2,5-dimercapto-1,3,4-thiadiazole

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

dimercaptothiadiazole: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	2723630
CHEMBL ID	3185279
SCHEMBL ID	12495049
SCHEMBL ID	19435
MeSH ID	M0059235

Synonyms (74)

Synonym
bismuththiol
1,3,4-thiadiazol-dithiol-(2,5)
unii-2s78t9t08c
2s78t9t08c ,
BB 0260229
1072-71-5
2,5-dimercapto-thiadiazole
nsc-4645
dimercaptothiadiazole
1,4-thiadiazolidine-2,5-dithione
wln: t5nn dsj csh esh
usaf a-8354
nsc4645
bismuthiol i
2,5-dimercaptothiadiazole
2,3,4-thiodiazole
1,4-thiadiazole-2,5-dithiol
usaf fa-4
usafa-8354
1,3,4-thiadiazolidine-2,5-dithione
wln: t5nndsj csh esh
STK367101
1,3,4-thiadiazole-2,5-dithiol, 98%
ai3-18635
nsc 4645
2,5-dimercapto-1,3,4-thiodiazole
einecs 214-014-1
py 61h
1,3,4-thiadiazol-dithiol-(2,5) [german]
2,5-dimercapto-1,3,4-thiadiazole ,
1,3,4-thiadiazole-2,5-dithiol
bismuthiol
D0622
B0593
AKOS000119872
A24678
1,3,4-thiadiazolidine-2,5-dithione;2,5-dimercapto-1,3,4-thiodiazole
AKOS005485976
NCGC00248309-01
cas-1072-71-5
tox21_301157
dtxcid4020115
NCGC00255055-01
dtxsid6040115 ,
132120-63-9
5-sulfanyl-1,3,4-thiadiazole-2(3h)-thione
STK560428
79509-46-9
FT-0610390
PS-4046
AM20080025
1,3,4- thiadiazole-2,5-dithiol
SCHEMBL12495049
SCHEMBL19435
.delta.2-1,3,4-thiadiazoline-5-thione, 2-mercapto-
2,5-dithiol-1,3,4-thiadiazole
vanchem dmtd
132120-64-0
bismuththiol i
d 2 (chinese flotation agent)
d 2
Q-200066
STR02271
CHEMBL3185279
mfcd00003103
AKOS028108714
F1995-0275
bismuthiol i, for spectrophotometric det. of bi, cu, pb, sb, >=99.0%
1,3,4-thiadiazole-2-thione-5-thiol
[1,3,4]thiadiazole-2,5-dithiol
Q15632681
D88151
1,3,4-thiadiazole-2(3h)-thione, 5-mercapto-
EN300-17339

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (7)

Potency Measurements

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Luciferase	Photinus pyralis (common eastern firefly)	Potency	11.2496	0.0072	15.7588	89.3584	AID1224835
nuclear receptor subfamily 1, group I, member 3	Homo sapiens (human)	Potency	17.7214	0.0010	22.6508	76.6163	AID1224838; AID1224893
vitamin D (1,25- dihydroxyvitamin D3) receptor	Homo sapiens (human)	Potency	54.9410	0.0237	23.2282	63.5986	AID743223
aryl hydrocarbon receptor	Homo sapiens (human)	Potency	44.7070	0.0007	23.0674	1,258.9301	AID743085; AID743122
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	0.2169	0.0016	28.0151	77.1139	AID1259385
Histone H2A.x	Cricetulus griseus (Chinese hamster)	Potency	50.4772	0.0391	47.5451	146.8240	AID1224845
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	7.9970	0.0006	27.2152	1,122.0200	AID743219
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (17)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (11.76)	18.7374
1990's	1 (5.88)	18.2507
2000's	6 (35.29)	29.6817
2010's	7 (41.18)	24.3611
2020's	1 (5.88)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 31.48

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	31.48 (24.57)
Research Supply Index	2.89 (2.92)
Research Growth Index	5.13 (4.65)
Search Engine Demand Index	35.22 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (31.48)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	1 (5.88%)	4.05%
Observational	0 (0.00%)	0.25%
Other	16 (94.12%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
uric acid Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.. uric acid : An oxopurine that is the final oxidation product of purine metabolism.. 6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.. 7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.	2.03	1	uric acid	Escherichia coli metabolite; human metabolite; mouse metabolite
suramin Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.. suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.	1.98	1	naphthalenesulfonic acid; phenylureas; secondary carboxamide	angiogenesis inhibitor; antinematodal drug; antineoplastic agent; apoptosis inhibitor; EC 2.7.11.13 (protein kinase C) inhibitor; GABA antagonist; GABA-gated chloride channel antagonist; purinergic receptor P2 antagonist; ryanodine receptor agonist; trypanocidal drug
1-naphthylphenylamine N-phenyl-1-naphthylamine: RN given refers to 1-naphthylamine cpd; structure	2.04	1	naphthalenes
dianisidine Dianisidine: Highly toxic compound which can cause skin irritation and sensitization. It is used in manufacture of azo dyes.	1.95	1	biphenyls
1-naphthylamine 1-Naphthylamine: A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.. naphthylamine : A primary arylamine that is naphthalene substituted by an amino group at unspecified position.. 1-naphthylamine : A naphthylamine that is naphthalene substituted by an amino group at position 1.	2.04	1	naphthylamine	human xenobiotic metabolite
thiazolidines Thiazolidines: Reduced (protonated) form of THIAZOLES. They can be oxidized to THIAZOLIDINEDIONES.	2.08	1	thiazolidine
acetylcysteine N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.	2.03	1	acetylcysteine; L-cysteine derivative; N-acetyl-L-amino acid	antidote to paracetamol poisoning; antiinfective agent; antioxidant; antiviral drug; ferroptosis inhibitor; geroprotector; human metabolite; mucolytic; radical scavenger; vulnerary
mercury Mercury: A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.. mercury(0) : Elemental mercury of oxidation state zero.	2.78	3	elemental mercury; zinc group element atom	neurotoxin
platinum Platinum: A heavy, soft, whitish metal, resembling tin, with atomic number 78, atomic weight 195.084, symbol Pt. It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as alutiae.	2.06	1	elemental platinum; nickel group element atom; platinum group metal atom
silver Silver: An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.	2.07	1	copper group element atom; elemental silver	Escherichia coli metabolite
gold Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.	3.32	6	copper group element atom; elemental gold
2,2-dimethylthiazolidine 2,2-dimethylthiazolidine: RN given refers to parent cpd; structure given in first source	2.6	1
2-methyl-1,3,4-thiadiazole-5-thiol 2-methyl-1,3,4-thiadiazole-5-thiol: structure given in first source	2.07	1
lithium Lithium: An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER.	7.03	1	alkali metal atom
lead Lead: A soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.2, symbol Pb.	7.39	2	carbon group element atom; elemental lead; metal atom	neurotoxin
cysteine Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.	7.6	1	cysteinium	fundamental metabolite
ascorbic acid Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.	2.03	1	ascorbic acid; vitamin C	coenzyme; cofactor; flour treatment agent; food antioxidant; food colour retention agent; geroprotector; plant metabolite; skin lightening agent

Condition	Relationship Strength	Studies
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.01	1
Allergic Contact Dermatitis [description not available]	2.04	1
Dermatitis, Occupational A recurrent contact dermatitis caused by substances found in the work place.	2.04	1
Dermatitis, Allergic Contact A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.	2.04	1

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