixed arterial ischemia is revealed as a rule for middle-aged and old patients." | ( Ignat'ev, EI; Kozlov, KL, 2009) |
| "The critical limb ischemia is diagnosed when the rest pain and/or distal necrosis or ishemic ulceration occur and last for more than two weeks." | ( Janczak, D; Pupka, A; Szyber, PP, 2010) |
| "Ischemia is a pathophysiological condition due to blockade in blood supply to a specific tissue thus damaging the physiological activity of the tissue." | ( Chatterjee, S; Ilayaraja, M; Majumder, S; Seerapu, HR; Siamwala, JH; Sinha, S, 2010) |
| "Perinatal ischemia is a common clinical problem with few successful therapies to prevent neuronal damage." | ( Johnson, SM; Turner, SM, 2010) |
| "Therefore, tissue ischemia is not sufficient to promote the recruitment of EPCs that have been demonstrated to be involved in the recovery from ischemia." | ( Botti, C; Cobellis, G; Da Ponte, A; Della Bella, S; Lillo, S; Sica, V; Silvestroni, A; Taddeo, A; Villa, ML, 2010) |
| "Although ischemia is known to causes synthesis and release of calcitonin gene-related peptide (CGRP), it is not clear whether CGRP regulates angiogenesis under ischemia and how does it function." | ( Bai, X; Han, J; Li, W; Shyy, JY; Wang, X; Xu, M; Zheng, S; Zhou, Z, 2010) |
| "Transitory Ischemia is a form of torture that has been insufficiently described and studied in forensic and psychiatric studies of torture." | ( Engst, G; Fernández-Liria, A; Parras, M; Pérez-Sales, P, 2010) |
| "Hindlimb ischemia is a simple and convenient animal model however standardization of the injection procedures in the devascularized and control limb is lacking, thus rendering difficult the interpretation of results." | ( Faintuch, BL; Faintuch, J; Nuñez, EG; Oliveira, EA; Teodoro, R, 2011) |
| "Where ischemia is suspected, fluorescein laparoscopy may have an added benefit in identifying necrotic segments." | ( Millar, AJ; Numanoglu, A, 2011) |
| "Hand ischemia is a rare phenomenom of various etiologies among which can be found Raynaud's phenomenon and autoimmune arteritis." | ( Gay, AM; Legré, R; Nguyen, PS, 2011) |
| "Intestinal ischemia is difficult to diagnose." | ( Erlandsen, EJ; Lindholt, JS; Mortensen, FV; Nielsen, C, 2011) |
| "Acute limb ischemia is serious situation, jeopardizing limb salvage, causing embolization or thrombosis of the native arteries or vascular graft." | ( Adamec, M; Baláz, P; Chlupác, J; Janousek, L; Rokosný, S, 2011) |
| "Acute limb ischemia is a medical emergency with management options ranging from urgent revascularization to limb amputation." | ( Jaffery, Z; Thornton, SN; White, CJ, 2011) |
| "Ischemia is a well-known cause of this event." | ( Aydin, T; Battal, M; Kamali, G; Karatepe, O; Kurtulus, I; Yalcin, O, 2011) |
| "Ischemia is a major factor contributing to failure of skin flap surgery, which is routinely used for coverage of wounds to prevent infection and to restore form and function." | ( Altavilla, D; Bitto, A; Calò, M; Galeano, M; Irrera, N; Marini, H; Polito, F; Squadrito, F, 2012) |
| "Intestinal ischemia is associated with high morbidity and mortality, but the underlying mechanisms are uncertain." | ( Chang, M; Kistler, EB; Schmid-Schönbein, GW, 2012) |
| "Lower extremity ischemia is common when the femoral artery is used for veno-arterial extracorporeal membrane oxygenation (VA ECMO)." | ( Bartlett, RH; Cooley, E; Haft, JW; Romano, MA; Spurlock, DJ; Toomasian, JM, 2012) |
| "Ischemia is defined as cell death caused by insufficient perfusion of the tissue due to reduction in arterial or venous blood flow, depletion of cellular energy storages, and accumulation of toxic metabolites." | ( Alp, HH; Calik, M; Gundogdu, C; Ingec, M; Isaoglu, U; Kurt, A; Polat, B; Suleyman, H; Yilmaz, M, 2011) |
| "Vasculopathy due to ischemia is a major contributor to the pathogenesis, natural history and outcome of the diabetic foot." | ( Chen, B; Jiang, XY; Lu, DB, 2012) |
| "Critical limb ischemia is an important component of this disease entity." | ( Dieter, RS; Nanjundappa, A; Parekh, N, 2012) |
| "Intestinal ischemia is difficult to diagnose noninvasively." | ( Bahrami, S; Hölzenbein, T; Khadem, A; Kröpfl, A; Redl, H; Sobhian, B, 2012) |
| "Because retinal ischemia is a common cause of vision loss, we sought to determine the effects of ischemia on neuroretinal function and survival in murine oxygen-induced retinopathy (OIR) and to define the role of endogenous erythropoietin (EPO) in this model." | ( Ali, RR; Bainbridge, JW; Duran, Y; Gonzalez, F; Lange, CA; Luhmann, UF; Maxwell, PH; Mowat, FM; Smith, AJ, 2012) |
| "Critical ischemia is defined by continuous pain, impending sleep, with ankle pressure less than 50mm Hg, and/or first toe pressure less than 30 mm Hg (Dormandy et Rutherford, 2000; Norgren et al." | ( Fichelle, JM, 2012) |
| "Intermittent ischemia is known to promote post perfusion bile flow, and hence recovery of liver function following ischemia reperfusion of the liver." | ( Barritt, GJ; Nieuwenhuijs, VB; Padbury, RT; Peters, J; Rademacher, W; Steenks, M, 2017) |
| "Intestinal ischemia is difficult to diagnose, and search for new biomarkers has led to interest in D-lactate, which arises from bacterial fermentation in the gastrointestinal tract." | ( Erlandsen, EJ; Lindholt, JS; Mortensen, FV; Nielsen, C, 2012) |
| "Critical limb ischemia is a severe form of peripheral artery disease (PAD) for which neither surgical revascularization nor endovascular therapy nor current medicinal therapy has sufficient therapeutic effects." | ( Egashira, K; Kim-Mitsuyama, S; Matoba, T; Nagahama, R; Nakano, K; Sunagawa, K, 2012) |
| "Ischemia is a blockage of blood supply due to an embolism or a hemorrhage in a blood vessel." | ( Ahn, YJ; Kang, Y; Kim, H; Kim, HH; Kim, HS; Lee, M; Lim, H; Moon, S, 2012) |
| "Lower extremity ischemia is an important source of morbidity with femoral venoarterial extracorporeal membrane oxygenation support." | ( Alten, JA; Borasino, S; Jackson, KW; Kirklin, JK; McIlwain, RB; O'Meara, C; Timpa, J, 2012) |
| "Ischemia is the major cause of acute kidney injury (AKI), associated with high mortality and morbidity." | ( Afzal, MZ; Anwar, SS; Khan, SN; Masoud, MS; Mehmood, A; Riazuddin, S, 2012) |
| "Skin ischemia is one of the crucial phenomena during chronic lower limb ischemia in patients with peripheral arterial occlusive disease and/or diabetes." | ( Adamiec, R; Kluz, J; Małecki, R, 2013) |
| "Since ischemia is caused by a critical shortage of oxygen and nutrients, ischemic damage is usually irreversible, even when the ischemic event is transient." | ( Agata, H; Asahina, I; Kagami, H; Sumita, Y; Tojo, A, 2013) |
| "Critical limb ischemia is a syndrome that combines several peripheral artery diseases with different ethiology and pathogenesis but with similar prognosis, high morbidity and mortality." | ( Karasev, AV; Kleĭmenova, EB; Kungurtsev, VV; Lebedev, SV; Lokhonina, AV, 2013) |
| "Critical limb ischemia is the most severe manifestation of chronic peripheral artery disease (PAD)." | ( Jaff, MR; Kiernan, TJ; Lobo, R, 2013) |
| "The optic pathway ischemia is believed to be secondary to Onyx penetration and occlusion of an SHA branch near the aneurysm neck." | ( Aziz-Sultan, MA; Ebersole, K; Elhammady, M; Johnson, JN; Pasol, J; Post, J, 2013) |
| "Acute intestinal ischemia is a medical emergency with a high mortality rate, attesting to the need for a better understanding of its pathogenesis and the development of effective therapies." | ( Balroop, J; Kashem, Z; Ko, EH; Lai, M; Lee, H; Wei, N; Zhang, M, 2014) |
| "Ischemia is a primary cause of neuronal death in retinal diseases and the somatostatin subtype receptor 2 agonist octreotide (OCT) is known to decrease ischemia-induced retinal cell death." | ( Casini, G; Catalani, E; Cervia, D; D'Alessandro, A; Gevi, F; Zolla, L, 2014) |
| "Acute limb ischemia is a complication of severe peripheral arterial disease that can be a threatening limb as well as life." | ( Hall, V; Long, J, 2014) |
| "Limb ischemia is one of the notorious complications of ECMO but can be avoided utilizing a proper distal limb perfusion method." | ( Amrani, M; Bahrami, T; DeRobertis, F; Fatullayev, J; Kaul, S; Maunz, O; Mohite, PN; Patil, NP; Popov, AF; Sabashnikov, A; Saez, DG; Simon, AR; Weymann, A; Zych, B, 2014) |
| "Critical limb ischemia is a disease in which macrophages have considerable pathogenic roles, and are potential targets for cell-based immunotherapy." | ( Chang, YT; Das, RK; Jow, ZY; Yoo, JS, 2014) |
| "Ischemia is a complex phenomenon modulated by the concerted action of several cell types." | ( Cohen, RA; Mei, Y; Shiraishi, Y; Thompson, MD; Tong, X, 2014) |
| "Ischemia is a leading cause of acute kidney injury." | ( Briley, NE; Gao, G; Love, MI; Miller, BA; Reeves, WB; Tadagavadi, RK; Wang, W, 2014) |
| "Limb ischemia is a complication that can occur in patients requiring percutaneously placed venoarterial extracorporeal membrane oxygenation (ECMO)." | ( Brehm, C; El-Banayosy, A; Ghodsizad, A; Gordon, C; Koerner, MM, 2014) |
| "Limb ischemia is a major complication of thromboembolic diseases." | ( Alhenc-Gelas, F; Bouby, N; Chollet, C; Desposito, D; Gobeil, F; Potier, L; Roussel, R; Waeckel, L, 2015) |
| "The causes of ischemia are variable and include connective tissue disease, embolism, atherosclerosis, and iatrogenic etiology." | ( De Martino, RR; Moran, SL, 2015) |
| "Neonatal hypoxia-ischemia is a major cause of brain damage in infants and may frequently present visual impairments." | ( Chan, KC; Fan, SJ; Kancherla, S; Wu, EX, 2014) |
| "Critical limb ischemia is a major public health problem in our western countries due to the epidemia of (diabesity)." | ( Calanca, L; Déglise, S; Doenz, F; Dubuis, C; Mazzolai, L; Qanadli, S; Salomon du Mont, L; Saucy, F, 2014) |
| "Intestinal ischemia is common after emergency gastrointestinal or cardiovascular surgery." | ( Cosse, C; Galmiche, A; Kamel, S; Regimbeau, JM; Sabbagh, C, 2014) |
| "Hand ischemia is rare but complex and multifactorial." | ( De Lambert, A; Palacin, P; Pichot, O; Pirvu, A; Sessa, C, 2015) |
| "Microvascular ischemia is linked to cardiovascular disease pathology, as well as alterations in mood and cognition." | ( Neigh, GN; Nemeth, CL, 2015) |
| "Retinal ischemia is a common risk factor for visual impairment and blindness." | ( Li, Y; Zhou, GM, 2015) |
| "Lower extremity ischemia is also associated with pathophysiologic changes in calf skeletal muscle, including smaller calf muscle area, increased calf muscle fat content, impaired leg strength, and impaired metabolic function." | ( McDermott, MM, 2015) |
| "Critical limb ischemia is a major clinical problem." | ( Carroll, O; Chen, X; Dash, BC; Monaghan, M; O'Brien, T; Pandit, A; Thomas, D; Woodhouse, K, 2015) |
| "Critical hand ischemia is an extremely rare and serious complication of transradial coronary angiography." | ( Abuzaid, A; Ayan, M; Azzouz, M; Mooss, A; Smer, A, 2015) |
| "Tissue ischemia is a known cause of visceral pain, and the goal of our present study was to determine whether esophageal wall blood perfusion (EWBP) is reduced in patients with NE." | ( Jiang, Y; Mittal, RK, 2016) |
| "Critical limb ischemia is a devastating manifestation of peripheral arterial disease with no effective strategies for improving morbidity and mortality outcomes." | ( Alleman, RJ; Brown, DA; Green, TD; McClung, JM; Neufer, PD; Ryan, TE; Schmidt, CA; Tsang, AM, 2016) |
| "Retinal ischemia is a pathological event present in several retinopathies such as diabetic retinopathy and glaucoma, leading to partial or full blindness with no effective treatment available." | ( Araújo, DSM; Calaza, KC; Miya-Coreixas, VS; Pandolfo, P, 2017) |
| "Intestinal ischemia is observed in conditions such as mesenteric ischemia, or during traumatic events such as intestinal transplantation." | ( AlKukhun, A; Caturegli, G; Geibel, JP; Judeeba, S; Morotti, R; Munoz-Abraham, AS; Patron-Lozano, R; Rodriguez-Davalos, MI, 2017) |
| "Lower-extremity ischemia is a significant complication in children on femoral venoarterial extracorporeal membrane oxygenation (VA ECMO)." | ( Aspelund, G; Cheung, EW; Fallon, BP; Kadenhe-Chiweshe, AV; Middlesworth, W; Monteagudo, J; Morrissey, NJ; Okochi, S; Schad, CA; Stylianos, S, 2017) |
| "Leg ischemia is associated frequently with other organs ischemia, and could be a pilot sign for abdominal organ ischemia." | ( Kuniyoshi, Y, 2017) |
| "Retinal ischemia is common in eye disorders, like diabetic retinopathy or retinal vascular occlusion." | ( Dick, HB; Faissner, A; Joachim, SC; Lohmann, S; Marcus, K; May, C; Reinehr, S; Reinhard, J; Renner, M; Stute, G; Theiss, C, 2017) |
| "Transient retinal ischemia is a major complication of retinal degenerative diseases and contributes to visual impairment and blindness." | ( Aires, ID; Ambrósio, AF; Baqi, Y; Boia, R; Cunha, RA; Elvas, F; Madeira, MH; Müller, CE; Rodrigues-Neves, AC; Santiago, AR; Szabó, EC; Tomé, ÂR; Tralhão, P, 2017) |
| "Retinal ischemia is involved in the pathogenesis of many major vision threatening diseases." | ( Acosta, ML; Kalloniatis, M; Khoo, P; Nivison-Smith, L, 2018) |
| "Ischemia is one of the main causes of the high rate of absorption of transplanted autologous fat." | ( Chen, Z; He, Y; Li, C; Li, L; Yang, L; Ye, L; Yu, X; Zhang, D, 2017) |
| "Peripheral ischemia is associated with higher degree of endothelial dysfunction and a worse prognosis after percutaneous coronary interventions (PCI)." | ( Camastra, C; Curcio, A; De Rosa, S; Esposito, G; Gareri, C; Iaconetti, C; Indolfi, C; Mancuso, T; Mignogna, C; Passafaro, F; Polimeni, A; Sabatino, J; Sorrentino, S; Tammè, L; Torella, D, 2018) |
| "In all cases, ischemia is followed by reperfusion and, although it is essential for the reestablishment of tissue function, reperfusion may cause greater damage than ischemia, an injury characterized as ischemia-reperfusion (I/R) damage." | ( Bistafa Liu, J; Carneiro d'Albuquerque, LA; Castro-E-Silva, O; de Almeida, TN; Graf, C; Jordani, MC; Mendes, KDS; Tófoli Queiroz Campos, D; Victorino, JP, 2018) |
| "Critical limb ischemia is a major cause of morbidity and mortality worldwide." | ( Li, Z; Zhang, K, 2020) |
| "Critical limb ischemia is a rare complication of systemic lupus erythematosus that requires immediate treatment." | ( Aziz, M; Damay, V; Pranata, R; Wiharja, W, 2019) |
| "Critical limb ischemia is associated with excessively high risk for cardiovascular events, including myocardial infarction and death." | ( Barbato, E; Bartus, S; Bil, J; Brodmann, M; Gil, R; Mangiacapra, F; Orias, V; Ruzsa, Z; Schneller, L; Toth, G, 2019) |
| "Critical limb ischemia is one of the most common types of peripheral arterial disease." | ( Choi, JJ; Chung, HM; Han, JS; Han, SS; Jin, Z; Kang, SW; Lee, BS; Moon, SH; Mukhtar, AS; Park, SJ, 2019) |
| "Retinal ischemia is a common condition that may lead into vision impairment and blindness." | ( Bermudez, MA; Gonzalez, F, 2020) |
| "Renal ischemia is the most common cause of acute kidney injury." | ( Mohamed, R; O'Connor, PM; Rafikova, O; Sullivan, JC, 2020) |
| "Hand ischemia is a relatively common complication of hemodialysis arteriovenous (AV) access." | ( Asif, A; Salman, L, 2020) |
| "Ovarian ischemia is a gynecological emergency case that occurs as a result of ovarian torsion." | ( Baser, E; Doganyigit, Z; Kara, M; Kirmizi, DA; Okan, A; Yalvac, ES, 2021) |
| "Lower extremity ischemia is associated with reduced calf skeletal muscle area and increased calf muscle fat infiltration and fibrosis on computed tomography or magnetic resonance imaging." | ( Ferrucci, L; Gonzalez-Freire, M; Kosmac, K; Leeuwenburgh, C; McDermott, MM; Peterson, CA; Saini, S; Sufit, R, 2020) |
| "Acute bowel ischemia is a condition with high mortality and requires rapid intervention to avoid catastrophic outcomes." | ( Benz, MR; Boll, DT; Heye, T; Obmann, MM; Obmann, VC; Punjabi, G; Yeh, BM, 2022) |
| "Mesenteric ischemia is a severe and potentially lethal event." | ( Debus, ES; Detter, C; Duprée, A; Izbicki, JR; Mann, O; Pinnschmidt, HO; Rieß, H; Russ, D; von Kroge, PH; Wipper, SH, 2021) |
| "Acute upper limb ischemia is an uncommon clinical manifestation of thromboembolism seen predominantly in patients with atrial fibrillation." | ( Bheem, V; Budhooram, S; Harnanan, D; Harnarayan, P; Islam, S, 2021) |
| "Acute limb ischemia is rarely seen in periarteritisnodosa." | ( Al Tayef, TA; Arbaoui, S; Benzirar, A; El Mahi, O; Miry, A; Rezziki, A, 2021) |
| "Ischemia is a condition in which blood flow to tissues is decreased or entirely stopped for various reasons." | ( Altuner, D; Bulut, S; Cankaya, M; Kunak, CS; Mammadov, R; Suleyman, B; Suleyman, H; Yazici, GN; Yuceli, S, 2021) |
| "Ovarian ischemia is a gynecological emergency case that occurs as a result of ovarian torsion." | ( Arpa, M; Atak, M; Deniz, E; Ozturk, A; Ozturk, SD; Topcu, A, 2022) |
| "Transient global ischemia is a leading cause of learning and memory dysfunction and induces a pattern of delayed neuronal death in the CA1 subfield of the hippocampus by down-regulating GluR2 mRNA AMPA receptors in this cerebral area." | ( Castro, CC; de Souza Pagnussat, A; Munhoz, CD; Netto, CA, 2022) |
| "Chronic limb threat ischemia is associated with cardiovascular events, resulting in high amputation, morbidity and mortality rates." | ( Cai, H; Dong, J; Lu, S; Song, Q; Ye, Y, 2022) |
| "Tissue ischemia is a key risk factor in anastomotic leak (AL)." | ( García-Nalda, A; Lucas-Guerrero, V; Mora-López, L; Navarro-Soto, S; Pallisera-Lloveras, A; Serra-Aracil, X; Serra-Gómez, A; Serra-Gómez, B, 2022) |
| "Heart ischemia is an irreversible condition that occurs via decreased blood flow in vessels by genetic factors, molecular regulators, and environmental conditions." | ( Abedi, H; Sharifi, G; Taghian, F; Zarei, S, 2022) |
| "Cerebral ischemia is the primary cause of morbidity and mortality worldwide due to the perturbations in the blood supply to the brain." | ( Grewal, AK; Kalra, P; Khan, H; Singh, TG, 2023) |
| "Cerebral ischemia is the primary cause of morbidity and mortality worldwide due to the perturbations in the blood supply to the brain." | ( Grewal, AK; Kalra, P; Khan, H; Singh, TG, 2023) |
| "Cerebral ischemia is the primary cause of morbidity and mortality worldwide due to the perturbations in the blood supply to the brain." | ( Grewal, AK; Kalra, P; Khan, H; Singh, TG, 2023) |
| "Glans ischemia is an extremely infrequent complication characterized by a total or partial compromise in the penile arterial perfusion." | ( Antona, G; Arredondo Montero, J; Bardají Pascual, C; Bronte Anaut, M; Ros Briones, R, 2023) |
| "Glans ischemia is an extremely infrequent complication characterized by a total or partial compromise in the penile arterial perfusion." | ( Antona, G; Arredondo Montero, J; Bardají Pascual, C; Bronte Anaut, M; Ros Briones, R, 2023) |
| "Acute intestinal ischemia is a severe complication of abdominal aortic surgery that is difficult to diagnose early and therefore to treat adequately and timely." | ( Krivka, T; Kruzliak, P; Kubicek, L; Novotny, T; Radova, L; Slaby, O; Smutna, J; Staffa, R; Tomandl, J; Tomandlova, M; Vlachovsky, R, 2023) |
| "Acute intestinal ischemia is a severe complication of abdominal aortic surgery that is difficult to diagnose early and therefore to treat adequately and timely." | ( Krivka, T; Kruzliak, P; Kubicek, L; Novotny, T; Radova, L; Slaby, O; Smutna, J; Staffa, R; Tomandl, J; Tomandlova, M; Vlachovsky, R, 2023) |
| "Ischemia is initiated by ischemia reperfusion injury (IRI), which involves disruption of intracellular signaling pathways and causes cell death." | ( Malinowski, B; Ohla, J; Słupski, M; Wiciński, M; Zabrzyński, J, 2023) |
| "Ischemia is known to be a major contributor for anastomotic leaks and indocyanine green (ICYG) fluorescence angiography has been utilized to assess perfusion." | ( Huston, J; LeBlanc, G; Meredith, K; Shridhar, R; Takahashi, C, 2023) |
| "Retinal ischemia is a common cause of a variety of eye diseases, such as retinopathy of prematurity, diabetic retinopathy, and vein occlusion." | ( Buscho, SE; Ding, C; Li, S; Liu, H; Motamedi, M; Shi, S; Xia, F; Zhang, W; Zhu, S, 2023) |
| "Placental ischemia is suggested as the primary trigger of preeclampsia-associated impairments of both endothelium-derived nitric oxide (NO) and the vascular activity of extracellular matrix metalloproteinase-2 (MMP-2)." | ( da Silva, MLS; Dias-Junior, CA; Gomes, SEB; Martins, LZ; Molezini, L; Montenegro, MF; Rizzi, E; Rodrigues, SD, 2023) |
| "Retinal ischemia is involved in the occurrence and development of various eye diseases, including glaucoma, diabetic retinopathy, and central retinal artery occlusion." | ( Liu, J; Peng, S; Xu, H; Xu, T; Yang, Z; Zhang, W; Zhang, Z; Zhao, L; Zhu, Y, 2023) |