Page last updated: 2024-08-05 11:06:44
piperidine alkaloid
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ChEBI ID: 26147
Members (9)
| Member | Definition | Role |
|---|---|---|
| 1-deoxynojirimycin | An optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration. | duvoglustat |
| ammodendrine | A piperidine alkaloid that is piperidine substituted by a 1-acetyl-1,4,5,6-tetrahydropyridin-3-yl group at position 2 (the 2R-stereoisomer). | ammodendrine |
| anabasine | A pyridine alkaloid that is pyridine substituted by a piperidin-2-yl group at position 3. | anabasine |
| himbacine | A piperidine alkaloid that is decahydronaphtho[2,3-c]furan-1(3H)-one substituted by a methyl group at position 3 and a 2-[(2R,6S)-1,6-dimethylpiperidin-2-yl]ethenyl group at position 4. It has been isolated from the bark of Australian magnolias. | himbacine |
| lobeline | An optically active piperidine alkaloid having a 2-oxo-2-phenylethyl substituent at the 2-position and a 2-hydroxy-2-phenylethyl group at the 6-position. | (-)-lobeline |
| mor-14 | A hydroxypiperidine that is duvoglustat in which the amino hydrogen is replaced by a methyl group. It is an inhibitor of alpha-glucosidase, an agonist of the glucose sensor SGLT3 and exhibits anti-HIV activity. | N-methyl-1-deoxynojirimycin |
| piperine | A N-acylpiperidine that is piperidine substituted by a (1E,3E)-1-(1,3-benzodioxol-5-yl)-5-oxopenta-1,3-dien-5-yl group at the nitrogen atom. It is an alkaloid isolated from the plant Piper nigrum. | piperine |
| stenusin | A member of the class of piperidines that is piperidine substituted by ethyl and 2-methylbutyl groups at positions 1 and 3, respectively. | 1-ethyl-3-(2-methylbutyl)piperidine |
| veratramine | A piperidine alkaloid comprising the 14,15,16,17-tetradehydro derivative of veratraman having two hydroxy groups at the 3- and 23-positions. | veratramine |
Research
Studies (2,570)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 238 (9.26) | 18.7374 |
| 1990's | 398 (15.49) | 18.2507 |
| 2000's | 589 (22.92) | 29.6817 |
| 2010's | 962 (37.43) | 24.3611 |
| 2020's | 383 (14.90) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 180 (6.66%) | 5.53% |
| Reviews | 188 (6.95%) | 6.00% |
| Case Studies | 55 (2.03%) | 4.05% |
| Observational | 10 (0.37%) | 0.25% |
| Other | 2,271 (83.99%) | 84.16% |