Roles > piscicide
Page last updated: 2024-08-05 15:24:02

piscicide

A substance which is poisonous to fish and is primarily used to eliminate dominant species of fish in water.

ChEBI ID: 167183

Members (3)

MemberDefinitionClass
antimycin aA nine-membered bis-lactone having methyl substituents at the 2- and 6-positions, an n-hexyl substituent at the 8-position, an acyloxy substituent at the 7-position and an aroylamido substituent at the 3-position. It is produced by Streptomyces bacteria and has found commercial use as a fish poison.antimycin A
niclosamideA secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.niclosamide
rotenoneA member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).rotenone

Research

Studies (5,152)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19901,427 (27.70)18.7374
1990's466 (9.05)18.2507
2000's1,013 (19.66)29.6817
2010's1,562 (30.32)24.3611
2020's684 (13.28)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials25 (0.46%)5.53%
Reviews148 (2.73%)6.00%
Case Studies68 (1.25%)4.05%
Observational0 (0.00%)0.25%
Other5,182 (95.56%)84.16%

Protein Targets (194)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency35.481311
67.9K proteinVaccinia virusPotency1.595422
activating transcription factor 6Homo sapiens (human)Potency8.089612
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency29.366915
Alpha-synucleinHomo sapiens (human)Potency1.413713
AR proteinHomo sapiens (human)Potency0.39791032
aryl hydrocarbon receptorHomo sapiens (human)Potency0.443135
arylsulfatase AHomo sapiens (human)Potency37.933011
ATAD5 protein, partialHomo sapiens (human)Potency0.717134
Ataxin-2Homo sapiens (human)Potency3.732323
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency0.849211
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency5.472812
atrial natriuretic peptide receptor 1 precursorHomo sapiens (human)Potency0.543712
atrial natriuretic peptide receptor 2 precursorHomo sapiens (human)Potency0.695912
Bloom syndrome protein isoform 1Homo sapiens (human)Potency21.169924
Cellular tumor antigen p53Homo sapiens (human)Potency0.3491313
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency2.622426
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency26.200012
Chain A, ATP-DEPENDENT DNA HELICASE Q1Homo sapiens (human)Potency3.162311
Chain A, Beta-lactamaseEscherichia coli K-12Potency5.623411
Chain A, CruzipainTrypanosoma cruziPotency22.717022
Chain A, Ferritin light chainEquus caballus (horse)Potency19.702012
Chain A, HADH2 proteinHomo sapiens (human)Potency31.622811
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency70.794611
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency8.387913
Chain B, HADH2 proteinHomo sapiens (human)Potency31.622811
chromobox protein homolog 1Homo sapiens (human)Potency35.481311
cytochrome P450 2C19 precursorHomo sapiens (human)Potency0.699012
cytochrome P450 2C9 precursorHomo sapiens (human)Potency11.588613
cytochrome P450 2C9, partialHomo sapiens (human)Potency5.468912
cytochrome P450 2D6Homo sapiens (human)Potency13.450411
cytochrome P450 2D6 isoform 1Homo sapiens (human)Potency31.622811
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency8.7363210
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency5.133712
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency17.223515
D(1A) dopamine receptorHomo sapiens (human)Potency0.344522
D(1A) dopamine receptorSus scrofa (pig)Potency1.060712
DNA polymerase betaHomo sapiens (human)Potency39.810711
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency36.253012
endonuclease IVEscherichia coliPotency11.220211
estrogen nuclear receptor alphaHomo sapiens (human)Potency7.05771040
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency16.612626
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency0.03811037
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency11.627913
EWS/FLI fusion proteinHomo sapiens (human)Potency3.8879412
farnesoid X nuclear receptorHomo sapiens (human)Potency13.718549
flap endonuclease 1Homo sapiens (human)Potency4.228411
Fumarate hydrataseHomo sapiens (human)Potency3.191914
GVesicular stomatitis virusPotency5.468912
GABA theta subunitRattus norvegicus (Norway rat)Potency8.736315
GALC proteinHomo sapiens (human)Potency0.316211
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency8.736315
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency8.736315
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency8.736315
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency8.736315
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency8.736315
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency8.736315
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency8.736315
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency8.736315
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency8.736315
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency8.736315
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency8.736315
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency8.736315
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency8.736315
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency8.736315
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency8.736315
gemininHomo sapiens (human)Potency2.4423412
GLI family zinc finger 3Homo sapiens (human)Potency4.868029
glp-1 receptor, partialHomo sapiens (human)Potency1.584911
GLS proteinHomo sapiens (human)Potency11.220211
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency23.3781410
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency0.831815
Guanine nucleotide-binding protein GHomo sapiens (human)Potency1.995311
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)Homo sapiens (human)Potency1.849311
heat shock protein beta-1Homo sapiens (human)Potency29.774626
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency9.5104211
histone deacetylase 9 isoform 3Homo sapiens (human)Potency0.736024
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency5.468912
huntingtin isoform 2Homo sapiens (human)Potency0.794311
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency40.740913
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency2.253624
IDH1Homo sapiens (human)Potency0.366311
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency5.468914
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency28.370812
Integrin alpha-IIbHomo sapiens (human)Potency3.417313
Integrin beta-3Homo sapiens (human)Potency3.417313
Interferon betaHomo sapiens (human)Potency5.050039
lamin isoform A-delta10Homo sapiens (human)Potency1.850028
lethal factor (plasmid)Bacillus anthracis str. A2012Potency2.354013
LuciferasePhotinus pyralis (common eastern firefly)Potency2.205545
M-phase phosphoprotein 8Homo sapiens (human)Potency39.336613
Microtubule-associated protein tauHomo sapiens (human)Potency6.384813
mitogen-activated protein kinase 1Homo sapiens (human)Potency0.750612
muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)Potency3.540622
neuropeptide S receptor isoform AHomo sapiens (human)Potency12.589311
nonstructural protein 1Influenza A virus (A/WSN/1933(H1N1))Potency21.679412
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency97.011313
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency6.5550311
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency58.708212
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency10.3304211
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency4.5308311
Ornithine decarboxylaseRattus norvegicus (Norway rat)Potency3.162311
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency0.766711
ParkinHomo sapiens (human)Potency1.632612
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency4.695824
peripheral myelin protein 22 isoform 1Homo sapiens (human)Potency0.213612
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency16.4366410
Peroxisome proliferator-activated receptor alphaHomo sapiens (human)Potency35.481311
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency7.2337411
PINK1Homo sapiens (human)Potency1.632612
plasminogen precursorMus musculus (house mouse)Potency3.548111
polyproteinZika virusPotency3.191914
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Potency0.158511
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency25.118911
PPM1D proteinHomo sapiens (human)Potency3.542914
pregnane X nuclear receptorHomo sapiens (human)Potency7.177224
pregnane X receptorRattus norvegicus (Norway rat)Potency0.050111
progesterone receptorHomo sapiens (human)Potency17.701326
pyruvate kinaseLeishmania mexicana mexicanaPotency2.511922
pyruvate kinase PKM isoform bHomo sapiens (human)Potency3.162322
Rap guanine nucleotide exchange factor 4Homo sapiens (human)Potency79.432811
RAR-related orphan receptor gammaMus musculus (house mouse)Potency0.178128
ras-related protein Rab-9AHomo sapiens (human)Potency24.419113
regulator of G-protein signaling 4Homo sapiens (human)Potency19.013012
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency2.1877312
retinoid X nuclear receptor alphaHomo sapiens (human)Potency7.1378414
serine/threonine-protein kinase mTOR isoform 1Homo sapiens (human)Potency0.836724
SMAD family member 2Homo sapiens (human)Potency0.901727
SMAD family member 3Homo sapiens (human)Potency0.901727
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency0.358623
survival motor neuron protein isoform dHomo sapiens (human)Potency8.096814
TAR DNA-binding protein 43Homo sapiens (human)Potency0.891311
TDP1 proteinHomo sapiens (human)Potency0.9572212
thioredoxin reductaseRattus norvegicus (Norway rat)Potency10.598812
ThrombopoietinHomo sapiens (human)Potency0.100022
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency0.1928210
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency25.699213
thyroid stimulating hormone receptorHomo sapiens (human)Potency12.2755412
TSHR proteinHomo sapiens (human)Potency92.537423
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency3.548111
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency3.548111
USP1 protein, partialHomo sapiens (human)Potency50.759613
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency39.254223
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency5.643159
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency0.831815

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
3-phosphoinositide-dependent protein kinase 1Homo sapiens (human)IC5083.900011
5-hydroxytryptamine receptor 6Homo sapiens (human)IC500.870011
5-hydroxytryptamine receptor 6Homo sapiens (human)Ki0.404011
Acyl carrier protein, mitochondrialBos taurus (cattle)IC500.005111
Angiopoietin-1 receptorHomo sapiens (human)IC5067.800011
Angiotensin-converting enzyme 2 Homo sapiens (human)IC5050.000011
Anoctamin-1Homo sapiens (human)IC500.028011
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000012
Aurora kinase AHomo sapiens (human)IC5054.100011
Bile salt export pumpHomo sapiens (human)IC5037.533323
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000011
Cytochrome P450 2C19Homo sapiens (human)IC503.648611
Dihydroorotate dehydrogenase Plasmodium falciparum (malaria parasite P. falciparum)IC5010.000012
Dihydroorotate dehydrogenase (fumarate)Saccharomyces cerevisiae S288CIC5010.000012
Epidermal growth factor receptorHomo sapiens (human)IC5010.500011
Fibroblast growth factor receptor 1Homo sapiens (human)IC5013.100011
glucose-6-phosphate 1-dehydrogenase isoform bHomo sapiens (human)IC5080.000011
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonasePlasmodium bergheiIC5057.900033
Glycogen synthase kinase-3 betaHomo sapiens (human)IC5077.500011
Mast/stem cell growth factor receptor KitHomo sapiens (human)IC5027.800011
Mitochondrial succinate dehydrogenase subunit C Zymoseptoria triticiIC5015.001022
Mitogen-activated protein kinase 1Homo sapiens (human)IC5051.058022
Mitogen-activated protein kinase 8Homo sapiens (human)IC50100.000011
Multidrug resistance-associated protein 4Homo sapiens (human)IC50133.000012
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialBos taurus (cattle)IC500.005111
NADH-ubiquinone oxidoreductase chain 1Bos taurus (cattle)IC500.015022
Pancreatic triacylglycerol lipaseSus scrofa (pig)IC50500.000011
Platelet-derived growth factor receptor betaHomo sapiens (human)IC50100.000011
Procathepsin LHomo sapiens (human)IC5050.000011
Protein kinase C alpha typeHomo sapiens (human)IC50100.000011
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)IC5010.250022
RAC-alpha serine/threonine-protein kinaseHomo sapiens (human)IC5059.400011
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)IC50100.000011
Replicase polyprotein 1aSevere acute respiratory syndrome-related coronavirusIC5050.000022
Replicase polyprotein 1abBetacoronavirus England 1IC5050.000011
Replicase polyprotein 1abHuman coronavirus 229EIC5050.000022
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2IC5030.093333
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirusIC5046.000055
Serine/threonine-protein kinase B-rafHomo sapiens (human)IC50100.000022
Signal transducer and activator of transcription 3Homo sapiens (human)IC500.230022
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)Ki2.200011
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)Ki3.820011
Spike glycoproteinBetacoronavirus England 1IC5050.000011
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusIC5050.000011
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialZymoseptoria triticiIC5015.001022
Transmembrane protease serine 2Homo sapiens (human)IC5050.000011
Tyrosine-protein kinase ABL1Homo sapiens (human)IC50100.000011
Tyrosine-protein kinase JAK2Homo sapiens (human)IC5055.000022
Tyrosine-protein kinase LynHomo sapiens (human)IC5023.800011
Vascular endothelial growth factor receptor 2Homo sapiens (human)IC5023.100011