An EC 1.11.2.* (oxidoreductase with H2O2 as acceptor, incorporating 1 O atom into product) inhibitor that interferes with the action of myeloperoxidase (EC 1.11.2.2).
ChEBI ID: 79093
| Member | Definition | Class |
|---|---|---|
| salicylhydroxamic acid | A hydroxamic acid that is N-hydroxybenzamide carrying a phenolic hydroxy group at position 2. | salicylhydroxamic acid |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 75 (31.51) | 18.7374 |
| 1990's | 38 (15.97) | 18.2507 |
| 2000's | 76 (31.93) | 29.6817 |
| 2010's | 42 (17.65) | 24.3611 |
| 2020's | 7 (2.94) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 3 (1.19%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 249 (98.81%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 8.9125 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 28.1838 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 1.9953 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 2.5929 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 3.9811 | 2 | 2 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 125.8920 | 1 | 1 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 9.9237 | 1 | 1 |
| snurportin-1 | Homo sapiens (human) | Potency | 125.8920 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 0.1259 | 1 | 1 |
| Vpr | Human immunodeficiency virus 1 | Potency | 63.0957 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Alternative oxidase, mitochondrial | Trypanosoma brucei brucei | IC50 | 5.9300 | 1 | 1 |
| Lactoperoxidase | Bos taurus (cattle) | IC50 | 1.2000 | 1 | 2 |
| Myeloperoxidase | Homo sapiens (human) | IC50 | 14.0000 | 2 | 2 |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | IC50 | 30.0998 | 2 | 2 |
| Thyroid peroxidase | Homo sapiens (human) | IC50 | 1.2000 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Myeloperoxidase | Homo sapiens (human) | Kd | 2.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Peptidylglycine alpha-amidating monooxygenase | Rattus norvegicus (Norway rat) | Kis | 300.0000 | 1 | 1 |