Roles > tolerogen
Page last updated: 2024-08-05 15:33:39

tolerogen

A substance that invokes a specific immune non-responsiveness due to its molecular form. If its molecular form is changed, a tolerogen can become an immunogen.

ChEBI ID: 73623

Members (1)

MemberDefinitionClass
2,4-dinitrothiocyanatobenzeneA thiocyanate compound having a 2,4-dinitrophenyl group attached to the sulfur atom.2,4-dinitro-1-thiocyanatobenzene

Research

Studies (45)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-199010 (22.22)18.7374
1990's10 (22.22)18.2507
2000's16 (35.56)29.6817
2010's6 (13.33)24.3611
2020's3 (6.67)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other47 (100.00%)84.16%

Protein Targets (38)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
acetylcholinesteraseHomo sapiens (human)Potency37.744622
activating transcription factor 6Homo sapiens (human)Potency23.634622
AR proteinHomo sapiens (human)Potency45.066488
Ataxin-2Homo sapiens (human)Potency68.589611
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency68.589611
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency27.306011
caspase-3Homo sapiens (human)Potency27.306011
Cellular tumor antigen p53Homo sapiens (human)Potency43.626022
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency27.306011
estrogen nuclear receptor alphaHomo sapiens (human)Potency64.68091010
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency24.336511
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency37.931866
farnesoid X nuclear receptorHomo sapiens (human)Potency29.248433
GLI family zinc finger 3Homo sapiens (human)Potency5.313422
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency57.418633
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency68.589611
heat shock protein beta-1Homo sapiens (human)Potency16.647222
histone deacetylase 9 isoform 3Homo sapiens (human)Potency32.938422
Histone H2A.xCricetulus griseus (Chinese hamster)Potency18.440622
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency14.168022
LuciferasePhotinus pyralis (common eastern firefly)Potency44.785311
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency17.228922
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency24.739122
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency17.599733
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency58.292922
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency30.907933
pregnane X nuclear receptorHomo sapiens (human)Potency1.933111
progesterone receptorHomo sapiens (human)Potency16.080922
RAR-related orphan receptor gammaMus musculus (house mouse)Potency12.490722
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency19.984733
retinoid X nuclear receptor alphaHomo sapiens (human)Potency4.700422
SMAD family member 2Homo sapiens (human)Potency54.941011
SMAD family member 3Homo sapiens (human)Potency54.941011
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency10.567633
thyroid stimulating hormone receptorHomo sapiens (human)Potency37.290744
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency14.168022
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency17.373911
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency68.589611
chemdatabank.com