Page last updated: 2024-11-13

preechinulin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID44445554
CHEMBL ID249258
CHEBI ID193003

Synonyms (13)

Synonym
CHEMBL249258
preechinulin
21008-43-5
cyclo-l-2-tert-dma-trp-l-ala
CHEBI:193003
NFA24NXF2J ,
2,5-piperazinedione, 3-((2-(1,1-dimethyl-2-propen-1-yl)-1h-indol-3-yl)methyl)-6-methyl-, (3s,6s)-
2,5-piperazinedione, 3-((2-(1,1-dimethyl-2-propenyl)-1h-indol-3-yl)methyl)-6-methyl-, (3s-cis)-
unii-nfa24nxf2j
NCGC00386110-01
ncgc00386110-01_c19h23n3o2_(3s,6s)-3-methyl-6-{[2-(2-methyl-3-buten-2-yl)-1h-indol-3-yl]methyl}-2,5-piperazinedione
Q27284843
AKOS040735363

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019
)
0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
2,5-diketopiperazinesAny piperazinone that has a piperazine-2,5-dione skeleton.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (12)

Assay IDTitleYearJournalArticle
AID1347160Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347159Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1200482Antiviral activity against influenza A virus A/WSN/33 (H1N1) infected in MDCK cells assessed as reduction in cytopathic effect at 100 uM after 48 hrs by plaque assay2015European journal of medicinal chemistry, Mar-26, Volume: 93Neoechinulin B and its analogues as potential entry inhibitors of influenza viruses, targeting viral hemagglutinin.
AID1818937Cytotoxicity against African green monkey Vero E6 cells expressing TMPRSS2 assessed as reduction in cell viability incubated for 24 hrs by DAPI staining based confocal microscopic analysis2022Journal of natural products, 01-28, Volume: 85, Issue:1
Synthesis and Antiviral Activities of Neoechinulin B and Its Derivatives.
AID1818932Antiviral activity against HCV JFH-1 infected in human Huh-7.5.1 cells assessed as reduction in viral replication measured after 72 hrs by chemiluminescent enzyme immunoassay2022Journal of natural products, 01-28, Volume: 85, Issue:1
Synthesis and Antiviral Activities of Neoechinulin B and Its Derivatives.
AID311562DPPH radical scavenging activity2007Journal of natural products, Oct, Volume: 70, Issue:10
Isoechinulin-type alkaloids, variecolorins A-L, from halotolerant Aspergillus variecolor.
AID1200484Cytotoxicity against MDCK cells assessed as cell growth after 40 hrs by CellTiter-Glo assay2015European journal of medicinal chemistry, Mar-26, Volume: 93Neoechinulin B and its analogues as potential entry inhibitors of influenza viruses, targeting viral hemagglutinin.
AID1818936Antiviral activity against SARS-CoV-2 WK-251 infected in African green monkey Vero E6 cells expressing TMPRSS2 assessed as reduction in viral RNA replication incubated for 24 hrs by qRT-PCR analysis2022Journal of natural products, 01-28, Volume: 85, Issue:1
Synthesis and Antiviral Activities of Neoechinulin B and Its Derivatives.
AID1818933Cytotoxicity against human Huh-7.5.1 cells assessed as reduction in cell viability measured at 72 hrs by MTT assay2022Journal of natural products, 01-28, Volume: 85, Issue:1
Synthesis and Antiviral Activities of Neoechinulin B and Its Derivatives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's2 (33.33)24.3611
2020's3 (50.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.18

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.18 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index5.12 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.18)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]