Page last updated: 2024-08-05 15:27:35

progestin

A synthetic progestogen.

ChEBI ID: 59826

Members (20)

MemberDefinitionClass
17-alpha-hydroxyprogesteroneA 17alpha-hydroxy steroid that is the 17alpha-hydroxy derivative of progesterone.17alpha-hydroxyprogesterone
algestoneA C21-steroid that is pregn-4-ene substituted by oxo groups at position 3 and 20 and hydroxy groups at positions 16 and 17.algestone
cyproterone acetateA steroid ester resulting from the formal condensation of the carboxy group of acetic acid with the 17-hydroxy group of cyproterone. It is an antiandrogenic drug which has recently been recognized to promote the occurrence and growth of intracranial meningiomas.cyproterone acetate
desogestreldesogestrel
dienogestA steroid hormone that is 17beta-hydroxy-3-oxoestra-4,9-diene substituted at position 17 by a cyanomethyl group. Used as an oral contraceptive.dienogest
drospirenonedrospirenone
dydrogesteronedydrogesterone
ethisteroneA 17beta-hydroxy steroid that is testosterone in which the 17beta hydrogen is replaced by an ethynyl group. Ethisterone was the first orally active progestin and is a metabolite of danazol.ethisterone
ethynodiolethynodiol
etonogestreletonogestrel
levonorgestrellevonorgestrel
medroxyprogesteroneA 3-oxo Delta(4)-steroid that is pregn-4-ene-3,20-dione substituted by an alpha-hydroxy group at position 17 and a methyl group at position 6.medroxyprogesterone
medroxyprogesterone acetateAn acetate ester resulting from the formal condensation of the 17alpha-hydroxy group of medroxyprogesterone with the carboxy group of acetic acid. A widely used progestin in menopausal hormone therapy and in progestogen-only birth control.medroxyprogesterone acetate
megestrolA 3-oxo Delta(4)-steroid that is pregna-4,6-diene-3,20-dione substituted by a methyl group at position 6 and a hydroxy group at position 17.megestrol
megestrol acetateA steroid ester resulting from the formal condensation of the hydroxy group of megestrol with the carboxy group of acetic acid. It is an appetite stimulant used for the treatment of anorexia and cachexia. Also used for birth control and for the treatment of breast cancer.megestrol acetate
norethindroneA 17beta-hydroxy steroid that is testosterone in which the hydrogen at position 17 is replaced by an ethynyl group and in which the methyl group attached to position 10 is replaced by hydrogen.norethisterone
norethindrone acetateA 3-oxo Delta(4)-steroid that is norethisterone in which the hydroxy group has been converted to its acetate ester.norethisterone acetate
norgestimatenorgestimate
promegestoneA progestin consisting of 17beta-propionylestra-4,9-dien-3-one substituted at position 17 by a methyl group.promegestone
ulipristal acetateA 20-oxo steroid obtained by acetylation of the 17-hydroxy group of (11beta,17alpha)-17-acetyl-11-[4-(dimethylamino)phenyl]-3-oxoestra-4,9-dien-17-ol (ulipristal). A selective progesterone receptor modulator, which is employed as an emergency contraceptive.ulipristal acetate

Research

Studies (22,862)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19907,407 (32.40)18.7374
1990's4,649 (20.34)18.2507
2000's5,103 (22.32)29.6817
2010's4,309 (18.85)24.3611
2020's1,394 (6.10)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials5,905 (19.80%)5.53%
Reviews2,582 (8.66%)6.00%
Case Studies1,960 (6.57%)4.05%
Observational202 (0.68%)0.25%
Other19,167 (64.28%)84.16%

Protein Targets (158)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
67.9K proteinVaccinia virusPotency14.795823
acetylcholinesteraseHomo sapiens (human)Potency40.957113
activating transcription factor 6Homo sapiens (human)Potency7.084713
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency31.622812
Alpha-synucleinHomo sapiens (human)Potency5.623411
AR proteinHomo sapiens (human)Potency6.180112194
aryl hydrocarbon receptorHomo sapiens (human)Potency3.857111
arylsulfatase AHomo sapiens (human)Potency0.047811
ATAD5 protein, partialHomo sapiens (human)Potency13.992224
Ataxin-2Homo sapiens (human)Potency34.117718
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency47.754811
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency34.117718
Cellular tumor antigen p53Homo sapiens (human)Potency37.8966213
Chain A, Beta-lactamaseEscherichia coli K-12Potency44.462026
Chain A, CruzipainTrypanosoma cruziPotency37.081413
Chain A, Ferritin light chainEquus caballus (horse)Potency35.481311
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency17.782811
chromobox protein homolog 1Homo sapiens (human)Potency81.855914
cytochrome P450 2C9, partialHomo sapiens (human)Potency12.7358111
cytochrome P450 2D6Homo sapiens (human)Potency21.027516
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency9.180424
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency7.6934211
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency11.3301112
D(1A) dopamine receptorHomo sapiens (human)Potency3.264111
DNA polymerase betaHomo sapiens (human)Potency85.397312
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency21.503214
estrogen nuclear receptor alphaHomo sapiens (human)Potency13.775212122
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency22.1818310
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency31.51878101
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency16.306916
farnesoid X nuclear receptorHomo sapiens (human)Potency31.7975415
Fumarate hydrataseHomo sapiens (human)Potency3.981111
GVesicular stomatitis virusPotency12.7358111
GABA theta subunitRattus norvegicus (Norway rat)Potency9.180412
GALC proteinHomo sapiens (human)Potency20.259312
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency9.180412
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency9.180412
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency9.180412
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency9.180412
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency9.180412
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency9.180412
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency9.180412
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency9.180412
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency9.180412
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency9.180412
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency9.180412
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency9.180412
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency9.180412
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency9.180412
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency9.180412
gemininHomo sapiens (human)Potency12.0058216
GLI family zinc finger 3Homo sapiens (human)Potency14.8226234
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency5.5696549
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency33.725516
Guanine nucleotide-binding protein GHomo sapiens (human)Potency15.782413
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)Homo sapiens (human)Potency19.952611
heat shock protein beta-1Homo sapiens (human)Potency42.386024
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency35.481311
Histone H2A.xCricetulus griseus (Chinese hamster)Potency46.4487210
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency12.7358111
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency32.435423
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency4.011424
IDH1Homo sapiens (human)Potency29.092911
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency12.7358122
Interferon betaHomo sapiens (human)Potency14.5792318
interleukin 8Homo sapiens (human)Potency74.978011
lamin isoform A-delta10Homo sapiens (human)Potency13.326917
Microtubule-associated protein tauHomo sapiens (human)Potency15.540213
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency39.810711
neuropeptide S receptor isoform AHomo sapiens (human)Potency3.218413
nonstructural protein 1Influenza A virus (A/WSN/1933(H1N1))Potency7.943311
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency28.8675337
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency9.063817
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency24.408219
Nuclear receptor ROR-gammaHomo sapiens (human)Potency27.181812
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency9.188724
nuclear receptor subfamily 1, group I, member 2Rattus norvegicus (Norway rat)Potency7.739119
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency41.3056316
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency58.634214
ParkinHomo sapiens (human)Potency43.953413
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency89.125111
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency17.065313
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency23.5028416
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency23.1035519
phosphopantetheinyl transferaseBacillus subtilisPotency79.432811
PINK1Homo sapiens (human)Potency43.953413
plasminogen precursorMus musculus (house mouse)Potency12.589311
polyproteinZika virusPotency3.981111
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency31.622811
PPM1D proteinHomo sapiens (human)Potency20.821212
pregnane X nuclear receptorHomo sapiens (human)Potency24.8187322
pregnane X receptorRattus norvegicus (Norway rat)Potency13.003015
progesterone receptorHomo sapiens (human)Potency8.2733343
RAR-related orphan receptor gammaMus musculus (house mouse)Potency29.4794231
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency30.5720337
retinoid X nuclear receptor alphaHomo sapiens (human)Potency21.0281428
SMAD family member 2Homo sapiens (human)Potency19.2471220
SMAD family member 3Homo sapiens (human)Potency19.2471220
Smad3Homo sapiens (human)Potency35.481311
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency28.325116
survival motor neuron protein isoform dHomo sapiens (human)Potency2.105313
TAR DNA-binding protein 43Homo sapiens (human)Potency27.829812
TDP1 proteinHomo sapiens (human)Potency16.8191234
thioredoxin reductaseRattus norvegicus (Norway rat)Potency57.902312
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency17.5948244
thyroid stimulating hormone receptorHomo sapiens (human)Potency31.7508610
transcriptional regulator ERG isoform 3Homo sapiens (human)Potency13.005112
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency12.589311
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency12.589311
USP1 protein, partialHomo sapiens (human)Potency41.454924
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency15.6087212
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency18.7600421
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency84.279012
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency33.725516

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)IC501.197011
Adenosine receptor A1Rattus norvegicus (Norway rat)IC500.045023
Adenosine receptor A1Rattus norvegicus (Norway rat)Ki0.001022
Adenosine receptor A2aRattus norvegicus (Norway rat)Ki0.336013
Adenosine receptor A2bRattus norvegicus (Norway rat)Ki0.336013
Adenosine receptor A3Homo sapiens (human)IC504.730011
Adenosine receptor A3Homo sapiens (human)Ki2.674011
Aldo-keto reductase family 1 member C1Homo sapiens (human)IC501.800011
Aldo-keto reductase family 1 member C2 Homo sapiens (human)IC504.040522
Aldo-keto reductase family 1 member C3Homo sapiens (human)IC501.405922
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)IC504.730011
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)Ki2.674011
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)IC504.730011
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)Ki2.674011
Androgen receptorHomo sapiens (human)IC500.073444
Androgen receptorRattus norvegicus (Norway rat)IC501.5753314
Androgen receptorHomo sapiens (human)Ki0.004866
Androgen receptorRattus norvegicus (Norway rat)Ki0.096218
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000014
Bile salt export pumpHomo sapiens (human)IC5036.622937
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000013
Corticosteroid-binding globulinHomo sapiens (human)Ki0.290312
Cytochrome P450 2C19Homo sapiens (human)IC501.400012
Cytochrome P450 2C9 Homo sapiens (human)IC5010.000011
Estrogen receptorHomo sapiens (human)IC500.885333
Estrogen receptorHomo sapiens (human)Ki0.231011
Estrogen receptor betaHomo sapiens (human)IC500.924022
Glucocorticoid receptorHomo sapiens (human)IC500.1641310
Glucocorticoid receptorHomo sapiens (human)Ki0.0617613
Glycine receptor subunit alpha-1Rattus norvegicus (Norway rat)IC500.202618
Glycine receptor subunit alpha-1Rattus norvegicus (Norway rat)Ki0.092018
Glycine receptor subunit alpha-2Rattus norvegicus (Norway rat)IC500.202618
Glycine receptor subunit alpha-2Rattus norvegicus (Norway rat)Ki0.092018
Glycine receptor subunit alpha-3Rattus norvegicus (Norway rat)IC500.202618
Glycine receptor subunit alpha-3Rattus norvegicus (Norway rat)Ki0.092018
Glycine receptor subunit betaRattus norvegicus (Norway rat)IC500.202618
Glycine receptor subunit betaRattus norvegicus (Norway rat)Ki0.092018
Histamine H2 receptorHomo sapiens (human)IC5027.920011
Histamine H2 receptorHomo sapiens (human)Ki27.453011
Mineralocorticoid receptor Homo sapiens (human)IC501.197033
Mitogen-activated protein kinase 3 Homo sapiens (human)IC503.157011
Mu-type opioid receptorHomo sapiens (human)IC502.183011
Mu-type opioid receptorHomo sapiens (human)Ki0.886011
Multidrug resistance-associated protein 4Homo sapiens (human)IC5081.600014
Polyphenol oxidase 2Agaricus bisporusIC502.610011
Progesterone receptorHomo sapiens (human)IC501.379588
Progesterone receptorHomo sapiens (human)Ki0.000689
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2IC506.300011
Sodium-dependent dopamine transporter Homo sapiens (human)IC506.905011
Sodium-dependent dopamine transporter Homo sapiens (human)Ki5.486011
Sodium-dependent serotonin transporterHomo sapiens (human)IC504.537011
Sodium-dependent serotonin transporterHomo sapiens (human)Ki2.411011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5-hydroxytryptamine receptor 2AMus musculus (house mouse)EC505.846011
Androgen receptorHomo sapiens (human)EC500.006111
Androgen receptorMus musculus (house mouse)EC500.006122
Androgen receptorHomo sapiens (human)Kd0.001011
Estrogen receptorHomo sapiens (human)EC500.924011
Estrogen receptorRattus norvegicus (Norway rat)Kd0.000611
Estrogen receptor betaHomo sapiens (human)EC500.924011
Estrogen receptor betaRattus norvegicus (Norway rat)Kd0.000611
Glucocorticoid receptorHomo sapiens (human)EC500.010033
mu-type opioid receptor isoform MOR-1Homo sapiens (human)EC5092.600011
ORF73Human gammaherpesvirus 8EC5075.000011
Progesterone receptorHomo sapiens (human)EC500.50541920
Progesterone receptorHomo sapiens (human)Kd0.000422
Sex hormone-binding globulinHomo sapiens (human)Kd0.166716

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
bioAMycobacterium tuberculosis UT205AC5011.010011