Bulimia Nervosa

An eating disorder that is characterized by a cycle of binge eating (BULIMIA or bingeing) followed by inappropriate acts (purging) to avert weight gain. Purging methods often include self-induced VOMITING, use of LAXATIVES or DIURETICS, excessive exercise, and FASTING.

Synonym
Bulimia Nervosa

Excerpt	Reference
"Bulimia nervosa is characterized by consuming large amounts of food over a defined period with a loss of control over the eating."	( Daughters, R; Eckert, ED; Faris, PL; Goodale, RL; Hartman, BK; Hofbauer, RD; Iversen, L; Maxwell, R; Vandenlangenberg, E, 2008)
"Patients with bulimia nervosa are at high risk for dental erosion."	( Ganss, C; Hannig, C; Klimek, J; Pötschke, S; Schlueter, N, 2012)
"Bulimia nervosa is characterized by purging behavior after binge eating episodes."	( Becker, S; Giel, KE; Kuprion, J; Lehr, J; Muthig, M; Teufel, M; Zipfel, S, 2013)
"Bulimia nervosa is an eating disorder defined by recurrent episodes of binge eating followed by compensatory behaviors, primarily self-induced vomiting."	( Cereda, E; Pedrolli, C; Sacchi, MC; Togni, M, 2015)
"Anorexia and bulimia nervosa are severe eating disorders that share many behaviors."	( Frank, GK; Pryor, TL; Riederer, J; Shott, ME, 2016)

Excerpt	Reference
"Bulimia nervosa has been associated with impaired satiety, decreased resting metabolic rate and abnormal neuroendocrine regulation."	( Agledahl, I; Birketvedt, GS; Drivenes, E; Florholmen, JR; Olstad, R; Sundsfjord, J, 2006)
"As bulimia nervosa has been associated with a dysregulated dopamine system and catecholamine depletion led to reward-processing deficits in remitted bulimia nervosa, the purpose of this study was to identify the role of catecholamine dysfunction and its relation to behavioral and neural reward-effort integration in bulimia nervosa."	( Federspiel, A; Hasler, G; Morishima, Y; Mueller, SV; Schwab, S; Wiest, R, 2018)

Excerpt	Reference
"Double-blind treatment of severe bulimia nervosa subjects with ONDAN resulted in a rapid and significant decrease in binge-eating and vomiting compared to placebo controls."	( Eckert, ED; Faris, PL; Goodale, RL; Hartman, BK; Kim, SW; Meller, WH; Pardo, JV, 2006)
"In practice, in patients seeking treatment for bulimia nervosa, fluoxetine has been shown to provide only transient efficacy, and patients are exposed to the drug's adverse effects."	( , 2006)
"This study compared the best available treatment for bulimia nervosa, cognitive-behavioural therapy (CBT) augmented by fluoxetine if indicated, with a stepped-care treatment approach in order to enhance treatment effectiveness."	( Agras, S; Bryson, S; Crow, S; Fairburn, CG; Halmi, K; Kraemer, H; Mitchell, JE, 2011)
"Antidepressants are commonly used to treat bulimia nervosa; high-dose fluoxetine is a standard approach, but many other antidepressants can be used."	( Crow, SJ, 2019)
"Advances in the treatment of bulimia nervosa and binge-eating disorder (BN/BED) have been marred by our limited understanding of the underpinning neurobiology."	( Leslie, M; Martins, D; Paloyelis, Y; Rodan, S; Treasure, J; Zelaya, F, 2020)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	1 (0.35)	23.3326
1990's	1 (0.35)	12.5806
2000's	108 (37.50)	18.1394
2010's	145 (50.35)	28.8240
2020's	33 (11.46)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	1	0
acetic acid	low	1	0
chlorine	low	1	0
salicylic acid	low	1	0
bupropion	low	2	0
glycerol	low	1	0
hydrogen carbonate	low	1	0
kynurenine	low	1	0
uric acid	low	1	0
8-hydroxy-2-(di-n-propylamino)tetralin	low	1	0
1-(3-chlorophenyl)piperazine	medium	1	1
homovanillic acid	medium	2	1
phenytoin	low	1	0
baclofen	low	3	0
buspirone	medium	1	1
caffeine	low	3	0
carbamazepine	medium	3	1
citalopram	medium	1	1
desipramine	low	1	0
amphetamine	low	1	0
valproic acid	low	1	0
racemetirosine	medium	4	2
fluoxetine	medium	18	9
furosemide	low	1	0
lamotrigine	medium	4	2
maprotiline	low	1	0
memantine	medium	3	1
methylphenidate	medium	3	1
octopamine	low	2	0
ondansetron	low	1	0
phenmetrazine	low	1	0
phenobarbital	low	1	0
risperidone	low	1	0
sibutramine	medium	5	2
tyramine	low	2	0
zonisamide	medium	2	1
thyroxine	low	1	0
dextroamphetamine	low	1	0
spironolactone	medium	2	1
sucrose	low	3	0
carbostyril	low	2	0
tyrosine	low	1	0
methionine	low	1	0
valine	low	1	0
tryptophan	medium	3	1
thiophenes	low	1	0
yohimbine	low	1	0
isoxazoles	medium	2	1
thiazoles	low	1	0
pyrazines	low	1	0
alpha-aminopyridine	low	1	0
dihydrotestosterone	low	2	0
methoxyhydroxyphenylglycol	medium	1	1
dehydroepiandrosterone sulfate	low	1	0
s,n,n'-tripropylthiocarbamate	medium	48	3
5-hydroxyindole	low	1	0
iodinated glycerol	low	1	0
titanium	low	1	0
zirconium	low	1	0
deuterium	low	1	0
iodine	low	1	0
carbimazole	low	1	0
cetylpyridinium chloride anhydrous	low	1	0
transferrin	low	1	0
glutamic acid	low	1	0
oxcarbazepine	low	1	0
hydroxymaprotilin	low	1	0
paroxetine	medium	2	1
fomesafen	low	1	0
atomoxetine hydrochloride	medium	1	1
aripiprazole	low	2	0
duloxetine hydrochloride	low	1	0
dexfenfluramine	low	1	0
sertraline	medium	3	2
trichlorosucrose	low	2	0
homocysteine	low	2	0
melamine phosphate	low	3	0
reboxetine	medium	2	1
aspartame	medium	1	1
psyllium	low	1	0
lithium chloride	low	1	0
oxytocin	medium	9	4
cocaine	low	4	0
propylthiouracil	low	1	0
cotinine	low	1	0
D-fructopyranose	medium	8	3
pica	low	1	0
raclopride	low	1	0
orlistat	medium	3	1
mcn 5652	low	2	0
vitamin k semiquinone radical	low	1	0
cholecalciferol	low	1	0
alpha-linolenic acid	low	1	0
humulene	low	1	0
isotretinoin	low	1	0
naloxone	low	1	0
oxycodone	low	1	0
fluvoxamine	low	2	0
naltrexone	medium	4	2
heroin	low	1	0
cinanserin	low	1	0
enkephalin, ala(2)-mephe(4)-gly(5)-	low	1	0
morphinans	low	1	0
qsymia	medium	1	1
mocetinostat	low	1	0
mk-9470	low	2	0
2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine	low	1	0
technetium tc 99m exametazime	low	2	0
pituitrin	low	1	0
cholecystokinin	medium	8	2
motilin	medium	1	1
neuropeptide y	low	5	0
glucagon-like peptide 1	medium	4	1
c-peptide	low	1	0
ascorbic acid	low	1	0
peptide yy	medium	5	2
muramidase	low	1	0
exudates	low	1	0
folic acid	low	1	0
clozapine	medium	2	1
olanzapine	medium	5	1
cholestyramine resin	low	1	0
ego	low	5	0
leptin	medium	20	1

Protein Targets (1,073)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	8	0	0	8
5-hydroxytryptamine receptor 3E	0	6	1	8
acetylcholinesterase	12	0	0	12
TDP1 protein	31	0	0	31
cytochrome P450 2D6	24	0	0	24
v-jun sarcoma virus 17 oncogene homolog (avian)	14	0	0	14
cytochrome P450 2D6 isoform 1	9	0	0	9
cellular tumor antigen p53 isoform a	2	0	0	2
cytochrome P450 2C19 precursor	8	0	0	8
cytochrome P450 2C9 precursor	6	0	0	6
thyroid hormone receptor beta isoform a	14	0	0	14
thyroid hormone receptor beta isoform 2	31	0	0	31
huntingtin isoform 2	4	0	0	4
peripheral myelin protein 22	18	0	0	18
cytochrome P450 3A4 isoform 1	11	0	0	11
muscarinic acetylcholine receptor M1	13	0	0	13
Gamma-aminobutyric acid receptor subunit pi	11	7	0	18
Polyunsaturated fatty acid lipoxygenase ALOX15B	5	0	0	5
ATP-binding cassette sub-family C member 3	0	27	0	27
Multidrug resistance-associated protein 4	0	28	0	30
5-hydroxytryptamine receptor 3B	0	6	1	8
Bile salt export pump	0	41	0	41
Beta-1 adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	11	9	21
5-hydroxytryptamine receptor 2C	0	22	3	25
D(2) dopamine receptor	0	21	1	25
5-hydroxytryptamine receptor 2A	0	22	3	26
Gamma-aminobutyric acid receptor subunit beta-1	11	7	0	18
Alpha-1B adrenergic receptor	0	19	3	22
Gamma-aminobutyric acid receptor subunit delta	11	7	0	18
Gamma-aminobutyric acid receptor subunit gamma-2	11	7	2	20
D	0	13	0	13
5-hydroxytryptamine receptor 1A	0	23	4	29
Gamma-aminobutyric acid receptor subunit alpha-5	11	7	0	18
Gamma-aminobutyric acid receptor subunit alpha-3	11	7	0	18
Gamma-aminobutyric acid receptor subunit gamma-1	11	7	0	18
Gamma-aminobutyric acid receptor subunit alpha-2	11	7	0	18
Alpha-1D adrenergic receptor	0	16	3	20
5-hydroxytryptamine receptor 2A	0	20	1	23
5-hydroxytryptamine receptor 2C	0	21	2	23
Gamma-aminobutyric acid receptor subunit alpha-4	11	7	0	18
Gamma-aminobutyric acid receptor subunit gamma-3	11	7	0	18
5-hydroxytryptamine receptor 1B	0	18	3	22
5-hydroxytryptamine receptor 1D	0	11	3	15
Gamma-aminobutyric acid receptor subunit alpha-6	11	7	0	18
5-hydroxytryptamine receptor 1F	0	11	3	15
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 2B	0	21	4	25
Sodium-dependent serotonin transporter	0	30	6	36
5-hydroxytryptamine receptor 7	0	8	3	11
5-hydroxytryptamine receptor 7	0	8	0	8
Alpha-1B adrenergic receptor	0	7	0	8
Glutamate receptor ionotropic, NMDA 1	0	6	1	9
5-hydroxytryptamine receptor 2B	0	22	2	24
Alpha-1A adrenergic receptor	0	19	3	22
5-hydroxytryptamine receptor 3A	0	8	3	12
Histamine H2 receptor	9	1	0	11
5-hydroxytryptamine receptor 6	0	15	0	17
Beta-2 adrenergic receptor	0	1	0	1
D(2) dopamine receptor	0	23	0	23
Gamma-aminobutyric acid receptor subunit alpha-1	11	7	2	20
Gamma-aminobutyric acid receptor subunit beta-3	11	7	0	18
Gamma-aminobutyric acid receptor subunit beta-2	11	7	2	20
Glutamate receptor ionotropic, NMDA 2A	0	6	1	9
Glutamate receptor ionotropic, NMDA 2B	0	7	1	10
Glutamate receptor ionotropic, NMDA 2C	0	7	1	10
Glutamate receptor ionotropic, NMDA 2D	0	6	1	9
5-hydroxytryptamine receptor 3D	0	6	1	8
Glutamate receptor ionotropic, NMDA 3B	0	6	1	9
5-hydroxytryptamine receptor 3C	0	6	1	8
GABA theta subunit	11	7	0	18
Canalicular multispecific organic anion transporter 1	0	26	0	26
Gamma-aminobutyric acid receptor subunit epsilon	11	7	0	18
Glutamate receptor ionotropic, NMDA 3A	0	6	1	9
Phenylethanolamine N-methyltransferase	0	5	0	5
Sodium-dependent noradrenaline transporter	0	29	6	35
Sodium-dependent dopamine transporter	0	20	1	21
Sodium-dependent serotonin transporter	0	16	2	19
Sodium-dependent dopamine transporter	0	24	4	28
Transporter	0	16	0	16
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
15-lipoxygenase, partial	4	0	0	4
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
ATAD5 protein, partial	10	0	0	10
lysosomal alpha-glucosidase preproprotein	5	0	0	5
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
geminin	34	0	0	34
neuropeptide S receptor isoform A	4	0	0	4
DNA repair and recombination protein RadA	0	0	1	1
Leukotriene A-4 hydrolase	0	2	0	2
Tyrosinase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	1	2
Sulfotransferase 1E1	0	0	0	1
Sulfotransferase 1A1	0	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
DNA repair protein RAD51 homolog 1	0	0	1	1
large T antigen	0	1	0	1
phosphopantetheinyl transferase	11	0	0	11
euchromatic histone-lysine N-methyltransferase 2	33	0	0	33
mu-type opioid receptor isoform MOR-1	0	0	2	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	9	0	0	9
5-hydroxytryptamine receptor 2A	0	0	2	2
Cytochrome P450 3A4	0	14	0	15
Neuronal acetylcholine receptor subunit alpha-4	1	3	1	5
Cytochrome P450 2C9	0	11	0	12
Neuronal acetylcholine receptor subunit beta-2	1	2	1	4
Translocator protein	0	3	0	3
D(3) dopamine receptor	0	12	0	12
Alpha-2B adrenergic receptor	0	12	2	15
D(2) dopamine receptor	0	4	0	4
Alpha-2C adrenergic receptor	0	12	2	15
Alpha-2A adrenergic receptor	0	13	2	16
Alpha-1D adrenergic receptor	0	16	0	17
5-hydroxytryptamine receptor 1D	0	1	0	2
5-hydroxytryptamine receptor 1B	0	1	1	2
Alpha-1A adrenergic receptor	0	8	0	9
5-hydroxytryptamine receptor 3A	0	6	4	10
5-hydroxytryptamine receptor 5A	0	2	0	2
5-hydroxytryptamine receptor 7	0	5	0	5
D	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	20	0	20
5-hydroxytryptamine receptor 3B	0	6	4	10
Lysosomal alpha-glucosidase	0	3	0	3
ATP-dependent phosphofructokinase	14	0	0	14
estrogen nuclear receptor alpha	44	0	0	44
Free fatty acid receptor 3	0	0	1	1
Free fatty acid receptor 2	0	1	1	2
Tyrosine-protein kinase Lck	0	0	1	1
Tyrosine-protein kinase Fyn	0	0	1	1
Fibrinogen C domain-containing protein 1	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	5	0	0	5
Chain A, 2-oxoglutarate Oxygenase	10	0	0	10
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
dopamine D1 receptor	4	0	0	4
pregnane X receptor	3	0	0	3
RAR-related orphan receptor gamma	25	0	0	25
USP1 protein, partial	14	0	0	14
NFKB1 protein, partial	5	0	0	5
Microtubule-associated protein tau	12	0	0	12
Thrombopoietin	3	0	0	3
AR protein	33	0	0	33
regulator of G-protein signaling 4	17	0	0	17
glucocorticoid receptor [Homo sapiens]	24	0	0	24
retinoic acid nuclear receptor alpha variant 1	30	0	0	30
retinoid X nuclear receptor alpha	20	0	0	20
farnesoid X nuclear receptor	12	0	0	12
vitamin D (1,25- dihydroxyvitamin D3) receptor	20	0	0	20
arylsulfatase A	14	0	0	14
Bloom syndrome protein isoform 1	10	0	0	10
D(1A) dopamine receptor	17	0	0	17
heat shock protein beta-1	7	0	0	7
flap endonuclease 1	5	0	0	5
survival motor neuron protein isoform d	8	0	0	8
Histone deacetylase 3	0	6	0	6
Solute carrier family 22 member 6	0	3	0	3
Histone deacetylase 4	0	5	0	5
Guanine nucleotide-binding protein G	1	0	0	1
Histone deacetylase 1	0	6	0	6
Histone deacetylase 7	0	5	0	5
Histone deacetylase 2	0	6	0	6
Polyamine deacetylase HDAC10	0	4	0	4
Histone deacetylase 11	0	5	0	5
Ataxin-2	15	0	0	15
Histone deacetylase 8	0	5	0	5
Histone deacetylase 6	0	5	0	5
Histone deacetylase 9	0	4	0	4
Histone deacetylase 5	0	5	0	5
Fumarate hydratase	8	0	0	8
EWS/FLI fusion protein	15	0	0	15
polyprotein	8	0	0	8
histone acetyltransferase KAT2A isoform 1	10	0	0	10
Cellular tumor antigen p53	21	0	0	21
Hydroxycarboxylic acid receptor 2	0	0	1	1
thyroid stimulating hormone receptor	11	0	0	11
Voltage-dependent calcium channel gamma-2 subunit	12	0	0	12
Heat shock protein HSP 90-alpha	0	0	1	1
Botulinum neurotoxin type A	0	1	0	1
Neutrophil cytosol factor 1	0	2	0	2
Glutamate receptor 2	12	2	1	15
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, brain	0	1	0	1
Nitric oxide synthase, brain	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Kappa-type opioid receptor	0	5	2	8
Phosphatidylinositol 4-kinase alpha	0	1	0	1
Mu-type opioid receptor	0	6	3	10
Tyrosine-protein kinase	0	0	1	1
Phosphatidylinositol 4-kinase type 2-beta	0	1	0	1
Phosphatidylinositol 4-kinase type 2-alpha	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	7	0	0	7
Chain A, Beta-lactamase	5	0	0	5
Chain A, HADH2 protein	6	0	0	6
Chain B, HADH2 protein	6	0	0	6
Chain A, Cruzipain	4	0	0	4
Luciferase	7	0	0	7
thioredoxin reductase	23	0	0	23
WRN	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	7	0	0	7
SMAD family member 2	5	0	0	5
GLS protein	17	0	0	17
SMAD family member 3	5	0	0	5
GLI family zinc finger 3	28	0	0	28
thioredoxin glutathione reductase	4	0	0	4
aldehyde dehydrogenase 1 family, member A1	13	0	0	13
estrogen receptor 2 (ER beta)	17	0	0	17
progesterone receptor	16	0	0	16
pregnane X nuclear receptor	24	0	0	24
peroxisome proliferator-activated receptor delta	16	0	0	16
peroxisome proliferator activated receptor gamma	19	0	0	19
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	17	0	0	17
activating transcription factor 6	10	0	0	10
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	12	0	0	12
Caspase-7	3	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
phospholipase A2 precursor	0	1	0	1
vitamin D3 receptor isoform VDRA	9	0	0	9
caspase-3	3	0	0	3
importin subunit beta-1 isoform 1	3	0	0	3
serine/threonine-protein kinase PLK1	4	0	0	4
snurportin-1	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	28	0	0	28
DNA polymerase eta isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	6	0	0	6
cysteine protease ATG4B isoform a	0	1	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	3	0	0	3
DNA polymerase kappa isoform 1	7	0	0	7
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
lamin isoform A-delta10	16	0	0	16
Free fatty acid receptor 1	0	0	1	1
Prostaglandin G/H synthase 1	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
Trypsin	0	1	0	1
Coagulation factor VII	0	1	0	1
Aromatase	0	2	0	3
Tissue factor	0	2	0	2
Prostaglandin G/H synthase 1	0	3	0	3
Peroxisome proliferator-activated receptor gamma	0	0	3	3
Prostaglandin G/H synthase 2	0	1	0	1
Free fatty acid receptor 4	0	0	1	1
Solute carrier family 22 member 3	0	2	0	2
Cytochrome P450 2A6	0	3	0	3
Substance-P receptor	0	1	0	1
Cytochrome P450 2A5	0	2	0	2
5-hydroxytryptamine receptor 6	0	3	3	6
5-hydroxytryptamine receptor 5A	0	3	3	6
5-hydroxytryptamine receptor 5B	0	3	3	6
Sigma non-opioid intracellular receptor 1	0	5	0	5
5-hydroxytryptamine receptor 4	0	3	3	6
Beta-2 adrenergic receptor	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	9	1	10
PPM1D protein	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	20	0	0	20
estrogen-related nuclear receptor alpha	30	0	0	30
G	11	0	0	11
67.9K protein	6	0	0	6
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	5	0	0	5
potassium voltage-gated channel subfamily H member 2 isoform d	15	0	0	15
transcriptional regulator ERG isoform 3	5	0	0	5
nuclear receptor ROR-gamma isoform 1	10	0	0	10
Solute carrier family 22 member 2	0	5	0	6
5-hydroxytryptamine receptor 3A	0	2	1	3
Interferon beta	15	0	0	15
HLA class I histocompatibility antigen, B alpha chain	11	0	0	11
ATP-dependent translocase ABCB1	0	7	0	10
Alpha-2C adrenergic receptor	0	14	0	14
Muscarinic acetylcholine receptor M3	0	13	1	14
D(1A) dopamine receptor	0	10	0	12
D(4) dopamine receptor	0	7	0	9
D(1B) dopamine receptor	0	3	0	4
D(4) dopamine receptor	0	9	0	9
Histamine H1 receptor	0	4	0	4
Histamine H1 receptor	0	12	3	17
D(3) dopamine receptor	0	12	1	15
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	4	0	4
Spike glycoprotein	16	0	0	16
Inositol monophosphatase 1	8	0	0	8
Potassium voltage-gated channel subfamily H member 2	0	30	0	30
Multidrug and toxin extrusion protein 2	0	4	0	4
Inositol hexakisphosphate kinase 1	11	0	0	11
Multidrug and toxin extrusion protein 1	0	7	0	7
Histamine H3 receptor	0	6	0	6
cytochrome P450 2C9, partial	11	0	0	11
Chain A, Hyaluronidase, phage associated	0	1	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	18	0	0	18
IDH1	8	0	0	8
chromobox protein homolog 1	14	0	0	14
lethal factor (plasmid)	5	0	0	5
Polyphenol oxidase 2	0	2	0	5
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	19	1	20
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
thyroid stimulating hormone receptor	11	0	0	11
aryl hydrocarbon receptor	8	0	0	8
glp-1 receptor, partial	9	0	0	9
Gamma-aminobutyric acid type B receptor subunit 2	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 2	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 1	0	2	0	2
Acetylcholine receptor subunit alpha	0	1	0	1
Acetylcholine receptor subunit gamma	0	1	0	1
Integrin alpha-5	0	1	0	1
Acetylcholine receptor subunit beta	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	2	0	4
Neuronal acetylcholine receptor subunit beta-2	0	3	0	4
UDP-glucuronosyltransferase 1-6	0	1	0	2
Cytochrome P450 2B6	0	0	1	3
UDP-glucuronosyltransferase 1A1	0	2	0	3
UDP-glucuronosyltransferase 1A4	0	1	0	3
Neuronal acetylcholine receptor subunit beta-4	0	2	0	3
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Cytochrome P450 2C19	0	7	0	8
UDP-glucuronosyltransferase 2B10	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	3	0	4
Acetylcholine receptor subunit delta	0	1	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
Bile salt export pump	0	6	0	6
Beta-2 adrenergic receptor	0	4	0	4
Angiotensin-converting enzyme	0	1	0	1
Beta-1 adrenergic receptor	0	4	0	4
D(1B) dopamine receptor	0	7	0	7
Beta-3 adrenergic receptor	0	3	0	3
Alpha-2A adrenergic receptor	0	1	0	1
D	0	3	0	3
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, glycogen phosphorylase, liver form	0	0	2	2
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, Chitinase	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
DNA polymerase beta	3	0	0	3
Potassium channel subfamily K member 2	0	1	1	2
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	1	0	1
Carbonic anhydrase 1	0	12	0	19
Carbonic anhydrase 2	0	14	3	24
Cholinesterase	0	1	0	1
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	2	0	2
Adenosine receptor A3	0	3	0	3
Replicase polyprotein 1ab	0	2	0	2
Amine oxidase [flavin-containing] A	0	2	0	3
Acetylcholinesterase	0	5	0	5
Adenosine receptor A1	0	4	0	6
Amine oxidase [flavin-containing] B	0	4	0	5
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	3	0	3
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	2	1	4
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	2	0	3
Adenosine receptor A1	0	2	1	5
Adenosine receptor A2a	0	2	0	5
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	2	0	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	2	3
Endochitinase B1	0	1	0	1
Muscarinic acetylcholine receptor	0	1	0	2
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	2
Guanine deaminase	0	2	0	2
mitogen-activated protein kinase 1	6	0	0	6
Vpr	3	0	0	3
Albumin	0	0	4	4
Major prion protein	0	0	1	1
Sodium channel protein type 1 subunit alpha	0	4	0	4
Sodium channel protein type 2 subunit alpha	0	5	0	5
Sodium channel protein type 3 subunit alpha	0	3	0	3
Sodium channel protein type 4 subunit alpha	0	3	0	6
Cytochrome P450 2J2	0	8	0	9
Sodium channel protein type 9 subunit alpha	0	4	0	4
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	3	0	3
Lactoperoxidase	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	7	0	0	7
Chain A, serum paraoxonase	0	1	0	1
Carbonic anhydrase 12	0	6	0	11
Carbonic anhydrase 3	0	6	0	8
Carbonic anhydrase 4	0	9	0	15
Carbonic anhydrase 6	0	6	0	11
Carbonic anhydrase 5A, mitochondrial	0	6	2	13
Carbonic anhydrase 7	0	6	0	11
Carbonic anhydrase 9	0	8	1	14
Carbonic anhydrase 13	0	4	0	4
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
Carbonic anhydrase 14	0	6	0	11
Carbonic anhydrase 5B, mitochondrial	0	6	0	11
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
Carbonic anhydrase 4	0	2	0	3
Chain A, Ferritin light chain	7	0	0	7
caspase 7, apoptosis-related cysteine protease	5	0	0	5
caspase-3	5	0	0	5
thyrotropin-releasing hormone receptor	3	0	0	3
Caspase-2	0	0	1	1
ATPase family AAA domain-containing protein 5	7	0	0	7
Carbonic anhydrase	0	4	0	6
Carbonic anhydrase 15	0	6	0	8
interleukin 8	3	0	0	3
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	2	0	2
Vitamin D3 receptor	0	1	1	4
Glycine receptor subunit alpha-1	0	0	2	2
Vitamin D3 receptor	0	0	1	1
Nuclear receptor ROR-gamma	3	0	0	3
10 kDa heat shock protein, mitochondrial	0	2	0	2
Thiosulfate sulfurtransferase	0	2	0	2
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
histone deacetylase 9 isoform 3	1	0	0	1
Platelet glycoprotein VI	0	1	1	2
NPC intracellular cholesterol transporter 1 precursor	5	0	0	5
Solute carrier family 22 member 1	0	7	0	8
Sodium-dependent noradrenaline transporter	0	3	0	3
5-hydroxytryptamine receptor 4	0	14	0	14
Aldo-keto reductase family 1 member B1	0	15	0	15
Tryptophan 5-hydroxylase 1	0	4	0	4
Angiotensin-converting enzyme	0	15	0	15
Aldo-keto reductase family 1 member B1	0	3	0	3
Aromatase	0	1	0	1
Sigma intracellular receptor 2	0	4	0	4
Sodium-dependent serotonin transporter	0	3	0	3
Sodium-dependent dopamine transporter	0	5	0	5
Nuclear receptor subfamily 3 group C member 3	0	15	0	15
Beta-1 adrenergic receptor	0	1	0	1
glucocerebrosidase	3	0	0	3
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
Adenylate cyclase type 1	0	1	0	1
Histone H2A.x	7	0	0	7
peripheral myelin protein 22 isoform 1	6	0	0	6
atrial natriuretic peptide receptor 2 precursor	5	0	0	5
short transient receptor potential channel 6 isoform 1	0	0	1	1
M-phase phosphoprotein 8	5	0	0	5
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	4	0	4
Muscarinic acetylcholine receptor M2	0	10	1	11
Muscarinic acetylcholine receptor M4	0	11	1	12
Muscarinic acetylcholine receptor M1	0	5	0	5
Muscarinic acetylcholine receptor M3	0	4	0	4
Muscarinic acetylcholine receptor M4	0	3	0	3
Muscarinic acetylcholine receptor M5	0	3	0	3
Muscarinic acetylcholine receptor M5	0	13	0	13
Alpha-2A adrenergic receptor	0	14	1	15
Calmodulin-1	0	1	0	1
Cytochrome P450 2D6	0	11	0	13
Muscarinic acetylcholine receptor M2	0	4	0	4
Muscarinic acetylcholine receptor M1	0	12	2	14
Endothelin receptor type B	0	1	0	1
Adenylate cyclase type 3	0	1	0	1
5-hydroxytryptamine receptor 3A	0	2	0	2
Endothelin receptor type B	0	1	0	1
Histamine H2 receptor	0	6	0	6
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
Histamine H1 receptor	0	4	0	4
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
Adenylate cyclase type 8	0	1	0	1
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
D(2) dopamine receptor	0	3	0	3
Calmodulin	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	4	0	4
5-hydroxytryptamine receptor 2B	0	2	0	2
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 5	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
Transporter	0	4	0	4
Cholecystokinin receptor type A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	2	0	2
Adenylyl cyclase 7	0	1	0	1
Histamine H4 receptor	0	1	1	2
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	4	0	4
Gamma-aminobutyric acid receptor subunit delta	0	4	0	4
Amyloid-beta precursor protein	0	1	0	1
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	4	1	5
Gamma-aminobutyric acid receptor subunit beta-1	0	4	1	5
Gamma-aminobutyric acid receptor subunit gamma-2	0	4	1	5
Liver carboxylesterase 1	0	1	0	3
Gamma-aminobutyric acid receptor subunit beta-3	0	4	1	5
Gamma-aminobutyric acid receptor subunit alpha-5	0	4	1	5
Gamma-aminobutyric acid receptor subunit alpha-3	0	4	1	5
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	4	1	5
Gamma-aminobutyric acid receptor subunit beta-2	0	4	1	5
Gamma-aminobutyric acid receptor subunit alpha-4	0	4	1	5
Gamma-aminobutyric acid receptor subunit epsilon	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	4	1	5
Gamma-aminobutyric acid receptor subunit gamma-1	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-3	0	4	0	4
Leukotriene B4 receptor 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	4	0	4
GALC protein	4	0	0	4
Cytochrome P450 1A2	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	2
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Steryl-sulfatase	0	0	0	1
Multidrug resistance-associated protein 1	0	0	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	3
G-protein coupled bile acid receptor 1	0	0	2	2
ATP-binding cassette sub-family C member 11	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	0	0	2
serine/threonine-protein kinase mTOR isoform 1	8	0	0	8
Solute carrier family 22 member 3	0	2	0	2
Albumin	0	2	2	4
Prostaglandin G/H synthase 1	0	1	0	1
D(1A) dopamine receptor	5	0	0	5
Voltage-dependent N-type calcium channel subunit alpha-1B	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	5	0	5
Solute carrier family 22 member 1	0	2	0	2
Histamine H3 receptor	0	2	0	3
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 4	0	1	0	1
Amine oxidase [flavin-containing] B	0	2	0	2
Amine oxidase [flavin-containing] B	0	1	0	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	2	2
Trace amine-associated receptor 1	0	0	3	3
Trace amine-associated receptor 1	0	0	3	3
Chain A, Sex Hormone-Binding Globulin	0	0	1	1
Plasma kallikrein	0	1	0	3
Glucocorticoid receptor	0	3	1	5
Sex hormone-binding globulin	0	1	1	2
Progesterone receptor	0	1	0	1
Progesterone receptor	0	3	2	5
Glucocorticoid receptor	0	1	0	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	3	0	4
Sex hormone-binding globulin	0	1	0	1
Androgen receptor	0	4	3	9
Androgen receptor	0	4	1	6
Androgen receptor	0	1	1	2
Mineralocorticoid receptor	0	1	0	1
Testosterone 17-beta-dehydrogenase 3	0	1	0	1
Angiotensin-converting enzyme	0	0	1	1
Cannabinoid receptor 2	0	1	0	1
Neuropeptide FF receptor 2	0	0	0	1
ALK tyrosine kinase receptor	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Smad3	5	0	0	5
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
Alpha-synuclein	2	0	0	2
Motilin receptor	0	0	1	1
acid sphingomyelinase	2	0	0	2
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
streptokinase A precursor	0	0	1	1
Motilin receptor	0	1	1	2
Rap guanine nucleotide exchange factor 3	5	0	0	5
30S ribosomal protein S6	0	1	1	2
30S ribosomal protein S7	0	1	1	2
50S ribosomal protein L15	0	1	1	2
ATP-dependent translocase ABCB1	0	2	0	2
50S ribosomal protein L10	0	1	1	2
50S ribosomal protein L11	0	1	1	2
50S ribosomal protein L7/L12	0	1	1	2
50S ribosomal protein L19	0	1	1	2
50S ribosomal protein L1	0	1	1	2
50S ribosomal protein L20	0	1	1	2
50S ribosomal protein L27	0	1	1	2
50S ribosomal protein L28	0	1	1	2
50S ribosomal protein L29	0	1	1	2
50S ribosomal protein L31	0	1	1	2
50S ribosomal protein L31 type B	0	1	1	2
50S ribosomal protein L32	0	1	1	2
50S ribosomal protein L33	0	1	1	2
50S ribosomal protein L34	0	1	1	2
50S ribosomal protein L35	0	1	1	2
50S ribosomal protein L36	0	1	1	2
30S ribosomal protein S10	0	1	1	2
30S ribosomal protein S11	0	1	1	2
30S ribosomal protein S12	0	1	1	2
30S ribosomal protein S13	0	1	1	2
30S ribosomal protein S16	0	1	1	2
30S ribosomal protein S18	0	1	1	2
30S ribosomal protein S19	0	1	1	2
30S ribosomal protein S20	0	1	1	2
30S ribosomal protein S2	0	1	1	2
30S ribosomal protein S3	0	1	1	2
30S ribosomal protein S4	0	1	1	2
30S ribosomal protein S5	0	1	1	2
30S ribosomal protein S8	0	1	1	2
30S ribosomal protein S9	0	1	1	2
50S ribosomal protein L13	0	1	1	2
50S ribosomal protein L14	0	1	1	2
50S ribosomal protein L16	0	1	1	2
50S ribosomal protein L23	0	1	1	2
30S ribosomal protein S15	0	1	1	2
50S ribosomal protein L17	0	1	1	2
50S ribosomal protein L21	0	1	1	2
50S ribosomal protein L30	0	1	1	2
50S ribosomal protein L6	0	1	1	2
30S ribosomal protein S14	0	1	1	2
30S ribosomal protein S17	0	1	1	2
30S ribosomal protein S1	0	1	1	2
50S ribosomal protein L18	0	1	1	2
Chitinase B	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
50S ribosomal protein L2	0	1	1	2
50S ribosomal protein L3	0	1	1	2
50S ribosomal protein L24	0	1	1	2
50S ribosomal protein L4	0	1	1	2
50S ribosomal protein L22	0	1	1	2
50S ribosomal protein L5	0	1	1	2
30S ribosomal protein S21	0	1	1	2
50S ribosomal protein L25	0	1	1	2
Cytochrome P450 1B1	0	2	0	2
Lanosterol 14-alpha demethylase	0	1	0	1
50S ribosomal protein L36 2	0	1	1	2
ras-related protein Rab-9A	4	0	0	4
Cytochrome P450 2C8	0	2	0	2
Dipeptidyl peptidase 4	0	1	0	1
Acetylcholinesterase	0	1	0	1
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Chain A, Dihydrofolate reductase	0	0	1	1
alpha-galactosidase	1	0	0	1
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	1	3
Aldo-keto reductase family 1 member B1	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Serum paraoxonase/arylesterase 1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Carbonic anhydrase 13	0	3	0	7
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Gamma-aminobutyric acid	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	0	1	1	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
TAR DNA-binding protein 43	1	0	0	1
Sterol O-acyltransferase 1	0	0	1	1
Proton-coupled amino acid transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit pi	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit theta	0	1	1	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	1	2
Glucagon-like peptide 1 receptor	0	0	1	1
Glucagon-like peptide 1 receptor	0	1	1	2
Glucagon receptor	0	0	1	1
Glucagon receptor	0	0	1	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Excitatory amino acid transporter 4	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
Integrin beta-3	0	1	1	2
Integrin alpha-IIb	0	1	1	2
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	2	0	2
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	3	0	3
Glutamate receptor ionotropic, NMDA 2A	0	3	0	3
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	3	0	3
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	3
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
ClpP	2	0	0	2
Solute carrier family 22 member 8	0	0	0	1
Parkin	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
Ornithine decarboxylase	0	0	0	1
Retinoic acid receptor alpha	0	1	0	1
Retinoic acid receptor gamma	0	1	0	1
Retinoic acid receptor beta	0	1	0	1
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	0	1
Retinoic acid receptor RXR-beta	0	1	0	1
Retinoic acid receptor RXR-gamma	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	1
Cellular retinoic acid-binding protein 1	0	0	1	1
Mitogen-activated protein kinase 14	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Olfactory receptor 51E2	0	1	0	1
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	3	0	3
Sodium channel protein type 3 subunit alpha	0	3	0	3
Sodium channel protein type 10 subunit alpha	0	1	0	1
inositol monophosphatase 1	1	0	0	1
Cholecystokinin receptor type A	1	1	0	2
Gastrin/cholecystokinin type B receptor	1	1	0	2
Glycogen synthase kinase-3 beta	0	1	1	2
histone-lysine N-methyltransferase NSD2 isoform 1	0	0	0	1
MBT domain-containing protein 1	0	1	0	1
Lethal(3)malignant brain tumor-like protein 4	0	1	0	1
Lethal(3)malignant brain tumor-like protein 3	0	1	0	1
Lethal(3)malignant brain tumor-like protein 1	0	1	0	1
Acetylcholinesterase	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Cholinesterase	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	3	0	3
Large neutral amino acids transporter small subunit 1	0	4	0	4
Cannabinoid receptor 1	0	3	0	3
Cannabinoid receptor 2	0	2	0	2
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Integrin alpha-4	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Histidine decarboxylase	0	0	2	2
Delta-type opioid receptor	0	6	2	10
Delta-type opioid receptor	0	8	3	11
Kappa-type opioid receptor	0	4	2	7
Mu-type opioid receptor	0	8	3	11
Kappa-type opioid receptor	0	5	3	8
Mu-type opioid receptor	0	5	4	12
Delta-type opioid receptor	0	4	4	11
Kappa-type opioid receptor	0	4	4	12
Mu-type opioid receptor	0	3	2	7
UDP-glucuronosyltransferase 1A8	0	0	0	2
Nociceptin receptor	0	1	0	1
Neuropeptide Y receptor type 1	0	2	0	2
Neuropeptide Y receptor type 2	0	2	0	2
POU domain, class 2, transcription factor 1	0	0	0	1
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Interleukin-6 receptor subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Thyrotropin-releasing hormone receptor	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Glycine receptor subunit alpha-4	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Leukotriene B4 receptor 1	0	1	0	1
Nischarin	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Phosphatidylserine lipase ABHD16A	0	1	0	1
Pancreatic triacylglycerol lipase	0	2	0	3
Lipoprotein lipase	0	1	0	1
Hepatic triacylglycerol lipase	0	1	0	1
Pancreatic triacylglycerol lipase	0	1	0	1
Proteasome subunit beta type-1	0	1	0	1
Proteasome subunit beta type-5	0	1	0	1
Proteasome subunit beta type-2	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Neutral cholesterol ester hydrolase 1	0	1	0	1
Diacylglycerol lipase-alpha	0	1	0	1
Lysophosphatidylserine lipase ABHD12	0	1	0	1
Diacylglycerol lipase-beta	0	1	0	1
Monoacylglycerol lipase ABHD6	0	1	0	1
Acyl-protein thioesterase 2	0	1	0	1
Diacylglycerol lipase-alpha	0	1	0	1
Endothelial lipase	0	1	0	1
nonstructural protein 1	2	0	0	2
polyadenylate-binding protein 1	0	1	0	1
bcl-2-related protein A1	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	2	2	4
Vasopressin V1a receptor	0	1	0	1
Vasopressin V1a receptor	0	2	1	3
Vasopressin V1b receptor	0	1	1	2
Vasopressin V1b receptor	0	1	0	1
Oxytocin receptor	0	1	0	1
Oxytocin receptor	0	0	1	1
Vasopressin V2 receptor	0	1	0	1
Myeloperoxidase	0	3	0	3
Quinolone resistance protein NorA	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	1	2
Substance-P receptor	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
P2X purinoceptor 4	0	1	0	1
Envelope glycoprotein	0	0	2	2
Rhodopsin kinase GRK1	0	1	0	1
Beta-adrenergic receptor kinase 1	0	0	0	1
Sodium channel protein type 1 subunit alpha	0	2	0	2
endonuclease IV	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Dihydrofolate reductase	0	1	0	1
NADH-cytochrome b5 reductase 3	0	1	0	1
Thyroid peroxidase	0	1	0	1
Taste receptor type 2 member 38	0	0	1	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	1	0	2
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	1	1	2
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	1	0	2
Cystathionine gamma-lyase	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	2
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	2	0	2
Solute carrier family 22 member 6	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Transcriptional activator protein LuxR	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Chain A, Mineralocorticoid receptor	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Estrogen receptor	0	2	1	3
Glycine receptor subunit alpha-1	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Estrogen receptor beta	0	1	1	2
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
apical membrane antigen 1, AMA1	1	0	0	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Chain A, Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Prolyl endopeptidase	0	2	0	2
Carbonic anhydrase-related protein 11	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Arachidonate 5-lipoxygenase-activating protein	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	2	0	4
Carbonic anhydrase	0	2	0	2
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	2	0	4
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	2	0	4
Carbonic anhydrase	0	2	0	2
Delta carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	4
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 1	0	0	1	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Substance-P receptor	0	1	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
SLC16A10 protein	0	0	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Monocarboxylate transporter 10	0	0	0	2
Phospholipase A-2-activating protein	0	1	0	1
guanine nucleotide-binding protein subunit alpha-15	0	1	1	2
D(3) dopamine receptor isoform e	1	0	0	1
trace amine-associated receptor 1	0	1	1	2
Dopamine beta-hydroxylase	0	0	0	1
Beta-secretase 1	0	0	1	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Chain A, Arginase 1	0	1	0	1
Cocaine esterase	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
POsterior Segregation	0	0	1	1
DNA topoisomerase 1	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
M-phase inducer phosphatase 1	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Zinc finger protein mex-5	0	0	1	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Amine oxidase [flavin-containing]	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (288)

Protein Targets (1,073)

Bulimia Nervosa

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (288)

Drugs Studied (158)

Protein Targets (1,073)