Page last updated: 2024-08-05 13:03:33
macrolide lactam
A macrolide in which the macrocyclic lactone ring includes an amide group.
ChEBI ID: 145565
Members (5)
| Member | Definition | Role |
|---|---|---|
| everolimus | A macrocyclic lactone that is rapamycin in which the hydroxy group attached to the cyclohexyl moiety has been converted into the corresponding 2-hydroxyethyl ether. It is an immunosuppressant and antineoplastic agent. | everolimus |
| ridaforolimus | AP 23573 | |
| sirolimus | A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent. | sirolimus |
| tacrolimus | A macrolide lactam containing a 23-membered lactone ring, originally isolated from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. | tacrolimus (anhydrous) |
| temsirolimus | Temsirolimus |
Research
Studies (37,425)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 99 (0.26) | 18.7374 |
| 1990's | 4,363 (11.66) | 18.2507 |
| 2000's | 11,504 (30.74) | 29.6817 |
| 2010's | 16,740 (44.73) | 24.3611 |
| 2020's | 4,719 (12.61) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 6,017 (13.60%) | 5.53% |
| Reviews | 4,795 (10.84%) | 6.00% |
| Case Studies | 4,561 (10.31%) | 4.05% |
| Observational | 536 (1.21%) | 0.25% |
| Other | 28,319 (64.03%) | 84.16% |