Page last updated: 2024-08-05 11:12:39
phenothiazines
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ChEBI ID: 38093
Members (73)
| Member | Definition | Role |
|---|---|---|
| (4-methylphenyl)-(10-phenothiazinyl)methanone | (4-methylphenyl)-(10-phenothiazinyl)methanone | |
| 1-(1-benzotriazolyl)-3-(10-phenothiazinyl)-2-propanol | 1-(1-benzotriazolyl)-3-(10-phenothiazinyl)-2-propanol | |
| 1-(10-methyl-2-phenothiazinyl)ethanone | 1-(10-methyl-2-phenothiazinyl)ethanone | |
| 1-(10h-phenothiazin-2-yl)ethanone | 1-(10H-phenothiazin-2-yl)ethanone | |
| 1-(2-chloro-10-phenothiazinyl)-2-[(1-methyl-5-tetrazolyl)thio]ethanone | 1-(2-chloro-10-phenothiazinyl)-2-[(1-methyl-5-tetrazolyl)thio]ethanone | |
| 10-methyl-3-phenothiazinamine | 10-methyl-3-phenothiazinamine | |
| 10H-phenothiazine 5-oxide | 10H-phenothiazine 5-oxide | |
| 2-chloro-N-[1-[oxo(10-phenothiazinyl)methyl]-4-piperidinyl]benzamide | 2-chloro-N-[1-[oxo(10-phenothiazinyl)methyl]-4-piperidinyl]benzamide | |
| 3-[4-(2-hydroxyethyl)-1-piperazinyl]-1-[2-(trifluoromethyl)-10-phenothiazinyl]-1-propanone | 3-[4-(2-hydroxyethyl)-1-piperazinyl]-1-[2-(trifluoromethyl)-10-phenothiazinyl]-1-propanone | |
| 7-hydroxychlorpromazine | 8-chloro-10-[3-(dimethylamino)propyl]-3-phenothiazinol | |
| acepromazine | A member of the class of phenothiazines that is 10H-phenothiazine substituted by an acetyl group at position 2 and a 3-(dimethylamino)propyl group at position 10. | acepromazine |
| acetophenazine | A member of the class of phenothiazines that is 10H-phenothiazine substituted by a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at the nitogen atom and an acetyl group at position 2. | acetophenazine |
| butaperazine | butaperazine | |
| chlorfenethazine | 2-(2-chloro-10-phenothiazinyl)-N,N-dimethylethanamine | |
| chlorproethazine | chlorproethazine | |
| chlorpromazine | A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety. | chlorpromazine |
| chlorpromazine hydrochloride | The hydrochloride salt of chlorpromazine. | chlorpromazine hydrochloride |
| chlorpromazine n-oxide | An organochlorine compound that is chlorpromazine in which the acyclic tertiary amino group has been converted into the corresponding N-oxide. | chlorpromazine N-oxide |
| cyamemazine | cyamemazine | |
| darunavir ethanolate | 2-[[4-ethyl-5-(2-furanyl)-1,2,4-triazol-3-yl]thio]-1-(10-phenothiazinyl)ethanone | |
| didemethylchlorpromazine | 3-(2-chloro-10-phenothiazinyl)-1-propanamine | |
| diethazine | diethazine | |
| dixyrazine | dixyrazine | |
| ethacizine | ethacizine | |
| fenethazine | fenethazine | |
| fenoverine | fenoverine | |
| fluoracizine | fluacizine | |
| fluphenazine | A member of the class of phenothiazines that is 10H-phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at the N-10 position. | fluphenazine |
| fluphenazine depot | The prodrug of fluphenazine, an antipsychotic drug used for the symptomatic management of psychosis in patients with schizophrenia. | fluphenazine decanoate |
| fluphenazine enanthate | Fluphenazine enanthate | |
| fluphenazine hydrochloride | Fluphenazine hydrochloride | |
| fonazine | dimetotiazine | |
| hydromethylthionine | A member of the class of phenothiazines that is 10H-phenothiazine in which the ring hydrogens at positions 3 and 7 have been replaced by dimethylamino groups. | leucomethylene blue |
| mepazine | pecazine | |
| mequitazine | Mequitazine | |
| mesoridazine | A phenothiazine substituted at position 2 (para to the S atom) by a methylsulfinyl group, and on the nitrogen by a 2-(1-methylpiperidin-2-yl)ethyl group. | mesoridazine |
| methdilazine | A phenothiazine substituted on nitrogen by a (1-methylpyrrolidin-3-yl)methyl group; a first-generation antihistamine with anticholinergic properties. | methdilazine |
| methopromazine | methopromazine | |
| methotrimeprazine | A member of the class of phenothiazines that is 10H-phenothiazine substituted by a (2R)-3-(dimethylamino)-2-methylpropyl group and a methoxy group at positions 10 and 2 respectively. | methotrimeprazine |
| methotrimeprazine sulfoxide | 10-[3-(dimethylamino)-2-methylpropyl]-2-methoxy-5lambda4-phenothiazin-5-one | |
| metiazinic acid | Phenothiazine substituted at nitrogen by a methyl group and at C-2 by a carboxymethyl group. | metiazinic acid |
| metofenazate | A phenothiazine derivative having a chloro subsitituent at the 2-position and a 4-substituted 3-(piperazin-1-yl)propyl group at the N-10 position. | metofenazate |
| metopimazine | metopimazine | |
| moricizine | A phenothiazine substituted on the nitrogen by a 3-(morpholin-4-yl)propanoyl group, and at position 2 by an (ethoxycarbonyl)amino group. | moricizine |
| n-methylphenothiazine | 10-methylphenothiazine | |
| norchlorpromazine | 3-(2-chloro-10-phenothiazinyl)-N-methyl-1-propanamine | |
| opromazine | 3-(2-chloro-5-oxo-10-phenothiazinyl)-N,N-dimethyl-1-propanamine | |
| oxomemazine | oxomemazine | |
| perazine | A phenothiazine derivative in which 10H-phenothiazinecarries a 3-(4-methylpiperazin-1-yl)propyl substituent at the N-10 position. | perazine |
| periciazine | A member of the class of phenothiazines that is 10H-phenothiazine substituted by a 3-(4-hydroxypiperidin-1-yl)propyl group at the nitrogen atom and a carbonitrile group at position 2. Periciazine is a first generation antipsychotic. | periciazine |
| perphenazine | A phenothiazine derivative in which the phenothiazine tricycle carries a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at N-10. | perphenazine |
| perphenazine decanoate | perphenazine decanoate | |
| piperacetazine | 1-[10-[3-[4-(2-hydroxyethyl)-1-piperidinyl]propyl]-2-phenothiazinyl]ethanone | |
| pipothiazine palmitate | pipotiazine palmitate | |
| prochlorperazine | A member of the class of phenothiazines that is 10H-phenothiazine having a chloro substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position. | prochlorperazine |
| profenamine | A member of the class of phenothiazines that is phenothiazine in which the hydrogen attached to the nitrogen is substituted by a 2-(diethylamino)propyl group. An antimuscarinic, it is used as the hydrochloride for the symptomatic treatment of Parkinson's disease. | profenamine |
| promazine | A phenothiazine deriative in which the phenothiazine tricycle has a 3-(dimethylaminopropyl) group at the N-10 position. | promazine |
| promethazine | A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety. | promethazine |
| promethazine sulfoxide | Promethazine sulfoxide | |
| propiomazine | A member of the class of phenothiazines that is 10H-phenothiazine substituted by a 2-(dimethylamino)propyl group at nitrogen atom and a propanoyl group at position 2. | propiomazine |
| pyrathiazine | parathiazine | |
| sk&f 7172-a2 | 10-[3-[4-(2-chloroethyl)-1-piperazinyl]propyl]-2-(trifluoromethyl)phenothiazine | |
| sulforidazine | sulforidazine | |
| thiazinamium | thiazinam | |
| thiethylperazine | A member of the class of phenothiazines that is perazine substituted by a ethylsulfanyl group at position 2. | thiethylperazine |
| thiopropazate | A phenothiazine derivative in which 10H-phenothiazine has a chloro subsitituent at the 2-position and a 3-[4-(2-acetoxyethyl)piperazin-1-yl]propyl group at N-10. | thiopropazate |
| thioproperazine | A phenothiazine derivative in which the phenothiazine tricycle has a dimethylaminosulfonyl substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at N-10. | thioproperazine |
| thioproperazine mesylate | Thioproperazine mesilate | |
| thioridazine | A phenothiazine derivative having a methylsulfanyl subsitituent at the 2-position and a (1-methylpiperidin-2-yl)ethyl] group at the N-10 position. | thioridazine |
| trifluoperazine | A member of the class of phenothiazines that is phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position. | trifluoperazine |
| trifluoromethylphenothiazine | 2-(trifluoromethyl)-10H-phenothiazine | |
| triflupromazine | A member of the class of phenothiazines that is 10H-phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-(dimethylamino)propyl group at the N-10 position. | triflupromazine |
| trimeprazine | Trimeprazine |
Research
Studies (29,432)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 22,087 (75.04) | 18.7374 |
| 1990's | 3,140 (10.67) | 18.2507 |
| 2000's | 2,095 (7.12) | 29.6817 |
| 2010's | 1,671 (5.68) | 24.3611 |
| 2020's | 439 (1.49) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 3,005 (7.86%) | 5.53% |
| Reviews | 1,211 (3.17%) | 6.00% |
| Case Studies | 2,241 (5.86%) | 4.05% |
| Observational | 25 (0.07%) | 0.25% |
| Other | 31,753 (83.05%) | 84.16% |