A substance that invokes a specific immune non-responsiveness due to its molecular form. If its molecular form is changed, a tolerogen can become an immunogen.
ChEBI ID: 73623
| Member | Definition | Class |
|---|---|---|
| 2,4-dinitrothiocyanatobenzene | A thiocyanate compound having a 2,4-dinitrophenyl group attached to the sulfur atom. | 2,4-dinitro-1-thiocyanatobenzene |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 10 (22.22) | 18.7374 |
| 1990's | 10 (22.22) | 18.2507 |
| 2000's | 16 (35.56) | 29.6817 |
| 2010's | 6 (13.33) | 24.3611 |
| 2020's | 3 (6.67) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 47 (100.00%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 37.7446 | 2 | 2 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 23.6346 | 2 | 2 |
| AR protein | Homo sapiens (human) | Potency | 45.0664 | 8 | 8 |
| Ataxin-2 | Homo sapiens (human) | Potency | 68.5896 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 68.5896 | 1 | 1 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 27.3060 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 27.3060 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 43.6260 | 2 | 2 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 27.3060 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 64.6809 | 10 | 10 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 24.3365 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 37.9318 | 6 | 6 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 29.2484 | 3 | 3 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 5.3134 | 2 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 57.4186 | 3 | 3 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 68.5896 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 16.6472 | 2 | 2 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 32.9384 | 2 | 2 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 18.4406 | 2 | 2 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 14.1680 | 2 | 2 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 44.7853 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 17.2289 | 2 | 2 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 24.7391 | 2 | 2 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 17.5997 | 3 | 3 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 58.2929 | 2 | 2 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 30.9079 | 3 | 3 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 1.9331 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 16.0809 | 2 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 12.4907 | 2 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 19.9847 | 3 | 3 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 4.7004 | 2 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 54.9410 | 1 | 1 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 54.9410 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 10.5676 | 3 | 3 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 37.2907 | 4 | 4 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 14.1680 | 2 | 2 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 17.3739 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 68.5896 | 1 | 1 |