An EC 2.4.1.* (hexosyltransferase) inhibitor that interferes with the action of peptidoglycan glycosyltransferase (EC 2.4.1.129).
ChEBI ID: 50696
| Member | Definition | Class |
|---|---|---|
| aztreonam | A synthetic monocyclic beta-lactam antibiotic (monobactam), used primarily to treat infections caused by Gram-negative bacteria. It inhibits mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking. | aztreonam |
| ceftazidime | A third-generation cephalosporin antibiotic bearing pyridinium-1-ylmethyl and {[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetamido groups at positions 3 and 7, respectively, of the cephem skeleton. | ceftazidime |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 4 (1.00) | 18.7374 |
| 1990's | 11 (2.75) | 18.2507 |
| 2000's | 217 (54.25) | 29.6817 |
| 2010's | 150 (37.50) | 24.3611 |
| 2020's | 18 (4.50) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 2 (0.35%) | 5.53% |
| Reviews | 8 (1.41%) | 6.00% |
| Case Studies | 13 (2.29%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 544 (95.94%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| AmpC | Escherichia coli | IC50 | 0.0600 | 1 | 1 |
| Beta-lactamase | Escherichia coli | IC50 | 0.0320 | 1 | 1 |
| Beta-lactamase | Klebsiella pneumoniae | IC50 | 0.0060 | 1 | 1 |
| Beta-lactamase | Acinetobacter baumannii | Ki | 1.5035 | 2 | 2 |
| Beta-lactamase | Citrobacter freundii | Ki | 2.0000 | 1 | 1 |
| Efflux transporter | Salmonella enterica subsp. enterica serovar Newport | IC50 | 0.0060 | 1 | 1 |
| Penicillin-binding protein 1A | Pseudomonas aeruginosa PAO1 | IC50 | 3.3400 | 1 | 1 |
| Solute carrier family 15 member 1 | Homo sapiens (human) | Ki | 10,000.0000 | 1 | 1 |
| Solute carrier family 15 member 2 | Rattus norvegicus (Norway rat) | Ki | 10,000.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| AmpC | Escherichia coli | Km | 21.0000 | 1 | 1 |
| B2 metallo-beta-lactamase | Chryseobacterium indologenes | Km | 22.0000 | 1 | 1 |
| Beta-lactamase | Enterobacter cloacae | Km | 29.8250 | 4 | 4 |
| Beta-lactamase | Morganella morganii | Km | 14.0000 | 1 | 1 |
| Beta-lactamase | Providencia stuartii | Km | 26.0000 | 1 | 1 |
| Beta-lactamase | Pseudomonas aeruginosa PAO1 | Km | 13.6000 | 5 | 5 |
| Beta-lactamase | Serratia marcescens | Km | 570.0000 | 1 | 1 |
| Beta-lactamase | Staphylococcus aureus | Km | 29.0000 | 1 | 1 |
| Beta-lactamase | Acinetobacter baumannii | Km | 53.3333 | 3 | 3 |
| Beta-lactamase | Acinetobacter pittii | Km | 39.1417 | 3 | 6 |
| Beta-lactamase | Aeromonas allosaccharophila | Km | 520.0000 | 1 | 2 |
| Beta-lactamase | Aeromonas caviae | Km | 20.0000 | 1 | 1 |
| Beta-lactamase | Burkholderia cenocepacia | Km | 2,750.0000 | 1 | 2 |
| Beta-lactamase | Citrobacter freundii | Km | 320.0000 | 1 | 1 |
| Beta-lactamase | Citrobacter gillenii | Km | 1,343.5000 | 1 | 2 |
| Beta-lactamase | Enterobacter cloacae | Km | 181.5000 | 1 | 2 |
| Beta-lactamase | Escherichia coli | Km | 109.0714 | 7 | 7 |
| Beta-lactamase | Klebsiella oxytoca | Km | 140.0000 | 1 | 1 |
| Beta-lactamase | Klebsiella pneumoniae | Km | 97.8000 | 3 | 5 |
| Beta-lactamase | Pseudomonas aeruginosa | Km | 209.2857 | 4 | 7 |
| Beta-lactamase | Pseudomonas luteola | Km | 37.5000 | 1 | 2 |
| Beta-lactamase | Salmonella enterica subsp. enterica serovar Westhampton | Km | 94.0000 | 1 | 2 |
| Beta-lactamase | Serratia fonticola | Km | 268.0000 | 1 | 2 |
| Beta-lactamase | Serratia marcescens | Km | 170.0000 | 2 | 2 |
| Beta-lactamase | Shouchella clausii | Km | 1,000.0000 | 1 | 1 |
| Beta-lactamase class B VIM-2 | Pseudomonas aeruginosa | Km | 304.4000 | 4 | 5 |
| Beta-lactamase IMP-1 | Pseudomonas aeruginosa | Km | 50.0000 | 1 | 1 |
| Beta-lactamase SHV-1 | Escherichia coli | Km | 142.0000 | 1 | 1 |
| Beta-lactamase SHV-1 | Klebsiella pneumoniae | Km | 380.6667 | 3 | 3 |
| Beta-lactamase TEM | Escherichia coli | Km | 200.0000 | 2 | 2 |
| Beta-lactamase Toho-1 | Escherichia coli | Km | 45.0000 | 1 | 1 |
| Beta-lactamase VIM-1 | Pseudomonas aeruginosa | Km | 1,132.0000 | 1 | 1 |
| BlaVIM-1 | Escherichia coli | Km | 900.0000 | 1 | 2 |
| Carbapenem-hydrolyzing beta-lactamase KPC | Klebsiella pneumoniae | Km | 211.3333 | 2 | 3 |
| Histamine H3 receptor | Cavia porcellus (domestic guinea pig) | Km | 181.5000 | 1 | 2 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | Km | 1,343.5000 | 1 | 2 |
| Metallo-b-lactamase | Pseudomonas aeruginosa | Km | 1,410.0000 | 1 | 2 |
| Metallo-beta-lactamase | Escherichia coli | Km | 166.0000 | 4 | 4 |
| Metallo-beta-lactamase | Stutzerimonas stutzeri | Km | 50.0000 | 1 | 1 |
| Metallo-beta-lactamase type 2 | Klebsiella pneumoniae | Km | 181.0000 | 1 | 1 |
| Metallo-beta-lactamase VIM-11 | Pseudomonas aeruginosa | Km | 110.0000 | 1 | 1 |
| Metallo-beta-lactamase VIM-13 | Pseudomonas aeruginosa | Km | 509.0000 | 1 | 1 |
| Metallo-beta-lactamase VIM-19 | Escherichia coli | Km | 1,000.0000 | 1 | 1 |
| Metallo-beta-lactamase VIM-2 | Klebsiella pneumoniae | Km | 98.0000 | 1 | 1 |
| Metallo-beta-lactamase VIM-2 | Pseudomonas aeruginosa | Km | 88.2000 | 1 | 1 |