Page last updated: 2024-08-05 12:46:16
4-hydroxy steroid
Any steroid bearing a 4-hydroxy substituent.
ChEBI ID: 62846
Members (8)
| Member | Definition | Role |
|---|---|---|
| 2,3-dihydro-3beta-methoxy withaferin A | A withanolide that is 2,3-dihydrowithaferin A substituted by a beta-methoxy group at position 3. It has been isolated from the aerial parts of Physalis longifolia. | 2,3-dihydro-3beta-methoxy withaferin A |
| 2,3-dihydro-3beta-O-sulfate withaferin A | A withanolide that is 2,3-dihydrowithaferin A substituted by a sulfoxy group at position 3. Isolated from Physalis longifolia, it exhibits antineoplastic activity. | 2,3-dihydro-3beta-O-sulfate withaferin A |
| 2,3-dihydrowithaferin A | A withanolide that is the 2,3-dihydro derivative of withaferin A. It has been isolated from the aerial parts of Physalis longifolia. | 2,3-dihydrowithaferin A |
| 4-hydroxyestradiol | A 4-hydroxy steroid that consists of 17beta-estradiol having an additional hydroxy group at position 4. | 4-hydroxy-17beta-estradiol |
| 4-hydroxyestrone | A 4-hydroxy steroid that is estrone substituted by a hydroxy group at position 4. | 4-hydroxyestrone |
| tubocapsanolide a | A withanolide that is 5beta,6beta:16alpha,17alpha-diepoxywitha-2,24-dienolide substituted by a hydroxy group at position 4 and an oxo group at position 1. Isolated from Tubocapsicum anomalum, it exhibits cytotoxic activity. | tubocapsanolide A |
| withaferin a | A withanolide that is 5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione substituted by hydroxy groups at positions 4 and 27 (the 4beta,5beta,6beta,22R stereoisomer). Isolated from Physalis longifolia, it exhibits cytotoxic activity. | withaferin A |
| withanolide d | A withanolide that is 5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione substituted by hydroxy groups at positions 4 and 22 (the 4beta,5beta,6beta,22R stereoisomer). Isolated from Tubocapsicum anomalum and Withania somnifera, it exhibits cytotoxic activity. | withanolide D |
Research
Studies (828)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 78 (9.42) | 18.7374 |
| 1990's | 55 (6.64) | 18.2507 |
| 2000's | 146 (17.63) | 29.6817 |
| 2010's | 392 (47.34) | 24.3611 |
| 2020's | 157 (18.96) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 24 (2.66%) | 5.53% |
| Reviews | 65 (7.21%) | 6.00% |
| Case Studies | 6 (0.67%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 806 (89.46%) | 84.16% |