Page last updated: 2024-08-05 15:00:04
ferroptosis inhibitor
Any substance that inhibits the process of ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms.
ChEBI ID: 173084
Members (29)
| Member | Definition | Class |
|---|---|---|
| 2,2'-dipyridyl | A bipyridine in which the two pyridine moieties are linked by a bond between positions C-2 and C-2'. | 2,2'-bipyridine |
| 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid | A chromanol that is 6-hydroxychromane which is substituted by a carboxy group at position 2 and by methyl groups at positions 2, 5, 7, and 8. A cell-permeable, water-soluble analogue of vitamin E, it is used as a standard for measuring the antioxidant capacity of complex mixtures. | Trolox |
| aa 861 | A member of the class of benzoquinones that is p-benzoquinone in which the hydrogens are substituted by three methyl groups and a 12-hydroxydodeca-5,10-diyn-1-yl group. | docebenone |
| acetylcysteine | An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine. | N-acetyl-L-cysteine |
| ammonium chloride | An inorganic chloride having ammonium as the counterion. | ammonium chloride |
| bafilomycin a1 | The most used of the bafilomycins, a family of toxic macrolide antibiotics derived from Streptomyces griseus. | bafilomycin A1 |
| baicalein | A trihydroxyflavone with the hydroxy groups at positions C-5, -6 and -7. | baicalein |
| baicalin | The glycosyloxyflavone which is the 7-O-glucuronide of baicalein. It is an active ingredient of Chinese herbal medicine Scutellaria baicalensis. | baicalin |
| beta carotene | A cyclic carotene obtained by dimerisation of all-trans-retinol. A strongly-coloured red-orange pigment abundant in plants and fruit and the most active and important provitamin A carotenoid. | beta-carotene |
| butylated hydroxytoluene | A member of the class of phenols that is 4-methylphenol substituted by tert-butyl groups at positions 2 and 6. | 2,6-di-tert-butyl-4-methylphenol |
| coenzyme q10 | A ubiquinone having a side chain of 10 isoprenoid units. In the naturally occurring isomer, all isoprenyl double bonds are in the E- configuration. | coenzyme Q10 |
| cycloheximide | A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus. | cycloheximide |
| deferoxamine | An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator. | desferrioxamine B |
| desferrioxamine b mesylate | A methanesulfonate salt obtained by reaction of desferrioxamine B with one molar equivalent of methanesulfonic acid. It is an iron-chelating medicine used to remove excess iron from the body. It binds to iron in the blood, which is then passed out in the urine. | desferrioxamine B mesylate |
| diphenylamine | An aromatic amine containing two phenyl substituents. It has been used as a fungicide for the treatment of superficial scald in apples and pears, but is no longer approved for this purpose within the European Union. | diphenylamine |
| ebselen | A benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase. | ebselen |
| ferrostatin-1 | An ethyl ester resulting from the formal condensation of the carboxy group of 3-amino-4-(cyclohexylamino)benzoic acid with ethanol. It is a potent inhibitor of ferroptosis, a distinct non-apoptotic form of cell death caused by lipid peroxidation. It is also a radical-trapping antioxidant and has the ability to reduce the accumulation of lipid peroxides and chain-carrying peroxyl radicals. | ferrostatin-1 |
| idebenone | A member of the class of 1,4-benzoquinones which is substituted by methoxy groups at positions 2 and 3, by a methyl group at positions 5, and by a 10-hydroxydecyl group at positions 6. Initially developed for the treatment of Alzheimer's disease, benefits were modest; it was subsequently found to be of benefit for the symptomatic treatment of Friedreich's ataxia. | idebenone |
| liproxstatin-1 | An azaspiro compound that is 1'H-spiro[piperidine-4,2'-quinoxaline] in which the hydrogen at position 3' is replaced by a (3-chlorobenzyl)amino group. It is a potent inhibitor of ferroptosis. | liproxstatin-1 |
| masoprocol | A tetrol that is butane which is substituted at positions 2 and 3 by 3,4-dihydroxybenzyl groups. Masoprocol, the meso-form found in the leaves of the creosote bush (Larrea divaricata), is a potent lipoxygenase inhibitor. | nordihydroguaiaretic acid |
| pd 146176 | An organic heterotetracyclic compound that is 1H-indole which is ortho-fused to a 2H-1-benzothiopyran group at positions 2-3. It is an inhibitor of 15-lipoxygenase that limits atherosclerotic lesion development in rabbits. | PD-146176 |
| phenothiazine | The 10H-tautomer of phenothiazine. | 10H-phenothiazine |
| phenoxazine | A member of the class of phenoxazines that is morpholine which is ortho-fused to two benzene rings at positions 2-3 and 5-6. | 10H-phenoxazine |
| pioglitazone | A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity. | pioglitazone |
| rosiglitazone | rosiglitazone | |
| tempo | A member of the class of aminoxyls that is piperidine that carries an oxidanediyl group at position 1 and methyl groups at positions 2, 2, 6, and 6, respectively. | TEMPO |
| tocotrienol, alpha | A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2, 5, 7 and 8 and a farnesyl chain at position 2. It has been found in palm oil derived from Elaeis guineensis. | alpha-tocotrienol |
| troglitazone | troglitazone | |
| zileuton | A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogen at position 2 is replaced by a 1-[carbamoyl(hydroxy)amino]ethyl group. A selective 5-lipoxygenase inhibitor, it inhibits the formation of leukotrienes LTB4, LTC4, LDT4, and LTE4. It is used for the management of chronic asthma. | zileuton |
Research
Studies (77,869)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 19,301 (24.79) | 18.7374 |
| 1990's | 14,388 (18.48) | 18.2507 |
| 2000's | 19,474 (25.01) | 29.6817 |
| 2010's | 19,583 (25.15) | 24.3611 |
| 2020's | 5,123 (6.58) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 4,442 (5.32%) | 5.53% |
| Reviews | 4,311 (5.16%) | 6.00% |
| Case Studies | 1,611 (1.93%) | 4.05% |
| Observational | 85 (0.10%) | 0.25% |
| Other | 73,118 (87.50%) | 84.16% |
Protein Targets (518)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 13.1363 | 1 | 10 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 2.6987 | 1 | 7 |
| 2,3-bisphosphoglycerate-independent phosphoglycerate mutase | Leishmania major strain Friedlin | Potency | 7.5686 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 11.1577 | 2 | 4 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 49.5930 | 3 | 7 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 34.6441 | 2 | 7 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 15.4778 | 1 | 15 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 32.4648 | 2 | 2 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 3.7547 | 1 | 4 |
| Amyloid-beta precursor protein | Homo sapiens (human) | Potency | 16.3601 | 1 | 1 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 9.9398 | 1 | 5 |
| AR protein | Homo sapiens (human) | Potency | 22.3447 | 11 | 78 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 24.0030 | 2 | 12 |
| arylsulfatase A | Homo sapiens (human) | Potency | 17.9304 | 1 | 3 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 13.7801 | 3 | 7 |
| Ataxin-2 | Homo sapiens (human) | Potency | 7.5244 | 2 | 6 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 12.6709 | 5 | 9 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 2.4865 | 2 | 6 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 6.7456 | 1 | 1 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 26.1216 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 5.2515 | 2 | 8 |
| BRCA1 | Homo sapiens (human) | Potency | 10.8820 | 1 | 2 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 36.6728 | 1 | 5 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 76.9588 | 1 | 1 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 76.9588 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 40.8834 | 3 | 18 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 8.8859 | 2 | 5 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 16.1273 | 1 | 17 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 28.2856 | 4 | 11 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 36.8266 | 2 | 4 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 26.6514 | 2 | 2 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 20.1277 | 2 | 5 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 8.2221 | 2 | 11 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 50.8162 | 1 | 7 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 15.2712 | 3 | 16 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 17.5942 | 3 | 15 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 17.1572 | 1 | 15 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 8.2221 | 2 | 11 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 36.2202 | 2 | 9 |
| ClpP | Bacillus subtilis | Potency | 31.6228 | 1 | 1 |
| core-binding factor subunit beta isoform 2 | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 2.9336 | 1 | 4 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 2.7758 | 1 | 4 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 9.5340 | 1 | 5 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 14.3029 | 1 | 4 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 18.5614 | 1 | 4 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 16.1701 | 2 | 17 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 9.2117 | 2 | 9 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 33.7102 | 1 | 12 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 14.0958 | 2 | 2 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 26.1216 | 1 | 1 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 0.6310 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3F isoform a | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 38.3152 | 1 | 6 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 11.6909 | 2 | 4 |
| DNA polymerase III, partial | Bacillus subtilis | Potency | 4.7444 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 33.3292 | 2 | 8 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 5.2954 | 1 | 7 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 0.0206 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 9.5818 | 2 | 2 |
| Endothelin receptor type B | Rattus norvegicus (Norway rat) | Potency | 22.3872 | 1 | 1 |
| Endothelin-1 receptor | Rattus norvegicus (Norway rat) | Potency | 22.3872 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 23.2360 | 11 | 71 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 23.1205 | 2 | 12 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 24.5532 | 9 | 65 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 14.5927 | 1 | 22 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 15.5841 | 4 | 16 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 36.8051 | 4 | 10 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 43.6950 | 1 | 7 |
| fructose-bisphosphate aldolase A | Oryctolagus cuniculus (rabbit) | Potency | 22.3872 | 1 | 1 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 5.0468 | 1 | 2 |
| G | Vesicular stomatitis virus | Potency | 9.5340 | 1 | 5 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 16.1523 | 1 | 9 |
| GALC protein | Homo sapiens (human) | Potency | 0.7079 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 16.1523 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 16.1523 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 16.1523 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 16.1523 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 16.1523 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 16.1523 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 16.1523 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 16.1523 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 16.1523 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 16.1523 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 16.1523 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 16.1523 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 16.1523 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 16.1523 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 16.1523 | 1 | 9 |
| geminin | Homo sapiens (human) | Potency | 9.6286 | 4 | 27 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 16.0071 | 3 | 18 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 7.4598 | 1 | 2 |
| GLS protein | Homo sapiens (human) | Potency | 6.6718 | 2 | 9 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 35.5869 | 1 | 4 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 25.4052 | 5 | 19 |
| glucokinase regulatory protein | Homo sapiens (human) | Potency | 8.6438 | 1 | 2 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | Potency | 0.6310 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 14.9109 | 2 | 8 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | Potency | 0.6310 | 1 | 1 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | Potency | 0.6310 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | Potency | 5.7988 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | Potency | 5.7988 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | Potency | 5.7988 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | Potency | 5.7988 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | Potency | 5.7988 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | Potency | 5.7988 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | Potency | 5.7988 | 1 | 1 |
| Glycoprotein hormones alpha chain | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 48.3019 | 2 | 3 |
| guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 43.6303 | 2 | 7 |
| hemoglobin subunit beta | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| hexokinase-4 isoform 1 | Homo sapiens (human) | Potency | 8.6438 | 1 | 2 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 3.5273 | 2 | 24 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 17.7480 | 1 | 10 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 58.2725 | 2 | 15 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 9.5340 | 1 | 5 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 35.4813 | 1 | 2 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 18.9667 | 4 | 8 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 35.9959 | 2 | 5 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 11.2035 | 2 | 10 |
| IDH1 | Homo sapiens (human) | Potency | 11.0134 | 1 | 3 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 141.2540 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 9.5340 | 1 | 10 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 9.1825 | 3 | 13 |
| interleukin 8 | Homo sapiens (human) | Potency | 74.9780 | 1 | 3 |
| isocitrate dehydrogenase 1, partial | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 13.2689 | 1 | 13 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 4.3443 | 1 | 7 |
| lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 34.5592 | 4 | 15 |
| luciferase | Photuris pensylvanica (Pennsylania firefly) | Potency | 18.0789 | 3 | 5 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 13.4574 | 1 | 3 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 19.3285 | 1 | 4 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 16.6069 | 2 | 24 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 37.0814 | 2 | 3 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 15.1861 | 1 | 2 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 12.9244 | 1 | 2 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 10.3938 | 2 | 6 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 2.1154 | 1 | 2 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 0.4467 | 1 | 1 |
| Nrf2 | Homo sapiens (human) | Potency | 29.2278 | 2 | 3 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 27.2837 | 4 | 26 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 7.8222 | 2 | 4 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 13.4670 | 1 | 3 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 37.8678 | 1 | 9 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 0.1934 | 1 | 2 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 14.1915 | 2 | 22 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 18.0575 | 3 | 28 |
| Ornithine decarboxylase | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| P53 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 84.3495 | 1 | 6 |
| Parkin | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 51.6252 | 1 | 2 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 17.2864 | 2 | 9 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 54.7470 | 1 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 18.7458 | 5 | 23 |
| Peroxisome proliferator-activated receptor alpha | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 18.7494 | 4 | 12 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 29.3239 | 1 | 13 |
| PINK1 | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 7.8422 | 1 | 5 |
| polyprotein | Zika virus | Potency | 5.0468 | 1 | 2 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 12.1591 | 1 | 6 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 4.2787 | 1 | 6 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 15.8014 | 1 | 6 |
| PPM1D protein | Homo sapiens (human) | Potency | 9.4095 | 1 | 4 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 37.1865 | 3 | 12 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 50.3175 | 1 | 3 |
| progesterone receptor | Homo sapiens (human) | Potency | 24.3168 | 2 | 13 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 15.5513 | 5 | 5 |
| pyruvate kinase PKM isoform a | Homo sapiens (human) | Potency | 5.1189 | 4 | 4 |
| pyruvate kinase PKM isoform b | Homo sapiens (human) | Potency | 10.0000 | 2 | 2 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 40.8708 | 1 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 16.7177 | 2 | 24 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 0.3162 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 15.3296 | 1 | 5 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 22.2294 | 3 | 27 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 10.8800 | 4 | 29 |
| RGS12 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| runt-related transcription factor 1 isoform AML1b | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 20.0061 | 3 | 4 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 19.3862 | 1 | 4 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Potency | 5.7988 | 1 | 1 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 18.3020 | 2 | 3 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 18.3020 | 2 | 3 |
| Smad3 | Homo sapiens (human) | Potency | 14.9316 | 1 | 4 |
| snurportin-1 | Homo sapiens (human) | Potency | 141.2540 | 1 | 1 |
| Sodium channel protein type 1 subunit alpha | Rattus norvegicus (Norway rat) | Potency | 5.7988 | 1 | 1 |
| Sodium channel protein type 2 subunit alpha | Rattus norvegicus (Norway rat) | Potency | 5.7988 | 1 | 1 |
| Sodium channel protein type 3 subunit alpha | Rattus norvegicus (Norway rat) | Potency | 5.7988 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 22.2818 | 1 | 5 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 6.8894 | 1 | 10 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 6.5356 | 1 | 3 |
| TDP1 protein | Homo sapiens (human) | Potency | 15.3355 | 2 | 51 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 31.1305 | 1 | 3 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 18.7522 | 3 | 11 |
| Thrombopoietin | Homo sapiens (human) | Potency | 17.3926 | 2 | 4 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 27.2411 | 3 | 30 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 21.9793 | 4 | 5 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 26.2382 | 5 | 12 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 3.3786 | 1 | 1 |
| transient receptor potential cation channel subfamily V member 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| tyrosine-protein kinase Yes | Homo sapiens (human) | Potency | 1.7291 | 1 | 1 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 0.6310 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 7.8422 | 1 | 5 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 7.8422 | 1 | 5 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 31.7516 | 2 | 10 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 31.0736 | 2 | 19 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 9.4122 | 4 | 7 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 33.6084 | 1 | 12 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 16.9509 | 1 | 7 |
| Vpr | Human immunodeficiency virus 1 | Potency | 12.5893 | 1 | 1 |
| WRN | Homo sapiens (human) | Potency | 11.5530 | 1 | 2 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a | Homo sapiens (human) | IC50 | 2.2555 | 2 | 2 |
| 1-deoxy-D-xylulose 5-phosphate reductoisomerase | Escherichia coli K-12 | IC50 | 2.2000 | 1 | 1 |
| 14-3-3 protein gamma | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| 17-beta-hydroxysteroid dehydrogenase type 1 | Homo sapiens (human) | IC50 | 5.5000 | 1 | 1 |
| 17-beta-hydroxysteroid dehydrogenase type 2 | Homo sapiens (human) | IC50 | 0.3800 | 1 | 1 |
| 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase | Cavia porcellus (domestic guinea pig) | IC50 | 1.7000 | 1 | 1 |
| 4-aminobutyrate aminotransferase, mitochondrial | Homo sapiens (human) | IC50 | 12,800.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 1.3120 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.8350 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 2.2360 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 1.1710 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 2.2360 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 1.1710 | 1 | 1 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | IC50 | 275.0000 | 1 | 2 |
| 5-lipoxygenase | Bos taurus (cattle) | IC50 | 0.7000 | 2 | 2 |
| 90-kda heat shock protein beta HSP90 beta, partial | Homo sapiens (human) | IC50 | 16.3116 | 2 | 2 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 28.0050 | 2 | 2 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 1,398.8000 | 3 | 3 |
| Acyl-CoA:cholesterol acyltransferase | Oryctolagus cuniculus (rabbit) | IC50 | 55.0000 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | IC50 | 15.4240 | 1 | 2 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 6.1717 | 2 | 3 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 0.4610 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 0.4570 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 15.4240 | 1 | 2 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 8.7175 | 1 | 2 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 15.4240 | 1 | 2 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 8.7175 | 1 | 2 |
| Alpha-synuclein | Homo sapiens (human) | IC50 | 8.6575 | 4 | 4 |
| Alpha-synuclein | Homo sapiens (human) | Ki | 0.5000 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 17.8305 | 1 | 2 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | Ki | 19.0500 | 2 | 2 |
| Amine oxidase [flavin-containing] A | Rattus norvegicus (Norway rat) | Ki | 12.5569 | 3 | 3 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 | 1.0667 | 2 | 6 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | Ki | 2.9340 | 4 | 5 |
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | Ki | 3.8540 | 4 | 5 |
| Androgen receptor | Homo sapiens (human) | IC50 | 32.9333 | 3 | 3 |
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | IC50 | 0.6700 | 1 | 1 |
| Arachidonate 5-lipoxygenase-activating protein | Homo sapiens (human) | IC50 | 0.5800 | 1 | 1 |
| Aromatase | Homo sapiens (human) | IC50 | 0.0110 | 1 | 1 |
| Arrestin, beta 1 | Homo sapiens (human) | IC50 | 1.5240 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 107.5000 | 1 | 4 |
| ATP-binding cassette sub-family C member 8 | Homo sapiens (human) | IC50 | 0.6665 | 1 | 2 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 41.0000 | 1 | 1 |
| ATP-sensitive inward rectifier potassium channel 11 | Homo sapiens (human) | IC50 | 0.6665 | 1 | 2 |
| Aurora kinase B | Homo sapiens (human) | IC50 | 8.1250 | 1 | 2 |
| Bifunctional epoxide hydrolase 2 | Homo sapiens (human) | IC50 | 0.7242 | 5 | 5 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 84.6014 | 7 | 24 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 124.1800 | 2 | 5 |
| C-C chemokine receptor type 1 | Homo sapiens (human) | IC50 | 125.9465 | 1 | 2 |
| C-C chemokine receptor type 2 | Homo sapiens (human) | Ki | 32.6000 | 1 | 1 |
| C-C chemokine receptor type 5 | Homo sapiens (human) | IC50 | 81.7164 | 1 | 2 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Rattus norvegicus (Norway rat) | Ki | 7.9500 | 1 | 1 |
| Cannabinoid receptor 1 | Homo sapiens (human) | IC50 | 24.8570 | 1 | 1 |
| Cannabinoid receptor 1 | Homo sapiens (human) | Ki | 19.6240 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 245.2000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | IC50 | 1.7177 | 1 | 3 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 0.6300 | 1 | 1 |
| Carnitine O-palmitoyltransferase 1, liver isoform | Homo sapiens (human) | IC50 | 10.0000 | 1 | 2 |
| Carnitine O-palmitoyltransferase 2, mitochondrial | Homo sapiens (human) | IC50 | 100.0000 | 1 | 2 |
| Carnitine O-palmitoyltransferase 2, mitochondrial | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 2 |
| Casein kinase II subunit alpha | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Casein kinase II subunit alpha 3 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Casein kinase II subunit alpha' | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Casein kinase II subunit beta | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Caspase-1 | Homo sapiens (human) | IC50 | 7.0200 | 1 | 2 |
| CDGSH iron-sulfur domain-containing protein 1 | Homo sapiens (human) | IC50 | 4.6905 | 1 | 2 |
| CDGSH iron-sulfur domain-containing protein 1 | Rattus norvegicus (Norway rat) | IC50 | 1.0500 | 1 | 2 |
| CDGSH iron-sulfur domain-containing protein 1 | Homo sapiens (human) | Ki | 0.2005 | 1 | 2 |
| CDGSH iron-sulfur domain-containing protein 2 | Homo sapiens (human) | IC50 | 3.5450 | 1 | 2 |
| Chain A, RNA-directed RNA polymerase NS5 | Dengue virus 2 16681-PDK53 | IC50 | 35.0600 | 1 | 1 |
| Cholinesterase | Equus caballus (horse) | IC50 | 10.4740 | 2 | 2 |
| core protein, partial | IC50 | 35.9843 | 3 | 4 | |
| COUP transcription factor 2 isoform a | Homo sapiens (human) | IC50 | 1.3150 | 1 | 1 |
| Cyclin-dependent kinase 1 | Homo sapiens (human) | IC50 | 10.4450 | 1 | 2 |
| Cysteinyl leukotriene receptor 1 | Homo sapiens (human) | IC50 | 0.4200 | 1 | 1 |
| Cysteinyl leukotriene receptor 2 | Homo sapiens (human) | IC50 | 0.4200 | 1 | 1 |
| Cytochrome P450 11B1, mitochondrial | Rattus norvegicus (Norway rat) | IC50 | 40.0000 | 1 | 2 |
| Cytochrome P450 1A1 | Homo sapiens (human) | Ki | 1.2200 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 0.0160 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | Ki | 117.0000 | 1 | 1 |
| Cytochrome P450 1B1 | Homo sapiens (human) | Ki | 0.2600 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 0.8000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 12.6667 | 2 | 3 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 8.1000 | 2 | 2 |
| Death-associated protein kinase 1 | Homo sapiens (human) | IC50 | 120.0000 | 1 | 1 |
| Dehydrogenase/reductase SDR family member 9 | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| Deoxyhypusine hydroxylase | Homo sapiens (human) | IC50 | 5.0000 | 1 | 2 |
| Dipeptidyl peptidase 4 | Homo sapiens (human) | IC50 | 212.5000 | 1 | 2 |
| Endothelial PAS domain-containing protein 1 | Homo sapiens (human) | IC50 | 0.0360 | 1 | 1 |
| Enoyl-[acyl-carrier-protein] reductase [NADH] | Francisella tularensis subsp. tularensis SCHU S4 | IC50 | 79.0000 | 1 | 1 |
| Estrogen receptor 1 | Homo sapiens (human) | IC50 | 22.1937 | 1 | 1 |
| Eukaryotic initiation factor 4A-I | Homo sapiens (human) | IC50 | 0.1390 | 4 | 4 |
| eukaryotic translation initiation factor 4 gamma 1 isoform 4 | Homo sapiens (human) | IC50 | 1.1500 | 1 | 1 |
| eukaryotic translation initiation factor 4E isoform 1 | Mus musculus (house mouse) | IC50 | 1.1500 | 1 | 1 |
| Forkhead box protein M1 | Homo sapiens (human) | IC50 | 122.4000 | 1 | 1 |
| Forkhead box protein M1 | Homo sapiens (human) | Ki | 0.0520 | 1 | 1 |
| Fructose-1,6-bisphosphatase 1 | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| G protein-coupled receptor kinase 6 | Homo sapiens (human) | IC50 | 8.7000 | 1 | 1 |
| G-protein coupled receptor 35 | Homo sapiens (human) | IC50 | 28.2000 | 1 | 1 |
| G2/mitotic-specific cyclin-B1 | Homo sapiens (human) | IC50 | 10.4450 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | Ki | 41.6241 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens (human) | Ki | 41.6241 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | Ki | 41.6241 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Homo sapiens (human) | Ki | 41.6241 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | Ki | 41.6241 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Homo sapiens (human) | Ki | 41.6241 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens (human) | Ki | 41.6241 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens (human) | Ki | 41.6241 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | Ki | 41.6241 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Homo sapiens (human) | Ki | 41.6241 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Homo sapiens (human) | Ki | 41.6241 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Homo sapiens (human) | Ki | 41.6241 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | Ki | 41.6241 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Homo sapiens (human) | Ki | 41.6241 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Homo sapiens (human) | Ki | 41.6241 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit theta | Homo sapiens (human) | Ki | 41.6241 | 1 | 2 |
| Gamma-butyrobetaine dioxygenase | Homo sapiens (human) | IC50 | 0.7420 | 5 | 5 |
| Glucocorticoid receptor | Homo sapiens (human) | IC50 | 19.0000 | 1 | 1 |
| Glucose transporter | Leishmania mexicana | IC50 | 0.2420 | 1 | 1 |
| glucose-6-phosphate 1-dehydrogenase isoform b | Homo sapiens (human) | IC50 | 46.6000 | 1 | 2 |
| glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | Plasmodium berghei | IC50 | 32.9600 | 3 | 6 |
| heat shock protein HSP 90-alpha isoform 2 | Homo sapiens (human) | IC50 | 16.3116 | 2 | 2 |
| hexokinase | Trypanosoma brucei brucei TREU927 | IC50 | 0.9009 | 1 | 1 |
| Hexose transporter 1 | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 0.3100 | 1 | 1 |
| Histone deacetylase 1 | Homo sapiens (human) | IC50 | 3,160.0000 | 1 | 1 |
| Histone deacetylase 11 | Homo sapiens (human) | IC50 | 3,160.0000 | 1 | 1 |
| Histone deacetylase 2 | Homo sapiens (human) | IC50 | 3,160.0000 | 1 | 1 |
| Histone deacetylase 3 | Homo sapiens (human) | IC50 | 3,160.0000 | 1 | 1 |
| Histone deacetylase 4 | Homo sapiens (human) | IC50 | 3,160.0000 | 1 | 1 |
| Histone deacetylase 5 | Homo sapiens (human) | IC50 | 1,581.7000 | 2 | 2 |
| Histone deacetylase 6 | Homo sapiens (human) | IC50 | 794.9000 | 4 | 4 |
| Histone deacetylase 7 | Homo sapiens (human) | IC50 | 3,160.0000 | 1 | 1 |
| Histone deacetylase 8 | Homo sapiens (human) | IC50 | 3,160.0000 | 1 | 1 |
| Histone deacetylase 9 | Homo sapiens (human) | IC50 | 1,581.8500 | 2 | 2 |
| Histone-lysine N-methyltransferase EHMT1 | Homo sapiens (human) | IC50 | 0.7300 | 1 | 1 |
| Histone-lysine N-methyltransferase EHMT2 | Homo sapiens (human) | IC50 | 0.4000 | 1 | 1 |
| Hypoxia-inducible factor 1-alpha | Homo sapiens (human) | IC50 | 0.0360 | 1 | 1 |
| Indoleamine 2,3-dioxygenase 1 | Mus musculus (house mouse) | IC50 | 61.0000 | 1 | 1 |
| Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) | Ki | 0.0940 | 3 | 3 |
| Indoleamine 2,3-dioxygenase 2 | Mus musculus (house mouse) | IC50 | 4.5000 | 1 | 1 |
| Insulin-degrading enzyme | Homo sapiens (human) | IC50 | 33.3520 | 3 | 3 |
| Insulin-like growth factor 1 receptor | Homo sapiens (human) | IC50 | 0.9000 | 1 | 1 |
| Integrase | Human immunodeficiency virus 1 | IC50 | 3.2960 | 5 | 5 |
| Lactoylglutathione lyase | Homo sapiens (human) | IC50 | 11.0000 | 1 | 1 |
| large T antigen | Betapolyomavirus macacae | IC50 | 17.8850 | 1 | 2 |
| Leukotriene A-4 hydrolase | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Leukotriene B4 receptor 1 | Homo sapiens (human) | IC50 | 0.2525 | 2 | 2 |
| Linoleate 9S-lipoxygenase-4 | Glycine max (soybean) | IC50 | 22.0000 | 1 | 1 |
| Lipoxygenase | Glycine max (soybean) | IC50 | 23.3460 | 5 | 5 |
| Lipoxygenase | Solanum tuberosum (potato) | IC50 | 10.0000 | 1 | 1 |
| Lysine-specific demethylase 4A | Homo sapiens (human) | IC50 | 3.2750 | 2 | 2 |
| Lysine-specific demethylase 4E | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Lysine-specific demethylase 4E | Homo sapiens (human) | Ki | 4.3300 | 1 | 1 |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | IC50 | 5.5175 | 3 | 4 |
| Lysosomal alpha-glucosidase | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| M17 leucyl aminopeptidase | Plasmodium falciparum 3D7 | IC50 | 53.4500 | 1 | 1 |
| Macrophage migration inhibitory factor | Homo sapiens (human) | IC50 | 2.4000 | 1 | 1 |
| Macrophage migration inhibitory factor | Homo sapiens (human) | Ki | 0.5700 | 2 | 2 |
| Methionine aminopeptidase 2 | Homo sapiens (human) | IC50 | 2.4300 | 1 | 1 |
| Methylcytosine dioxygenase TET2 | Homo sapiens (human) | IC50 | 46.0000 | 1 | 1 |
| Mitogen-activated protein kinase 1 | Homo sapiens (human) | IC50 | 1.2380 | 1 | 1 |
| MPI protein | Homo sapiens (human) | IC50 | 0.2905 | 2 | 2 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.0380 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 66.1250 | 1 | 4 |
| NAD-dependent protein deacetylase | Schistosoma mansoni | IC50 | 1.9000 | 1 | 1 |
| NAD-dependent protein deacetylase sirtuin-2 | Homo sapiens (human) | IC50 | 15.4000 | 1 | 1 |
| NADPH oxidase 1 | Homo sapiens (human) | IC50 | 0.3588 | 2 | 2 |
| neutrophil cytosol factor 1 | Homo sapiens (human) | IC50 | 0.3900 | 1 | 1 |
| Neutrophil cytosol factor 1 | Homo sapiens (human) | Ki | 125.0000 | 3 | 3 |
| P2X purinoceptor 3 | Homo sapiens (human) | IC50 | 0.7550 | 1 | 1 |
| Peptidyl-prolyl cis-trans isomerase FKBP14 | Homo sapiens (human) | Ki | 76.2000 | 1 | 1 |
| Peptidyl-prolyl cis-trans isomerase FKBP1A | Homo sapiens (human) | IC50 | 3.6000 | 1 | 1 |
| Peptidyl-prolyl cis-trans isomerase FKBP1A | Homo sapiens (human) | Ki | 3.4000 | 1 | 1 |
| Peptidyl-prolyl cis-trans isomerase FKBP3 | Homo sapiens (human) | Ki | 124.0000 | 1 | 1 |
| Peptidyl-prolyl cis-trans isomerase FKBP4 | Homo sapiens (human) | Ki | 24.2000 | 1 | 1 |
| Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Ki | 200.0000 | 1 | 1 |
| Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 | Homo sapiens (human) | Ki | 187.0000 | 1 | 1 |
| perilipin-1 | Homo sapiens (human) | IC50 | 3.4100 | 1 | 1 |
| perilipin-5 | Homo sapiens (human) | IC50 | 1.1010 | 1 | 1 |
| Peroxisome proliferator-activated receptor alpha | Homo sapiens (human) | IC50 | 25.5266 | 18 | 19 |
| Peroxisome proliferator-activated receptor alpha | Mus musculus (house mouse) | IC50 | 0.6150 | 1 | 2 |
| Peroxisome proliferator-activated receptor alpha | Homo sapiens (human) | Ki | 33.3000 | 1 | 1 |
| Peroxisome proliferator-activated receptor delta | Homo sapiens (human) | IC50 | 32.0010 | 5 | 5 |
| Peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Ki | 33.3000 | 1 | 1 |
| Peroxisome proliferator-activated receptor gamma | Homo sapiens (human) | IC50 | 1.3583 | 52 | 61 |
| Peroxisome proliferator-activated receptor gamma | Mus musculus (house mouse) | IC50 | 0.7000 | 1 | 1 |
| Peroxisome proliferator-activated receptor gamma | Rattus norvegicus (Norway rat) | IC50 | 0.7000 | 1 | 1 |
| Peroxisome proliferator-activated receptor gamma | Homo sapiens (human) | Ki | 0.2588 | 25 | 30 |
| phosphoethanolamine/phosphocholine phosphatase isoform 1 | Homo sapiens (human) | IC50 | 0.1110 | 1 | 1 |
| phosphomannomutase 2 | Homo sapiens (human) | IC50 | 0.6720 | 1 | 1 |
| Pleiotropic ABC efflux transporter of multiple drugs | Saccharomyces cerevisiae S288C | IC50 | 400.0000 | 1 | 1 |
| Polyamine deacetylase HDAC10 | Homo sapiens (human) | IC50 | 3,160.0000 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 200.0000 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | IC50 | 5.2867 | 86 | 91 |
| Polyunsaturated fatty acid 5-lipoxygenase | Mus musculus (house mouse) | IC50 | 0.2073 | 3 | 3 |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | IC50 | 1.4779 | 27 | 31 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | Ki | 24.2000 | 1 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | IC50 | 20.5955 | 7 | 11 |
| Polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Ki | 1.6000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Homo sapiens (human) | IC50 | 12.6921 | 10 | 14 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 2.6986 | 4 | 5 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Homo sapiens (human) | Ki | 2.7400 | 3 | 3 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | IC50 | 42.4722 | 4 | 9 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Rattus norvegicus (Norway rat) | IC50 | 0.2600 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 29.5000 | 1 | 1 |
| Procathepsin L | Homo sapiens (human) | IC50 | 0.6700 | 1 | 1 |
| Progesterone receptor | Homo sapiens (human) | IC50 | 15.0000 | 1 | 1 |
| Prolyl endopeptidase | Homo sapiens (human) | IC50 | 20.1000 | 2 | 3 |
| Prostaglandin E synthase | Homo sapiens (human) | IC50 | 0.6000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 | 3.4420 | 3 | 3 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | IC50 | 150.0000 | 1 | 2 |
| Prostaglandin G/H synthase 1 | Bos taurus (cattle) | IC50 | 22.0333 | 3 | 3 |
| Prostaglandin G/H synthase 1 | Rattus norvegicus (Norway rat) | IC50 | 26.2580 | 3 | 5 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 53.3974 | 6 | 7 |
| Prostaglandin G/H synthase 2 | Bos taurus (cattle) | IC50 | 14.0000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Rattus norvegicus (Norway rat) | IC50 | 26.2580 | 3 | 5 |
| Protein farnesyltransferase subunit beta | Homo sapiens (human) | IC50 | 100,000.0000 | 1 | 1 |
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Homo sapiens (human) | IC50 | 100,000.0000 | 1 | 1 |
| Proto-oncogene c-Fos | Homo sapiens (human) | IC50 | 0.0079 | 1 | 1 |
| rac GTPase-activating protein 1 isoform a | Homo sapiens (human) | IC50 | 18.5000 | 1 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Receptor-type tyrosine-protein phosphatase S | Homo sapiens (human) | IC50 | 10.3000 | 1 | 1 |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | IC50 | 0.6700 | 1 | 1 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | IC50 | 7.6675 | 2 | 4 |
| Replicase polyprotein 1ab | Human coronavirus 229E | IC50 | 0.6700 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 1.9314 | 19 | 30 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 1.8420 | 2 | 5 |
| RNA polymerase beta subunit (EC 2.7.7.6), partial | Escherichia coli | IC50 | 12.0617 | 1 | 2 |
| Seed linoleate 13S-lipoxygenase-1 | Glycine max (soybean) | IC50 | 13.1350 | 8 | 8 |
| Seed linoleate 9S-lipoxygenase | Glycine max (soybean) | IC50 | 400.0000 | 1 | 1 |
| Serine/threonine-protein kinase PLK1 | Homo sapiens (human) | IC50 | 6.3050 | 2 | 2 |
| Serine/threonine-protein kinase PLK2 | Homo sapiens (human) | IC50 | 314.0000 | 1 | 1 |
| Serine/threonine-protein kinase PLK3 | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Sialidase-2 | Homo sapiens (human) | IC50 | 130.0000 | 1 | 1 |
| Sodium- and chloride-dependent betaine transporter | Rattus norvegicus (Norway rat) | IC50 | 40.0000 | 1 | 2 |
| Sodium- and chloride-dependent GABA transporter 1 | Rattus norvegicus (Norway rat) | IC50 | 40.0000 | 1 | 2 |
| Sodium- and chloride-dependent GABA transporter 2 | Rattus norvegicus (Norway rat) | IC50 | 40.0000 | 1 | 2 |
| Sodium- and chloride-dependent GABA transporter 3 | Rattus norvegicus (Norway rat) | IC50 | 40.0000 | 1 | 2 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 18.6360 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 14.8070 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 0.4610 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 0.4570 | 1 | 1 |
| Sodium/bile acid cotransporter | Homo sapiens (human) | IC50 | 5.1000 | 1 | 1 |
| Solute carrier family 2, facilitated glucose transporter member 1 | Homo sapiens (human) | IC50 | 0.2280 | 1 | 1 |
| Solute carrier family 22 member 6 | Rattus norvegicus (Norway rat) | Ki | 2,000.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | IC50 | 0.6166 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | Ki | 0.3400 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | IC50 | 2.9512 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | Ki | 2.2600 | 1 | 1 |
| Spike glycoprotein | Betacoronavirus England 1 | IC50 | 0.6700 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | IC50 | 0.6700 | 1 | 1 |
| Steryl-sulfatase | Homo sapiens (human) | IC50 | 0.8000 | 1 | 1 |
| Structural capsid protein | Human immunodeficiency virus 1 | IC50 | 0.0467 | 1 | 1 |
| Sucrase-isomaltase, intestinal | Homo sapiens (human) | IC50 | 43.5000 | 2 | 2 |
| Sucrase-isomaltase, intestinal | Rattus norvegicus (Norway rat) | IC50 | 156.0000 | 2 | 2 |
| Sulfhydryl oxidase 1 | Homo sapiens (human) | IC50 | 5.4000 | 1 | 1 |
| Testosterone 17-beta-dehydrogenase 3 | Homo sapiens (human) | IC50 | 97.6100 | 2 | 2 |
| Thromboxane-A synthase | Rattus norvegicus (Norway rat) | IC50 | 20.0000 | 1 | 1 |
| Thromboxane-A synthase | Homo sapiens (human) | IC50 | 3.2630 | 1 | 2 |
| Toxin B | Clostridioides difficile | IC50 | 0.0172 | 1 | 1 |
| TPA: protein transporter TIM10 | Saccharomyces cerevisiae S288C | IC50 | 5.2900 | 2 | 2 |
| TPA: protein transporter TIM23 | Saccharomyces cerevisiae S288C | IC50 | 0.8800 | 1 | 1 |
| transactivating tegument protein VP16 [Human herpesvirus 1] | Human alphaherpesvirus 1 (Herpes simplex virus type 1) | IC50 | 85.4210 | 1 | 1 |
| Transcription factor AP-1 | Homo sapiens (human) | IC50 | 0.0079 | 1 | 1 |
| Transmembrane prolyl 4-hydroxylase | Homo sapiens (human) | IC50 | 34.2000 | 1 | 1 |
| Transmembrane protease serine 2 | Homo sapiens (human) | IC50 | 0.6700 | 1 | 1 |
| Trypsin-1 | Homo sapiens (human) | IC50 | 501.8500 | 1 | 2 |
| Trypsin-2 | Homo sapiens (human) | IC50 | 501.8500 | 1 | 2 |
| Trypsin-3 | Homo sapiens (human) | IC50 | 501.8500 | 1 | 2 |
| Tubulin alpha-1A chain | Sus scrofa (pig) | IC50 | 10.0000 | 1 | 1 |
| Tubulin beta chain | Sus scrofa (pig) | IC50 | 10.0000 | 1 | 1 |
| Tumor necrosis factor ligand superfamily member 11 | Mus musculus (house mouse) | IC50 | 20.0000 | 1 | 1 |
| Tyrosine-protein kinase Yes | Homo sapiens (human) | IC50 | 3.3000 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 176.2500 | 2 | 4 |
| UDP-glucose 4-epimerase | Homo sapiens (human) | IC50 | 0.0140 | 1 | 1 |
| UDP-glucuronosyltransferase 1-6 | Homo sapiens (human) | Ki | 20.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 1A1 | Homo sapiens (human) | IC50 | 5.7000 | 2 | 2 |
| Urease subunit alpha | Helicobacter pylori 26695 | IC50 | 82.5780 | 5 | 5 |
| Urease subunit alpha | Helicobacter pylori 26695 | Ki | 0.2260 | 1 | 1 |
| Urease subunit beta | Helicobacter pylori 26695 | IC50 | 82.5780 | 5 | 5 |
| Urease subunit beta | Helicobacter pylori 26695 | Ki | 0.2260 | 1 | 1 |
| V-type proton ATPase subunit S1 | Homo sapiens (human) | IC50 | 0.1000 | 1 | 1 |
| Vacuolar proton pump subunit B | Gallus gallus (chicken) | IC50 | 0.0300 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | IC50 | 37.4000 | 2 | 2 |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | IC50 | 501.3950 | 2 | 2 |
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | EC50 | 1.6330 | 1 | 3 |
| C-C chemokine receptor type 1 | Homo sapiens (human) | EC50 | 32.8114 | 1 | 2 |
| C-C chemokine receptor type 5 | Homo sapiens (human) | EC50 | 19.4763 | 1 | 2 |
| C-C chemokine receptor type 8 | Homo sapiens (human) | EC50 | 40.9054 | 1 | 2 |
| calcineurin A1, putative | Candida dubliniensis CD36 | EC50 | 180.0000 | 1 | 1 |
| Cannabinoid receptor 2 | Mus musculus (house mouse) | EC50 | 0.0330 | 1 | 1 |
| Catechol O-methyltransferase | Rattus norvegicus (Norway rat) | EC50 | 0.2200 | 1 | 3 |
| Cytochrome P450 2C9 | Homo sapiens (human) | EC50 | 0.0110 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | EC50 | 0.0110 | 1 | 1 |
| Cytochrome P450 3A5 | Homo sapiens (human) | EC50 | 0.0110 | 1 | 1 |
| Free fatty acid receptor 1 | Homo sapiens (human) | EC50 | 412.1562 | 1 | 2 |
| G-protein coupled receptor 35 | Homo sapiens (human) | EC50 | 16.5000 | 2 | 2 |
| Gamma-butyrobetaine dioxygenase | Homo sapiens (human) | Kd | 4.1000 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 1 | Homo sapiens (human) | EC50 | 0.0210 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | EC50 | 0.0210 | 1 | 2 |
| Glutamate receptor ionotropic, NMDA 2A | Homo sapiens (human) | EC50 | 0.0210 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Homo sapiens (human) | EC50 | 0.0210 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Homo sapiens (human) | EC50 | 0.0210 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Homo sapiens (human) | EC50 | 0.0210 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Homo sapiens (human) | EC50 | 0.0210 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Homo sapiens (human) | EC50 | 0.0210 | 1 | 1 |
| heat shock protein 90 | Candida albicans | EC50 | 112.6818 | 3 | 4 |
| hexokinase HKDC1 | Homo sapiens (human) | EC50 | 38.8000 | 1 | 1 |
| hexokinase-1 isoform HKI | Homo sapiens (human) | EC50 | 41.9000 | 1 | 1 |
| Hsf1 protein | Mus musculus (house mouse) | EC50 | 2.3190 | 1 | 1 |
| Hypoxia-inducible factor 1-alpha | Homo sapiens (human) | EC50 | 17.8000 | 1 | 1 |
| Leukotriene B4 receptor 1 | Homo sapiens (human) | EC50 | 0.4700 | 1 | 1 |
| Leukotriene B4 receptor 2 | Homo sapiens (human) | EC50 | 0.4700 | 1 | 1 |
| Methionine aminopeptidase 1 | Homo sapiens (human) | EC50 | 66.7733 | 3 | 3 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | EC50 | 1.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | EC50 | 0.4687 | 1 | 6 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | EC50 | 0.4687 | 1 | 6 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | EC50 | 0.4687 | 1 | 6 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | EC50 | 0.4687 | 1 | 6 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | EC50 | 0.4687 | 1 | 6 |
| Nuclear receptor subfamily 1 group I member 2 | Homo sapiens (human) | EC50 | 15.8833 | 3 | 6 |
| Peroxisome proliferator-activated receptor alpha | Homo sapiens (human) | EC50 | 6.7705 | 41 | 43 |
| Peroxisome proliferator-activated receptor alpha | Mus musculus (house mouse) | EC50 | 3.0000 | 1 | 1 |
| Peroxisome proliferator-activated receptor delta | Homo sapiens (human) | EC50 | 6.1110 | 10 | 10 |
| Peroxisome proliferator-activated receptor gamma | Homo sapiens (human) | EC50 | 51.4692 | 185 | 202 |
| Peroxisome proliferator-activated receptor gamma | Mus musculus (house mouse) | EC50 | 0.4551 | 4 | 7 |
| Peroxisome proliferator-activated receptor gamma | Homo sapiens (human) | Kd | 1.1677 | 8 | 8 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | EC50 | 0.4700 | 1 | 1 |
| POsterior Segregation | Caenorhabditis elegans | EC50 | 26.1110 | 1 | 1 |
| Procathepsin L | Homo sapiens (human) | EC50 | 1.6330 | 1 | 3 |
| regulator of G-protein signaling 16 | Homo sapiens (human) | EC50 | 1.8500 | 1 | 1 |
| regulator of G-protein signaling 19 | Homo sapiens (human) | EC50 | 4.0900 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | EC50 | 1.5700 | 1 | 1 |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | EC50 | 1.6330 | 1 | 3 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | EC50 | 1.6330 | 1 | 3 |
| Replicase polyprotein 1ab | Human coronavirus 229E | EC50 | 1.6330 | 1 | 3 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | EC50 | 3.4956 | 3 | 7 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | EC50 | 2.5018 | 2 | 5 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | Kd | 15.8200 | 3 | 5 |
| RGS7, partial | Homo sapiens (human) | EC50 | 1.2400 | 1 | 1 |
| RPL19A | Saccharomyces cerevisiae (brewer's yeast) | EC50 | 0.7570 | 2 | 2 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | EC50 | 8.7550 | 1 | 1 |
| Spike glycoprotein | Betacoronavirus England 1 | EC50 | 1.6330 | 1 | 3 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | EC50 | 1.6330 | 1 | 3 |
| streptokinase A precursor | Streptococcus pyogenes M1 GAS | EC50 | 1.5190 | 1 | 1 |
| Thrombin | Oryctolagus cuniculus (rabbit) | EC50 | 0.0110 | 1 | 1 |
| Transient receptor potential cation channel subfamily A member 1 | Homo sapiens (human) | EC50 | 25.1271 | 2 | 3 |
| Transmembrane protease serine 2 | Homo sapiens (human) | EC50 | 1.6330 | 1 | 3 |
| Transthyretin | Homo sapiens (human) | EC50 | 9.4667 | 3 | 3 |
| Zinc finger protein mex-5 | Caenorhabditis elegans | EC50 | 8.7550 | 1 | 1 |
Other Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Androgen receptor | Homo sapiens (human) | EC150 | 18.9000 | 1 | 1 |
| Cyclic AMP-responsive element-binding protein 1 | Homo sapiens (human) | AC50 | 13.5000 | 1 | 1 |
| dual specificity tyrosine-phosphorylation-regulated kinase 1A | Rattus norvegicus (Norway rat) | AC50 | 14.5280 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | EC150 | 18.9000 | 1 | 1 |
| H3 histone acetyltransferase | Candida albicans SC5314 | AC50 | 1.5500 | 1 | 1 |
| heat shock protein 90, putative | Plasmodium falciparum 3D7 | AC50 | 0.1950 | 1 | 1 |
| heat shock protein HSP 90-alpha isoform 2 | Homo sapiens (human) | AC50 | 0.1950 | 1 | 1 |
| hypothetical protein CAALFM_CR05890CA | Candida albicans SC5314 | AC50 | 1.5500 | 1 | 1 |
| Peroxisome proliferator-activated receptor alpha | Homo sapiens (human) | Fold activation | 1.1200 | 1 | 1 |
| Peroxisome proliferator-activated receptor gamma | Homo sapiens (human) | Activity | 1.6475 | 4 | 4 |
| Peroxisome proliferator-activated receptor gamma | Homo sapiens (human) | Fold activation | 3.1600 | 1 | 1 |
| Pleiotropic ABC efflux transporter of multiple drugs | Saccharomyces cerevisiae S288C | INH | 433.0000 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | Change | 0.3500 | 2 | 2 |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | ID50 | 0.1400 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Rattus norvegicus (Norway rat) | Change | 16.0000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Bos taurus (cattle) | ID50 | 750.0000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Rattus norvegicus (Norway rat) | Change | 16.0000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Bos taurus (cattle) | ID50 | 750.0000 | 1 | 1 |
| Snq2p | Saccharomyces cerevisiae EC1118 | INH | 90.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 1A1 | Homo sapiens (human) | Km | 58.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 1A10 | Homo sapiens (human) | Km | 11.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 1A4 | Homo sapiens (human) | Km | 240.0000 | 1 | 1 |