An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of dimethylallyltranstransferase (EC 2.5.1.1).
ChEBI ID: 50643
| Member | Definition | Class |
|---|---|---|
| alendronate | A 1,1-bis(phosphonic acid) that is methanebis(phosphonic acid) in which the two methylene hydrogens are replaced by hydroxy and 3-aminopropyl groups. | alendronic acid |
| alendronate sodium | A hydride that is the trihydrate of alendronate sodium | alendronate sodium trihydrate |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 6 (0.15) | 18.7374 |
| 1990's | 415 (10.69) | 18.2507 |
| 2000's | 1,559 (40.15) | 29.6817 |
| 2010's | 1,499 (38.60) | 24.3611 |
| 2020's | 404 (10.40) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 731 (17.80%) | 5.53% |
| Reviews | 488 (11.88%) | 6.00% |
| Case Studies | 435 (10.59%) | 4.05% |
| Observational | 25 (0.61%) | 0.25% |
| Other | 2,428 (59.12%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 2.6832 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 27,450.0000 | 1 | 1 |
| Chain A, farnesyl pyrophosphate synthase | Trypanosoma cruzi | IC50 | 147.0000 | 1 | 1 |
| Farnesyl pyrophosphate synthase | Homo sapiens (human) | IC50 | 0.7523 | 6 | 6 |
| Farnesyl pyrophosphate synthase | Homo sapiens (human) | Ki | 0.1761 | 3 | 3 |
| Farnesyl pyrophosphate synthase | Leishmania donovani | Ki | 0.0950 | 1 | 1 |
| Farnesyl pyrophosphate synthase | Leishmania major | Ki | 0.0910 | 1 | 1 |
| Geranylgeranyl pyrophosphate synthase | Homo sapiens (human) | IC50 | 427.7868 | 3 | 4 |
| Hypoxanthine-guanine phosphoribosyltransferase | Trypanosoma brucei brucei | Ki | 188.6000 | 1 | 1 |